메뉴 건너뛰기




Volumn 43, Issue 6, 2013, Pages 610-620

Effects of thrombopoietin on growth of hepatocellular carcinoma: Is thrombopoietin therapy for liver disease safe or not?

Author keywords

Akt; Hepatocellular carcinoma; Huh7; MPL; Thrombopoietin

Indexed keywords

RECOMBINANT THROMBOPOIETIN; THROMBOPOIETIN RECEPTOR;

EID: 84878809348     PISSN: 13866346     EISSN: 1872034X     Source Type: Journal    
DOI: 10.1111/hepr.12006     Document Type: Article
Times cited : (15)

References (52)
  • 1
    • 40149102010 scopus 로고    scopus 로고
    • Platelets strongly induce hepatocyte proliferation with IGF-1 and HGF in vitro
    • Matsuo R, Ohkohchi N, Murata S etal. Platelets strongly induce hepatocyte proliferation with IGF-1 and HGF in vitro. J Surg Res 2008; 145: 279-286.
    • (2008) J Surg Res , vol.145 , pp. 279-286
    • Matsuo, R.1    Ohkohchi, N.2    Murata, S.3
  • 2
    • 77956263996 scopus 로고    scopus 로고
    • Activation of human liver sinusoidal endothelial cell by human platelets induces hepatocyte proliferation
    • Kawasaki T, Murata S, Takahashi K etal. Activation of human liver sinusoidal endothelial cell by human platelets induces hepatocyte proliferation. J Hepatol 2010; 53: 648-654.
    • (2010) J Hepatol , vol.53 , pp. 648-654
    • Kawasaki, T.1    Murata, S.2    Takahashi, K.3
  • 3
    • 48449090296 scopus 로고    scopus 로고
    • Role of platelets on liver regeneration after 90% hepatectomy in mice
    • Myronovych A, Murata S, Chiba M etal. Role of platelets on liver regeneration after 90% hepatectomy in mice. J Hepatol 2008; 49: 363-372.
    • (2008) J Hepatol , vol.49 , pp. 363-372
    • Myronovych, A.1    Murata, S.2    Chiba, M.3
  • 4
  • 5
    • 43949097244 scopus 로고    scopus 로고
    • Platelets promote liver regeneration under conditions of Kupffer cell depletion after hepatectomy in mice
    • Murata S, Matsuo R, Ikeda O etal. Platelets promote liver regeneration under conditions of Kupffer cell depletion after hepatectomy in mice. World J Surg 2008; 32: 1088-1096.
    • (2008) World J Surg , vol.32 , pp. 1088-1096
    • Murata, S.1    Matsuo, R.2    Ikeda, O.3
  • 6
    • 58549109430 scopus 로고    scopus 로고
    • Platelets contribute to the reduction of liver fibrosis in mice
    • Watanabe M, Murata S, Hashimoto I etal. Platelets contribute to the reduction of liver fibrosis in mice. J Gastroenterol Hepatol 2009; 24: 78-89.
    • (2009) J Gastroenterol Hepatol , vol.24 , pp. 78-89
    • Watanabe, M.1    Murata, S.2    Hashimoto, I.3
  • 7
    • 84055199659 scopus 로고    scopus 로고
    • Platelet-derived adenosine 5′-triphosphate suppresses activation of human hepatic stellate cell: In vitro study
    • Ikeda N, Murata S, Maruyama T etal. Platelet-derived adenosine 5′-triphosphate suppresses activation of human hepatic stellate cell: In vitro study. Hepatol Res 2012; 42: 91-102.
    • (2012) Hepatol Res , vol.42 , pp. 91-102
    • Ikeda, N.1    Murata, S.2    Maruyama, T.3
  • 8
    • 0025366177 scopus 로고
    • Platelet transfusion therapy for the cancer patient
    • Heyman MR, Schiffer CA. Platelet transfusion therapy for the cancer patient. Semin Oncol 1990; 17: 198-209.
