Advancing the management of childhood epilepsies

European Journal of Paediatric Neurology

Volumn 17, Issue 4, 2013, Pages 334-347

  Cross, J Helen ^a   Kluger, Gerhard ^b,c   Lagae, Lieven ^d  

^a GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^b Schon Klinik Vogtareuth   (Germany)

^c PARACELSUS MEDICAL UNIVERSITY   (Austria)

^d UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Antiepileptic drug; Childhood epilepsies; Experimental devices; Genetic testing; Paediatric epilepsies; Quality of life

Indexed keywords

BRIVARACETAM; BROMIDE; CARBAMAZEPINE; CORTICOSTEROID; ESLICARBAZEPINE ACETATE; ETIRACETAM; FENFLURAMINE; GABAPENTIN; IMMUNOGLOBULIN; PREGABALIN; RUFINAMIDE; STIRIPENTOL; TACROLIMUS; VALPROIC ACID; VIGABATRIN;

ALGORITHM; ANTICONVULSANT ACTIVITY; AUTOSOMAL RECESSIVE DISORDER; BENIGN CHILDHOOD EPILEPSY; BINDING AFFINITY; BRAIN DEPTH STIMULATION; CELL BASED GENE THERAPY; CLINICAL PRACTICE; CORTICOSTEROID THERAPY; DIFFERENTIAL DIAGNOSIS; DISEASE CLASSIFICATION; DISEASE COURSE; DRUG DELIVERY SYSTEM; DRUG TOLERABILITY; ELECTROSTIMULATION; EPIGENETICS; EVIDENCE BASED PRACTICE; GENETIC SCREENING; HEALTH CARE AVAILABILITY; HEALTH CARE DELIVERY; HEALTH STATUS; HUMAN; IMMUNOMODULATION; IMMUNOTHERAPY; INTRACTABLE EPILEPSY; KETOGENIC DIET; KNOWLEDGE BASE; LENNOX GASTAUT SYNDROME; MEDICAL DECISION MAKING; MEDICAL TECHNOLOGY; NEUROSURGERY; OBESITY; PARKINSON DISEASE; PLASMAPHERESIS; PRIORITY JOURNAL; PSYCHOSOCIAL CARE; QUALITY OF LIFE; RASMUSSEN SYNDROME; REVIEW; SEVERE MYOCLONIC EPILEPSY IN INFANCY; VAGUS NERVE STIMULATION; VISUAL FIELD DEFECT;

CHILD; DEVELOPMENTAL DISABILITIES; DISEASE MANAGEMENT; EPILEPSY; HUMANS;

EID: 84878879386     PISSN: 10903798     EISSN: 15322130     Source Type: Journal    
DOI: 10.1016/j.ejpn.2013.02.003     Document Type: Review

References (171)

1. M. Sillanpää Epilepsy in children: prevalence, disability, and handicap Epilepsia 33 1992 444 449
2. A. Serdaroǧlu, S. Ozkan, and K. Aydin Prevalence of epilepsy in Turkish children between the ages of 0 and 16 years J Child Neurol 19 2004 271 274
3. P. Uldall, J. Alving, L.K. Hansen, M. Kibaek, and J. Buchholt The misdiagnosis of epilepsy in children admitted to a tertiary epilepsy centre with paroxysmal events Arch Dis Child 91 2006 219 221
4. D. Muthugovindan, and A.L. Hartman Pediatric epilepsy syndromes Neurologist 16 2010 223 237
5. D. Hindley, A. Ali, and C. Robson Diagnoses made in a secondary care 'fits, faints, and funny turns' clinic Arch Dis Child 91 2006 214 218
6. P. Camfield, and C. Camfield Epileptic syndromes in childhood: clinical features, outcomes, and treatment Epilepsia 43 Suppl. 3 2002 27 32
7. A. Arzimanoglou, and T. Resnick All children who experience epileptic falls do not necessarily have Lennox-Gastaut syndrome. but many do Epileptic Disord 13 Suppl. 1 2011 S3 S13
8. R. Guerrini, C. Dravet, and P. Genton Lamotrigine and seizure aggravation in severe myoclonic epilepsy Epilepsia 39 1998 508 512
9. A. Arzimanoglou, R. Guerrini, and J. Aicardi Epilepsies with predominantly myoclonic seizures Aicardi's epilepsy in children 3rd ed. 2004 Lippincott Williams & Wilkins Philadelphia 58 80
10. J.A. French, A.M. Kanner, J. Bautista Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology; Quality Standards Subcommittee of the American Academy of Neurology; American Epilepsy Society Efficacy and tolerability of the new antiepileptic drugs I: treatment of new onset epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society Neurology 62 2004 1252 1260
11. J.A. French, A.M. Kanner, and J. Bautista Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology; Quality Standards Subcommittee of the American Academy of Neurology; American Epilepsy Society Efficacy and tolerability of the new antiepileptic drugs II: treatment of refractory epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society Neurology 62 2004 1261 1273
