-
1
-
-
33845558717
-
Sesquiterpene lactones of Tithonia diversifolia. Stereochemistry of the tagitinins and related compounds
-
10.1021/jo01325a018
-
Barua NC, Sharma RP, Madhusudanan KP, Thyagaraian G, Herz W, Murari R (1979) Sesquiterpene lactones of Tithonia diversifolia. Stereochemistry of the tagitinins and related compounds. J Org Chem 44:1831-1835
-
(1979)
J Org Chem
, vol.44
, pp. 1831-1835
-
-
Barua, N.C.1
Sharma, R.P.2
Madhusudanan, K.P.3
Thyagaraian, G.4
Herz, W.5
Murari, R.6
-
2
-
-
0037428442
-
Antidiabetic action of a liver X receptor agonist mediated by inhibition of hepatic gluconeogenesis
-
12414791 10.1074/jbc.M210208200 1:CAS:528:DC%2BD3sXnsl2k
-
Cao G, Liang Y, Broderick CL, Oldham BA, Beyer TP, Schmidt RJ, Zhang Y, Stayrook KR, Suen C, Otto KA, Miller AR, Dai J, Foxworthy P, Gao H, Ryan TP, Jiang XC, Burris TP, Eacho PI, Etgen GJ (2003) Antidiabetic action of a liver X receptor agonist mediated by inhibition of hepatic gluconeogenesis. J Biol Chem 278:1131-1136
-
(2003)
J Biol Chem
, vol.278
, pp. 1131-1136
-
-
Cao, G.1
Liang, Y.2
Broderick, C.L.3
Oldham, B.A.4
Beyer, T.P.5
Schmidt, R.J.6
Zhang, Y.7
Stayrook, K.R.8
Suen, C.9
Otto, K.A.10
Miller, A.R.11
Dai, J.12
Foxworthy, P.13
Gao, H.14
Ryan, T.P.15
Jiang, X.C.16
Burris, T.P.17
Eacho, P.I.18
Etgen, G.J.19
-
3
-
-
22544474215
-
Transient impairment of the adaptive response to fasting in FXR-deficient mice
-
16023103 10.1016/j.febslet.2005.06.033 1:CAS:528:DC%2BD2MXmvVChurc%3D
-
Cariou B, Van Harmelen K, Duran-Sandoval D, Van Dijk T, Grefhorst A, Bouchaert E, Fruchart JC, Gonzalez FJ, Kuipers F, Staels B (2005) Transient impairment of the adaptive response to fasting in FXR-deficient mice. FEBS Lett 579:4076-4080
-
(2005)
FEBS Lett
, vol.579
, pp. 4076-4080
-
-
Cariou, B.1
Van Harmelen, K.2
Duran-Sandoval, D.3
Van Dijk, T.4
Grefhorst, A.5
Bouchaert, E.6
Fruchart, J.C.7
Gonzalez, F.J.8
Kuipers, F.9
Staels, B.10
-
4
-
-
0035657634
-
Nuclear receptor-mediated repression of human cholesterol 7α-hydroxylase gene transcription by bile acids
-
11518759 1:CAS:528:DC%2BD3MXmslSqtLw%3D
-
Chen W, Owsley E, Yang Y, Stroup D, Chiang JY (2001) Nuclear receptor-mediated repression of human cholesterol 7α-hydroxylase gene transcription by bile acids. J Lipid Res 42:1402-1412
-
(2001)
J Lipid Res
, vol.42
, pp. 1402-1412
-
-
Chen, W.1
Owsley, E.2
Yang, Y.3
Stroup, D.4
Chiang, J.Y.5
-
5
-
-
0035834868
-
Regulation of cholesterol 7α-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRα)
-
11179691 10.1016/S0378-1119(00)00518-7 1:CAS:528:DC%2BD3MXhtV2lu70%3D
-
Chiang JY, Kimmel R, Stroup D (2001) Regulation of cholesterol 7α-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRα). Gene 262:257-265
-
(2001)
Gene
, vol.262
, pp. 257-265
-
-
Chiang, J.Y.1
Kimmel, R.2
Stroup, D.3
-
6
-
-
21744432879
-
In vitro anti-leukemic and antiviral activities of traditionally used medicinal plants in Taiwan
-
15633805 10.1142/S0192415X04002284
-
