Structures of down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition

Structure

Volumn 21, Issue 6, 2013, Pages 986-996

  Soundararajan, Meera ^a,d   Roos, Annette K ^a,e   Savitsky, Pavel ^a   Filippakopoulos, Panagis ^a   Kettenbach, Arminja N ^b   Olsen, Jesper V ^c   Gerber, Scott A ^b   Eswaran, Jeyanthy ^a,f   Knapp, Stefan ^a   Elkins, Jonathan M ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

^c University of Copenhagen   (Denmark)

^d NORTHUMBRIA UNIVERSITY   (United Kingdom)

^e UPPSALA UNIVERSITY   (Sweden)

^f GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DUAL SPECIFICITY TYROSINE PHOSPHORYLATION REGULATED KINASE 1A; DUAL SPECIFICITY TYROSINE PHOSPHORYLATION REGULATED KINASE 2; MUTANT PROTEIN; PROTEIN TYROSINE KINASE; TYROSINE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; MOLECULAR MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; RNA TRANSLATION; WILD TYPE;

AMINO ACID SEQUENCE; CATALYTIC DOMAIN; DOWN SYNDROME; ENZYME ACTIVATION; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; SERINE; SUBSTRATE SPECIFICITY; THREONINE;

EID: 84878851513     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2013.03.012     Document Type: Article

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