12. T. Glauser, E. Ben-Menachem, and B. Bourgeois ILAE treatment guidelines: evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes Epilepsia 47 2006 1094 1120
13. Clinical Guideline 137 National Institute for Health and Clinical Excellence The epilepsies: the diagnosis and management of the epilepsies in adults and children in primary and secondary care 2012 National Institute for Health and Clinical Excellence London Available at: http://publications.nice. org.uk/the-epilepsies-the-diagnosis-and-management-of-the-epilepsies-in-adults- and-children-in-primary-and-cg137 [accessed 02.11.12]
14. E. Garofalo Clinical development of antiepileptic drugs for children Neurotherapeutics 4 2007 70 74
15. C. Chiron, O. Dulac, and G. Pons Antiepileptic drug development in children: considerations for a revisited strategy Drugs 68 2008 17 25
16. R.D. Elterman, T.A. Glauser, and E. Wyllie A double-blind, randomized trial of topiramate as adjunctive therapy for partial-onset seizures in children. Topiramate YP Study Group Neurology 52 1999 1338 1344
17. M. Duchowny, J.M. Pellock, and W.D. Graf A placebo-controlled trial of lamotrigine add-on therapy for partial seizures in children. Lamictal Pediatric Partial Seizure Study Group Neurology 53 1999 1724 1731
18. R. Appleton, K. Fichtner, and L. LaMoreaux Gabapentin as add-on therapy in children with refractory partial seizures: a 12-week, multicentre, double-blind, placebo-controlled study. Gabapentin Paediatric Study Group Epilepsia 40 1999 1147 1154
19. T.A. Glauser, M. Nigro, and R. Sachdeo Adjunctive therapy with oxcarbazepine in children with partial seizures. The Oxcarbazepine Pediatric Study Group Neurology 54 2000 2237 2244
20. T.A. Glauser, R. Ayala, R.D. Elterman N159 Study Group Double-blind placebo-controlled trial of adjunctive levetiracetam in pediatric partial seizures Neurology 66 2006 1654 1660
21. A. Rosati, P. Pellacani, M. Falchi, and R. Guerrini Preliminary results from the CATZ Study: a Phase III, double-blind, randomized, placebo-controlled trial to assess the efficacy and safety of adjunctive zonisamide in pediatric patients with partial-onset seizures Epilepsia 52 Suppl. 6 2011 263 [abstract p. 870]
22. A.G. Marson, A.M. Al-Kharusi, M. Alwaidh SANAD Study group The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial Lancet 369 2007 1000 1015
23. A.G. Marson, A.M. Al-Kharusi, M. Alwaidh SANAD Study group The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial Lancet 369 2007 1016 1026
24. C. von Stülpnagel, M. Leichsenring, A. Müller, M. Staudt, and G. Kluger Refractory focal epilepsy in a patient with methylmalonic aciduria: case report on positive and long-lasting effect of rufinamide Neuropediatrics 42 2011 71 73
25. M. Häusler, G. Kluger, and M. Nikanorova Epilepsy with myoclonic absences-favourable response to add-on rufinamide treatment in 3 cases Neuropediatrics 42 2011 28 29
26. N. Specchio, M. Trivisano, and V. Di Ciommo Panayiotopoulos syndrome: a clinical, EEG, and neuropsychological study of 93 consecutive patients Epilepsia 51 2010 2098 2107
27. B.F. Bourgeois Chronic management of seizures in the syndromes of idiopathic generalized epilepsy Epilepsia 44 Suppl. 2 2003 27 32
28. U. Stephani The natural history of myoclonic astatic epilepsy (Doose syndrome) and Lennox-Gastaut syndrome Epilepsia 47 Suppl. 2 2006 53 55
29. A.M. Kanner, and A. Balabanov Depression and epilepsy: how closely related are they? Neurology 58 8 Suppl. 5 2002 S27 S39
30. A.M. Kanner Depression in epilepsy: prevalence, clinical semiology, pathogenic mechanisms, and treatment Biol Psychiatry 54 2003 388 398
31. M. Kerr, G. Kluger, and S. Philip Evolution and management of Lennox-Gastaut syndrome through adolescence and into adulthood: are seizures always the primary issue? Epileptic Disord 13 Suppl. 1 2011 S15 S26
