Msx1 and Tbx2 antagonistically regulate Bmp4 expression during the bud-to-cap stage transition in tooth development

Development (Cambridge)

Volumn 140, Issue 13, 2013, Pages 2697-2702

  Saadi, Irfan ^a,b   Das, Pragnya ^a   Zhao, Minglian ^a   Raj, Lakshmi ^c   Ruspita, Intan ^a   Xia, Yan ^a   Papaioannou, Virginia E ^d   Bei, Marianna ^a,c  

^a FORSYTH INSTITUTE   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d College of Physicians and Surgeons of Columbia University ^*  (United States)

Author keywords

Bmp4; Msx1; Protein protein interaction; Tbx2; Tooth

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; TRANSCRIPTION FACTOR MSX1; TRANSCRIPTION FACTOR T BET;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BUD; CONTROLLED STUDY; EMBRYO; ENAMEL; EPITHELIUM CELL; GENE DOSAGE; MESENCHYME; MOUSE; NONHUMAN; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; TOOTH DEVELOPMENT;

BMP4; MSX1; PROTEIN-PROTEIN INTERACTION; TBX2; TOOTH;

ANIMALS; BONE MORPHOGENETIC PROTEIN 4; CELL LINE; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN SITU HYBRIDIZATION; MESODERM; MICE; MICE, MUTANT STRAINS; MSX1 TRANSCRIPTION FACTOR; ODONTOGENESIS; PROTEIN BINDING; T-BOX DOMAIN PROTEINS; TOOTH;

MUS;

EID: 84878884752     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.088393     Document Type: Article

References (34)