    • (1990) Semin Oncol , vol.17 , pp. 198-209
    • Heyman, M.R.1    Schiffer, C.A.2
  • 9
    • 43049149455 scopus 로고    scopus 로고
    • Complications of splenectomy
    • Cadili A, de Gara C. Complications of splenectomy. Am J Med 2008; 121: 371-375.
    • (2008) Am J Med , vol.121 , pp. 371-375
    • Cadili, A.1    de Gara, C.2
  • 10
    • 0029117375 scopus 로고
    • The thrombopoietin receptor c-MPL activates JAK2 and TYK2 tyrosine kinases
    • Sattler M, Durstin M, Frank D etal. The thrombopoietin receptor c-MPL activates JAK2 and TYK2 tyrosine kinases. Exp Hematol 1995; 23: 1040-1048.
    • (1995) Exp Hematol , vol.23 , pp. 1040-1048
    • Sattler, M.1    Durstin, M.2    Frank, D.3
  • 11
    • 0029835344 scopus 로고    scopus 로고
    • Constitutive expression of Mpl ligand transcripts during thrombocytopenia or thrombocytosis
    • Cohen-Solal K, Villeval JL, Titeux M, Lok S, Vainchenker W, Wendling F. Constitutive expression of Mpl ligand transcripts during thrombocytopenia or thrombocytosis. Blood 1996; 88: 2578-2584.
    • (1996) Blood , vol.88 , pp. 2578-2584
    • Cohen-Solal, K.1    Villeval, J.L.2    Titeux, M.3    Lok, S.4    Vainchenker, W.5    Wendling, F.6
  • 12
    • 0031035555 scopus 로고    scopus 로고
    • Localization and regulation of thrombopoietin mRNA expression in human kidney, liver, bone marrow, and spleen using in situ hybridization
    • Sungaran R, Markovic B, Chong BH. Localization and regulation of thrombopoietin mRNA expression in human kidney, liver, bone marrow, and spleen using in situ hybridization. Blood 1997; 89: 101-107.
    • (1997) Blood , vol.89 , pp. 101-107
    • Sungaran, R.1    Markovic, B.2    Chong, B.H.3
  • 13
    • 0032005935 scopus 로고    scopus 로고
    • Thrombopoietin and its receptor, c-mpl, are constitutively expressed by mouse liver endothelial cells: evidence of thrombopoietin as a growth factor for liver endothelial cells
    • Cardier JE, Dempsey J. Thrombopoietin and its receptor, c-mpl, are constitutively expressed by mouse liver endothelial cells: evidence of thrombopoietin as a growth factor for liver endothelial cells. Blood 1998; 91: 923-929.
    • (1998) Blood , vol.91 , pp. 923-929
    • Cardier, J.E.1    Dempsey, J.2
  • 16
    • 84875722319 scopus 로고    scopus 로고
    • Efficacy and safety of eltrombopag in Japanese patients with chronic liver disease and thrombocytopenia: a randomized, open-label, phase II study
    • Kawaguchi T, Komori A, Seike M etal. Efficacy and safety of eltrombopag in Japanese patients with chronic liver disease and thrombocytopenia: a randomized, open-label, phase II study. J Gastroenterol 2012 (in press).
    • (2012) J Gastroenterol
    • Kawaguchi, T.1    Komori, A.2    Seike, M.3
  • 17
    • 0037708562 scopus 로고    scopus 로고
    • Establishment of immortalized human hepatic stellate scavenger cells to develop bioartificial livers
    • Watanabe T, Shibata N, Westerman KA etal. Establishment of immortalized human hepatic stellate scavenger cells to develop bioartificial livers. Transplantation 2003; 75: 1873-1880.
    • (2003) Transplantation , vol.75 , pp. 1873-1880
    • Watanabe, T.1    Shibata, N.2    Westerman, K.A.3
  • 19
    • 0029150245 scopus 로고
    • Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size
    • Yuan F, Dellian M, Fukumura D etal. Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size. Cancer Res 1995; 55: 3752-3756.
