Characterization of a domain that transiently converts class 2 DYRKs into intramolecular tyrosine kinases

Science Signaling

Volumn 3, Issue 111, 2010, Pages

  Kinstrie, Ross ^a   Luebbering, Nathan ^b   Miranda Saavedra, Diego ^c   Sibbet, Gary ^d   Han, Jingfen ^b   Lochhead, Pamela A ^e   Cleghon, Vaughn ^b  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^e BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CLASS 2 DUAL SPECIFICITY TYROSINE PHOSPHORYLATION REGULATED KINASE; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; DROSOPHILA PROTEIN; DYRK KINASE; DYRK2 PROTEIN, DROSOPHILA; MINIBRAIN PROTEIN, DROSOPHILA; PROTEIN SERINE THREONINE KINASE; RECOMBINANT PROTEIN; TYROSINE;

AMINO TERMINAL SEQUENCE; ARTICLE; AUTOPHOSPHORYLATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; TRYPANOSOMA; AMINO ACID SEQUENCE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CLASSIFICATION; ENZYME SPECIFICITY; GENE DELETION; GENETIC COMPLEMENTATION; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; SPECIES DIFFERENCE;

AMINO ACID SEQUENCE; ANIMALS; CONSERVED SEQUENCE; DROSOPHILA PROTEINS; ENZYME ACTIVATION; GENETIC COMPLEMENTATION TEST; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; RECOMBINANT PROTEINS; SEQUENCE DELETION; SEQUENCE HOMOLOGY, AMINO ACID; SPECIES SPECIFICITY; SUBSTRATE SPECIFICITY; TYROSINE;

EID: 77952565593     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2000579     Document Type: Article

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46. Acknowledgments: We thank M. Shirayama and C. Mello for providing us with the GST-OMA-1 fusion construct (B108251), and W. Becker and J. Lessard for suggestions on the manuscript. Author contributions: P. A. L. and V. C. initiated the study. R. K. and N. L. expanded the study and coordinated its completion. J. H. and G. S. provided expert assistance in tissue culture and viral stock generation. D. M.-S., P. A. L., and V. C. conducted bioinformatic analysis. R. K., N. L., D. M.-S., G. S., J. H., P. A. L., and V. C. significantly contributed to the experiments and data analysis. N. L. and V. C. wrote the paper. Competing interests: The authors declare no conflicts of interest.