Bioactivity and bioavailability of ginsenosides are dependent on the glycosidase activities of the A/J mouse intestinal microbiome defined by pyrosequencing

Pharmaceutical Research

Volumn 30, Issue 3, 2013, Pages 836-846

  Niu, Tao ^a   Smith, Diane L ^b   Yang, Zhen ^a   Gao, Song ^a   Yin, Taijun ^a   Jiang, Zhi Hong ^c   You, Ming ^d   Gibbs, Richard A ^b   Petrosino, Joseph F ^b   Hu, Ming ^a  

^a UNIVERSITY OF HOUSTON   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

^d MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

16S rRNA gene sequencing; F2 and C K; ginseng; ginsenosides Rb1; microbiome; permeability; pharmacokinetic profile; rate limiting step; Rd; stepwise metabolism

Indexed keywords

GINSENOSIDE; GINSENOSIDE C K; GINSENOSIDE F2; GINSENOSIDE RB 1; GINSENOSIDE RD; GLYCOSIDASE; RNA 16S; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG EXPOSURE; DRUG HYDROLYSIS; DRUG STRUCTURE; DRUG TRANSFORMATION; ENZYME ACTIVITY; EXPERIMENTAL MOUSE; HYDROLYSIS KINETICS; INTESTINE FLORA; LIMIT OF QUANTITATION; LUNG CANCER; MALE; MICROBIOME; MOUSE; NONHUMAN; POPULATION ABUNDANCE; PRIORITY JOURNAL; PYROSEQUENCING; RNA SEQUENCE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BACTERIA; BIOLOGICAL AVAILABILITY; BIOTRANSFORMATION; CACO-2 CELLS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUGS, CHINESE HERBAL; GINSENOSIDES; GLYCOSIDE HYDROLASES; HUMANS; HYDROLYSIS; INTESTINES; MALE; METAGENOME; MICE; NEOPLASMS; PANAX; RNA, BACTERIAL;

EID: 84878857317     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-012-0925-z     Document Type: Article

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