    • (1995) Cancer Res , vol.55 , pp. 3752-3756
    • Yuan, F.1    Dellian, M.2    Fukumura, D.3
  • 20
    • 0029129618 scopus 로고
    • Thrombopoietin receptor expression in human cancer cell lines and primary tissues
    • Columbyova L, Loda M, Scadden DT. Thrombopoietin receptor expression in human cancer cell lines and primary tissues. Cancer Res 1995; 55: 3509-3512.
    • (1995) Cancer Res , vol.55 , pp. 3509-3512
    • Columbyova, L.1    Loda, M.2    Scadden, D.T.3
  • 22
    • 33644797198 scopus 로고    scopus 로고
    • Thrombopoietin stimulates migration and activates multiple signaling pathways in hepatoblastoma cells
    • Romanelli RG, Petrai I, Robino G etal. Thrombopoietin stimulates migration and activates multiple signaling pathways in hepatoblastoma cells. Am J Physiol Gastrointest Liver Physiol 2006; 290: G120-128.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290
    • Romanelli, R.G.1    Petrai, I.2    Robino, G.3
  • 23
    • 79952202792 scopus 로고    scopus 로고
    • Thrombopoietin receptor levels in tumor cell lines and primary tumors
    • Erickson-Miller CL, Chadderton A, Gibbard A etal. Thrombopoietin receptor levels in tumor cell lines and primary tumors. J Oncol 2010; 2010: 135354.
    • (2010) J Oncol , vol.2010 , pp. 135354
    • Erickson-Miller, C.L.1    Chadderton, A.2    Gibbard, A.3
  • 24
    • 0028899548 scopus 로고
    • Genomic structure, chromosomal localization, and conserved alternative splice forms of thrombopoietin
    • Gurney AL, Kuang WJ, Xie MH, Malloy BE, Eaton DL, de Sauvage FJ. Genomic structure, chromosomal localization, and conserved alternative splice forms of thrombopoietin. Blood 1995; 85: 981-988.
    • (1995) Blood , vol.85 , pp. 981-988
    • Gurney, A.L.1    Kuang, W.J.2    Xie, M.H.3    Malloy, B.E.4    Eaton, D.L.5    de Sauvage, F.J.6
  • 26
    • 77953691205 scopus 로고    scopus 로고
    • The role of erythropoietin and its receptor in growth, survival and therapeutic response of human tumor cells: From clinic to bench-a critical review
    • Szenajch J, Wcislo G, Jeong JY, Szczylik C, Feldman L. The role of erythropoietin and its receptor in growth, survival and therapeutic response of human tumor cells: From clinic to bench-a critical review. Biochim Biophys Acta 2010; 1806: 82-95.
    • (2010) Biochim Biophys Acta , vol.1806 , pp. 82-95
    • Szenajch, J.1    Wcislo, G.2    Jeong, J.Y.3    Szczylik, C.4    Feldman, L.5
  • 27
    • 35148857257 scopus 로고    scopus 로고
    • Erythropoietin blockade inhibits the induction of tumor angiogenesis and progression
    • Hardee ME, Cao Y, Fu P etal. Erythropoietin blockade inhibits the induction of tumor angiogenesis and progression. PLoS ONE 2007; 2: e549.
    • (2007) PLoS ONE , vol.2
    • Hardee, M.E.1    Cao, Y.2    Fu, P.3
  • 28
    • 0027501958 scopus 로고
    • Effect of recombinant human erythropoietin on hematopoietic and non-hematopoietic malignant cell growth in vitro
    • Rosti V, Pedrazzoli P, Ponchio L etal. Effect of recombinant human erythropoietin on hematopoietic and non-hematopoietic malignant cell growth in vitro. Haematologica 1993; 78: 208-212.