32. G. Regesta, and P. Tanganelli Clinical aspects and biological bases of drug-resistant epilepsies Epilepsy Res 34 1999 109 122
33. P. Kwan, A. Arzimanoglou, and A.T. Berg Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies Epilepsia 51 2010 1069 1077
34. S. Sinha, and K.A. Siddiqui Definition of intractable epilepsy Neurosciences (Riyadh) 16 2011 3 9
35. S. Pujar, S. Calvert, and M. Cortina-Borja Statistical process control (SPC)-a simple objective method for monitoring seizure frequency and evaluating effectiveness of drug interventions in refractory childhood epilepsy Epilepsy Res 91 2010 205 213
36. P. Kwan, and M.J. Brodie Refractory epilepsy: a progressive, intractable but preventable condition? Seizure 11 2002 77 84
37. P. Kwan, and M.J. Brodie Potential role of drug transporters in the pathogenesis of medically intractable epilepsy Epilepsia 46 2005 224 235
38. S.M. Sisodiya, L. Martinian, and G.L. Scheffer Major vault protein, a marker of drug resistance, is upregulated in refractory epilepsy Epilepsia 44 2003 1388 1396
39. A.L. Luciano, and S.D. Shorvon Results of treatment changes in patients with apparently drug-resistant chronic epilepsy Ann Neurol 62 2007 375 381
40. B.C. Callaghan, K. Anand, D. Hesdorffer, W.A. Hauser, and J.A. French Likelihood of seizure remission in an adult population with refractory epilepsy Ann Neurol 62 2007 382 389
41. H. Choi, G. Heiman, and D. Pandis Seizure remission and relapse in adults with intractable epilepsy: a cohort study Epilepsia 49 2008 1440 1445
42. Y. Schiller, and Y. Najjar Quantifying the response to antiepileptic drugs: effect of past treatment history Neurology 70 2008 54 65
43. H. Choi, G.A. Heiman, and H. Munger Clary Seizure remission in adults with long-standing intractable epilepsy: an extended follow-up Epilepsy Res 93 2011 115 119
44. L.M. Selwa, S.L. Schmidt, B.A. Malow, and A. Beydoun Long-term outcome of nonsurgical candidates with medically refractory localization-related epilepsy Epilepsia 44 2003 1568 1572
45. C.G. Bien, A. Schulze-Bonhage, and B.M. Soeder Assessment of the long-term effects of epilepsy surgery with three different reference groups Epilepsia 47 2006 1865 1869
46. I. Benavente-Aguilar, C. Morales-Blánquez, E.A. Rubio, and J.M. Rey Quality of life of adolescents suffering from epilepsy living in the community J Paediatr Child Health 40 2004 110 113
47. R.D. Sheth, and B.E. Gidal Optimizing epilepsy management in teenagers J Child Neurol 21 2006 273 279
48. E. Ben-Menachem Weight issues for people with epilepsy-a review Epilepsia 48 Suppl. 9 2007 42 45
49. A. Arzimanoglou, J. French, and W.T. Blume Lennox-Gastaut syndrome: a consensus approach on diagnosis, assessment, management, and trial methodology Lancet Neurol 8 2009 82 93
50. G.M. Ronen, N. Fayed, and P.L. Rosenbaum Outcomes in pediatric neurology: a review of conceptual issues and recommendations. The 2010 Ronnie Mac Keith Lecture Dev Med Child Neurol 53 2011 305 312
51. S. Byrne, J. Kearns, and R. Carolan Refractory absence epilepsy associated with GLUT-1 deficiency syndrome Epilepsia 52 2011 1021 1024
52. P. Veggiotti, F. Teutonico, and E. Alfei Glucose transporter type 1 deficiency: ketogenic diet in three patients with atypical phenotype Brain Dev 32 2010 404 408
53. J. Klepper Glucose transporter deficiency syndrome (GLUT1DS) and the ketogenic diet Epilepsia 49 Suppl. 8 2008 46 49
54. Y. Ito, H. Oguni, S. Ito, M. Oguni, and M. Osawa A modified Atkins diet is promising as a treatment for glucose transporter type 1 deficiency syndrome Dev Med Child Neurol 53 2011 658 663
55. R. Steinfeld, M. Grapp, and R. Kraetzner Folate receptor alpha defect causes cerebral folate transport deficiency: a treatable neurodegenerative disorder associated with disturbed myelin metabolism Am J Hum Genet 85 2009 354 363
