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Tummers M., and Thesleff I. The importance of signal pathway modulation in all aspects of tooth development. J Exp Zool (Mol Dev Evol) 312B 5 (2009) 309-319. In this review the authors discuss the complexity of the regulatory network involved in all facets of tooth development. This complexity leads to the availability of numerous developmental solutions to the same problem, all of which are accomplished by regulatory tinkering. We conclude that the complexity and nature of the signalling network probably facilitated the change of tooth shapes and patterns during evolution.
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