Chiang LC, Cheng HY, Chen CC, Lin CC (2004) In vitro anti-leukemic and antiviral activities of traditionally used medicinal plants in Taiwan. Am J Chin Med 32:695-704
-
(2004)
Am J Chin Med
, vol.32
, pp. 695-704
-
-
Chiang, L.C.1
Cheng, H.Y.2
Chen, C.C.3
Lin, C.C.4
-
7
-
-
0348111308
-
Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor α
-
12970362 10.1074/jbc.M302287200 1:CAS:528:DC%2BD3sXpt1Gjtrg%3D
-
Dalen KT, Ulven SM, Bamberg K, Gustafsson JA, Nebb HI (2003) Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor α. J Biol Chem 278:48283-48291
-
(2003)
J Biol Chem
, vol.278
, pp. 48283-48291
-
-
Dalen, K.T.1
Ulven, S.M.2
Bamberg, K.3
Gustafsson, J.A.4
Nebb, H.I.5
-
8
-
-
0035852770
-
Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands
-
11171976 10.1073/pnas.98.4.1477 1:CAS:528:DC%2BD3MXhsVWjtL8%3D
-
DeBose-Boyd RA, Ou J, Goldstein JL, Brown MS (2001) Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands. Proc Natl Acad Sci USA 98:1477-1482
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 1477-1482
-
-
Debose-Boyd, R.A.1
Ou, J.2
Goldstein, J.L.3
Brown, M.S.4
-
9
-
-
0036164154
-
BAREing it all: The adoption of LXR and FXR and their roles in lipid homeostasis
-
11792716 1:CAS:528:DC%2BD38XhtFWmt7s%3D
-
Edwards PA, Kast HR, Anisfeld AM (2002) BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis. J Lipid Res 43:2-12
-
(2002)
J Lipid Res
, vol.43
, pp. 2-12
-
-
Edwards, P.A.1
Kast, H.R.2
Anisfeld, A.M.3
-
10
-
-
0142223221
-
The three-dimensional structure of the liver X receptor β reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands
-
12819202 10.1074/jbc.M304842200
-
Färnegårdh M, Bonn T, Sun S, Ljunggren J, Ahola H, Wilhelmsson A, Gustafsson JA, Carlquist M (2003) The three-dimensional structure of the liver X receptor β reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands. J Biol Chem 278:38821-38828
-
(2003)
J Biol Chem
, vol.278
, pp. 38821-38828
-
-
Färnegårdh, M.1
Bonn, T.2
Sun, S.3
Ljunggren, J.4
Ahola, H.5
Wilhelmsson, A.6
Gustafsson, J.A.7
Carlquist, M.8
-
11
-
-
64249153603
-
Identification of an N-oxide pyridine GW4064 analog as a potent FXR agonist
-
19328688 10.1016/j.bmcl.2009.03.008 1:CAS:528:DC%2BD1MXkslyiu7Y%3D
-
Feng S, Yang M, Zhang Z, Wang Z, Hong D, Richter H, Benson GM, Bleicher K, Grether U, Martin RE, Plancher JM, Kuhn B, Rudolph MG, Chen L (2009) Identification of an N-oxide pyridine GW4064 analog as a potent FXR agonist. Bioorg Med Chem Lett 19:2595-2598
-
(2009)
Bioorg Med Chem Lett
, vol.19
, pp. 2595-2598
-
-
Feng, S.1
Yang, M.2
Zhang, Z.3
Wang, Z.4
Hong, D.5
Richter, H.6
Benson, G.M.7
Bleicher, K.8
Grether, U.9
Martin, R.E.10
Plancher, J.M.11
Kuhn, B.12
Rudolph, M.G.13
Chen, L.14
-
12
-
-
25644443217
-
Cross-talk between farnesoid-X-receptor (FXR) and peroxisome proliferator-activated receptor γ contributes to the antifibrotic activity of FXR ligands in rodent models of liver cirrhosis
-
15980055 10.1124/jpet.105.085597 1:CAS:528:DC%2BD2MXhtVOksrfJ
-
