-
1
-
-
79957916298
-
The insulin receptor substrate (IRS) proteins: at the intersection of metabolism and cancer
-
Shaw LM. The insulin receptor substrate (IRS) proteins: at the intersection of metabolism and cancer. Cell Cycle. 2011; 10(11):1750-1756.
-
(2011)
Cell Cycle.
, vol.10
, Issue.11
, pp. 1750-1756
-
-
Shaw, L.M.1
-
2
-
-
73349099049
-
Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1
-
Tolcher AW, Sarantopoulos J, Patnaik A, Papadopoulos K, Lin CC, Rodon J, Murphy B, Roth B, McCaffery I, Gorski KS, Kaiser B, Zhu M, Deng H, Friberg G and Puzanov I. Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1. J Clin Oncol. 2009; 27(34):5800-5807.
-
(2009)
J Clin Oncol.
, vol.27
, Issue.34
, pp. 5800-5807
-
-
Tolcher, A.W.1
Sarantopoulos, J.2
Patnaik, A.3
Papadopoulos, K.4
Lin, C.C.5
Rodon, J.6
Murphy, B.7
Roth, B.8
Mccaffery, I.9
Gorski, K.S.10
Kaiser, B.11
Zhu, M.12
Deng, H.13
Friberg, G.14
Puzanov, I.15
-
3
-
-
54049108939
-
Early drug development of inhibitors of the insulin-like growth factor-I receptor pathway: lessons from the first clinical trials
-
Rodon J, DeSantos V, Ferry RJ, Jr. and Kurzrock R. Early drug development of inhibitors of the insulin-like growth factor-I receptor pathway: lessons from the first clinical trials. Mol Cancer Ther. 2008; 7(9):2575-2588.
-
(2008)
Mol Cancer Ther.
, vol.7
, Issue.9
, pp. 2575-2588
-
-
Rodon, J.1
Desantos, V.2
Ferry Jr., R.J.3
Kurzrock, R.4
-
4
-
-
77950974697
-
A phase I study of weekly R1507, a human monoclonal antibody insulin-like growth factor-I receptor antagonist, in patients with advanced solid tumors
-
Kurzrock R, Patnaik A, Aisner J, Warren T, Leong S, Benjamin R, Eckhardt SG, Eid JE, Greig G, Habben K, McCarthy CD and Gore L. A phase I study of weekly R1507, a human monoclonal antibody insulin-like growth factor-I receptor antagonist, in patients with advanced solid tumors. Clin Cancer Res. 2010; 16(8):2458-2465.
-
(2010)
Clin Cancer Res.
, vol.16
, Issue.8
, pp. 2458-2465
-
-
Kurzrock, R.1
Patnaik, A.2
Aisner, J.3
Warren, T.4
Leong, S.5
Benjamin, R.6
Eckhardt, S.G.7
Eid, J.E.8
Greig, G.9
Habben, K.10
Mccarthy, C.D.11
Gore, L.12
-
5
-
-
84863900275
-
Insulin-like growth factor receptor inhibitors: baby or the bathwater?
-
Yee D. Insulin-like growth factor receptor inhibitors: baby or the bathwater? J Natl Cancer Inst. 2012; 104(13):975- 981.
-
(2012)
J Natl Cancer Inst.
, vol.104
, Issue.13
, pp. 975-981
-
-
Yee, D.1
-
6
-
-
77956227862
-
Randomized, open label, phase III trial of figitumumab in combination with paclitaxel and carboplatin versus paclitaxel and carboplatin in patients with non-small cell lung cancer (NSCLC)
-
abstr 7500
-
Jassem J, Langer CJ, Karp DD, Mok T, Benner RJ, Green SJ, Park K, Novello S, Strausz J and Gualberto A. Randomized, open label, phase III trial of figitumumab in combination with paclitaxel and carboplatin versus paclitaxel and carboplatin in patients with non-small cell lung cancer (NSCLC). J Clin Oncol. 2010; 28(15s):abstr 7500.
-
(2010)
J Clin Oncol.