    • (1993) Haematologica , vol.78 , pp. 208-212
    • Rosti, V.1    Pedrazzoli, P.2    Ponchio, L.3
  • 29
    • 0033773958 scopus 로고    scopus 로고
    • Erythropoietin receptor expression in human melanoma cells
    • Selzer E, Wacheck V, Kodym R etal. Erythropoietin receptor expression in human melanoma cells. Melanoma Res 2000; 10: 421-426.
    • (2000) Melanoma Res , vol.10 , pp. 421-426
    • Selzer, E.1    Wacheck, V.2    Kodym, R.3
  • 30
    • 0036269105 scopus 로고    scopus 로고
    • Erythropoietin and G-CSF receptors in human tumor cells: expression and aspects regarding functionality
    • Westphal G, Niederberger E, Blum C etal. Erythropoietin and G-CSF receptors in human tumor cells: expression and aspects regarding functionality. Tumori 2002; 88: 150-159.
    • (2002) Tumori , vol.88 , pp. 150-159
    • Westphal, G.1    Niederberger, E.2    Blum, C.3
  • 31
  • 32
    • 7344249544 scopus 로고    scopus 로고
    • Expression and function of the megakaryocyte growth and development factor receptor in acute myeloid leukemia blasts
    • Wetzler M, Bernstein SH, Baumann H etal. Expression and function of the megakaryocyte growth and development factor receptor in acute myeloid leukemia blasts. Leuk Lymphoma 1998; 30: 415-433.
    • (1998) Leuk Lymphoma , vol.30 , pp. 415-433
    • Wetzler, M.1    Bernstein, S.H.2    Baumann, H.3
  • 33
    • 0033574444 scopus 로고    scopus 로고
    • Thrombopoietin stimulates endothelial cell motility and neoangiogenesis by a platelet-activating factor-dependent mechanism
    • Brizzi MF, Battaglia E, Montrucchio G etal. Thrombopoietin stimulates endothelial cell motility and neoangiogenesis by a platelet-activating factor-dependent mechanism. Circ Res 1999; 84: 785-796.
    • (1999) Circ Res , vol.84 , pp. 785-796
    • Brizzi, M.F.1    Battaglia, E.2    Montrucchio, G.3
  • 34
    • 0032875330 scopus 로고    scopus 로고
    • Effects of megakaryocyte growth and development factor (thrombopoietin) on liver endothelial cells in vitro
    • Cardier JE. Effects of megakaryocyte growth and development factor (thrombopoietin) on liver endothelial cells in vitro. Microvasc Res 1999; 58: 108-113.
    • (1999) Microvasc Res , vol.58 , pp. 108-113
    • Cardier, J.E.1
  • 35
    • 0029019022 scopus 로고
    • Growth response of acute myeloblastic leukemia cells to recombinant human thrombopoietin
    • Matsumura I, Kanakura Y, Kato T etal. Growth response of acute myeloblastic leukemia cells to recombinant human thrombopoietin. Blood 1995; 86: 703-709.
    • (1995) Blood , vol.86 , pp. 703-709
    • Matsumura, I.1    Kanakura, Y.2    Kato, T.3
  • 36
    • 0029831997 scopus 로고    scopus 로고
    • Growth stimulatory effect of thrombopoietin on the blast cells of acute myelogenous leukaemia
    • Motoji T, Takanashi M, Motomura S etal. Growth stimulatory effect of thrombopoietin on the blast cells of acute myelogenous leukaemia. Br J Haematol 1996; 94: 513-516.
    • (1996) Br J Haematol , vol.94 , pp. 513-516
    • Motoji, T.1    Takanashi, M.2    Motomura, S.3
  • 37
    • 0032765221 scopus 로고    scopus 로고
    • Thrombopoietin and interleukin 11 have different modulatory effects on cell cycle and programmed cell death in primary acute myeloid leukemia cells
    • Tafuri A, Lemoli RM, Petrucci MT etal. Thrombopoietin and interleukin 11 have different modulatory effects on cell cycle and programmed cell death in primary acute myeloid leukemia cells. Exp Hematol 1999; 27: 1255-1263.
