Thrombopoietin and interleukin 11 have different modulatory effects on cell cycle and programmed cell death in primary acute myeloid leukemia cells

Experimental Hematology

Volumn 27, Issue 8, 1999, Pages 1255-1263

  Tafuri, Agostino ^a   Lemoli, Roberto M ^b   Petrucci, Maria T ^a   Ricciardi, Maria R ^a   Fogli, Miriam ^b   Bonsi, Laura ^b   Ariola, Cristina ^a   Strippoli, Pierluigi ^b   Gregorj, Chiara ^a   Petti, Maria C ^a   Tura, Sante ^a   Mandelli, Franco ^a   Bagnara, Gian P ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Acute myeloid leukemia; Cell cycle; Interleukin 11; Programmed cell death; Thrombopoietin

Indexed keywords

ANTINEOPLASTIC AGENT; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; RECOMBINANT INTERLEUKIN 11; RECOMBINANT INTERLEUKIN 3; RECOMBINANT INTERLEUKIN 6; RECOMBINANT MEGAKARYOCYTE GROWTH AND DEVELOPMENT FACTOR; RECOMBINANT STEM CELL FACTOR; RECOMBINANT THROMBOPOIETIN;

ACUTE GRANULOCYTIC LEUKEMIA; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CELL CYCLE; CELL PROLIFERATION; CLINICAL ARTICLE; CLONOGENESIS; COLONY FORMING UNIT; CONTROLLED STUDY; DRUG EFFECT; HUMAN; HUMAN CELL; IMMUNOMODULATION; LEUKEMIA CELL LINE; PRIORITY JOURNAL; THROMBOCYTOPENIA;

ACUTE DISEASE; APOPTOSIS; CELL CYCLE; DRUG INTERACTIONS; HUMANS; INTERLEUKIN-11; INTERLEUKIN-3; INTERLEUKIN-6; LEUKEMIA, MYELOID; RECOMBINANT PROTEINS; STEM CELL FACTOR; THROMBOPOIETIN; TUMOR CELLS, CULTURED; TUMOR STEM CELL ASSAY;

EID: 0032765221     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-472X(99)00063-6     Document Type: Article

References (43)