Fiorucci S, Rizzo G, Antonelli E, Renga B, Mencarelli A, Riccardi L, Morelli A, Pruzanski M, Pellicciari R (2005) Cross-talk between farnesoid-X-receptor (FXR) and peroxisome proliferator-activated receptor γ contributes to the antifibrotic activity of FXR ligands in rodent models of liver cirrhosis. J Pharmacol Exp Ther 315:58-68
-
(2005)
J Pharmacol Exp Ther
, vol.315
, pp. 58-68
-
-
Fiorucci, S.1
Rizzo, G.2
Antonelli, E.3
Renga, B.4
Mencarelli, A.5
Riccardi, L.6
Morelli, A.7
Pruzanski, M.8
Pellicciari, R.9
-
13
-
-
0029046931
-
Identification of a nuclear receptor that is activated by farnesol metabolites
-
7774010 10.1016/0092-8674(95)90530-8 1:CAS:528:DyaK2MXmtFOitbk%3D
-
Forman BM, Goode E, Chen J, Oro AE, Bradley DJ, Perlmann T, Noonan DJ, Burka LT, McMorris T, Lamph WW, Evans RM, Weinberger C (1995) Identification of a nuclear receptor that is activated by farnesol metabolites. Cell 81:687-693
-
(1995)
Cell
, vol.81
, pp. 687-693
-
-
Forman, B.M.1
Goode, E.2
Chen, J.3
Oro, A.E.4
Bradley, D.J.5
Perlmann, T.6
Noonan, D.J.7
Burka, L.T.8
McMorris, T.9
Lamph, W.W.10
Evans, R.M.11
Weinberger, C.12
-
14
-
-
0842347855
-
Structure-activity relationship of bile acids and bile acid analogs in regard to FXR activation
-
13130122 10.1194/jlr.M300215-JLR200 1:CAS:528:DC%2BD2cXhsVSksbg%3D
-
Fujino T, Une M, Imanaka T, Inoue K, Nishimaki-Mogami T (2004) Structure-activity relationship of bile acids and bile acid analogs in regard to FXR activation. J Lipid Res 45:132-138
-
(2004)
J Lipid Res
, vol.45
, pp. 132-138
-
-
Fujino, T.1
Une, M.2
Imanaka, T.3
Inoue, K.4
Nishimaki-Mogami, T.5
-
15
-
-
0033637121
-
A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
-
11030332 10.1016/S1097-2765(00)00051-4 1:CAS:528:DC%2BD3cXntVyhs7o%3D
-
Goodwin B, Jones SA, Price RR, Watson MA, McKee DD, Moore LB, Galardi C, Wilson JG, Lewis MC, Roth ME, Maloney PR, Willson TM, Kliewer SA (2000) A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol Cell 6:517-526
-
(2000)
Mol Cell
, vol.6
, pp. 517-526
-
-
Goodwin, B.1
Jones, S.A.2
Price, R.R.3
Watson, M.A.4
McKee, D.D.5
Moore, L.B.6
Galardi, C.7
Wilson, J.G.8
Lewis, M.C.9
Roth, M.E.10
Maloney, P.R.11
Willson, T.M.12
Kliewer, S.A.13
-
16
-
-
27744486832
-
Evidence for an indirect transcriptional regulation of glucose-6-phosphatase gene expression by liver X receptors
-
16256938 10.1016/j.bbrc.2005.10.030 1:CAS:528:DC%2BD2MXht1Wju7zM
-
Grempler R, Günther S, Steffensen KR, Nilsson M, Barthel A, Schmoll D, Walther R (2005) Evidence for an indirect transcriptional regulation of glucose-6-phosphatase gene expression by liver X receptors. Biochem Biophys Res Commun 338:981-986
-
(2005)
Biochem Biophys Res Commun
, vol.338
, pp. 981-986
-
-
Grempler, R.1
Günther, S.2
Steffensen, K.R.3
Nilsson, M.4
Barthel, A.5
Schmoll, D.6
Walther, R.7
-
17
-
-
0036241537
-
Sesquiterpenoids from Tithonia diversifolia with potential cancer chemopreventive activity
-
11975495 10.1021/np010545m 1:CAS:528:DC%2BD38Xit1WgsL0%3D
-