56. N.S. Yeghiazaryan, F. Zara, and G. Capovilla Pyridoxine-dependent epilepsy: an under-recognised cause of intractable seizures J Paediatr Child Health 48 2012 E113 E115
57. P.B. Mills, E.J. Footitt, and K.A. Mills Genotypic and phenotypic spectrum of pyridoxine-dependent epilepsy (ALDH7A1 deficiency) Brain 133 2010 2148 2159
58. D. Carranza Rojo, L. Hamiwka, and J.M. McMahon De novo SCN1A mutations in migrating partial seizures of infancy Neurology 77 2011 380 383
59. C. Marini, I.E. Scheffer, and R. Nabbout The genetics of Dravet syndrome Epilepsia 52 Suppl. 2 2011 24 29
60. N. Specchio, C. Marini, and A. Terracciano Spectrum of phenotypes in female patients with epilepsy due to protocadherin 19 mutations Epilepsia 52 2011 1251 1257
61. C. Depienne, O. Trouillard, and D. Bouteiller Mutations and deletions in PCDH19 account for various familial or isolated epilepsies in females Hum Mutat 32 2011 E1959 E1975
62. L.M. Dibbens, P.S. Tarpey, and K. Hynes X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment Nat Genet 40 2008 776 781
63. P. De Jonghe Molecular genetics of Dravet syndrome Dev Med Child Neurol 53 Suppl. 2 2011 7 10
64. C.F. Wright, and H. Burton The use of cell-free fetal nucleic acids in maternal blood for non-invasive prenatal diagnosis Hum Reprod Update 15 2009 139 151
65. H.L. Archer, J. Evans, and S. Edwards CDKL5 mutations cause infantile spasms, early onset seizures, and severe mental retardation in female patients J Med Genet 43 2006 729 734
66. D. Mei, C. Marini, and F. Novara Xp22.3 genomic deletions involving the CDKL5 gene in girls with early onset epileptic encephalopathy Epilepsia 51 2010 647 654
67. G. Kollberg, A.R. Moslemi, and N. Darin POLG1 mutations associated with progressive encephalopathy in childhood J Neuropathol Exp Neurol 65 2006 758 768
68. R.P. Saneto, I.C. Lee, and M.K. Koenig POLG DNA testing as an emerging standard of care before instituting valproic acid therapy for pediatric seizure disorders Seizure 19 2010 140 146
69. P. Isohanni, A.H. Hakonen, and L. Euro POLG1 manifestations in childhood Neurology 76 2011 811 815
70. J.R. Lemke, E. Riesch, and T. Scheurenbrand Targeted next generation sequencing as a diagnostic tool in epileptic disorders Epilepsia 53 2012 1387 1398
71. S. Biskup, and T. Gasser Genetic testing in neurological diseases J Neurol 259 2012 1249 1254
72. A.D. Goldberg, C.D. Allis, and E. Bernstein Epigenetics: a landscape takes shape Cell 128 2007 635 638
73. B. Monti, E. Polazzi, and A. Contestabile Biochemical, molecular and epigenetic mechanisms of valproic acid neuroprotection Curr Mol Pharmacol 2 2009 95 109
74. M. Stettner, T. Dehmel, and A.K. Mausberg Levetiracetam exhibits protective properties on rat Schwann cells in vitro J Peripher Nerv Syst 16 2011 250 260
75. S.B. Foti, and A.J. Roskams A tale of two epiphenomena: the complex interplay of epigenetics and epilepsy F.S. Kaneez, Underlying mechanisms of epilepsy 2011 InTech Rijeka, Croatia 219 240
76. A. Arzimanoglou, E. Ben-Menachem, and J. Cramer The evolution of antiepileptic drug development and regulation Epileptic Disord 12 2010 3 15
77. J.M. Wild, C. Chiron, and H. Ahn Visual field loss in patients with refractory partial epilepsy treated with vigabatrin: final results from an open-label, observational, multicentre study CNS Drugs 23 2009 965 982
78. G. Kluger, B. Schäuble, K. Rettig, A. Schreiner, and H. Holthausen Effectiveness of low dose of topiramate following rapid titration in multiply handicapped children and difficult-to-treat epilepsy Neuropediatrics 40 2009 61 65
79. K.K. Jain An assessment of rufinamide as an anti-epileptic in comparison with other drugs in clinical development Expert Opin Investig Drugs 9 2000 829 840
