Evolution and management of Lennox-Gastaut syndrome through adolescence and into adulthood: Are seizures always the primary issue?

Epileptic Disorders

Volumn 13, Issue , 2011, Pages S15-S26

  Kerr, Michael ^a   Kluger, Gerhard ^b   Philip, Sunny ^c  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b Schoen Klinik Vogtareuth   (Germany)

^c Department of Dermatology   (United Kingdom)

Author keywords

Adolescence; Adulthood; Co morbidity; Lennox Gastaut syndrome; Quality of life

Indexed keywords

ANTICONVULSIVE AGENT; BENZODIAZEPINE DERIVATIVE; ORAL CONTRACEPTIVE AGENT;

ADOLESCENT; BEHAVIOR DISORDER; BODY WEIGHT DISORDER; COGNITIVE DEFECT; COMORBIDITY; DROP ATTACK; DRUG ANTAGONISM; DRUG BLOOD LEVEL; ELECTROENCEPHALOGRAPHY; EPILEPTIC STATE; HUMAN; INTELLECTUAL IMPAIRMENT; LENNOX GASTAUT SYNDROME; PATIENT COMPLIANCE; PATIENT GUIDANCE; PHYSICAL DISABILITY; POLYPHARMACY; PRIORITY JOURNAL; QUALITY OF LIFE; REVIEW; SEIZURE; SEXUAL FUNCTION; SLEEP DISORDER; SOCIAL CARE; SOCIAL ISOLATION; SUDDEN DEATH; TRANSITION TO ADULT CARE; ADULT; AGE; BEHAVIOR; CHILD; COGNITION; INFANTILE SPASM; MENTAL DEFICIENCY; MENTAL HEALTH SERVICE; PATHOPHYSIOLOGY; PSYCHOLOGICAL ASPECT; SLEEP; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGE FACTORS; ANTICONVULSANTS; BEHAVIOR; CHILD; COGNITION; ELECTROENCEPHALOGRAPHY; HUMANS; MENTAL HEALTH SERVICES; MENTAL RETARDATION; QUALITY OF LIFE; SEIZURES; SLEEP; SPASMS, INFANTILE; TREATMENT OUTCOME;

EID: 80052572987     PISSN: 12949361     EISSN: 19506945     Source Type: Journal    
DOI: 10.1684/epd.2011.0409     Document Type: Review

References (59)