, vol.28
, Issue.15 S
-
-
Jassem, J.1
Langer, C.J.2
Karp, D.D.3
Mok, T.4
Benner, R.J.5
Green, S.J.6
Park, K.7
Novello, S.8
Strausz, J.9
Gualberto, A.10
-
7
-
-
77955049754
-
The insulin-like growth factor-I receptor inhibitor figitumumab (CP-751,871) in combination with docetaxel in patients with advanced solid tumours: results of a phase Ib dose-escalation, open-label study
-
Molife LR, Fong PC, Paccagnella L, Reid AH, Shaw HM, Vidal L, Arkenau HT, Karavasilis V, Yap TA, Olmos D, Spicer J, Postel-Vinay S, Yin D, Lipton A, Demers L, Leitzel K, et al. The insulin-like growth factor-I receptor inhibitor figitumumab (CP-751,871) in combination with docetaxel in patients with advanced solid tumours: results of a phase Ib dose-escalation, open-label study. Br J Cancer. 2010; 103(3):332-339.
-
(2010)
Br J Cancer.
, vol.103
, Issue.3
, pp. 332-339
-
-
Molife, L.R.1
Fong, P.C.2
Paccagnella, L.3
Reid, A.H.4
Shaw, H.M.5
Vidal, L.6
Arkenau, H.T.7
Karavasilis, V.8
Yap, T.A.9
Olmos, D.10
Spicer, J.11
Postel-Vinay, S.12
Yin, D.13
Lipton, A.14
Demers, L.15
Leitzel, K.16
-
8
-
-
79551703145
-
Pharmacokinetically guided phase 1 trial of the IGF-1 receptor antagonist RG1507 in children with recurrent or refractory solid tumors
-
Bagatell R, Herzog CE, Trippett TM, Grippo JF, Cirrincione-Dall G, Fox E, Macy M, Bish J, Whitcomb P, Aikin A, Wright G, Yurasov S, Balis FM and Gore L. Pharmacokinetically guided phase 1 trial of the IGF-1 receptor antagonist RG1507 in children with recurrent or refractory solid tumors. Clin Cancer Res. 2011; 17(3):611- 619.
-
(2011)
Clin Cancer Res.
, vol.17
, Issue.3
, pp. 611-619
-
-
Bagatell, R.1
Herzog, C.E.2
Trippett, T.M.3
Grippo, J.F.4
Cirrincione-Dall, G.5
Fox, E.6
Macy, M.7
Bish, J.8
Whitcomb, P.9
Aikin, A.10
Wright, G.11
Yurasov, S.12
Balis, F.M.13
Gore, L.14
-
9
-
-
77957962308
-
Randomized, phase II study of the insulin-like growth factor-1 receptor inhibitor IMC-A12, with or without cetuximab, in patients with cetuximab- or panitumumab-refractory metastatic colorectal cancer
-
Reidy DL, Vakiani E, Fakih MG, Saif MW, Hecht JR, Goodman-Davis N, Hollywood E, Shia J, Schwartz J, Chandrawansa K, Dontabhaktuni A, Youssoufian H, Solit DB and Saltz LB. Randomized, phase II study of the insulin-like growth factor-1 receptor inhibitor IMC-A12, with or without cetuximab, in patients with cetuximab- or panitumumab-refractory metastatic colorectal cancer. J Clin Oncol. 2010; 28(27):4240-4246.
-
(2010)
J Clin Oncol.
, vol.28
, Issue.27
, pp. 4240-4246
-
-
Reidy, D.L.1
Vakiani, E.2
Fakih, M.G.3
Saif, M.W.4
Hecht, J.R.5
Goodman-Davis, N.6
Hollywood, E.7
Shia, J.8
Schwartz, J.9
Chandrawansa, K.10
Dontabhaktuni, A.11
Youssoufian, H.12
Solit, D.B.13
Saltz, L.B.14
-
10
-
-
80052831572
-
Phase I trial of cixutumumab combined with temsirolimus in patients with advanced cancer
-
Naing A, Kurzrock R, Burger A, Gupta S, Lei X, Busaidy N, Hong D, Chen HX, Doyle LA, Heilbrun LK, Rohren E, Ng C, Chandhasin C and LoRusso P. Phase I trial of cixutumumab combined with temsirolimus in patients with advanced cancer. Clin Cancer Res. 2011; 17(18):6052- 6060.
-
(2011)
Clin Cancer Res.
