Ac-cel, a novel antioxidant, protects against hydrogen peroxide-induced injury in PC12 cells via attenuation of mitochondrial dysfunction

Journal of Molecular Neuroscience

Volumn 50, Issue 3, 2013, Pages 453-461

  Guo, Xianjun ^a   Chen, Yuting ^a   Liu, Qunfang ^a   Wu, Jian ^a   Wang, Luoyi ^a   Tang, Xican ^a   Zhao, Weimin ^a   Zhang, Haiyan ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Antioxidant; Apoptosis; Hydrogen peroxide; Mitochondria; Neuroprotection; Reactive oxygen species

Indexed keywords

AC CEL; ANTIOXIDANT; CASPASE 3; HYDROGEN PEROXIDE; LIPOCORTIN 5; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CELL PROTECTION; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG EXPOSURE; MALE; NONHUMAN; PROTEIN CLEAVAGE; RAT;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; HYDROGEN PEROXIDE; MALE; MITOCHONDRIA; NEURONS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PC12 CELLS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; TRITERPENES;

RATTUS;

EID: 84878936070     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-013-9955-1     Document Type: Article

References (40)

1. Abdel-Kader R, Hauptmann S, Keil U et al (2007) Stabilization of mitochondrial function by Ginkgo biloba extract (EGb 761). Pharmacol Res 56(6):493-502
2. Bae YS, Oh H, Rhee SG, Yoo YD (2011) Regulation of reactive oxygen species generation in cell signaling. Mol Cells 32(6):491-509
3. Benedi J, Arroyo R, Romero C, Martin-Aragon S, Villar AM (2004) Antioxidant properties and protective effects of a standardized extract of Hypericum perforatum on hydrogen peroxide-induced oxidative damage in PC12 cells. Life Sci 75(10):1263-1276
4. Budihardjo I, Oliver H, Lutter M, Luo X, Wang XD (1999) Biochemical pathways of caspase activation during apoptosis. Annu Rev Cell Dev Biol 15:269-290
5. Carafoli E, Rossi CS, Lehninger AL (1964) Cation and anion balance during active accumulation of Ca++ and Mg++ by isolated mitochondria. J Biol Chem 239:3055-3061
6. Chong ZZ, Li F, Maiese K (2005) Oxidative stress in the brain: novel cellular targets that govern survival during neurodegenerative disease. Prog Neurobiol 75(3):207-246
7. 2-induced apoptosis in PC12 cells. Biochem Biophys Res Commun 393(4):773-778
8. Darzynkiewicz Z, Bruno S, Del Bino G et al (1992) Features of apoptotic cells measured by flow cytometry. Cytometry 13(8):795-808
9. Finkel T (2003) Oxidant signals and oxidative stress. Curr Opin Cell Biol 15(2):247-254
10. Gao X, Zheng CY, Yang L, Tang XC, Zhang HY (2009) Huperzine A protects isolated rat brain mitochondria against beta-amyloid peptide. Free Radic Biol Med 46(11):1454-1462
11. Giorgio M, Trinei M, Migliaccio E, Pelicci PG (2007) Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals? Nat Rev Mol Cell Biol 8(9):722-728
12. Gough DR, Cotter TG (2011) Hydrogen peroxide: a Jekyll and Hyde signalling molecule. Cell Death Dis 2:e213
13. Hakem R, Hakem A, Duncan GS et al (1998) Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell 94(3):339-352
14. Halliwell B (2012) Free radicals and antioxidants: updating a personal view. Nutr Rev 70(5):257-265
15. Halliwell B, Aruoma OI (1991) DNA damage by oxygen-derived species. Its mechanism and measurement in mammalian systems. FEBS Lett 281(1-2):9-19
16. Hockenbery DM, Oltvai ZN, Yin XM, Milliman CL, Korsmeyer SJ (1993) Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75(2):241-251
17. Jomova K, Vondrakova D, Lawson M, Valko M (2010) Metals, oxidative stress and neurodegenerative disorders. Mol Cell Biochem 345(1-2):91-104
18. Jurgensmeier JM, Xie ZH, Deveraux Q, Ellerby L, Bredesen D, Reed JC (1998) Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci U S A 95(9):4997-5002
19. Kluck RM, BossyWetzel E, Green DR, Newmeyer DD (1997) The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275(5303):1132-1136