Gu JQ, Gills JJ, Park EJ, Mata-Greenwood E, Hawthorne ME, Axelrod F, Chavez PI, Fong HH, Mehta RG, Pezzuto JM, Kinghorn AD (2002) Sesquiterpenoids from Tithonia diversifolia with potential cancer chemopreventive activity. J Nat Prod 65:532-536
-
(2002)
J Nat Prod
, vol.65
, pp. 532-536
-
-
Gu, J.Q.1
Gills, J.J.2
Park, E.J.3
Mata-Greenwood, E.4
Hawthorne, M.E.5
Axelrod, F.6
Chavez, P.I.7
Fong, H.H.8
Mehta, R.G.9
Pezzuto, J.M.10
Kinghorn, A.D.11
-
18
-
-
0036295401
-
LXRα is the dominant regulator of CYP7A1 transcription
-
12054605 10.1016/S0006-291X(02)00229-2 1:CAS:528:DC%2BD38XksVGiur0%3D
-
Gupta S, Pandak WM, Hylemon PB (2002) LXRα is the dominant regulator of CYP7A1 transcription. Biochem Biophys Res Commun 293:338-343
-
(2002)
Biochem Biophys Res Commun
, vol.293
, pp. 338-343
-
-
Gupta, S.1
Pandak, W.M.2
Hylemon, P.B.3
-
19
-
-
0004100536
-
Trans-1, 2-cis-4, 5-germacradienolide and other new germacranolides from Tithonia species
-
10.1021/jo00909a022 1:CAS:528:DyaE2MXlsl2gs7c%3D
-
Herz W, Sharma RP (1975) Trans-1, 2-cis-4, 5-germacradienolide and other new germacranolides from Tithonia species. J Org Chem 40:3118-3123
-
(1975)
J Org Chem
, vol.40
, pp. 3118-3123
-
-
Herz, W.1
Sharma, R.P.2
-
20
-
-
4744354632
-
T0901317 is a dual LXR/FXR agonist
-
15464433 10.1016/j.ymgme.2004.07.007 1:CAS:528:DC%2BD2cXotF2ntrc%3D
-
Houck KA, Borchert KM, Hepler CD, Thomas JS, Bramlett KS, Michael LF, Burris TP (2004) T0901317 is a dual LXR/FXR agonist. Mol Genet Metab 83:184-187
-
(2004)
Mol Genet Metab
, vol.83
, pp. 184-187
-
-
Houck, K.A.1
Borchert, K.M.2
Hepler, C.D.3
Thomas, J.S.4
Bramlett, K.S.5
Michael, L.F.6
Burris, T.P.7
-
21
-
-
0029805887
-
An oxysterol signalling pathway mediated by the nuclear receptor LXR α
-
8878485 10.1038/383728a0 1:CAS:528:DyaK28XmsVGns78%3D
-
Janowski BA, Willy PJ, Devi TR, Falck JR, Mangelsdorf DJ (1996) An oxysterol signalling pathway mediated by the nuclear receptor LXR α. Nature 383:728-731
-
(1996)
Nature
, vol.383
, pp. 728-731
-
-
Janowski, B.A.1
Willy, P.J.2
Devi, T.R.3
Falck, J.R.4
Mangelsdorf, D.J.5
-
22
-
-
23944439351
-
Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure
-
Jaye MC, Krawiec JA, Campobasso N, Smallwood A, Qiu C, Lu Q, Kerrigan JJ, De Los Frailes Alvaro M, Laffitte B, Liu WS, Marino JP Jr, Meyer CR, Nichols JA, Parks DJ, Perez P, Sarov-Blat L, Seepersaud SD, Steplewski KM, Thompson SK, Wang P, Watson MA, Webb CL, Haigh D, Caravella JA, Macphee CH, Willson TM, Collins JL (2005) Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure. J Med Chem 48:5419-5422
-
(2005)
J Med Chem
, vol.48
, pp. 5419-5422
-
-
Jaye, M.C.1
Krawiec, J.A.2
Campobasso, N.3
Smallwood, A.4
Qiu, C.5
Lu, Q.6
Kerrigan, J.J.7
De Los Frailes Alvaro, M.8
Laffitte, B.9
Liu, W.S.10
Marino Jr., J.P.11
Meyer, C.R.12
Nichols, J.A.13
Parks, D.J.14
Perez, P.15
Sarov-Blat, L.16
Seepersaud, S.D.17
Steplewski, K.M.18
Thompson, S.K.19
Wang, P.20
Watson, M.A.21
Webb, C.L.22
Haigh, D.23
Caravella, J.A.24
Macphee, C.H.25
Willson, T.M.26
Collins, J.L.27
more..
