Osr2 acts downstream of Pax9 and interacts with both Msx1 and Pax9 to pattern the tooth developmental field

Developmental Biology

Volumn 353, Issue 2, 2011, Pages 344-353

  Zhou, Jing ^a   Gao, Yang ^a   Zhang, Zunyi ^a   Zhang, Yuan ^a   Maltby, Kathleen M ^a   Liu, Zhaoyang ^a   Lan, Yu ^a   Jiang, Rulang ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

Msx1; Odd skipped; Odontogenic; Osr2; Pax9; Tooth development

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MSX1; TRANSCRIPTION FACTOR OSR2; TRANSCRIPTION FACTOR PAX9; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ELECTROPORATION; EMBRYO; EXPRESSION VECTOR; GENE CASSETTE; GENE DELETION; GENE DISRUPTION; GENE EXPRESSION; GENETIC TRANSCRIPTION; IMMUNOPRECIPITATION; MESENCHYME; MORPHOGENESIS; MOUSE; NEWBORN; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; TOOTH DEVELOPMENT;

MAMMALIA; MUS;

EID: 79955042505     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2011.03.012     Document Type: Article

References (44)

1. Andl T., Ahn K., Kairo A., Chu E.Y., Wine-Lee L., Reddy S.T., Croft N.J., Cebra-Thomas J.A., Metzger D., Chambon P., Lyons K.M., Mishina Y., Seykora J.T., Crenshaw E.B., Millar S.E. Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development. Development 2004, 131:2257-2268.
2. Bei M., Kratochwil K., Maas R.L. BMP4 rescues a non-cell-autonomous function of Msx1 in tooth development. Development 2000, 127:4711-4718.
3. Catron K.M., Zhang H., Marshall S.C., Inostroza J.A., Wilson J.M., Abate C. Transcriptional repression by Msx-1 does not require homeodomain DNA-binding sites. Mol. Cell. Biol. 1995, 15:861-871.
4. Chen Y., Bei M., Woo I., Satokata I., Maas R. Msx1 controls inductive signaling in mammalian tooth morphogenesis. Development 1996, 122:3035-3044.
5. Coulter D.E., Wieschaus E. Gene activities and segmental patterning in Drosophila: analysis of odd-skipped and pair-rule double mutants. Genes Dev. 1988, 2:1812-1823.
6. Dassule H.R., McMahon A.P. Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth. Dev. Biol. 1998, 202:215-227.
7. Farley F.W., Soriano P., Steffen L.S., Dymecki S.M. Widespread recombinase expression using FLPeR (flipper) mice. Genesis 2000, 28:106-110.
8. Gao Y., Lan Y., Ovitt C.E., Jiang R. Functional equivalence of the zinc finger transcription factors Osr1 and Osr2 in mouse development. Dev. Biol. 2009, 328:200-209.
9. Green R.B., Hatini V., Johansen K.A., Liu X.J., Lengyel J.A. Drumstick is a zinc finger protein that antagonizes Lines to control patterning and morphogenesis of the Drosophila hindgut. Development 2002, 129:3645-3656.
10. Hao I., Green R.B., Dunaevsky O., Lengyel J.A., Rauskolb C. The odd-skipped family of zinc finger genes promotes Drosophila leg segmentation. Dev. Biol. 2003, 263:282-295.
11. Hart M.C., Wang L., Coulter D.E. Comparison of the structure and expression of odd-skipped and two related genes that encode a new family of zinc finger proteins in Drosophila. Genetics 1996, 144:171-182.
12. Kawai S., Kato T., Inaba H., Okahashi N., Amano A. Odd-skipped related 2 splicing variants show opposite transcriptional activity. Biochem. Biophys. Res. Commun. 2005, 328:306-311.
13. Kist R., Watson M., Wang X., Cairns P., Miles C., Reid D.J., Peters H. Reduction of Pax9 gene dosage in an allelic series of mouse mutants causes hypodontia and oligodontia. Hum. Mol. Genet. 2005, 14:3605-3617.
14. Kollar E.J., Fisher C. Tooth induction in chick epithelium: expression of quiescent genes for enamel synthesis. Science 1980, 207:993-995.
15. Lakso M., Pichel J.G., Gorman J.R., Sauer B., Okamoto Y., Lee E., Alt F.W., Westphal H. Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc. Natl Acad. Sci. U.S.A. 1996, 93:5860-5865.
16. Lan Y., Kingsley P.D., Cho E.S., Jiang R. Osr2, a new mouse gene related to Drosophila odd-skipped, exhibits dynamic expression patterns during craniofacial, limb, and kidney development. Mech. Dev. 2001, 107:175-179.
17. Lan Y., Ovitt C.E., Cho E.S., Maltby K.M., Wang Q., Jiang R. Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis. Development 2004, 131:3207-3216.
18. Liu W., Sun X., Braut A., Mishina Y., Behringer R.R., Mina M., Martin J.F. Distinct functions for Bmp signaling in lip and palate fusion in mice. Development 2005, 132:1453-1461.