, vol.17
, Issue.18
, pp. 6052-6060
-
-
Naing, A.1
Kurzrock, R.2
Burger, A.3
Gupta, S.4
Lei, X.5
Busaidy, N.6
Hong, D.7
Chen, H.X.8
Doyle, L.A.9
Heilbrun, L.K.10
Rohren, E.11
Ng, C.12
Chandhasin, C.13
LoRusso, P.14
-
11
-
-
79952672340
-
Clinical Phase I study with an Insulin-like Growth Factor-1 receptor inhibitor: experiences in patients with squamous non-small cell lung carcinoma
-
Ekman S, Frodin JE, Harmenberg J, Bergman A, Hedlund A, Dahg P, Alvfors C, Stahl B, Bergstrom S and Bergqvist M. Clinical Phase I study with an Insulin-like Growth Factor-1 receptor inhibitor: experiences in patients with squamous non-small cell lung carcinoma. Acta Oncol. 2011; 50(3):441-447.
-
(2011)
Acta Oncol.
, vol.50
, Issue.3
, pp. 441-447
-
-
Ekman, S.1
Frodin, J.E.2
Harmenberg, J.3
Bergman, A.4
Hedlund, A.5
Dahg, P.6
Alvfors, C.7
Stahl, B.8
Bergstrom, S.9
Bergqvist, M.10
-
12
-
-
75249097799
-
Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP- 751,871) in patients with sarcoma and Ewing's sarcoma: a phase 1 expansion cohort study
-
Olmos D, Postel-Vinay S, Molife LR, Okuno SH, Schuetze SM, Paccagnella ML, Batzel GN, Yin D, Pritchard-Jones K, Judson I, Worden FP, Gualberto A, Scurr M, de Bono JS and Haluska P. Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP- 751,871) in patients with sarcoma and Ewing's sarcoma: a phase 1 expansion cohort study. Lancet Oncol. 2010; 11(2):129-135.
-
(2010)
Lancet Oncol.
, vol.11
, Issue.2
, pp. 129-135
-
-
Olmos, D.1
Postel-Vinay, S.2
Molife, L.R.3
Okuno, S.H.4
Schuetze, S.M.5
Paccagnella, M.L.6
Batzel, G.N.7
Yin, D.8
Pritchard-Jones, K.9
Judson, I.10
Worden, F.P.11
Gualberto, A.12
Scurr, M.13
De Bono, J.S.14
Haluska, P.15
-
13
-
-
75749102231
-
Safety, tolerability, and pharmacokinetics of the anti-IGF-1R monoclonal antibody figitumumab in patients with refractory adrenocortical carcinoma
-
Haluska P, Worden F, Olmos D, Yin D, Schteingart D, Batzel GN, Paccagnella ML, de Bono JS, Gualberto A and Hammer GD. Safety, tolerability, and pharmacokinetics of the anti-IGF-1R monoclonal antibody figitumumab in patients with refractory adrenocortical carcinoma. Cancer Chemother Pharmacol. 2010; 65(4):765-773.
-
(2010)
Cancer Chemother Pharmacol.
, vol.65
, Issue.4
, pp. 765-773
-
-
Haluska, P.1
Worden, F.2
Olmos, D.3
Yin, D.4
Schteingart, D.5
Batzel, G.N.6
Paccagnella, M.L.7
De Bono, J.S.8
Gualberto, A.9
Hammer, G.D.10
-
14
-
-
77952060250
-
Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor
-
Mulvihill MJ, Cooke A, Rosenfeld-Franklin M, Buck E, Foreman K, Landfair D, O'Connor M, Pirritt C, Sun Y, Yao Y, Arnold LD, Gibson NW and Ji QS. Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor. Future Med Chem. 2009; 1(6):1153-1171.
-
(2009)
Future Med Chem.
, vol.1
, Issue.6
, pp. 1153-1171
-
-
Mulvihill, M.J.1
Cooke, A.2
Rosenfeld-Franklin, M.3
Buck, E.4
Foreman, K.5
Landfair, D.6
O'Connor, M.7
Pirritt, C.8
Sun, Y.9
Yao, Y.10
Arnold, L.D.11
Gibson, N.W.12
Ji, Q.S.13
-
15
-
-
84856097810
-
A MEK-independent role for CRAF in mitosis and tumor progression
-
Mielgo A, Seguin L, Huang M, Camargo MF, Anand S, Franovic A, Weis SM, Advani SJ, Murphy EA and Cheresh DA. A MEK-independent role for CRAF in mitosis and tumor progression. Nat Med. 2011; 17(12):1641-1645.