-
23
-
-
34948838912
-
Farnesoid X receptor modulates renal lipid metabolism, fibrosis, and diabetic nephropathy
-
17660268 10.2337/db06-1642 1:CAS:528:DC%2BD2sXhtFygt7zN
-
Jiang T, Wang XX, Scherzer P, Wilson P, Tallman J, Takahashi H, Li J, Iwahashi M, Sutherland E, Arend L, Levi M (2007) Farnesoid X receptor modulates renal lipid metabolism, fibrosis, and diabetic nephropathy. Diabetes 56:2485-2493
-
(2007)
Diabetes
, vol.56
, pp. 2485-2493
-
-
Jiang, T.1
Wang, X.X.2
Scherzer, P.3
Wilson, P.4
Tallman, J.5
Takahashi, H.6
Li, J.7
Iwahashi, M.8
Sutherland, E.9
Arend, L.10
Levi, M.11
-
24
-
-
0347034082
-
Characterization of the human ABCG1 gene: Liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein
-
11500512 10.1074/jbc.M105863200 1:CAS:528:DC%2BD3MXnvVemt7o%3D
-
Kennedy MA, Venkateswaran A, Tarr PT, Xenarios I, Kudoh J, Shimizu N, Edwards PA (2001) Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein. J Biol Chem 276:39438-39447
-
(2001)
J Biol Chem
, vol.276
, pp. 39438-39447
-
-
Kennedy, M.A.1
Venkateswaran, A.2
Tarr, P.T.3
Xenarios, I.4
Kudoh, J.5
Shimizu, N.6
Edwards, P.A.7
-
25
-
-
67649386143
-
Interrelationship between liver X receptor α, sterol regulatory element-binding protein-1c, peroxisome proliferator-activated receptor γ, and small heterodimer partner in the transcriptional regulation of glucokinase gene expression in liver
-
19366697 10.1074/jbc.M109.006742 1:CAS:528:DC%2BD1MXmtlChur0%3D
-
Kim TH, Kim H, Park JM, Im SS, Bae JS, Kim MY, Yoon HG, Cha JY, Kim KS, Ahn YH (2009) Interrelationship between liver X receptor α, sterol regulatory element-binding protein-1c, peroxisome proliferator-activated receptor γ, and small heterodimer partner in the transcriptional regulation of glucokinase gene expression in liver. J Biol Chem 284:15071-15083
-
(2009)
J Biol Chem
, vol.284
, pp. 15071-15083
-
-
Kim, T.H.1
Kim, H.2
Park, J.M.3
Im, S.S.4
Bae, J.S.5
Kim, M.Y.6
Yoon, H.G.7
Cha, J.Y.8
Kim, K.S.9
Ahn, Y.H.10
-
26
-
-
0031844983
-
Sesquiterpenes from the leaves of Tithonia diversifolia
-
9644077 10.1021/np970530h 1:CAS:528:DyaK1cXjs1Wgsb0%3D
-
Kuo YH, Chen CH (1998) Sesquiterpenes from the leaves of Tithonia diversifolia. J Nat Prod 61:827-828
-
(1998)
J Nat Prod
, vol.61
, pp. 827-828
-
-
Kuo, Y.H.1
Chen, C.H.2
-
27
-
-
34548318815
-
Sesquiterpenoids and flavonoids from the aerial parts of Tithonia diversifolia and their cytotoxic activity
-
17666852 10.1248/cpb.55.1240 1:CAS:528:DC%2BD1cXlvF2mtrc%3D
-
Kuroda M, Yokosuka A, Kobayashi R, Jitsuno M, Kando H, Nosaka K, Ishii H, Yamori T (2007) Sesquiterpenoids and flavonoids from the aerial parts of Tithonia diversifolia and their cytotoxic activity. Chem Pharm Bull 55:1240-1244
-
(2007)
Chem Pharm Bull
, vol.55
, pp. 1240-1244
-
-
Kuroda, M.1
Yokosuka, A.2
Kobayashi, R.3
Jitsuno, M.4
Kando, H.5
Nosaka, K.6
Ishii, H.7
Yamori, T.8
-
28
-
-
0035895202
-
LXRs control lipid-inducible expression of the apolipoprotein e gene in macrophages and adipocytes
-
11149950 10.1073/pnas.98.2.507 1:CAS:528:DC%2BD3MXnslKhtw%3D%3D
-
Laffitte BA, Repa JJ, Joseph SB, Wilpitz DC, Kast HR, Mangelsdorf DJ, Tontonoz P (2001) LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. Proc Natl Acad Sci USA 98:507-512
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 507-512