1. Alldredge BK, Wall DB, Ferriero DM. Effect of prehospital treatment on the outcome of status epilepticus in children. Pediatr Neurol 1995;12:213-6.
2. Alldredge BK, Gelb AM, Isaacs SM, et al. A comparison of lorazepam, diazepam, and placebo for the treatment of outof-hospital status epilepticus. N Engl J Med 2001;345:631-7.
3. Anderson GD, Kim H, Warner MH. Impact of taking antiepileptic drugs at school in a group of children and adolescents. Epilepsy Behav 2000;1:17-21.
4. Appleton RE, Chadwick D, Sweeney A. Managing the teenager with epilepsy: paediatric to adult care. Seizure 1997;6:27-30.
5. Appleton RE. Transition from paediatric clinic to the adult service. J R Soc Med 2001;94:554.
6. Arzimanoglou A, Guerrini R, Aicardi J. Lennox-Gastaut syndrome. In: Aicardi's Epilepsy in Children. 3rd edition. Philadelphia: Lippincott Williams & Wilkins, 2004: p. 38-50.
7. Arzimanoglou A, French J, Blume WT, et al. Lennox-Gastaut syndrome: a consensus approach on diagnosis, assessment, management, and trial methodology. Lancet Neurol 2009;8:82-93.
8. Batista BH, Nunes ML. Evaluation of sleep habits in children with epilepsy. Epilepsy Behav 2007;11:60-4.
9. Bauer G, Aichner F, Saltuari L. Epilepsies with diffuse slow spikes and waves of late onset. Eur Neurol 1983;22:344-50.
10. Bell GS, Sander JW. Sudden unexpected death in epilepsy. Risk factors, possible mechanisms and prevention: a reappraisal. Acta Neurol Taiwan 2006;15:72-83.
11. Benavente-Aguilar I, Morales-Blánquez C, Rubio EA, Rey JM. Quality of life of adolescents suffering from epilepsy living in the community. J Paediatr Child Health 2004;40:110-3.
12. Ben-Menachem E. Weight issues for people with epilepsy - a review. Epilepsia 2007;48(Suppl. 9):42-5.
13. Besag FM. Modern management of epilepsy: adolescents. Baillieres Clin Neurol 1996;5:803-20.
14. Besag FM. Behavioral aspects of pediatric epilepsy syndromes. Epilepsy Behav 2004;5(Suppl. 1):S3-S13.
15. Brust JC. Seizures, illicit drugs, and ethanol. Curr Neurol Neurosci Rep 2008;8:333-8.
16. Camfield P, Camfield C. Epileptic syndromes in childhood: clinical features, outcomes, and treatment. Epilepsia 2002;43(Suppl. 3):27-32.
17. Dulac O, N'Guyen T. The Lennox-Gastaut syndrome. Epilepsia 1993;34(Suppl. 7):S7-S17.
18. Dunn DW, Austin JK, Huster GA. Symptoms of depression in adolescents with epilepsy. J Am Acad Child Adolesc Psychiatry 1999;38:1132-8.
19. Ferlazzo E, Nikaronova M, Italiano D, et al. Lennox-Gastaut syndrome in adulthood: clinical and EEG features. Epilepsy Res 2010;89:271-7.
20. Ferrie CD, Patel A. Treatment of Lennox-Gastaut Syndrome (LGS). Eur J Paediatr Neurol 2009;13:493-504.
21. Gallop K, Wild D, Nixon A, Verdian L, Cramer JA. Impact of Lennox-Gastaut Syndrome (LGS) on health-related quality of life (HRQL) of patients and caregivers: literature review. Seizure 2009;18:554-8.
22. Gallop K, Wild D, Verdian L, et al. Lennox-Gastaut syndrome (LGS): development of conceptual models of health-related quality of life (HRQL) for caregivers and children. Seizure 2010;19:23-30.
23. Gayatri NA, Livingston JH. Aggravation of epilepsy by antiepileptic drugs. Dev Med Child Neurol 2006;48:394-8.
24. Gospe Jr. SM. Pyridoxine-dependent seizures: new genetic and biochemical clues to help with diagnosis and treatment. Curr Opin Neurol 2006;19:148-53.
25. Guerrini R, Belmonte A, Genton P. Antiepileptic druginduced worsening of seizures in children. Epilepsia 1998;39(Suppl. 3):S2-S10.
26. Jurasek L, Ray L, Quigley D. Development and implementation of an adolescent epilepsy transition clinic. J Neurosci Nurs 2010;42:181-9.
27. Kanner AM, Dunn DW. Diagnosis and management of depression and psychosis in children and adolescents with epilepsy. J Child Neurol 2004;19(Suppl. 1):S65-72.
28. Katz DA, McHorney CA. The relationship between insomnia and health-related quality of life in patients with chronic illness. J Fam Pract 2002;51:229-35.
29. Krueger DA, Franz DN. Current management of tuberous sclerosis complex. Paediatr Drugs 2008;10:299-313.
30. Lipinski CG. Epilepsies with astatic seizures of late onset. Epilepsia 1977;18:13-20.