20. Koopman G, Reutelingsperger CP, Kuijten GA, Keehnen RM, Pals ST, van Oers MH (1994) Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood 84(5):1415-1420
21. Kroemer G, Zamzami N, Susin SA (1997) Mitochondrial control of apoptosis. Immunol Today 18(1):44-51
22. Niatsetskaya ZV, Sosunov SA, Matsiukevich D et al (2012) The oxygen free radicals originating from mitochondrial complex I contribute to oxidative brain injury following hypoxia-ischemia in neonatal mice. J Neurosci 32(9):3235-3244
23. Ochiai T, Takenaka Y, Kuramoto Y et al (2008) Molecular mechanism for neuro-protective effect of prosaposin against oxidative stress: its regulation of dimeric transcription factor formation. Biochim Biophys Acta 1780(12):1441-1447
24. Pletjushkina OY, Fetisova EK, Lyamzaev KG et al (2005) Long-distance apoptotic killing of cells is mediated by hydrogen peroxide in a mitochondrial ROS-dependent fashion. Cell Death Differ 12(11):1442-1444
25. Scaffidi C, Fulda S, Srinivasan A et al (1998) Two CD95 (APO-1/Fas) signaling pathways. EMBO J 17(6):1675-1687
26. Shen W, Song D, Wu J, Zhang W (2011) Protective effect of a polysaccharide isolated from a cultivated Cordyceps mycelia on hydrogen peroxide-induced oxidative damage in PC12 cells. Phytother Res: PTR 25(5):675-680
27. Shi GX, Liu CZ, Wang LP, Guan LP, Li SQ (2012) Biomarkers of oxidative stress in vascular dementia patients. Can J Neurol Sci 39(1):65-68
28. Sims NR, Anderson MF (2008) Isolation of mitochondria from rat brain using Percoll density gradient centrifugation. Nat Protoc 3(7):1228-1239
29. Su MY, Huang HY, Li L, Lu YH (2011) Protective effects of 2′,4′-dihydroxy-6′-methoxy-3′,5′-dimethylchalcone to PC12 cells against cytotoxicity induced by hydrogen peroxide. J Agric Food Chem 59(2):521-527
30. Sultana R, Butterfield DA (2013) Oxidative modification of brain proteins in Alzheimer's disease: perspective on future studies based on results of redox proteomics studies. J Alzheimers Dis 33:S243-51
31. Swalwell H, Latimer J, Haywood RM, Birch-Machin MA (2012) Investigating the role of melanin in UVA/UVB- and hydrogen peroxide-induced cellular and mitochondrial ROS production and mitochondrial DNA damage in human melanoma cells. Free Radic Biol Med 52(3):626-634
32. Thannickal VJ, Fanburg BL (2000) Reactive oxygen species in cell signaling. Am J Physiol Lung Cell Mol Physiol 279(6):L1005-1028
33. VanderHeiden MG, Chandel NS, Williamson EK, Schumacker PT, Thompson CB (1997) Bcl-x(L) regulates the membrane potential and volume homeostasis of mitochondria. Cell 91(5):627-637
34. Wang X, Michaelis EK (2010) Selective neuronal vulnerability to oxidative stress in the brain. Front Aging Neurosci 2:12
35. Wang R, Xiao XQ, Tang XC (2001) Huperzine A attenuates hydrogen peroxide-induced apoptosis by regulating expression of apoptosis-related genes in rat PC12 cells. Neuroreport 12(12):2629-2634
36. Xiao XQ, Yang JW, Tang XC (1999) Huperzine A protects rat pheochromocytoma cells against hydrogen peroxide-induced injury. Neurosci Lett 275(2):73-76
37. Zamzami N, Susin SA, Marchetti P et al (1996) Mitochondrial control of nuclear apoptosis. J Exp Med 183(4):1533-1544
38. Zhang HY, Tang XC (2000) Huperzine B, a novel acetylcholinesterase inhibitor, attenuates hydrogen peroxide induced injury in PC12 cells. Neurosci Lett 292(1):41-44
39. Zhang J, Zhu D, Sheng R et al (2009) BZYX, a novel acetylcholinesterase inhibitor, significantly improved chemicals-induced learning and memory impairments on rodents and protected PC12 cells from apoptosis induced by hydrogen peroxide. Eur J Pharmacol 613(1-3):1-9
40. Zhang S, Ye J, Dong G (2010) Neuroprotective effect of baicalein on hydrogen peroxide-mediated oxidative stress and mitochondrial dysfunction in PC12 cells. J Mol Neurosci 40(3):311-320