Acrolein-induced activation of mitogen-activated protein kinase signaling is mediated by alkylation of thioredoxin reductase and thioredoxin 1

Redox Biology

Volumn 1, Issue 1, 2013, Pages 265-275

  Randall, Matthew J ^a   Spiess, Page C ^a   Hristova, Milena ^a   Hondal, Robert J ^b   van der Vliet, Albert ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF VERMONT   (United States)

Author keywords

c Jun N terminal kinase; Cigarette smoke; Electrophile; Epithelium; GSH; Michael addition

Indexed keywords

ACROLEIN; GLUTATHIONE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SMALL INTERFERING RNA; SODIUM SELENITE; STRESS ACTIVATED PROTEIN KINASE; THIOREDOXIN 1; THIOREDOXIN REDUCTASE; SELENIOUS ACID; THIOREDOXIN; THIOREDOXIN REDUCTASE 1; TXNRD1 PROTEIN, HUMAN;

ALKYLATION; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; EPITHELIUM CELL; HUMAN; HUMAN CELL; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; CELL CULTURE; DRUG EFFECTS; GENE SILENCING; GENETICS; METABOLISM; SMOKING;

NICOTIANA TABACUM;

ACROLEIN; ALKYLATION; CELLS, CULTURED; EPITHELIAL CELLS; GENE KNOCKDOWN TECHNIQUES; HUMANS; MAP KINASE SIGNALING SYSTEM; SELENIOUS ACID; SMOKING; THIOREDOXIN REDUCTASE 1; THIOREDOXINS;

EID: 84878810885     PISSN: 22132317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.redox.2013.02.001     Document Type: Article

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