19. Lumsden A.G. Spatial organization of the epithelium and the role of neural crest cells in the initiation of the mammalian tooth germ. Development 1988, 103(Suppl):155-169.
20. Lyons K.M., Pelton R.W., Hogan B.L. Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic development. Genes Dev. 1989, 3:1657-1668.
21. Mandler M., Neubuser A. FGF signaling is necessary for the specification of the odontogenic mesenchyme. Dev. Biol. 2001, 240:548-559.
22. Martin J.F., Bradley A., Olson E.N. The paired-like homeo box gene MHox is required for early events of skeletogenesis in multiple lineages. Genes Dev. 1995, 9:1237-1249.
23. Mensah J.K., Ogawa T., Kapadia H., Cavender A.C., D'Souza R.N. Functional analysis of a mutation in PAX9 associated with familial tooth agenesis in humans. J. Biol. Chem. 2004, 279:5924-5933.
24. Mina M., Kollar E.J. The induction of odontogenesis in non-dental mesenchyme combined with early murine mandibular arch epithelium. Arch. Oral Biol. 1987, 32:123-127.
25. Nakatomi M., Wang X.P., Key D., Lund J.J., Turbe-Doan A., Kist R., Aw A., Chen Y., Maas R.L., Peters H. Genetic interactions between Pax9 and Msx1 regulate lip development and several stages of tooth morphogenesis. Dev. Biol. 2010, 340:438-449.
26. Neubuser A., Koseki H., Balling R. Characterization and developmental expression of Pax9, a paired-box-containing gene related to Pax1. Dev. Biol. 1995, 170:701-716.
27. Neubuser A., Peters H., Balling R., Martin G.R. Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation. Cell 1997, 90:247-255.
28. Ogawa T., Kapadia H., Feng J.Q., Raghow R., Peters H., D'Souza R.N. Functional consequences of interactions between Pax9 and Msx1 genes in normal and abnormal tooth development. J. Biol. Chem. 2006, 281:18363-18369.
29. Peters H., Neubuser A., Kratochwil K., Balling R. Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities. Genes Dev. 1998, 12:2735-2747.
30. Pispa J., Thesleff I. Mechanisms of ectodermal organogenesis. Dev. Biol. 2003, 262:195-205.
31. Rave-Harel N., Miller N.L.G., Givens M.L., Mellon P.L. The Groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins MSX1 and OCT1. J. Biol. Chem. 2005, 280:30975-30983.
32. Ruch J.V., Karcher-Djuricic V., Gerber R. Determinants of morphogenesis and cytodifferentiations of dental anloges in mice. J. Biol. Buccale 1973, 1:45-56.
33. Ruch J.V., Lesot H., Karcher-Djuricic V., Meyer J.M. Extracellular matrix-mediated interactions during odontogenesis. Prog. Clin. Biol. Res. 1984, 151:103-114.
34. Satokata I., Maas R. Msx1 deficient mice exhibit cleft palate and abnormalities of craniofacial and tooth development. Nat. Genet. 1994, 6:348-356.
35. Saulier-Le Drean B., Nasiadka A., Dong J., Krause H.M. Dynamic changes in the functions of Odd-skipped during early Drosophila embryogenesis. Development 1998, 125:4851-4861.
36. Swiatek P.J., Gridley T. Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20. Genes Dev. 1993, 7:2071-2084.
37. Thesleff I., Vaahtokari A., Kettunen P., Aberg T. Epithelial-mesenchymal signaling during tooth development. Connect. Tissue Res. 1995, 32:9-15.
38. Vainio S., Karavanova I., Jowett A., Thesleff I. Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development. Cell 1993, 75:45-58.
39. Wang L., Coulter D.E. bowel, an odd-skipped homolog, functions in the terminal pathway during Drosophila embryogenesis. EMBO J. 1996, 15:3182-3196.
40. Wozney J.M., Rosen V., Celeste A.J., Mitsock L.M., Whitters M.J., Kriz R.W., Hewick R.M., Wang E.A. Novel regulators of bone formation: molecular clones and activities. Science 1988, 242:1528-1534.
41. Xie Z.H., Huang Y.N., Chen Z.X., Riggs A.D., Ding J.P., Gowher H., Jeltsch A., Sasaki H., Hata K., Xu G.L. Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect its regulation by DNMT3L. Hum. Mol. Genet. 2006, 15:1375-1385.
42. Zhang H., Catron K.M., Abate-Shen C. A role for the Msx-1 homeodomain in transcriptional regulation: residues in the N-terminal arm mediate TATA binding protein interaction and transcriptional repression. Proc. Natl Acad. Sci. U.S.A. 1996, 93:1764-1769.
43. Zhang Y.D., Zhao X., Hu Y., St.Amand T.R., Ramamurthy R., Qiu M.S., Chen Y.P. Msx1 is required for the induction of Patched by Sonic hedgehog in the mammalian tooth germ. Dev. Dyn. 1999, 215:45-53.
44. Zhang Z., Lan Y., Chai Y., Jiang R. Antagonistic actions of Msx1 and Osr2 pattern mammalian teeth into a single row. Science 2009, 323:1232-1234.