80. ® summary of product characteristics 2012 Eisai Ltd Available at: http://www.medicines.org.uk/emc/medicine/20165/SPC/ [accessed 02.11.12]
81. BANZEL™ prescribing information 2011 Eisai Inc Available at: http://us.eisai.com/package-inserts/Banzel-PI.pdf [accessed 02.11.12]
82. T. Glauser, G. Kluger, and R. Sachdeo Rufinamide for generalized seizures associated with Lennox-Gastaut syndrome Neurology 70 2008 1950 1958
83. M. Nikanorova, and I. Chouette An ongoing European non-interventional registry study of patients with Lennox-Gastaut Syndrome: interim analysis Epilepsia 53 Suppl. 5 2012 219 [abstract p. 755]
84. G. Kluger, G. Kurlemann, and E. Haberlandt Effectiveness and tolerability of rufinamide in children and adults with refractory epilepsy: first European experience Epilepsy Behav 14 2009 491 495
85. G. Kluger, E. Haberlandt, and G. Kurlemann First European long-term experience with the orphan drug rufinamide in childhood-onset refractory epilepsy Epilepsy Behav 17 2010 546 548
86. G. Coppola, S. Grosso, and E. Franzoni Rufinamide in children and adults with Lennox-Gastaut syndrome: first Italian multicenter experience Seizure 19 2010 587 591
87. M. Vendrame, T. Loddenkemper, and V.D. Gooty Experience with rufinamide in a pediatric population: a single center's experience Pediatr Neurol 43 2010 155 158
88. G. Kluger, T. Glauser, and G. Krauss Adjunctive rufinamide in Lennox-Gastaut syndrome: a long-term, open-label extension study Acta Neurol Scand 122 2010 202 208
89. T. Resnick, A. Arzimanoglou, and L.W. Brown Rufinamide from clinical trials to clinical practice in the United States and Europe Epileptic Disord 13 Suppl. 1 2011 S27 S43
90. D.J. Critchley, J. Aluri, and P. Boyd Bioavailability of three rufinamide oral suspensions compared with the marketed 400-mg tablet formulation: results from a randomized-sequence, open-label, four-period, four-sequence crossover study in healthy subjects Clin Ther 33 2011 146 157
91. H. Oguni, K. Hayashi, and M. Oguni Treatment of severe myoclonic epilepsy in infants with bromide and its borderline variant Epilepsia 35 1994 1140 1145
92. C. Chiron Current therapeutic procedures in Dravet syndrome Dev Med Child Neurol 53 Suppl. 2 2011 16 18
93. K. Hayashi, S. Ueshima, and M. Ouchida Therapy for hyperthermia-induced seizures in Scn1a mutant rats Epilepsia 52 2011 1010 1017
94. J. Lotte, E. Haberlandt, B. Neubauer, M. Staudt, and G.J. Kluger Bromide in patients with SCN1A-mutations manifesting as Dravet syndrome Neuropediatrics 43 2012 17 21
95. B. Ceulemans, M. Boel, and K. Leyssens Successful use of fenfluramine as an add-on treatment for Dravet syndrome Epilepsia 53 2012 1131 1139
96. E. Ben-Menachem Pregabalin pharmacology and its relevance to clinical practice Epilepsia 45 Suppl. 6 2004 13 18
97. H.N. Bockbrader, D. Wesche, and R. Miller A comparison of the pharmacokinetics and pharmacodynamics of pregabalin and gabapentin Clin Pharmacokinet 49 2010 661 669
98. P. von Rosenstiel Brivaracetam (UCB 34714) Neurotherapeutics 4 2007 84 87
99. A. Schulze-Bonhage Brivaracetam for the treatment of epilepsy Expert Opin Pharmacother 12 2011 1959 1966
100. L. Almeida, and P. Soares-da-Silva Eslicarbazepine acetate (BIA 2-093) Neurotherapeutics 4 2007 88 96
101. T. Mestre, and J.J. Ferreira Eslicarbazepine acetate: a new option for the treatment of focal epilepsy Expert Opin Investig Drugs 18 2009 221 229
102. M. Bialer, S.I. Johannessen, and H.J. Kupferberg Progress report on new antiepileptic drugs: a summary of the Eighth Eilat Conference (EILAT VIII) Epilepsy Res 73 2007 1 52
103. P. Kwan, and M.J. Brodie Early identification of refractory epilepsy N Engl J Med 342 2000 314 319
104. A. Verrotti, G. Loiacono, and G. Coppola Pharmacotherapy for children and adolescents with epilepsy Expert Opin Pharmacother 12 2011 175 194
