CTGF/CCN2 activates canonical Wnt signalling in mesangial cells through LRP6: Implications for the pathogenesis of diabetic nephropathy

FEBS Letters

Volumn 585, Issue 3, 2011, Pages 531-538

  Rooney, Brian ^a   O'Donovan, Helen ^a   Gaffney, Andrew ^a   Browne, Marie ^a   Faherty, Noel ^a   Curran, Simon P ^a   Sadlier, Denise ^a   Godson, Catherine ^a   Brazil, Derek P ^b   Crean, John ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Catenin; Connective tissue growth factor; Diabetic nephropathy; Glycogen synthase kinase 3 ; LRP6; Wnt

Indexed keywords

BETA CATENIN; CONNECTIVE TISSUE GROWTH FACTOR; CYCLIN D1; DICKKOPF 1 PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; MYC PROTEIN; PROTEIN TYROSINE KINASE A; SERINE; SMALL INTERFERING RNA; TYROSINE; WNT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL FRACTIONATION; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DISEASE COURSE; HUMAN; HUMAN CELL; HYPERGLYCEMIA; HYPERTENSION; IMMUNOCYTOCHEMISTRY; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MESANGIUM CELL; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALS; BETA CATENIN; CELLS, CULTURED; CONNECTIVE TISSUE GROWTH FACTOR; DIABETES MELLITUS, TYPE 1; DIABETIC NEPHROPATHIES; GLYCOGEN SYNTHASE KINASE 3; HUMANS; HYPERGLYCEMIA; HYPERTENSION; KIDNEY CORTEX; LDL-RECEPTOR RELATED PROTEINS; MALE; MESANGIAL CELLS; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; PROTEIN TRANSPORT; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; URETERAL OBSTRUCTION; WNT PROTEINS;

MUS;

EID: 79551483244     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.01.004     Document Type: Article

References (31)