    • (1999) Exp Hematol , vol.27 , pp. 1255-1263
    • Tafuri, A.1    Lemoli, R.M.2    Petrucci, M.T.3
  • 39
    • 34249733156 scopus 로고    scopus 로고
    • New thrombopoietic growth factors
    • Kuter DJ. New thrombopoietic growth factors. Blood 2007; 109: 4607-4616.
    • (2007) Blood , vol.109 , pp. 4607-4616
    • Kuter, D.J.1
  • 40
    • 79954584820 scopus 로고    scopus 로고
    • Developmental differences in megakaryocytopoiesis are associated with up-regulated TPO signaling through mTOR and elevated GATA-1 levels in neonatal megakaryocytes
    • Liu ZJ, Italiano J, Ferrer-Marin F etal. Developmental differences in megakaryocytopoiesis are associated with up-regulated TPO signaling through mTOR and elevated GATA-1 levels in neonatal megakaryocytes. Blood 2011; 117: 4106-4117.
    • (2011) Blood , vol.117 , pp. 4106-4117
    • Liu, Z.J.1    Italiano, J.2    Ferrer-Marin, F.3
  • 42
    • 0345700813 scopus 로고    scopus 로고
    • Cyclin D1 over-expression correlates with β-catenin activation, but not with H-ras mutations, and phosphorylation of Akt, GSK3β and ERK1/2 in mouse hepatic carcinogenesis
    • Gotoh J, Obata M, Yoshie M, Kasai S, Ogawa K. Cyclin D1 over-expression correlates with β-catenin activation, but not with H-ras mutations, and phosphorylation of Akt, GSK3β and ERK1/2 in mouse hepatic carcinogenesis. Carcinogenesis 2003; 24: 435-442.
    • (2003) Carcinogenesis , vol.24 , pp. 435-442
    • Gotoh, J.1    Obata, M.2    Yoshie, M.3    Kasai, S.4    Ogawa, K.5
  • 43
    • 23744499946 scopus 로고    scopus 로고
    • Progesterone inhibits the estrogen-induced phosphoinositide 3-kinase-->AKT-->GSK-3beta-->cyclin D1-->pRB pathway to block uterine epithelial cell proliferation
    • Chen B, Pan H, Zhu L, Deng Y, Pollard JW. Progesterone inhibits the estrogen-induced phosphoinositide 3-kinase-->AKT-->GSK-3beta-->cyclin D1-->pRB pathway to block uterine epithelial cell proliferation. Mol Endocrinol 2005; 19: 1978-1990.
    • (2005) Mol Endocrinol , vol.19 , pp. 1978-1990
    • Chen, B.1    Pan, H.2    Zhu, L.3    Deng, Y.4    Pollard, J.W.5
  • 44
    • 26244463553 scopus 로고    scopus 로고
    • Compensatory recovery of liver mass by Akt-mediated hepatocellular hypertrophy in liver-specific STAT3-deficient mice
    • Haga S, Ogawa W, Inoue H etal. Compensatory recovery of liver mass by Akt-mediated hepatocellular hypertrophy in liver-specific STAT3-deficient mice. J Hepatol 2005; 43: 799-807.
    • (2005) J Hepatol , vol.43 , pp. 799-807
    • Haga, S.1    Ogawa, W.2    Inoue, H.3
  • 45
    • 0142084679 scopus 로고    scopus 로고
    • Akt promotes increased mammalian cell size by stimulating protein synthesis and inhibiting protein degradation
    • Faridi J, Fawcett J, Wang L, Roth RA. Akt promotes increased mammalian cell size by stimulating protein synthesis and inhibiting protein degradation. Am J Physiol Endocrinol Metab 2003; 285: E964-972.