1. Abrahams, A., Parker, M. I. and Prince, S. (2010). The T-box transcription factor Tbx2: its role in development and possible implication in cancer. IUBMB Life 62, 92-102.
2. Andl, T., Ahn, K., Kairo, A., Chu, E. Y., Wine-Lee, L., Reddy, S. T., Croft, N. J., Cebra-Thomas, J. A., Metzger, D., Chambon, P. et al. (2004). Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development. Development 131, 2257-2268.
3. Bamshad, M., Le, T., Watkins, W. S., Dixon, M. E., Kramer, B. E., Roeder, A. D., Carey, J. C., Root, S., Schinzel, A., Van Maldergem, L. et al. (1999). The spectrum of mutations in TBX3: genotype/phenotype relationship in ulnarmammary syndrome. Am. J. Hum. Genet. 64, 1550-1562.
4. Behesti, H., Holt, J. K. and Sowden, J. C. (2006). The level of BMP4 signaling is critical for the regulation of distinct T-box gene expression domains and growth along the dorso-ventral axis of the optic cup. BMC Dev. Biol. 6, 62.
5. Bei, M. (2009). Molecular genetics of tooth development. Curr. Opin. Genet. Dev. 19, 504-510.
6. Bei, M. and Maas, R. (1998). FGFs and BMP4 induce both Msx1-independent and Msx1-dependent signaling pathways in early tooth development. Development 125, 4325-4333.
7. Bei, M., Kratochwil, K. and Maas, R. L. (2000). BMP4 rescues a non-cellautonomous function of Msx1 in tooth development. Development 127, 4711-4718.
8. Boogerd, K. J., Wong, L. Y., Christoffels, V. M., Klarenbeek, M., Ruijter, J. M., Moorman, A. F. and Barnett, P. (2008). Msx1 and Msx2 are functional interacting partners of T-box factors in the regulation of Connexin43. Cardiovasc. Res. 78, 485-493.
9. Catón, J., Luder, H. U., Zoupa, M., Bradman, M., Bluteau, G., Tucker, A. S., Klein, O. and Mitsiadis, T. A. (2009). Enamel-free teeth: Tbx1 deletion affects amelogenesis in rodent incisors. Dev. Biol. 328, 493-505.
10. Catron, K. M., Zhang, H., Marshall, S. C., Inostroza, J. A., Wilson, J. M. and Abate, C. (1995). Transcriptional repression by Msx-1 does not require homeodomain DNA-binding sites. Mol. Cell. Biol. 15, 861-871.
11. Chen, Y., Bei, M., Woo, I., Satokata, I. and Maas, R. (1996). Msx1 controls inductive signaling in mammalian tooth morphogenesis. Development 122, 3035-3044.
12. D'Souza, R. N., Aberg, T., Gaikwad, J., Cavender, A., Owen, M., Karsenty, G. and Thesleff, I. (1999). Cbfa1 is required for epithelial-mesenchymal interactions regulating tooth development in mice. Development 126, 2911-2920.
13. Harrelson, Z., Kelly, R. G., Goldin, S. N., Gibson-Brown, J. J., Bollag, R. J., Silver, L. M. and Papaioannou, V. E. (2004). Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development. Development 131, 5041-5052.
14. Jia, S., Zhou, J., Gao, Y., Baek, J.-A., Martin, J. F., Lan, Y. and Jiang, R. (2013). Roles of Bmp4 during tooth morphogenesis and sequential tooth formation. Development 140, 423-432.
15. Liu, W., Sun, X., Braut, A., Mishina, Y., Behringer, R. R., Mina, M. and Martin, J. F. (2005). Distinct functions for Bmp signaling in lip and palate fusion in mice. Development 132, 1453-1461.
16. Miletich, I., Yu, W. Y., Zhang, R., Yang, K., Caixeta de Andrade, S., Pereira, S. F., Ohazama, A., Mock, O. B., Buchner, G., Sealby, J. et al. (2011). Developmental stalling and organ-autonomous regulation of morphogenesis. Proc. Natl. Acad. Sci. USA 108, 19270-19275.
17. Naiche, L. A., Harrelson, Z., Kelly, R. G. and Papaioannou, V. E. (2005). T-box genes in vertebrate development. Annu. Rev. Genet. 39, 219-239.
18. O'Connell, D. J., Ho, J. W. K., Mammoto, T., Turbe-Doan, A., O'Connell, J. T., Haseley, P. S., Koo, S., Kamiya, N., Ingber, D. E., Park, P. J. et al. (2012). A Wnt-bmp feedback circuit controls intertissue signaling dynamics in tooth organogenesis. Sci. Signal. 5, ra4.
19. Ogawa, T., Kapadia, H., Feng, J. Q., Raghow, R., Peters, H. and D'Souza, R. N. (2006). Functional consequences of interactions between Pax9 and Msx1 genes in normal and abnormal tooth development. J. Biol. Chem. 281, 18363-18369.
20. Packham, E. A. and Brook, J. D. (2003). T-box genes in human disorders. Hum. Mol. Genet. 12 Spec No 1, R37-R44.
21. Papaioannou, V. E. and Silver, L. M. (1998). The T-box gene family. BioEssays 20, 9-19.
22. Peters, H. and Balling, R. (1999). Teeth. Where and how to make them. Trends Genet. 15, 59-65.
23. Peters, H., Neubüser, A., Kratochwil, K. and Balling, R. (1998). Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities. Genes Dev. 12, 2735-2747.
24. Satokata, I. and Maas, R. (1994). Msx1 deficient mice exhibit cleft palate and abnormalities of craniofacial and tooth development. Nat. Genet. 6, 348-356.
25. Showell, C., Binder, O. and Conlon, F. L. (2004). T-box genes in early embryogenesis. Dev. Dyn. 229, 201-218.
26. Thesleff, I. and Mikkola, M. (2002). The role of growth factors in tooth development. Int. Rev. Cytol. 217, 93-135.
27. van Genderen, C., Okamura, R. M., Fariñas, I., Quo, R. G., Parslow, T. G., Bruhn, L. and Grosschedl, R. (1994). Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice. Genes Dev. 8, 2691-2703.
28. Wang, X. P., Aberg, T., James, M. J., Levanon, D., Groner, Y. and Thesleff, I. (2005). Runx2 (Cbfa1) inhibits Shh signaling in the lower but not upper molars of mouse embryos and prevents the budding of putative successional teeth. J. Dent. Res. 84, 138-143.
29. Yamada, M., Revelli, J. P., Eichele, G., Barron, M. and Schwartz, R. J. (2000). Expression of chick Tbx-2, Tbx-3, and Tbx-5 genes during early heart development: evidence for BMP2 induction of Tbx2. Dev. Biol. 228, 95-105.
30. Zhang, H., Catron, K. M. and Abate-Shen, C. (1996). A role for the Msx-1 homeodomain in transcriptional regulation: residues in the N-terminal arm mediate TATA binding protein interaction and transcriptional repression. Proc. Natl. Acad. Sci. USA 93, 1764-1769.
31. Zhao, X., Zhang, Z., Song, Y., Zhang, X., Zhang, Y., Hu, Y., Fromm, S. H. and Chen, Y. (2000). Transgenically ectopic expression of Bmp4 to the Msx1 mutant dental mesenchyme restores downstream gene expression but represses Shh and Bmp2 in the enamel knot of wild type tooth germ. Mech. Dev. 99, 29-38.
32. Zhao, M., Gupta, V., Raj, L., Roussel, M. and Bei, M. (2013). A regulatory network operates during early tooth morphogenesis. Mol. Cell. Biol. (in press)
33. Zhou, J., Gao, Y., Zhang, Z., Zhang, Y., Maltby, K. M., Liu, Z., Lan, Y. and Jiang, R. (2011). Osr2 acts downstream of Pax9 and interacts with both Msx1 and Pax9 to pattern the tooth developmental field. Dev. Biol. 353, 344-353.
34. Zirzow, S., Lüdtke, T. H., Brons, J. F., Petry, M., Christoffels, V. M. and Kispert, A. (2009). Expression and requirement of T-box transcription factors Tbx2 and Tbx3 during secondary palate development in the mouse. Dev. Biol. 336, 145-155.