-
(2011)
Nat Med.
, vol.17
, Issue.12
, pp. 1641-1645
-
-
Mielgo, A.1
Seguin, L.2
Huang, M.3
Camargo, M.F.4
Anand, S.5
Franovic, A.6
Weis, S.M.7
Advani, S.J.8
Murphy, E.A.9
Cheresh, D.A.10
-
16
-
-
42949176742
-
Survival of cancer cells is maintained by EGFR independent of its kinase activity
-
Weihua Z, Tsan R, Huang WC, Wu Q, Chiu CH, Fidler IJ and Hung MC. Survival of cancer cells is maintained by EGFR independent of its kinase activity. Cancer Cell. 2008; 13(5):385-393.
-
(2008)
Cancer Cell.
, vol.13
, Issue.5
, pp. 385-393
-
-
Weihua, Z.1
Tsan, R.2
Huang, W.C.3
Wu, Q.4
Chiu, C.H.5
Fidler, I.J.6
Hung, M.C.7
-
19
-
-
5144229336
-
Combined epidermal growth factor receptor targeting with the tyrosine kinase inhibitor gefitinib (ZD1839) and the monoclonal antibody cetuximab (IMC-C225): superiority over single-agent receptor targeting
-
Matar P, Rojo F, Cassia R, Moreno-Bueno G, Di Cosimo S, Tabernero J, Guzman M, Rodriguez S, Arribas J, Palacios J and Baselga J. Combined epidermal growth factor receptor targeting with the tyrosine kinase inhibitor gefitinib (ZD1839) and the monoclonal antibody cetuximab (IMC-C225): superiority over single-agent receptor targeting. Clin Cancer Res. 2004; 10(19):6487-6501.
-
(2004)
Clin Cancer Res.
, vol.10
, Issue.19
, pp. 6487-6501
-
-
Matar, P.1
Rojo, F.2
Cassia, R.3
Moreno-Bueno, G.4
Di Cosimo, S.5
Tabernero, J.6
Guzman, M.7
Rodriguez, S.8
Arribas, J.9
Palacios, J.10
Baselga, J.11
-
20
-
-
3442891161
-
Dual-agent molecular targeting of the epidermal growth factor receptor (EGFR): combining anti-EGFR antibody with tyrosine kinase inhibitor
-
Huang S, Armstrong EA, Benavente S, Chinnaiyan P and Harari PM. Dual-agent molecular targeting of the epidermal growth factor receptor (EGFR): combining anti-EGFR antibody with tyrosine kinase inhibitor. Cancer Res. 2004; 64(15):5355-5362.
-
(2004)
Cancer Res.
, vol.64
, Issue.15
, pp. 5355-5362
-
-
Huang, S.1
Armstrong, E.A.2
Benavente, S.3
Chinnaiyan, P.4
Harari, P.M.5
-
21
-
-
80052385006
-
Erlotinib is a viable treatment for tumors with acquired resistance to cetuximab
-
Brand TM, Dunn EF, Iida M, Myers RA, Kostopoulos KT, Li C, Peet CR and Wheeler DL. Erlotinib is a viable treatment for tumors with acquired resistance to cetuximab. Cancer Biol Ther. 2011; 12(5):436-446.
-
(2011)
Cancer Biol Ther.
, vol.12
, Issue.5
, pp. 436-446
-
-
Brand, T.M.1
Dunn, E.F.2
Iida, M.3
Myers, R.A.4
Kostopoulos, K.T.5
Li, C.6
Peet, C.R.7
Wheeler, D.L.8
-
22
-
-
43249110958
-
Dual inhibition of the epidermal growth factor receptor with cetuximab, an IgG1 monoclonal antibody, and gefitinib, a tyrosine kinase inhibitor, in patients with refractory non-small cell lung cancer (NSCLC): a phase I study
-
Ramalingam S, Forster J, Naret C, Evans T, Sulecki M, Lu H, Teegarden P, Weber MR and Belani CP. Dual inhibition of the epidermal growth factor receptor with cetuximab, an IgG1 monoclonal antibody, and gefitinib, a tyrosine kinase inhibitor, in patients with refractory non-small cell lung cancer (NSCLC): a phase I study. J Thorac Oncol. 2008; 3(3):258-264.
-
(2008)
J Thorac Oncol.