1. M. Murphy, J. Crean, D.P. Brazil, D. Sadlier, F. Martin, and C. Godson Regulation and consequences of differential gene expression in diabetic kidney disease Biochem. Soc. Trans. 36 Pt. 5 2008 941 945
2. N. Schor, I. Ichikawa, H.G. Rennke, J.L. Troy, and B.M. Brenner Pathophysiology of altered glomerular function in aminoglycoside-treated rats Kidney Int. 19 2 1981 288 296
3. S.H. Ayo, R.A. Radnik, J.A. Garoni, W.F. Glass II, and J.I. Kreisberg High glucose causes an increase in extracellular matrix proteins in cultured mesangial cells Am. J. Pathol. 136 6 1990 1339 1348
4. M. Essawy, O. Soylemezoglu, E.C. Muchaneta-Kubara, J. Shortland, C.B. Brown, and A.M. El Nahas Myofibroblasts and the progression of diabetic nephropathy Nephrol. Dial. Transplant. 12 1 1997 43 50
5. K. Sharma, and F.N. Ziyadeh Renal hypertrophy is associated with upregulation of TGF-beta 1 gene expression in diabetic BB rat and NOD mouse Am. J. Physiol. 267 6 Pt. 2 1994 F1094 F1101
6. S. Silbiger, S. Crowley, Z. Shan, M. Brownlee, J. Satriano, and D. Schlondorff Nonenzymatic glycation of mesangial matrix and prolonged exposure of mesangial matrix to elevated glucose reduces collagen synthesis and proteoglycan charge Kidney Int. 43 4 1993 853 864
7. B.L. Riser, P. Cortes, J. Yee, A.K. Sharba, K. Asano, and A. Rodriguez-Barbero Mechanical strain- and high glucose-induced alterations in mesangial cell collagen metabolism: role of TGF-beta J. Am. Soc. Nephrol. 9 5 1998 827 836
8. C.L. Lin, J.Y. Wang, Y.T. Huang, Y.H. Kuo, K. Surendran, and F.S. Wang Wnt/beta-catenin signaling modulates survival of high glucose-stressed mesangial cells J. Am. Soc. Nephrol. 17 10 2006 2812 2820
9. C.L. Lin, J.Y. Wang, J.Y. Ko, Y.T. Huang, Y.H. Kuo, and F.S. Wang Dickkopf-1 promotes hyperglycemia-induced accumulation of mesangial matrix and renal dysfunction J. Am. Soc. Nephrol. 21 1 2010 124 135
10. C. Dai, D.B. Stolz, L.P. Kiss, S.P. Monga, L.B. Holzman, and Y. Liu Wnt/beta-catenin signaling promotes podocyte dysfunction and albuminuria J. Am. Soc. Nephrol. 20 9 2009 1997 2008
11. K. Kim, Z. Lu, and E.D. Hay Direct evidence for a role of beta-catenin/LEF-1 signaling pathway in induction of EMT Cell Biol. Int. 26 5 2002 463 476
12. I. Hwang, E.Y. Seo, and H. Ha Wnt/beta-catenin signaling: a novel target for therapeutic intervention of fibrotic kidney disease Arch Pharm. Res. 32 12 2009 1653 1662
13. A. Smerdel-Ramoya, S. Zanotti, V. Deregowski, and E. Canalis Connective tissue growth factor enhances osteoblastogenesis in vitro J. Biol. Chem. 283 33 2008 22690 22699
14. B. Zhang, K.K. Zhou, and J.X. Ma Inhibition of CTGF over-expression in diabetic retinopathy by SERPINA3K via blocking the WNT/beta-catenin pathway Diabetes 2010
15. S. Mercurio, B. Latinkic, N. Itasaki, R. Krumlauf, and J.C. Smith Connective-tissue growth factor modulates WNT signalling and interacts with the WNT receptor complex Development 131 9 2004 2137 2147
16. Q. Luo, Q. Kang, W. Si, W. Jiang, J.K. Park, and Y. Peng Connective tissue growth factor (CTGF) is regulated by Wnt and bone morphogenetic proteins signaling in osteoblast differentiation of mesenchymal stem cells J. Biol. Chem. 279 53 2004 55958 55968
17. S. Chen, and A. Leask Wnt 10b activates the CCN2 promoter in NIH 3T3 fibroblasts through the Smad response element J. Cell Commun. Signal. 3 1 2009 57 59
18. S. Chen, S. McLean, D.E. Carter, and A. Leask The gene expression profile induced by Wnt 3a in NIH 3T3 fibroblasts J. Cell Commun. Signal. 1 3-4 2007 175 183
19. A. Smerdel-Ramoya, S. Zanotti, L. Stadmeyer, D. Durant, and E. Canalis Skeletal overexpression of connective tissue growth factor impairs bone formation and causes osteopenia Endocrinology 149 9 2008 4374 4381
20. P.R. Segarini, J.E. Nesbitt, D. Li, L.G. Hays, J.R. Yates III, and D.F. Carmichael The low density lipoprotein receptor-related protein/alpha2- macroglobulin receptor is a receptor for connective tissue growth factor J. Biol. Chem. 276 44 2001 40659 40667
21. R. Gao, and D.R. Brigstock Low density lipoprotein receptor-related protein (LRP) is a heparin-dependent adhesion receptor for connective tissue growth factor (CTGF) in rat activated hepatic stellate cells Hepatol. Res. 27 3 2003 214 220
22. N.A. Wahab, B.S. Weston, and R.M. Mason Connective tissue growth factor CCN2 interacts with and activates the tyrosine kinase receptor TrkA J. Am. Soc. Nephrol. 16 2 2005 340 351
23. R. Gao, and D.R. Brigstock Connective tissue growth factor (CCN2) in rat pancreatic stellate cell function: integrin alpha5beta1 as a novel CCN2 receptor Gastroenterology 129 3 2005 1019 1030
24. J.K. Crean, D. Finlay, M. Murphy, C. Moss, C. Godson, and F. Martin The role of p42/44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production, cell migration, and actin cytoskeletal rearrangement in human mesangial cells J. Biol. Chem. 277 46 2002 44187 44194
25. Y.Z. Deng, P.P. Chen, Y. Wang, D. Yin, H.P. Koeffler, and B. Li Connective tissue growth factor is overexpressed in esophageal squamous cell carcinoma and promotes tumorigenicity through beta-catenin-T-cell factor/Lef signaling J. Biol. Chem. 282 50 2007 36571 36581
26. K. Surendran, S. Schiavi, and K.A. Hruska Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis J. Am. Soc. Nephrol. 16 8 2005 2373 2384
27. H. Schmid, C.D. Cohen, A. Henger, S. Irrgang, D. Schlondorff, and M. Kretzler Validation of endogenous controls for gene expression analysis in microdissected human renal biopsies Kidney Int. 64 1 2003 356 360
28. H. Schmid, C.D. Cohen, A. Henger, D. Schlondorff, and M. Kretzler Gene expression analysis in renal biopsies Nephrol. Dial. Transplant. 19 6 2004 1347 1351
29. S.H. Anagnostou, and P.R. Shepherd Glucose induces an autocrine activation of the Wnt/beta-catenin pathway in macrophage cell lines Biochem. J. 416 2 2008 211 218
30. W. He, C. Dai, Y. Li, G. Zeng, S.P. Monga, and Y. Liu Wnt/beta-catenin signaling promotes renal interstitial fibrosis J. Am. Soc. Nephrol. 20 4 2009 765 776
31. K.M. Schmidt-Ott Unraveling the role of connective tissue growth factor in diabetic nephropathy Kidney Int. 73 4 2008 375 376