105. D. Zhang, R. Thimmapaya, and X.F. Zhang KCNQ2/3 openers show differential selectivity and site of action across multiple KCNQ channels J Neurosci Methods 200 2011 54 62
106. E.D. Deeks Retigabine (ezogabine): in partial-onset seizures in adults with epilepsy CNS Drugs 25 2011 887 900
107. M.A. Rogawski Revisiting AMPA receptors as an antiepileptic drug target Epilepsy Curr 11 2011 56 63
108. W. Löscher, and D. Schmidt Modern antiepileptic drug development has failed to deliver: ways out of the current dilemma Epilepsia 52 2011 657 678
109. A. Vincent, C. Buckley, and J.M. Schott Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis Brain 127 2004 701 712
110. A. Vincent, S.R. Irani, and B. Lang The growing recognition of immunotherapy-responsive seizure disorders with autoantibodies to specific neuronal proteins Curr Opin Neurol 23 2010 144 150
111. E. Haberlandt, T. Bast, and A. Ebner Limbic encephalitis in children and adolescents Arch Dis Child 96 2011 186 191
112. C.G. Bien, and I.E. Scheffer Autoantibodies and epilepsy Epilepsia 52 Suppl. 3 2011 18 22
113. S.R. Irani, C.G. Bien, and B. Lang Autoimmune epilepsies Curr Opin Neurol 24 2011 146 153
114. S.R. Irani, A.W. Michell, and B. Lang Faciobrachial dystonic seizures precede Lgi1 antibody limbic encephalitis Ann Neurol 69 2011 892 900
115. A. van Baalen, U. Stephani, G. Kluger, M. Häusler, and O. Dulac FIRES: febrile infection responsive epileptic (FIRE) encephalopathies of school age Brain Dev 31 2009 91
116. A. van Baalen, M. Häusler, and R. Boor Febrile infection-related epilepsy syndrome (FIRES): a nonencephalitic encephalopathy in childhood Epilepsia 51 2010 1323 1328
117. H. Greiner, J.L. Leach, K.H. Lee, and D.A. Krueger Anti-NMDA receptor encephalitis presenting with imaging findings and clinical features mimicking Rasmussen syndrome Seizure 20 2011 266 270
118. M.A. Illingworth, D. Hanrahan, and C.E. Anderson Elevated VGKC-complex antibodies in a boy with fever-induced refractory epileptic encephalopathy in school-age children (FIRES) Dev Med Child Neurol 53 2011 1053 1057
119. C.G. Bien, T. Granata, and C. Antozzi Pathogenesis, diagnosis and treatment of Rasmussen encephalitis: a European consensus statement Brain 128 2005 454 471
120. R. Nabbout, M. Mazzuca, and P. Hubert Efficacy of ketogenic diet in severe refractory status epilepticus initiating fever induced refractory epileptic encephalopathy in school age children (FIRES) Epilepsia 51 2010 2033 2037
121. R.T. Daniel, S.G. Thomas, and M. Thomas Role of surgery in pediatric epilepsy Indian Pediatr 44 2007 263 273
122. M. Hemb, T.R. Velasco, and M.S. Parnes Improved outcomes in pediatric epilepsy surgery: the UCLA experience, 1986-2008 Neurology 74 2010 1768 1775
123. J.H. Cross, P. Jayakar, D. Nordli International League Against Epilepsy, Subcommission for Paediatric Epilepsy Surgery; Commissions of Neurosurgery and Paediatrics Proposed criteria for referral and evaluation of children for epilepsy surgery: recommendations of the Subcommission for Pediatric Epilepsy Surgery Epilepsia 47 2006 952 959
124. A.S. Harvey, J.H. Cross, S. Shinnar, B.W. Mathern ILAE Pediatric Epilepsy Surgery Survey Taskforce Defining the spectrum of international practice in pediatric epilepsy surgery patients Epilepsia 49 2008 146 155
125. E.H. Kossoff More fat and fewer seizures: dietary therapies for epilepsy Lancet Neurol 3 2004 415 420
126. N.E. Payne, J.H. Cross, J.W. Sander, and S.M. Sisodiya The ketogenic and related diets in adolescents and adults - a review Epilepsia 52 2011 1941 1948
127. E.G. Neal, H. Chaffe, and R.H. Schwartz The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial Lancet Neurol 7 2008 500 506
128. E.H. Kossoff, B.A. Zupec-Kania, P.E. Amark Charlie Foundation, Practice Committee of the Child Neurology Society; Practice Committee of the Child Neurology Society; International Ketogenic Diet Study Group Optimal clinical management of children receiving the ketogenic diet: recommendations of the International Ketogenic Diet Study Group Epilepsia 50 2009 304 317