, vol.3
, Issue.3
, pp. 258-264
-
-
Ramalingam, S.1
Forster, J.2
Naret, C.3
Evans, T.4
Sulecki, M.5
Lu, H.6
Teegarden, P.7
Weber, M.R.8
Belani, C.P.9
-
23
-
-
79954586068
-
Phase I/II trial of cetuximab and erlotinib in patients with lung adenocarcinoma and acquired resistance to erlotinib
-
Janjigian YY, Azzoli CG, Krug LM, Pereira LK, Rizvi NA, Pietanza MC, Kris MG, Ginsberg MS, Pao W, Miller VA and Riely GJ. Phase I/II trial of cetuximab and erlotinib in patients with lung adenocarcinoma and acquired resistance to erlotinib. Clin Cancer Res. 2011; 17(8):2521-2527.
-
(2011)
Clin Cancer Res.
, vol.17
, Issue.8
, pp. 2521-2527
-
-
Janjigian, Y.Y.1
Azzoli, C.G.2
Krug, L.M.3
Pereira, L.K.4
Rizvi, N.A.5
Pietanza, M.C.6
Kris, M.G.7
Ginsberg, M.S.8
Pao, W.9
Miller, V.A.10
Riely, G.J.11
-
24
-
-
77953973648
-
Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy
-
Ulanet DB, Ludwig DL, Kahn CR and Hanahan D. Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy. Proc Natl Acad Sci U S A. 2010; 107(24):10791-10798.
-
(2010)
Proc Natl Acad Sci U S A.
, vol.107
, Issue.24
, pp. 10791-10798
-
-
Ulanet, D.B.1
Ludwig, D.L.2
Kahn, C.R.3
Hanahan, D.4
-
25
-
-
80053994190
-
R1507, an antiinsulin- like growth factor-1 receptor (IGF-1R) antibody, and EWS/FLI-1 siRNA in Ewing's sarcoma: convergence at the IGF/IGFR/Akt axis
-
Huang HJ, Angelo LS, Rodon J, Sun M, Kuenkele KP, Parsons HA, Trent JC and Kurzrock R. R1507, an antiinsulin- like growth factor-1 receptor (IGF-1R) antibody, and EWS/FLI-1 siRNA in Ewing's sarcoma: convergence at the IGF/IGFR/Akt axis. PLoS One. 2011; 6(10):e26060.
-
(2011)
PLoS One.
, vol.6
, Issue.10
-
-
Huang, H.J.1
Angelo, L.S.2
Rodon, J.3
Sun, M.4
Kuenkele, K.P.5
Parsons, H.A.6
Trent, J.C.7
Kurzrock, R.8
-
26
-
-
0037267005
-
Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins
-
Wood IS and Trayhurn P. Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins. Br J Nutr. 2003; 89(1):3-9.
-
(2003)
Br J Nutr.
, vol.89
, Issue.1
, pp. 3-9
-
-
Wood, I.S.1
Trayhurn, P.2
-
27
-
-
57749111596
-
Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond
-
Ganapathy V, Thangaraju M and Prasad PD. Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond. Pharmacol Ther. 2009; 121(1):29-40.
-
(2009)
Pharmacol Ther.
, vol.121
, Issue.1
, pp. 29-40
-
-
Ganapathy, V.1
Thangaraju, M.2
Prasad, P.D.3
-
28
-
-
78349276861
-
Autophagy is activated by proteasomal inhibition and involved in aggresome clearance in cultured astrocytes
-
Janen SB, Chaachouay H and Richter-Landsberg C. Autophagy is activated by proteasomal inhibition and involved in aggresome clearance in cultured astrocytes. Glia. 2010; 58(14):1766-1774.
-
(2010)
Glia.
, vol.58
, Issue.14
, pp. 1766-1774
-
-
Janen, S.B.1
Chaachouay, H.2
Richter-Landsberg, C.3
-
29
-
-
0000906170
-
Induction of autophagy and inhibition of tumorigenesis by beclin 1
-
Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H and Levine B. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature. 1999; 402(6762):672-676.
-
(1999)
Nature.
