Regulation of forkhead box O1 (FOXO1) by protein kinase B and glucocorticoids: Different mechanisms of induction of beta cell death in vitro

Diabetologia

Volumn 56, Issue 7, 2013, Pages 1587-1595

  Kaiser, G ^a   Gerst, F ^a   Michael, D ^a   Berchtold, S ^a   Friedrich, B ^a   Strutz Seebohm, N ^a,b   Lang, F ^a   Haring H U ^a   Ullrich, S ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

AKT isoforms; Apoptosis; Dexamethasone; FOXO1; Glucocorticoids; Insulin secreting cells; SGK1

Indexed keywords

BIM PROTEIN; DEXAMETHASONE; ISOPROTEIN; MESSENGER RNA; PROTEIN KINASE B; PROTEIN KINASE B BETA; PROTEIN KINASE B INHIBITOR; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR PDX 1;

AKT1 GENE; AKT2 GENE; AKT3 GENE; ANIMAL CELL; APOPTOSIS; ARTICLE; BIM GENE; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FOXO1 GENE; GENE; GENE EXPRESSION REGULATION; IN VITRO STUDY; INTRACELLULAR SIGNALING; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PDX1 GENE; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SGK1 GENE; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; CELL LINE; DEXAMETHASONE; FORKHEAD TRANSCRIPTION FACTORS; GLUCOCORTICOIDS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INSULIN-SECRETING CELLS; MICE; PROTO-ONCOGENE PROTEINS C-AKT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84878872943     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-013-2863-7     Document Type: Article

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