129. S.H. Tonekaboni, P. Mostaghimi, and P. Mirmiran Efficacy of the Atkins diet as therapy for intractable epilepsy in children Arch Iran Med 13 2010 492 497
130. E.H. Kossoff, J.R. McGrogan, and R.M. Bluml A modified Atkins diet is effective for the treatment of intractable pediatric epilepsy Epilepsia 47 2006 421 424
131. H.C. Kang, H.S. Lee, and S.J. You Use of a modified Atkins diet in intractable childhood epilepsy Epilepsia 48 2007 182 186
132. M. Smith, N. Politzer, D. Macgarvie, M.P. McAndrews, and M. Del Campo Efficacy and tolerability of the modified Atkins diet in adults with pharmacoresistant epilepsy: a prospective observational study Epilepsia 52 2011 775 780
133. M.C. Cervenka, N.N. Terao, and J.L. Bosarge E-mail management of the modified Atkins Diet for adults with epilepsy is feasible and effective Epilepsia 53 2012 728 732
134. D.A. Muzykewicz, D.A. Lyczkowski, and N. Memon Efficacy, safety, and tolerability of the low glycemic index treatment in pediatric epilepsy Epilepsia 50 2009 1118 1126
135. W.C. Stacey, and B. Litt Technology insight: neuroengineering and epilepsy-designing devices for seizure control Nat Clin Pract Neurol 4 2008 190 201
136. S.L. Helmers, M.S. Duh, and A. Guérin Clinical outcomes, quality of life, and costs associated with implantation of vagus nerve stimulation therapy in pediatric patients with drug-resistant epilepsy Eur J Paediatr Neurol 16 2012 449 458
137. National Institute for Health and Clinical Excellence Investigational procedure guidance 50: Vagus nerve stimulation for refractory epilepsy in children 2004 National Institute for Health and Clinical Excellence London Available at: http://publications.nice.org.uk/vagus-nerve-stimulation-for- refractory-epilepsy-in-children-ipg50 [accessed 02.11.12]
138. R.S. Fisher, G.L. Krauss, E. Ramsay, K. Laxer, and J. Gates Assessment of vagus nerve stimulation for epilepsy: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology Neurology 49 1997 293 297
139. R. Fisher, V. Salanova, T. Witt SANTE Study Group Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy Epilepsia 51 2010 899 908
140. A.L. Velasco, F. Velasco, and M. Velasco Electrical stimulation of the hippocampal epileptic foci for seizure control: a double-blind, long-term follow-up study Epilepsia 48 2007 1895 1903
141. E.A. Pereira, A.L. Green, R.J. Stacey, and T.Z. Aziz Refractory epilepsy and deep brain stimulation J Clin Neurosci 19 2012 27 33
142. M.A. Rogawski Convection-enhanced delivery in the treatment of epilepsy Neurotherapeutics 6 2009 344 351
143. A. Van Dycke, R. Raedt, and I. Dauwe Continuous local intrahippocampal delivery of adenosine reduces seizure frequency in rats with spontaneous seizures Epilepsia 51 2010 1721 1728
144. A. Serralta, J.A. Barcia, and P. Ortiz Effect of intracerebroventricular continuous infusion of valproic acid versus single i.p. and i.c.v. injections in the amygdala kindling epilepsy model Epilepsy Res 70 2006 15 26
145. J.A. Barcia, and J.M. Gallego Intraventricular and intracerebral delivery of anti-epileptic drugs in the kindling model Neurotherapeutics 6 2009 337 343
146. S.L. Baptiste, H.M. Tang, and R.I. Kuzniecky Comparison of the antiepileptic properties of transmeningeally delivered muscimol, lidocaine, midazolam, pentobarbital and GABA, in rats Neurosci Lett 469 2010 421 424
147. H.M. Tang, J.A. French, R.I. Kuzniecky, O. Devinsky, and N. Ludvig Periodic transmeningeal muscimol maintains its antiepileptic efficacy over three weeks without inducing tolerance, in rats Neurosci Lett 494 2011 135 138
148. Z. Li, Q. Li, and S. Simon Formulation of spray-dried phenytoin loaded poly(epsilon-caprolactone) microcarrier intended for brain delivery to treat epilepsy J Pharm Sci 96 2007 1018 1030