, vol.402
, Issue.6762
, pp. 672-676
-
-
Liang, X.H.1
Jackson, S.2
Seaman, M.3
Brown, K.4
Kempkes, B.5
Hibshoosh, H.6
Levine, B.7
-
30
-
-
34249664257
-
The insulin-like growth factor 1 (IGF-1) receptor is a substrate for gammasecretase- mediated intramembrane proteolysis
-
McElroy B, Powell JC and McCarthy JV. The insulin-like growth factor 1 (IGF-1) receptor is a substrate for gammasecretase- mediated intramembrane proteolysis. Biochem Biophys Res Commun. 2007; 358(4):1136-1141.
-
(2007)
Biochem Biophys Res Commun.
, vol.358
, Issue.4
, pp. 1136-1141
-
-
Mcelroy, B.1
Powell, J.C.2
McCarthy, J.V.3
-
31
-
-
77951628921
-
SUMOylation mediates the nuclear translocation and signaling of the IGF-1 receptor
-
Sehat B, Tofigh A, Lin Y, Trocme E, Liljedahl U, Lagergren J and Larsson O. SUMOylation mediates the nuclear translocation and signaling of the IGF-1 receptor. Sci Signal. 2010; 3(108):ra10.
-
(2010)
Sci Signal.
, vol.3
, Issue.108
-
-
Sehat, B.1
Tofigh, A.2
Lin, Y.3
Trocme, E.4
Liljedahl, U.5
Lagergren, J.6
Larsson, O.7
-
32
-
-
77955736995
-
Type 1 insulin-like growth factor receptor translocates to the nucleus of human tumor cells
-
Aleksic T, Chitnis MM, Perestenko OV, Gao S, Thomas PH, Turner GD, Protheroe AS, Howarth M and Macaulay VM. Type 1 insulin-like growth factor receptor translocates to the nucleus of human tumor cells. Cancer Res. 2010; 70(16):6412-6419.
-
(2010)
Cancer Res.
, vol.70
, Issue.16
, pp. 6412-6419
-
-
Aleksic, T.1
Chitnis, M.M.2
Perestenko, O.V.3
Gao, S.4
Thomas, P.H.5
Turner, G.D.6
Protheroe, A.S.7
Howarth, M.8
Macaulay, V.M.9
-
33
-
-
84872787640
-
The Interfaces Between Signal Transduction Pathways: IGF-1/mTor, p53 and the Parkinson Disease Pathway
-
Levine AJ, Harris CR and Puzio-Kuter AM. The Interfaces Between Signal Transduction Pathways: IGF-1/mTor, p53 and the Parkinson Disease Pathway. Oncotarget. 2012; 3(11):1301-1307.
-
(2012)
Oncotarget.
, vol.3
, Issue.11
, pp. 1301-1307
-
-
Levine, A.J.1
Harris, C.R.2
Puzio-Kuter, A.M.3
-
34
-
-
84866266455
-
Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth
-
Ucar DA, Kurenova E, Garrett TJ, Cance WG, Nyberg C, Cox A, Massoll N, Ostrov DA, Lawrence N, Sebti SM, Zajac-Kaye M and Hochwald SN. Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth. Cell Cycle. 2012; 11(17):3250-3259.
-
(2012)
Cell Cycle.
, vol.11
, Issue.17
, pp. 3250-3259
-
-
Ucar, D.A.1
Kurenova, E.2
Garrett, T.J.3
Cance, W.G.4
Nyberg, C.5
Cox, A.6
Massoll, N.7
Ostrov, D.A.8
Lawrence, N.9
Sebti, S.M.10
Zajac-Kaye, M.11
Hochwald, S.N.12
-
35
-
-
79960438373
-
Human colon cancer stem cells are enriched by insulin-like growth factor-1 and are sensitive to figitumumab
-
Hart LS, Dolloff NG, Dicker DT, Koumenis C, Christensen JG, Grimberg A and El-Deiry WS. Human colon cancer stem cells are enriched by insulin-like growth factor-1 and are sensitive to figitumumab. Cell Cycle. 2011; 10(14):2331-2338.
-
(2011)
Cell Cycle.
, vol.10
, Issue.14
, pp. 2331-2338
-
-
Hart, L.S.1
Dolloff, N.G.2
Dicker, D.T.3
Koumenis, C.4
Christensen, J.G.5
Grimberg, A.6
El-Deiry, W.S.7
-
36
-
-
80052397117
-
Potent anti-proliferative effects of metformin on trastuzumab-resistant breast cancer cells via inhibition of erbB2/IGF-1 receptor interactions
-
Liu B, Fan Z, Edgerton SM, Yang X, Lind SE and Thor AD. Potent anti-proliferative effects of metformin on trastuzumab-resistant breast cancer cells via inhibition of erbB2/IGF-1 receptor interactions. Cell Cycle. 2011; 10(17):2959-2966.