    • (2003) Am J Physiol Endocrinol Metab , vol.285
    • Faridi, J.1    Fawcett, J.2    Wang, L.3    Roth, R.A.4
  • 47
    • 0033504024 scopus 로고    scopus 로고
    • Hepatocyte growth factor promotes migration of human hepatocellular carcinoma via phosphatidylinositol 3-kinase
    • Nakanishi K, Fujimoto J, Ueki T etal. Hepatocyte growth factor promotes migration of human hepatocellular carcinoma via phosphatidylinositol 3-kinase. Clin Exp Metastasis 1999; 17: 507-514.
    • (1999) Clin Exp Metastasis , vol.17 , pp. 507-514
    • Nakanishi, K.1    Fujimoto, J.2    Ueki, T.3
  • 48
    • 36549047972 scopus 로고    scopus 로고
    • Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C
    • McHutchison JG, Dusheiko G, Shiffman ML etal. Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C. N Engl J Med 2007; 357: 2227-2236.
    • (2007) N Engl J Med , vol.357 , pp. 2227-2236
    • McHutchison, J.G.1    Dusheiko, G.2    Shiffman, M.L.3
  • 49
    • 79958792649 scopus 로고    scopus 로고
    • Portal vein thrombosis as complication of romiplostim treatment in a cirrhotic patient with hepatitis C-associated immune thrombocytopenic purpura
    • Dultz G, Kronenberger B, Azizi A etal. Portal vein thrombosis as complication of romiplostim treatment in a cirrhotic patient with hepatitis C-associated immune thrombocytopenic purpura. J Hepatol 2011; 55: 229-232.
    • (2011) J Hepatol , vol.55 , pp. 229-232
    • Dultz, G.1    Kronenberger, B.2    Azizi, A.3
  • 50
    • 68549092703 scopus 로고    scopus 로고
    • Comparative analyses of the small molecule thrombopoietin receptor agonist eltrombopag and thrombopoietin on in vitro platelet function
    • Erhardt JA, Erickson-Miller CL, Aivado M, Abboud M, Pillarisetti K, Toomey JR. Comparative analyses of the small molecule thrombopoietin receptor agonist eltrombopag and thrombopoietin on in vitro platelet function. Exp Hematol 2009; 37: 1030-1037.
    • (2009) Exp Hematol , vol.37 , pp. 1030-1037
    • Erhardt, J.A.1    Erickson-Miller, C.L.2    Aivado, M.3    Abboud, M.4    Pillarisetti, K.5    Toomey, J.R.6
  • 51
    • 70449726874 scopus 로고    scopus 로고
    • Effect of the nonpeptide thrombopoietin receptor agonist Eltrombopag on bone marrow cells from patients with acute myeloid leukemia and myelodysplastic syndrome
    • Will B, Kawahara M, Luciano JP etal. Effect of the nonpeptide thrombopoietin receptor agonist Eltrombopag on bone marrow cells from patients with acute myeloid leukemia and myelodysplastic syndrome. Blood 2009; 114: 3899-3908.
    • (2009) Blood , vol.114 , pp. 3899-3908
    • Will, B.1    Kawahara, M.2    Luciano, J.P.3
  • 52
    • 77955271313 scopus 로고    scopus 로고
    • Reduced proliferation of non-megakaryocytic acute myelogenous leukemia and other leukemia and lymphoma cell lines in response to eltrombopag
    • Erickson-Miller CL, Kirchner J, Aivado M, May R, Payne P, Chadderton A. Reduced proliferation of non-megakaryocytic acute myelogenous leukemia and other leukemia and lymphoma cell lines in response to eltrombopag. Leuk Res 2010; 34: 1224-1231.
    • (2010) Leuk Res , vol.34 , pp. 1224-1231
    • Erickson-Miller, C.L.1    Kirchner, J.2    Aivado, M.3    May, R.4    Payne, P.5    Chadderton, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.