149. I. Kanter-Schlifke, L. Fjord-Larsen, and P. Kusk GDNF released from encapsulated cells suppresses seizure activity in the epileptic hippocampus Exp Neurol 216 2009 413 419
150. C. Szybala, E.M. Pritchard, and T.A. Lusardi Antiepileptic effects of silk-polymer based adenosine release in kindled rats Exp Neurol 219 2009 126 135
151. D.P. Wermeling Intranasal delivery of antiepileptic medications for treatment of seizures Neurotherapeutics 6 2009 352 358
152. M. Le Van Quyen, J. Martinerie, and V. Navarro Anticipation of epileptic seizures from standard EEG recordings Lancet 357 2001 183 188
153. A.M. Chan, F.T. Sun, E.H. Boto, and B.M. Wingeier Automated seizure onset detection for accurate onset time determination in intracranial EEG Clin Neurophysiol 119 2008 2687 2696
154. K. Cuppens, L. Lagae, B. Ceulemans, S. Van Huffel, and B. Vanrumste Detection of nocturnal frontal lobe seizures in pediatric patients by means of accelerometers: a first study Conf Proc IEEE Eng Med Biol Soc 2009 2009 6608 6611
155. K. Cuppens, L. Lagae, B. Ceulemans, S. Van Huffel, and B. Vanrumste Automatic video detection of body movement during sleep based on optical flow in pediatric patients with epilepsy Med Biol Eng Comput 48 2010 923 931
156. U.R. Acharya, S.V. Sree, S. Chattopadhyay, W. Yu, and P.C. Ang Application of recurrence quantification analysis for the automated identification of epileptic EEG signals Int J Neural Syst 21 2011 199 211
157. K.N. Fountas, and J.R. Smith A novel closed-loop stimulation system in the control of focal, medically refractory epilepsy Acta Neurochir Suppl 97 2007 357 362
158. F.T. Sun, M.J. Morrell, and R.E. Wharen Jr. Responsive cortical stimulation for the treatment of epilepsy Neurotherapeutics 5 2008 68 74
159. V.S. Sohal, and F.T. Sun Responsive neurostimulation suppresses synchronized cortical rhythms in patients with epilepsy Neurosurg Clin N Am 22 2011 481 488 [vi]
160. M.J. Morrell RNS System in Epilepsy Study Group Responsive cortical stimulation for the treatment of medically intractable partial epilepsy Neurology 77 2011 1295 1304
161. M. Fujii, H. Fujioka, and T. Oku Application of focal cerebral cooling for the treatment of intractable epilepsy Neurol Med Chir (Tokyo) 50 2010 839 844
162. M.A. Nitsche, and W. Paulus Noninvasive brain stimulation protocols in the treatment of epilepsy: current state and perspectives Neurotherapeutics 6 2009 244 250
163. A. Rotenberg Prospects for clinical applications of transcranial magnetic stimulation and real-time EEG in epilepsy Brain Topogr 22 2010 257 266
164. V.K. Kimiskidis Transcranial magnetic stimulation for drug-resistant epilepsies: rationale and clinical experience Eur Neurol 63 2010 205 210
165. A.M. Mazarati Galanin and galanin receptors in epilepsy Neuropeptides 38 2004 331 343
166. E.C. NsGene Biodelivery™ platform Available at: http://nsgene.dk/NsGene-419.aspx [accessed 02.11.12]
167. S.A. Masino, M. Kawamura, C.D. Wasser, L.T. Pomeroy, and D.N. Ruskin Adenosine, ketogenic diet and epilepsy: the emerging therapeutic relationship between metabolism and brain activity Curr Neuropharmacol 7 2009 257 268
168. D. Boison Adenosine augmentation therapies (AATs) for epilepsy: prospect of cell and gene therapies Epilepsy Res 85 2009 131 141
169. K. Thompson Transplantation of GABA-producing cells for seizure control in models of temporal lobe epilepsy Neurotherapeutics 6 2009 284 294
170. F. Noè, A.H. Pool, and J. Nissinen Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy Brain 131 2008 1506 1515
171. Y.H. Raol, I.V. Lund, and S. Bandyopadhyay Enhancing GABA(A) receptor alpha 1 subunit levels in hippocampal dentate gyrus inhibits epilepsy development in an animal model of temporal lobe epilepsy J Neurosci 26 2006 11342 11346