-
-
Laffitte, B.A.1
Repa, J.J.2
Joseph, S.B.3
Wilpitz, D.C.4
Kast, H.R.5
Mangelsdorf, D.J.6
Tontonoz, P.7
-
29
-
-
84862782011
-
Sesquiterpene lactones from Tithonia diversifolia act as peroxisome proliferator-activated receptor agonists
-
22424975 10.1016/j.bmcl.2012.02.043 1:CAS:528:DC%2BC38XktFSgsbs%3D
-
Lin HR (2012) Sesquiterpene lactones from Tithonia diversifolia act as peroxisome proliferator-activated receptor agonists. Bioorg Med Chem Lett 22:2954-2958
-
(2012)
Bioorg Med Chem Lett
, vol.22
, pp. 2954-2958
-
-
Lin, H.R.1
-
30
-
-
0033636789
-
Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors
-
11030331 10.1016/S1097-2765(00)00050-2 1:CAS:528:DC%2BD3cXntVyhs70%3D
-
Lu TT, Makishima M, Repa JJ, Schoonjans K, Kerr TA, Auwerx J, Mangelsdorf DJ (2000) Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Mol Cell 6:507-515
-
(2000)
Mol Cell
, vol.6
, pp. 507-515
-
-
Lu, T.T.1
Makishima, M.2
Repa, J.J.3
Schoonjans, K.4
Kerr, T.A.5
Auwerx, J.6
Mangelsdorf, D.J.7
-
31
-
-
77954837070
-
FXR regulates liver repair after CCl4-induced toxic injury
-
20211986 10.1210/me.2009-0286 1:CAS:528:DC%2BC3cXlslOqurg%3D
-
Meng Z, Wang Y, Wang L, Jin W, Liu N, Pan H, Liu L, Wagman L, Forman BM, Huang W (2010) FXR regulates liver repair after CCl4-induced toxic injury. Mol Endocrinol 24:886-897
-
(2010)
Mol Endocrinol
, vol.24
, pp. 886-897
-
-
Meng, Z.1
Wang, Y.2
Wang, L.3
Jin, W.4
Liu, N.5
Pan, H.6
Liu, L.7
Wagman, L.8
Forman, B.M.9
Huang, W.10
-
32
-
-
0038752647
-
Structural basis for bile acid binding and activation of the nuclear receptor FXR
-
12718893 10.1016/S1097-2765(03)00112-6 1:CAS:528:DC%2BD3sXjslGhtrs%3D
-
Mi LZ, Deverakonda S, Harp JM, Han Q, Pelliciari R, Wilson TM, Khorasanizadeh S, Rastinejad F (2003) Structural basis for bile acid binding and activation of the nuclear receptor FXR. Mol Cell 11:1093-1100
-
(2003)
Mol Cell
, vol.11
, pp. 1093-1100
-
-
Mi, L.Z.1
Deverakonda, S.2
Harp, J.M.3
Han, Q.4
Pelliciari, R.5
Wilson, T.M.6
Khorasanizadeh, S.7
Rastinejad, F.8
-
33
-
-
27744523196
-
Antidiabetic effect of Nitobegiku, the herb Tithonia diversifolia, in KK-Ay diabetic mice
-
16272709 10.1248/bpb.28.2152 1:CAS:528:DC%2BD2MXhtlals7jI
-
Miura T, Nosaka K, Ishii H, Ishida T (2005) Antidiabetic effect of Nitobegiku, the herb Tithonia diversifolia, in KK-Ay diabetic mice. Biol Pharm Bull 28:2152-2154
-
(2005)
Biol Pharm Bull
, vol.28
, pp. 2152-2154
-
-
Miura, T.1
Nosaka, K.2
Ishii, H.3
Ishida, T.4
-
34
-
-
0034680787
-
Peroxisome proliferator-activated receptors and hepatic stellate cell activation
-
10969082 10.1074/jbc.M006577200 1:CAS:528:DC%2BD3cXosVSksbo%3D
-
Miyahara T, Schrum L, Rippe R, Xiong S, Yee HF Jr, Motomura K, Anania FA, Willson TM, Tsukamoto H (2000) Peroxisome proliferator-activated receptors and hepatic stellate cell activation. J Biol Chem 275:35715-35722
-
(2000)
J Biol Chem
, vol.275
, pp. 35715-35722
-
-
Miyahara, T.1
Schrum, L.2
Rippe, R.3
Xiong, S.4
Yee Jr., H.F.5
Motomura, K.6
Anania, F.A.7
Willson, T.M.8
Tsukamoto, H.9
-
35
-
-
0036186337
-
Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump
-
11870371 10.1053/jhep.2002.31724 1:CAS:528:DC%2BD38Xitlyqsbo%3D
-