1. Gordon M.S., Hoffman R. Growth factors affecting human thrombocytopoiesis. potential agents for the treatment of thrombocytopenia Blood. 80:1982;302.
2. Kaushansky K. Thrombopoietin. the primary regulator of platelet production Blood. 86:1995;419.
3. Ikebuchi K., Wong G.C., Clark S.C., Ihle J.N., Hirai Y., Ogawa M. Interleukin-6 enhancement of interleukins 3-dependent proliferation of multipotential hemopoietic progenitors. Proc Natl Acad Sci U S A. 84:1987;9035.
4. Paul S.R., Bennett F., Calvetti J.A., Kelleher K., Wood C.R., O'Hara R.M. Jr., Leary A.C., Sibley B., Clark S.C., Williams D.A., Yang Y.-C. Molecular cloning of a cDNA encoding interleukin-11, a stromal cell-derived lymphopoietic and hematopoietic cytokine. Proc Natl Acad Sci U S A. 87:1990;7512.
5. Neben S., Donaldson D., Sieff C., Mauch P., Bodine D., Ferrara J., Yetz-Aldape J., Turner K. Synergistic effects of interleukin-11 with other growth factors on the expansion of murine hematopoietic progenitors and maintenance of stem cells in liquid culture. Exp Hematol. 22:1990;353.
6. Vigon I., Mornon J.-P., Cocault L., Mitjavila M.-T., Tambourin P., Gisselbrecht S., Souyri M. Molecular cloning and characterization of MPL, the human homologue of the v-mpl oncogene. identification of a member of the hematopoietic growth factor receptor superfamily Proc Natl Acad Sci U S A. 89:1992;5640.
7. de Sauvage F.J., Hass P.E., Spencer S.D., Malloy B.E., Gurney A.L., Spencer S.A., Darbonne W.C., Henzel W.J., Wong S.C., Kuang W.-J., Oles K.J., Hultgren B.et al. Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature. 369:1994;533.
8. Bartley T.D., Bogenberger J., Hunt P., Li H.S., Martin F., Chang M.-S., Samal B., Nichol J.L., Swift S., Johnson M.J., Hsu R.-Y., Parker V.P.et al. Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell. 77:1994;1117.
9. Lok S., Kaushansy K., Holly R.D., Kuijper J.L., Lofton-Day C.E., Oort P.J., Grant F.J., Helpel M.D., Burkhead S.K., Kramer J.M., Bell L.A., Sprecher C.A.et al. Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature. 369:1994;565.
10. Kato T., Iwamatsu A., Shimada Y., Horie K., Kokubo A., Maeda E., Ogami K., Sohma Y., Akahori H., Kudo Y., Kubomura N., Matsumoto A.et al. Purification and characterization of thrombopoietin derived from thrombocytopenic rat plasma. Blood. 84:1994;329a.
11. Kuter D.J., Beeler D.L., Rosenberg R.D. The purification of megapoietin. a physiologic regulator of megakaryocytic growth and platelet production Proc Natl Acad Sci U S A. 91:1994;11104.
12. Kaushansky K., Lok S., Holly R.D., Broudy V.C., Lin N., Bailey M.C., Forstrom J.W., Buddle M.M., Oort P.J., Hagen F.S., Roth G.R., Papayamnopolou T.et al. Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Nature. 369:1994;568.
13. Drexler H.G., Quentmeier H. Thrombopoietin. expression of its receptor MPL and proliferative effects on leukemic cells Leukemia. 10:1996;1405.
14. Farese A.M., Hunt P., Boone T., MacVittie T.J. Recombinant human megakaryocytic growth and development factor stimulates thrompoiesis in normal human primates. Blood. 86:1995;54.
15. Fibbe W.E., Heemskerk D.P.M., ;Laterveer L., Priijt J.F.M., Foster D., Kaushansky K., Willemze R. Accelerated reconstitution of platelets and erythrocytes after syngeneic transplantation of bone marrow cells derived from thrombopoietin pretreated donor mice. Blood. 86:1995;3308.
16. Gurney A.L., Carver-Moore K., de Sauvage F.J., Moore M.W. Thrombocytopenia in c-mpl-deficient mice. Science. 265:1994;1445.
17. Crawford J., Ozer H., Stoller R., Johnson D., Lyman G., Tabbara I., Kris M., Grous J., Picozzi V., Rausch G., Smith R., Gradishar W.et al. Reduction by granulocyte colony-stimulating factor of fever and neutropenia induced by chemotherapy in patients with small-cell lung cancer. N Engl J Med. 325:1991;164.
18. Shiffer C.A. Hematopoietic growth factors as adjuncts to the treatment of acute myeloid leukemia. Blood. 88:1996;3675.
19. Archimbaud F., Ottmann O., Liu J.A., Lechner K., Dombret H., Sanz M.A., Herrmann F., Gruss H., Fenaux P., Ganser A., Heil G., Kanz L.et al. A randomized double-blind, placebo controlled study using PEG-rHuMGDF as an adjunct to chemotherapy for adults with de-novo AML. early results Blood. 88:1996;1778a.
20. Vadhan-Raj S., Patel S., Broxmeyer H.E., Bueso-Ramos C., Reddy S.P., Papadopulos N., Burgess A., Johnston T., Yang T., Paton V., Hellmann S., Benjamin R.S. Phase I-II investigation of recombinant human thrombopoietin (rhTPO) in patients with sarcoma receiving high dose chemotherapy with adriamicin and ifosfamide. Blood. 88:1996;1779a.
21. Nash R., Kurzrock R., Dipersio J., Tremblay T., Jones D., Appelbaum F., Champlin R. Safety and activity of recombinant human thrombopoietin in patients with delayed platelet recovery. Blood. 90:1997;1151a.
22. Du X., Williams D. Interleukin-11. review of molecular, cell biology and clinical use Blood. 89:1997;3897.