31. Lossius R, Nakken KO. Epilepsy in adolescence. Need for multi-professional diagnosis and treatment. Tidsskr Nor Laegeforen 1999;119:528-30.
32. Luef GJ. Epilepsy and sexuality. Seizure 2008;17:127-30.
33. Mula M, Trimble MR. Antiepileptic drug-induced cognitive adverse effects: potential mechanisms and contributing factors. CNS Drugs 2009;23:121-37.
34. Neckelmann D, Mykletun A, Dahl AA. Chronic insomnia as a risk factor for developing anxiety and depression. Sleep 2007;30:873-80.
35. Nordli Jr. DR. Special needs of the adolescent with epilepsy. Epilepsia 2001;42(Suppl. 8):10-7.
36. O'Brien LM. The neurocognitive effects of sleep disruption in children and adolescents. Child Adolesc Psychiatr Clin N Am 2009;18:813-23.
37. Ogawa K, Kanemoto K, Ishii Y, et al. Long-term follow-up study of Lennox-Gastaut syndrome in patients with severe motor and intellectual disabilities: with special reference to the problem of dysphagia. Seizure 2001;10:197-202.
38. Oguni H, Hayashi K, Osawa M. Long-term prognosis of Lennox-Gastaut syndrome. Epilepsia 1996;37(Suppl. 3):44-7.
39. Ohtsuka Y, Amano R, Mizukawa M, Ohtahara S. Long-term prognosis of the Lennox-Gastaut syndrome. Jpn J Psychiatry Neurol 1990;44:257-64.
40. Ott D, Siddarth P, Gurbani S, et al. Behavioral disorders in pediatric epilepsy: unmet psychiatric need. Epilepsia 2003;44:591-7.
41. Paolicchi JM. Epilepsy in adolescents: diagnosis and treatment. Adolesc Med 2002;13:443-59.
42. Parisi P, Bruni O, Pia Villa M, et al. The relationship between sleep and epilepsy: the effect on cognitive functioning in children. Dev Med Child Neurol 2010;52:805-10.
43. Perucca E, Gram L, Avanzini G, Dulac O. Antiepileptic drugs as a cause of worsening seizures. Epilepsia 1998;39:5-17.
44. Perucca E, Cloyd J, Critchley D, Fuseau E. Rufinamide: clinical pharmacokinetics and concentration-response relationships in patients with epilepsy. Epilepsia 2008;49:1123-41.
45. Ramsay RE, Shields WD, Shinnar S. Special issues in the management of young children, older adults, and the developmentally disabled. J Child Neurol 2007;22(5 Suppl.):53S-60S.
46. Reddy DS. Clinical pharmacokinetic interactions between antiepileptic drugs and hormonal contraceptives. Expert Rev Clin Pharmacol 2010;3:183-92.
47. Samokhvalov AV, Irving H, Mohapatra S, Rehm J. Alcohol consumption, unprovoked seizures, and epilepsy: a systematic review and meta-analysis. Epilepsia 2010;51:1177-84.
48. Sheth RD. Adolescent issues in epilepsy. J Child Neurol 2002;17(Suppl. 2):2S23-2S12.
49. Sheth RD, Gidal BE. Optimizing epilepsy management in teenagers. J Child Neurol 2006;21:273-9.
50. Smith PE, Myson V, Gibbon F. A teenager epilepsy clinic: observational study. Eur J Neurol 2002;9:373-6.
51. Smith PE, Wallace SJ. Taking over epilepsy from the paediatric neurologist. J Neurol Neurosurg Psychiatry 2003;74(Suppl. 1):i37-41.
52. Surges R, Thijs RD, Tan HL, Sander JW, & Medscape. Sudden unexpected death in epilepsy: risk factors and potential pathomechanisms. Nat Rev Neurol 2009;5:492-504.
53. Tomson T, Walczak T, Sillanpaa M, Sander JW. Sudden unexpected death in epilepsy: a review of incidence and risk factors. Epilepsia 2005;46(Suppl. 11):54-61.
54. Turky A, Beavis JM, Thapar AK, Kerr MP. Psychopathology in children and adolescents with epilepsy: an investigation of predictive variables. Epilepsy Behav 2008;12:136-44.
55. Unterberger I, Bauer G, Walser G, et al. Lennox-Gastaut syndrome in adulthood: a cross-sectional study. Epilepsia 2010;51(Suppl. 4):154 (abstract p522).
56. van Rijckevorsel K. Treatment of Lennox-Gastaut syndrome: overview and recent findings. Neuropsychiatr Dis Treat 2008;4:1001-19.
57. Warnell P. The transition experience of epilepsy patients/families: results of a telephone survey. Axone 1998;20:31-3.
58. World Health Organization. International Classification of Functioning, Disability and Health (ICF). Geneva, Switzerland, World Health Organization, 2001. Available at: http://www.who.int/classifications/icf/en/. Accessed 13 December 2010.
59. Yagi K. Evolution of Lennox-Gastaut syndrome: a long-term longitudinal study. Epilepsia 1996;37(Suppl. 3):48-51.