Plass JR, Mol O, Heegsma J, Geuken M, Faber KN, Jansen PL, Muller MF (2002) Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump. Hepatology 35:589-596
-
(2002)
Hepatology
, vol.35
, pp. 589-596
-
-
Plass, J.R.1
Mol, O.2
Heegsma, J.3
Geuken, M.4
Faber, K.N.5
Jansen, P.L.6
Muller, M.F.7
-
36
-
-
39849083646
-
SREBPs: The crossroads of physiological and pathological lipid homeostasis
-
18291668 10.1016/j.tem.2007.10.009 1:CAS:528:DC%2BD1cXjtVCjsrY%3D
-
Raghow R, Yellaturu C, Deng X, Park EA, Elam MB (2008) SREBPs: the crossroads of physiological and pathological lipid homeostasis. Trends Endocrinol Metab 19:65-73
-
(2008)
Trends Endocrinol Metab
, vol.19
, pp. 65-73
-
-
Raghow, R.1
Yellaturu, C.2
Deng, X.3
Park, E.A.4
Elam, M.B.5
-
37
-
-
74849097076
-
The bile acid sensor FXR regulates insulin transcription and secretion
-
20060466 10.1016/j.bbadis.2010.01.002 1:CAS:528:DC%2BC3cXhtlCqurY%3D
-
Renga B, Mencarelli A, Vavassori P, Brancaleone V, Fiorucci S (2010) The bile acid sensor FXR regulates insulin transcription and secretion. Biochim Biophys Acta 1802:363-372
-
(2010)
Biochim Biophys Acta
, vol.1802
, pp. 363-372
-
-
Renga, B.1
Mencarelli, A.2
Vavassori, P.3
Brancaleone, V.4
Fiorucci, S.5
-
38
-
-
0034669025
-
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ
-
11090130 10.1101/gad.844900 1:CAS:528:DC%2BD3cXos1ehsLs%3D
-
Repa JJ, Liang G, Ou J, Bashmakov Y, Lobaccaro JM, Shimomura I, Shan B, Brown MS, Goldstein JL, Mangelsdorf DJ (2000) Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ. Genes Dev 14:2819-2830
-
(2000)
Genes Dev
, vol.14
, pp. 2819-2830
-
-
Repa, J.J.1
Liang, G.2
Ou, J.3
Bashmakov, Y.4
Lobaccaro, J.M.5
Shimomura, I.6
Shan, B.7
Brown, M.S.8
Goldstein, J.L.9
Mangelsdorf, D.J.10
-
39
-
-
0001130671
-
Sesquiterpene lactones from two Tithonia species
-
10.1016/0031-9422(92)83461-7 1:CAS:528:DyaK38XmsVymtrk%3D
-
Schuster A, Stokes S, Papastergiou F, Castro V, Poveda L, Jakupovic J (1992) Sesquiterpene lactones from two Tithonia species. Phytochemistry 31:3139-3141
-
(1992)
Phytochemistry
, vol.31
, pp. 3139-3141
-
-
Schuster, A.1
Stokes, S.2
Papastergiou, F.3
Castro, V.4
Poveda, L.5
Jakupovic, J.6
-
40
-
-
14244264780
-
Regulation of carbohydrate metabolism by the farnesoid X receptor
-
15564327 10.1210/en.2004-0965 1:CAS:528:DC%2BD2MXitlehs7g%3D
-
Stayrook KR, Bramlett KS, Savkur RS, Ficorilli J, Cook T, Christe ME, Michael LF, Burris TP (2005) Regulation of carbohydrate metabolism by the farnesoid X receptor. Endocrinology 146:984-991
-
(2005)
Endocrinology
, vol.146
, pp. 984-991
-
-
Stayrook, K.R.1
Bramlett, K.S.2
Savkur, R.S.3
Ficorilli, J.4
Cook, T.5
Christe, M.E.6
Michael, L.F.7
Burris, T.P.8
-
41
-
-
0036896653
-
Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue
-
12435796 10.1124/mol.62.6.1299 1:CAS:528:DC%2BD38XptVylsrc%3D
-
Stulnig TM, Steffensen KR, Gao H, Reimers M, Dahlman-Wright K, Schuster GU, Gustafsson JA (2002) Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue. Mol Pharmacol 62:1299-1305
-
(2002)
Mol Pharmacol
, vol.62
, pp. 1299-1305
-
-
Stulnig, T.M.1
Steffensen, K.R.2
Gao, H.3
Reimers, M.4
Dahlman-Wright, K.5
Schuster, G.U.6
Gustafsson, J.A.7
-
42
-
-
0141737105
-
Crystal structure of the heterodimeric complex of LXRα and RXRβ ligand-binding domains in a fully agonistic conformation
-