-
(2011)
Cell Cycle.
, vol.10
, Issue.17
, pp. 2959-2966
-
-
Liu, B.1
Fan, Z.2
Edgerton, S.M.3
Yang, X.4
Lind, S.E.5
Thor, A.D.6
-
37
-
-
0038364056
-
Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy
-
Ravikumar B, Stewart A, Kita H, Kato K, Duden R and Rubinsztein DC. Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy. Hum Mol Genet. 2003; 12(9):985- 994.
-
(2003)
Hum Mol Genet.
, vol.12
, Issue.9
, pp. 985-994
-
-
Ravikumar, B.1
Stewart, A.2
Kita, H.3
Kato, K.4
Duden, R.5
Rubinsztein, D.C.6
-
38
-
-
84860339842
-
Enhancement of doxorubicin cytotoxicity of human cancer cells by tyrosine kinase inhibition of insulin receptor and type I IGF receptor
-
Zeng X, Zhang H, Oh A, Zhang Y and Yee D. Enhancement of doxorubicin cytotoxicity of human cancer cells by tyrosine kinase inhibition of insulin receptor and type I IGF receptor. Breast Cancer Res Treat. 2012; 133(1):117-126.
-
(2012)
Breast Cancer Res Treat.
, vol.133
, Issue.1
, pp. 117-126
-
-
Zeng, X.1
Zhang, H.2
Oh, A.3
Zhang, Y.4
Yee, D.5
-
39
-
-
79959370793
-
A phase I study of bevacizumab in combination with sunitinib, sorafenib, and erlotinib plus cetuximab, and trastuzumab plus lapatinib
-
abstr 2512
-
Falchook GS, Wheler JJ, Naing A, Hong DS, Moulder SL, Piha-Paul SA, Ng CS, Jackson E and Kurzrock R. A phase I study of bevacizumab in combination with sunitinib, sorafenib, and erlotinib plus cetuximab, and trastuzumab plus lapatinib. J Clin Oncol. 2010; 28(15s):abstr 2512.
-
(2010)
J Clin Oncol.
, vol.28
, Issue.15 S
-
-
Falchook, G.S.1
Wheler, J.J.2
Naing, A.3
Hong, D.S.4
Moulder, S.L.5
Piha-Paul, S.A.6
Ng, C.S.7
Jackson, E.8
Kurzrock, R.9
-
40
-
-
77949884661
-
Randomized study of Lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer
-
Blackwell KL, Burstein HJ, Storniolo AM, Rugo H, Sledge G, Koehler M, Ellis C, Casey M, Vukelja S, Bischoff J, Baselga J and O'Shaughnessy J. Randomized study of Lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer. J Clin Oncol. 2010; 28(7):1124- 1130.
-
(2010)
J Clin Oncol.
, vol.28
, Issue.7
, pp. 1124-1130
-
-
Blackwell, K.L.1
Burstein, H.J.2
Storniolo, A.M.3
Rugo, H.4
Sledge, G.5
Koehler, M.6
Ellis, C.7
Casey, M.8
Vukelja, S.9
Bischoff, J.10
Baselga, J.11
O'Shaughnessy, J.12
-
41
-
-
82355191854
-
Impact of lapatinib plus trastuzumab versus single-agent lapatinib on quality of life of patients with trastuzumab-refractory HER2+ metastatic breast cancer
-
Wu Y, Amonkar MM, Sherrill BH, O'Shaughnessy J, Ellis C, Baselga J, Blackwell KL and Burstein HJ. Impact of lapatinib plus trastuzumab versus single-agent lapatinib on quality of life of patients with trastuzumab-refractory HER2+ metastatic breast cancer. Ann Oncol. 2011; 22(12):2582-2590.
-
(2011)
Ann Oncol.
, vol.22
, Issue.12
, pp. 2582-2590
-
-
Wu, Y.1
Amonkar, M.M.2
Sherrill, B.H.3
O'Shaughnessy, J.4
Ellis, C.5
Baselga, J.6
Blackwell, K.L.7
Burstein, H.J.8
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