Progress and prospects: Foamy virus vectors enter a new age

Gene Therapy

Volumn 17, Issue 12, 2010, Pages 1423-1429

  Erlwein, O ^a   McClure, M O ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

foamy virus; retroviral vector; spumaretrovirus

Indexed keywords

FOAMY VIRUS VECTOR; RETROVIRUS VECTOR; UNCLASSIFIED DRUG;

DISEASE ASSOCIATION; GENETIC DISORDER; HOST CELL; HOST RANGE; HUMAN; IN VIVO GENE TRANSFER; LEUKOCYTE ADHESION DEFICIENCY; MUTAGENESIS; NONHUMAN; OCCUPATIONAL EXPOSURE; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SPUMA VIRUS; STEM CELL; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; VIRUS REPLICATION;

ANIMALS; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC DISEASES, INBORN; GENETIC VECTORS; HUMANS; SPUMAVIRUS;

CANIS FAMILIARIS; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN SPUMARETROVIRUS; MAMMALIA; MURINE LEUKEMIA VIRUS;

EID: 78650029660     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2010.95     Document Type: Review

References (35)

1. Murray SM, Picker LJ, Axthelm MK, Hudkins K, Alpers CE, Linial ML. Replication in a superficial epithelial cell niche explains the lack of pathogenicity of primate foamy virus infections. J Virol 2008; 82: 5981-5985.
2. Liu W, Worobey M, Li Y, Keele BF, Bibollet-Ruche F, Guo Y et al. Molecular ecology and natural history of simian foamy virus infection in wild-living chimpanzees. PLoS Pathog 2008; 4: e1000097.
3. Morozov VA, Leendertz FH, Junglen S, Boesch C, Pauli G, Ellerbrok H. Frequent foamy virus infection in free-living chimpanzees of the Ta?̈ National Park (Côte d'Ivoire). J Gen Virol 2009; 90: 500-506.
4. Jones-Engel L, Steinkraus KA, Murray SM, Engel GA, Grant R, Aggimarangsee N et al. Sensitive assays for simian foamy viruses reveal a high prevalence of infection in commensal, free-ranging Asian monkeys. J Virol 2007; 81: 7330-7337.
5. Engel GA, Pizarro M, Shaw E, Cortes J, Fuentes A, Barry P et al. Unique pattern of enzootic primate viruses in Gibraltar macaques. Emerg Infect Dis 2008; 14: 1112-1115.
6. Leendertz FH, Zirkel F, Couacy-Hymann E, Ellerbrok H, Morozov VA, Pauli G et al. Interspecies transmission of simian foamy virus in a natural predator-prey system. J Virol 2008; 82: 7741-7744.
7. Boneva RS, Switzer WM, Spira TJ, Bhullar VB, Shanmugam V, Cong ME et al. Clinical and virological characterization of persistent human infection with simian foamy viruses. AIDS Res Hum Retroviruses 2007; 23: 1330-1337.
8. Jones-Engel L, May CC, Engel GA, Steinkraus KA, Schillaci MA, Fuentes A et al. Diverse contexts of zoonotic transmission of simian foamy viruses in Asia. Emerg Infect Dis 2008; 14: 1200-1208.
9. Brooks JI, Merks HW, Fournier J, Boneva RS, Sandstrom PA. Characterization of blood-borne transmission of simian foamy virus. Transfusion 2007; 47: 162-170.
10. Perkovic M, Schmidt S, Marino D, Russell RA, Stauch B, Hofmann H et al. Species-specific inhibition of APOBEC3C by the prototype foamy virus protein bet. J Biol Chem 2009; 284: 5819-5826.
11. Yap MW, Lindemann D, Stanke N, Reh J, Westphal D, Hanenberg H et al. Restriction of foamy viruses by primate Trim5alpha. J Virol 2008; 82: 5429-5439.
12. Lee EG, Linial ML. The C terminus of foamy retrovirus Gag contains determinants for encapsidation of Pol protein into virions. J Virol 2008; 82: 10803-10810.
13. Rethwilm A. Foamy virus vectors: an awaited alternative to gammaretro- and lentiviral vectors. Curr Gene Ther 2007; 7: 261-271.
14. Hacein-Bey-Abina S, Garrigue A, Wang GP, Soulier J, Lim A, Morillon E et al. Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1. J Clin Invest 2008; 118: 3132-3142.
15. Bauer Jr TR, Allen JM, Hai M, Tuschong LM, Khan IF, Olson EM et al. Successful treatment of canine leukocyte adhesion deficiency by foamy virus vectors. Nat Med 2008; 14: 93-97.