23. Isaacs C., Robert N.J., Bailey A., Schuster M.W., Overmayer B., Graham M., Cai B., Beach K.J., Loewy J.W., Kaye J.A. Randomized placebo-controlled study of recombinant human interleukin-11 to prevent chemotherapy-induced thrombocytopenia in patients with breast cancer receiving dose-intensive cyclophosphamide and doxorubicin. J Clin Oncol. 15:1997;3368.
24. Tepler I., Elias L., Smith J.W. II, Hussein M., Rosen G., Chang A.-Y.-C., Moore J.O., Gordon M.S., Kuca B., Beach K.J., Loewy J.W., Garnick M.B.et al. A randomized placebo-controlled trial of recombinant human interleukin-11 in cancer patients with severe thrombocytopenia due to chemotherapy. Blood. 87:1996;3607.
25. Matsumura I., Kanakura Y., Kato T., Ikeda H., Ishikawa J., Horikawa Y., Hahimoto K., Moriyama Y., Tsujimura T., Nishiura T., Miyazaki H., Matsuzawa Y. Growth response of acute myeloblastic leukemia cells to recombinant human thrombopoietin. Blood. 86:1995;703.
26. Matsumura I., Kanakura Y., Kato T., Ikeda H., Horikawa Y., Ishikawa J., Kitayama H., Nishiura T., Tomiyama Y., Miyazaki H., Matsuzawa Y. The biologic properties of recombinant human thrombopoietin in the proliferation and megakaryocytic differentiation of acute myeloblastic leukemia cells. Blood. 88:1996;3074.
27. Quentmeier H., Zaborski M., Graf G., Ludwig W.D., Drexler H.G. Expression of the receptor MPL and proliferative effects of its ligand thrombopoietin on human leukemia cells. Leukemia. 10:1996;297.
28. Motoji T., Takanashi M., Motomura S., Yan-Hua W., Shiozaki H., Aoyama M., Mizoguchi H. Growth stimulatory effect of thrombopoietin on the blast cells of acute myelogenous leukemia. Br J Haematol. 94:1996;513.
29. Piacibello W., Sanavio F., Brizzi M.F., Garetto L., Severino A., Aronica M.G., Dragonetti G., Aglietta M., Pegoraro L. Megakaryocyte growth and development factor (MGDF)-induced acute leukemia cell proliferation and clonal growth is associated with functional c-mpl. Leukemia. 11:1997;531.
30. Tafuri A., De Felice L., Goodacre A., Fenu S., Petrucci M.T., Valentini T., Alimena G., Petti M.C., Meloni G., Mandelli F. IL-3 priming in acute myeloid leukemia patients. Br J Haematol. 91:1995;234.
31. Tafuri A., Petrucci M.T., Mascolo M.G., Ciliberti C., Ricciardi M.R., De Felice L. Preclinical evaluation of GM-CSF/IL-3 fusion protein (PIXY 321) in acute myeloid leukemic cells. Büchner T., Hiddemann W., Wormann B., Schellong G., Ritter J., Crentzig U. Acute leukemia VI. prognostic factor and treatment strategies:1997;Springer-Verlag. p 465, Berlin.
32. Lemoli R.M., Fogli M., Fortuna A., Amabile M., Zucchini P., Grande A., Martinelli G., Visani G., Ferrari S., Tura S. IL-11 acts as a synergistic factor for the proliferation of human myeloid laeukemic cells. Br J Haematol. 91:1995;319.
33. Lemoli R.M., Fortuna A., Tafuri A., Fogli M., Amabile M., Grande A., Ricciardi M.R., Petrucci M.T., Bonsi L., Bagnara G.P., Visani G., Martinelli G.et al. IL-9 stimulates the proliferation of human myeloid leukemic cells. Blood. 87:1996;3852.
34. Avanzi G.C., Lista P., Giovinazzo B., Miniero R., Saglio G., Benetton G., Coda R., Cattoretti G., Pegoraro L. Selective growth response to IL-3 of a human laeukemic cell line with megakaryoblastic features. Br J Haematol. 69:1988;359.
35. Tafuri A., Andreeff M. Kinetic rationale for cytosine-induced recruitment of myeloblastic leukemia followed by cycle-specific chemotherapy in vitro. Leukemia. 12:1990;826.
36. Tafuri A., Lemoli R.M., Chen R., Gulati S., Clarkson B.D., Andreeff M. Combination of hematopoietic growth factors containing IL-3 induced acute myeloid leukemia cell sensitization to cycle specific and cycle non specific drugs. Leukemia. 8:1994;749.
37. Andreeff M., Darzynkiewicz Z., Sharpless T.K., Clarkson B.D., Melamed M.R. Discrimination of human leukemia subtypes by flow cytometric analysis of cellular DNA and RNA. Blood. 55:1980;282.
38. Hiddemann W., Schumann J., Andreeff M., Barlogie B., Herman C.J., Leif R.C., Mayall B.H., Murphy R.F., Sandberg A.A. Convention on nomenclature for DNA cytometry. Cytometry. 5:1984;445.
39. Vigon I., Dreyfus F., Melle J., Viguiè F., Ribrag V., Cocault L., Souyri M., Gisselbrecht S. Expression of the c-mpl proto-oncogene in human hematologic malignancies. Blood. 82:1993;877.
40. Quentmeier H., Drexler H.G. Thrombopoietin-induced proliferation is paralleled by expression of cyclin-dependent kinase inhibitors. Blood. 90:1997;3456a.
41. Ritchie A., Vadhan-Raj S., Broxmeyer H.E. Thrombopoietin suppresses apoptosis and behaves as a survival factor for the human growth factor-dependent cell line, M07e. Stem Cells. 14:1996;330.
42. Hirayama Y., Sakamaki S., Matsunaga T., Kuga T., Kuroda H., Kusakabe K., Sasaki K., Fujikawa K., Kato J., Kogawa K., Koyama R., Niitsu Y. Concentration of thrombopoietin in bone marrow in normal subjects and in patients with idiopathic trombocytopenic purpura, aplastic anemia, and essential thrombocythemia correlate with its mRNA expression of bone marrow stromal cells. Blood. 92:1998;46.
43. Wang J.C., Chen C., Lou L.-H., Mora M. Blood thrombopoietin, IL-6 and IL-11 levels in patients with agnogenic myeloid metaplasia. Leukemia. 11:1997;1827.