Cyclic strain induces dual-mode endothelialmesenchymal transformation of the cardiac valve

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 50, 2011, Pages 19943-19948

  Balachandran, Kartik ^a   Alford, Patrick W ^a   Wylie Sears, Jill ^b,c   Goss, Josue A ^a   Grosberg, Anna ^a   Bischoff, Joyce ^b,c   Aikawa, Elena ^c,d   Levine, Robert A ^c,e   Parker, Kevin Kit ^a  

^a HARVARD UNIVERSITY   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Activated myofibroblast; Cytokines; Tight junctions

Indexed keywords

ACTIN; ALPHA SMOOTH MUSCLE ACTIN; BETA CATENIN; FIBRONECTIN; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; WNT PROTEIN;

ANIMAL TISSUE; ANISOTROPY; ARTICLE; BIOMECHANICS; BLOOD FLOW VELOCITY; CARDIOVASCULAR SYSTEM; CELL JUNCTION; CELL STRUCTURE; CYTOSKELETON; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; HEART MUSCLE CONTRACTILITY; HEART VALVE; HEMODYNAMIC PARAMETERS; IN VITRO STUDY; ISCHEMIC CARDIOMYOPATHY; MECHANICAL STRESS; MICROENVIRONMENT; MUSCLE STRETCHING; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STRESS STRAIN RELATIONSHIP; TISSUE ENGINEERING;

ACTINS; ANIMALS; ANISOTROPY; CELL NUCLEUS; ENDOTHELIUM; HEART VALVES; MESODERM; MODELS, BIOLOGICAL; MORPHOGENESIS; MYOCARDIAL CONTRACTION; SHEEP; SIGNAL TRANSDUCTION; STRESS, MECHANICAL; TISSUE ENGINEERING;

EID: 84055179016     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1106954108     Document Type: Article

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