Statistical Process Control (SPC)-A simple objective method for monitoring seizure frequency and evaluating effectiveness of drug interventions in refractory childhood epilepsy

Epilepsy Research

Volumn 91, Issue 2-3, 2010, Pages 205-213

  Pujar, Suresh ^a,b,c   Calvert, Sophie ^a,d   Cortina Borja, Mario ^c   Chin, Richard F M ^a,b,c   Smith, Ralph A ^a,b   Cross, J Helen ^a,b,c   Das, Krishna ^a,b   Pitt, Matthew ^b,c   Scott, Rod C ^a,b,c  

^a YOUNG EPILEPSY   (United Kingdom)

^b GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d ROYAL CHILDREN'S HOSPITAL   (Australia)

Author keywords

Drug load; I charts; Refractory epilepsy; Seizure fluctuation; Statistical Process Control (SPC)

Indexed keywords

ANTICONVULSIVE AGENT;

ADOLESCENT; ADULT; ARTICLE; BENIGN CHILDHOOD EPILEPSY; CHILD; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CLINICAL ASSESSMENT TOOL; CLINICAL EVALUATION; CLINICAL STUDY; CONTROLLED STUDY; DISEASE CLASSIFICATION; DISEASE DURATION; DISEASE SEVERITY; DOSE CALCULATION; DOSE RESPONSE; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG WITHDRAWAL; FEMALE; HUMAN; PATIENT MONITORING; PRIORITY JOURNAL; RISK REDUCTION; SCHOOL CHILD; STATISTICAL ANALYSIS; STATISTICAL PROCESS CONTROL; UNSPECIFIED SIDE EFFECT;

ADOLESCENT; ANTICONVULSANTS; CHILD; DRUG EVALUATION; EPILEPSY, ABSENCE; FEMALE; HUMANS; MALE; MONITORING, PHYSIOLOGIC; PROCESS ASSESSMENT (HEALTH CARE); RETROSPECTIVE STUDIES; YOUNG ADULT;

EID: 77957017366     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2010.07.013     Document Type: Article

References (14)

1. Deckers C.L., Hekster Y.A., Keyser A., Meinardi H., Renier W.O. Drug load in clinical trials: a neglected factor. Clin. Pharmacol. Ther. 1997, 62:592-595.
2. Deckers C.L. Overtreatment in adults with epilepsy. Epilepsy Res. 2002, 52:43-52.
3. Harter H.L. Tables of range and studentized range. Ann. Math. Stat. 1960, 31:1122-1147.
4. Haut S.R., Hall C.B., Masur J., Lipton R.B. Seizure occurrence: precipitants and prediction. Neurology 2007, 69:1905-1910.
5. Holmes G.L. Overtreatment in children with epilepsy. Epilepsy Res. 2002, 52:35-42.
6. Nelson L.S. The Shewhart control chart-tests for special causes. J. Qual. Technol. 1984, 16:237-239.
7. Perucca E., Kwan P. Overtreatment in epilepsy: how it occurs and how it can be avoided. CNS Drugs 2005, 19:897-908.
8. Raspall-Chaure M., Neville B.G., Scott R.C. The medical management of the epilepsies in children: conceptual and practical considerations. Lancet Neurol. 2008, 7:57-69.
9. R Development Core Team R: A Language and Environment for Statistical Computing 2008, R Foundation for Statistical Computing, Vienna.
10. Sander J.W. Some aspects of prognosis in the epilepsies: a review. Epilepsia 1993, 34:1007-1016.
11. Shewhart, WA., 1986. Statistical method from the viewpoint of Quality Control. Graduate School, Department of Agriculture, Washington 1939: Dover 1986.
12. Shorvon S.D. The epidemiology and treatment of chronic and refractory epilepsy. Epilepsia 1996, 37(Suppl. 2):S1-S3.
13. Spilker B., Segreti A. Validation of the phenomenon of regression of seizure frequency in epilepsy. Epilepsia 1984, 25:443-449.
14. Thor J., Lundberg J., Ask J., Olsson J., Carli C., Harenstam K.P., Brommels M. Application of statistical process control in healthcare improvement: systematic review. Qual. Saf. Health Care 2007, 16:387-399.