16. Beard BC, Keyser KA, Trobridge GD, Peterson LJ, Miller DG, Jacobs M et al. Unique integration profiles in a canine model of long-term repopulating cells transduced with gammaretrovirus, lentivirus, or foamy virus. Hum Gene Ther 2007; 18: 423-434.
17. Valkov E, Gupta SS, Hare S, Helander A, Roversi P, McClure M et al. Functional and structural characterization of the integrase from the prototype foamy virus. Nucleic Acids Res 2009; 37: 243-255.
18. Kang SY, Ahn DG, Lee C, Lee YS, Shin CG. Functional nucleotides of U5 LTR determining substrate specificity of prototype foamy virus integrase. J Microbiol Biotechnol 2008; 18: 1044-1049.
19. Delelis O, Carayon K, Guiot E, Leh H, Tauc P, Brochon JC et al. Insight into the integrase-DNA recognition mechanism. A specific DNA-binding mode revealed by an enzymatically labeled integrase. J Biol Chem 2008; 10: 27838-27849.
20. Hendrie PC, Huo Y, Stolitenko RB, Russell DW. A rapid and quantitative assay for measuring neighboring gene activation by vector proviruses. Mol Ther 2008; 16: 534-540.
21. Bokhoven M, Stephen SL, Knight S, Gevers EF, Robinson IC, Takeuchi Y et al. Insertional gene activation by lentiviral and gammaretroviral vectors. J Virol 2009; 83: 283-294.
22. Zychlinski D, Schambach A, Modlich U, Maetzig T, Meyer J, Grassman E et al. Physiological Promoters Reduce the Genotoxic Risk of Integrating Gene Vectors. Mol Ther 2008; 4: 718-725.
23. Bastone P, Romen F, Liu W, Wirtz R, Koch U, Josephson N et al. Construction and characterization of efficient, stable and safe replication-deficient foamy virus vectors. Gene Ther 2007; 7: 613-620.
24. Kiem HP, Allen J, Trobridge G, Olson E, Keyser K, Peterson L et al. Foamy-virus-mediated gene transfer to canine repopulating cells. Blood 2007; 109: 65-70.
25. Wiktorowicz T, Peters K, Armbruster N, Steinert AF, Rethwilm A. Generation of an improved foamy virus vector by dissection of cis-acting sequences. J Gen Virol 2009; 90: 481-487.
26. Lehmann-Che J, Renault N, Giron ML, Roingeard P, Clave E, Tobaly-Tapiero J et al. Centrosomal latency of incoming foamy viruses in resting cells. PLoS Pathog 2007; 3: e74.
27. Sun Y, Li Z, Li L, Li J, Liu X, Li W. Effective inhibition of hepatitis B virus replication by small interfering RNAs expressed from human foamy virus vectors. Int J Mol Med 2007; 19: 705-711.
28. Taylor JA, Vojtech L, Bahner I, Kohn DB, Laer DV, Russell DW et al. Foamy virus vectors expressing anti-HIV transgenes efficiently block HIV-1 replication. Mol Ther 2008; 16: 46-51.
29. Rothenaigner I, Kramer S, Meggendorfer M, Rethwilm A, Brack-Werner R. Transduction of human neural progenitor cells with foamy virus vectors for differentiation-dependent gene expression. Gene Ther 2009; 16: 349-358.
30. Gharwan H, Hirata RK, Wang P, Richard RE, Wang L, Olson E et al. Transduction of human embryonic stem cells by foamy virus vectors. Mol Ther 2007; 15: 1827-1833.
31. Cai S, Ernstberger A, Wang H, Bailey BJ, Hartwell JR, Sinn AL et al. In vivo selection of hematopoietic stem cells transduced at a low multiplicity-of-infection with a foamy viral MGMT(P140K) vector. Exp Hematol 2008; 36: 283-292.
32. Caprariello AV, Miller RH, Selkirk SM. Foamy virus as a gene transfer vector to the central nervous system. Gene Ther 2009; 16: 448-452.
33. Liu W, Liu Z, Liu L, Xiao Z, Cao X, Cao Z et al. A novel human foamy virus mediated gene transfer of GAD67 reduces neuropathic pain following spinal cord injury. Neurosci Lett 2008; 432: 13-18.
34. Si Y, Pulliam AC, Linka Y, Ciccone S, Leurs C, Yuan J et al. Overnight transduction with foamy viral vectors restores the long-term repopulating activity of Fancc-/- stem cells. Blood 2008; 112: 4458-4465.
35. Trobridge GD, Allen JM, Peterson L, Ironside CG, Russell D, Kiem HP. Foamy and Lentiviral Vectors Transduce Canine Long-term Repopulating Cells at Similar Efficiency. Hum Gene Ther 2009; 5: 519-523.