Transient expression of an LEDGF/p75 chimera retargets lentivector integration and functionally rescues in a model for X-CGD

Molecular Therapy Nucleic Acids

Volumn 2, Issue , 2013, Pages e77-

  Vets, Sofie ^a   De Rijck, Jan ^a   Brendel, Christian ^b   Grez, Manuel ^b   Bushman, Frederic ^c   Debyser, Zeger ^a   Gijsbers, Rik ^a  

^a DEPARTMENT OF PHARMACEUTICAL AND PHARMACOLOGICAL SCIENCES   (Belgium)

^b INSTITUTE FOR TUMOR BIOLOGY AND EXPERIMENTAL THERAPY   (Germany)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Gene therapy; LEDGF p75; Lentiviral vector; Retargeted integration

Indexed keywords

HETEROCHROMATIN BINDING PROTEIN 1BETA; HETEROCHROMATIN PROTEIN 1; LENS EPITHELIUM DERIVED GROWTH FACTOR; LENTIVIRUS VECTOR; PROTEIN P75; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CHRONIC GRANULOMATOUS DISEASE; CONTROLLED STUDY; ELECTROPORATION; ENZYME ACTIVITY; GENE SILENCING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; X LINKED CHRONIC GRANULOMATOUS DISEASE;

EID: 84878835490     PISSN: None     EISSN: 21622531     Source Type: Journal    
DOI: 10.1038/mtna.2013.4     Document Type: Article

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