12970175 10.1093/emboj/cdg456 1:CAS:528:DC%2BD3sXnt1Kjsb4%3D
-
Svensson S, Ostberg T, Jacobsson M, Norström C, Stefansson K, Hallén D, Johansson IC, Zachrisson K, Ogg D, Jendeberg L (2003) Crystal structure of the heterodimeric complex of LXRα and RXRβ ligand-binding domains in a fully agonistic conformation. EMBO J 22:4625-4633
-
(2003)
EMBO J
, vol.22
, pp. 4625-4633
-
-
Svensson, S.1
Ostberg, T.2
Jacobsson, M.3
Norström, C.4
Stefansson, K.5
Hallén, D.6
Johansson, I.C.7
Zachrisson, K.8
Ogg, D.9
Jendeberg, L.10
-
43
-
-
0037503924
-
Liver X receptor signaling pathways in cardiovascular disease
-
12690094 10.1210/me.2003-0061 1:CAS:528:DC%2BD3sXktlymsb8%3D
-
Tontonoz P, Mangelsdorf DJ (2003) Liver X receptor signaling pathways in cardiovascular disease. Mol Endocrinol 17:985-993
-
(2003)
Mol Endocrinol
, vol.17
, pp. 985-993
-
-
Tontonoz, P.1
Mangelsdorf, D.J.2
-
44
-
-
0034537181
-
FXR, a bile acid receptor and biological sensor
-
11150726 10.1016/S1050-1738(00)00043-8 1:CAS:528:DC%2BD3MXitlyitA%3D%3D
-
Tu H, Okamoto AY, Shan B (2000) FXR, a bile acid receptor and biological sensor. Trends Cardiovasc Med 10:30-35
-
(2000)
Trends Cardiovasc Med
, vol.10
, pp. 30-35
-
-
Tu, H.1
Okamoto, A.Y.2
Shan, B.3
-
45
-
-
0034710965
-
Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR α
-
11035776 10.1073/pnas.200367697 1:CAS:528:DC%2BD3cXnvVSgtL0%3D
-
Venkateswaran A, Laffitte BA, Joseph SB, Mak PA, Wilpitz DC, Edwards PA, Tontonoz P (2000) Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR α. Proc Natl Acad Sci USA 97:12097-12102
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 12097-12102
-
-
Venkateswaran, A.1
Laffitte, B.A.2
Joseph, S.B.3
Mak, P.A.4
Wilpitz, D.C.5
Edwards, P.A.6
Tontonoz, P.7
-
46
-
-
78650769613
-
Farnesoid X receptor activation improves erectile function in animal models of metabolic syndrome and diabetes
-
20955313 10.1111/j.1743-6109.2010.02073.x 1:CAS:528:DC%2BC3MXisFajurg%3D
-
Vignozzi L, Morelli A, Filippi S, Comeglio P, Chavalmane AK, Marchetta M, Toce M, Yehiely-Cohen R, Vannelli GB, Adorini L, Maggi M (2011) Farnesoid X receptor activation improves erectile function in animal models of metabolic syndrome and diabetes. J Sex Med 8:57-77
-
(2011)
J Sex Med
, vol.8
, pp. 57-77
-
-
Vignozzi, L.1
Morelli, A.2
Filippi, S.3
Comeglio, P.4
Chavalmane, A.K.5
Marchetta, M.6
Toce, M.7
Yehiely-Cohen, R.8
Vannelli, G.B.9
Adorini, L.10
Maggi, M.11
-
47
-
-
32244447570
-
Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice
-
16410358 10.1073/pnas.0506982103 1:CAS:528:DC%2BD28XhsVKgtLY%3D
-
Zhang Y, Lee FY, Barrera G, Lee H, Vales C, Gonzalez FJ, Willson TM, Edwards PA (2006) Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. Proc Natl Acad Sci USA 103:1006-1011
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 1006-1011
-
-
Zhang, Y.1
Lee, F.Y.2
Barrera, G.3
Lee, H.4
Vales, C.5
Gonzalez, F.J.6
Willson, T.M.7
Edwards, P.A.8
-
48
-
-
79958243702
-
Role of nuclear receptor SHP in metabolism and cancer
-
20970497 10.1016/j.bbadis.2010.10.006 1:CAS:528:DC%2BC3MXnsVOkur4%3D
-
Zhang Y, Hagedorn CH, Wang L (2011) Role of nuclear receptor SHP in metabolism and cancer. Biochim Biophys Acta 1812:893-908
-
(2011)
Biochim Biophys Acta
, vol.1812
, pp. 893-908
-
-
Zhang, Y.1
Hagedorn, C.H.2
Wang, L.3
|