Expression and function of the megakaryocyte growth and development factor receptor in acute myeloid leukemia blasts

Leukemia and Lymphoma

Volumn 30, Issue 5-6, 1998, Pages 415-433

  Wetzler, Meir ^a   Bernstein, Steven H ^a   Baumann, Heinz ^a   Fries, Kristin M ^b   Stewart, Carleton ^a   Blumenson, Leslie ^a   Baer, Maria R ^a   Herzig, Geoffrey P ^a   Bloomfield, Clara D ^a   Slack, James L ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b DAEMEN COLLEGE   (United States)

Author keywords

Acute myeloid leukemia blasts; AML; Function; Megakaryocyte growth and development factor; MGDF; MGDF receptor

Indexed keywords

CYTARABINE; GRANULOCYTE COLONY STIMULATING FACTOR; GROWTH FACTOR RECEPTOR; MEGAKARYOCYTE GROWTH AND DEVELOPMENT FACTOR; MESSENGER RNA; STEM CELL FACTOR; TRANSCRIPTION FACTOR;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; APOPTOSIS; ARTICLE; BLAST CELL; CELL CYCLE S PHASE; CELL PROLIFERATION; CLINICAL ARTICLE; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 7344249544     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428199809057554     Document Type: Article

References (45)

1. Lowenberg, B. and Touw, I. P. (1993). Hematopoietic growth factors and their receptors in acute leukemia. Blood, 81, 281-292.
2. Budel, L. M., Touw, I. P., Delwel, R. and Lowenberg, B. (1989). Granulocyte colony-stimulating factor receptors in human acute myelocytic leukemia. Blood, 74, 2668-2673.
3. Wang, C., Curtis, J. E., Geissler, E. N., McCulloch, E. A. and Minden, M. D. (1989). The expression of the proto-oncogene c-kit in the blast cells of acute myeloblastic leukemia. Leukemia, 3, 699-702.
4. Ikeda, H., Kanakura, Y., Tamaki, T., Kuriu, A., Kitayama, H., Ishikawa, J., Kanayama, T., Yonezawa, T., Tarui, S. and Griffin, J. D. (1991). Expression and functional role of the proto-oncogene c-kit in acute myeloblastic leukemia cells. Blood, 78, 2962-2968.
5. Vigon, I., Mornon, J. P., Cocault, L., Mitjavila, M. T., Tambourin, P., Gisselbrecht, S. and Souyri, M. (1992). Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily. Proceedings of the National Academy of Sciences USA, 89, 5640-5644.
6. Bartley, T. D., Bogenberger, J., Hunt, P., Li, Y.-S., Lu, H. S., Martin, F., Chang, M.-S., Samal, B., Nichol, J. L., Swift, S., Johnson, J., Hsu, R.-Y., Parker, P., Suggs, S., Skrine, J. D., Merewether, L. A., Clogston, C., Hsu, E., Hokom, M. M., Hornkohl, A., Choi, E., Pangelinan, M., Sun, Y., Mar, V., McNinch, J., Simonet, L., Jacobsen, F., Xie, C., Shutter, J., Chute, H., Basu, R., Selander, L., Trollinger, D., Sieu, L., Padila, D., Trail, G., Elliot, G., Izumi, R., Covey, T., Crouse, J., Garcia, A., Xu, W., Del Castillo, J., Biron, J., Cole, S., Hu, MC.-T., Pacifici, R., Ponting, I., Saris, C., Wen, D., Yung, Y. P., Lin, H. and Bosselman, R. A. (1994). Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell, 77, 1117-1124.
7. de Sauvage, F. J., Hass, P. E., Spencer, S. D., Malloy, B. E., Gurney, A. L., Spencer, S. A., Darbonne, W. C., Henzel, W. J., Wong, S. C., Kuang, W.-J., Oles, K. J., Hultgren, B., Solberg, L. A., Jr., Goeddel, D. V. and Eaton, D. L. (1994). Stimulation of megakarocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature (Lond.), 369, 533-538.
8. Lok, S. L., Kaushansky, K., Holly, R. D., Kuijper, J. L., Lofton-Day, C. E., Oort, P. J., Grant, F. J., Heipel, M. D., Burkhead, S. K., Kramer, J. M., Bell, L. A., Sprecher, C. A., Blumberg, H., Johnson, R., Prunkard, D., Ching, A. F. T., Mathewes, S. L., Balley, M. C., Forstrom, J. W., Buddle, M. M., Osborn, S. G., Evans, S. J., Sheppard, P. O., Presnell, S. R., O'Hara, P. J., Hagen, F. S., Roth, G. J. and Foster, D. C. (1994). Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature (Lond.), 369, 565-568.
9. Kaushansky, K., Lok, S. L., Holly, R. D., Broudy, V. C., Lin, N., Bailey, M. C., Forstrom, J. W., Buddle, M. M., Oort, P. J., Hagen, F. S., Roth, G. J., Papayannopoulou, T. and Foster, D. C. (1994). Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Nature (Lond.), 369, 568-571.
10. Wendling, F., Maraskovsky, E., Debill, N., Florindo, C., Teepe, M., Tlteux, M., Methia, N., Breton-Gorius, J., Cosman, D. and Vainchenker, W. (1994). c-Mpl ligand is a humoral regulator of megakarocytopoiesis. Nature (Lond.), 369, 574-574.
11. Stewart, C. C. (1992). Clinical applications of flow cytometry. Immunologic methods for measuring cell membrane and cytoplasmic antigens. Cancer, 69 (Suppl), 1543-1552.
12. Terstappen, L. W., Safford, M., Konemann, S., Loken, M. R., Zurlutter, K., Buchner, T., Hiddemann, W. and Wormann, B. (1992). Flow cytometric characterization of acute myeloid leukemia. Part II. Phenotypic heterogeneity at diagnosis. Leukemia, 6, 70-80.
13. Reading, C. L., Estey, E. H., Huh, Y. O., Claxton, D. F., Sanchez, G., Terstappen, L. W., O'Brien, M. C., Baron, S. and Deisseroth, A. B. (1993). Expression of unusual immunophenotype combinations in acute myelogenous leukemia. Blood, 81, 3083-3090.
14. Mignotte, V., Vigon, I., de Crevecoeur, E. B., Romeo, P.-H., Lemarchandel, V. and Chretien, S. (1994). Structure and transcription of the human c-mpl gene (MPL). Genomics, 20, 5-12.
15. Vigon, I., Dreyfus, F., Melle, J., Viguie, F., Ribrag, V., Cocault, I., Souyn, M. and Gisselbrecht, S. (1993). Expression of the c-mpl proto-oncogene in human hematologic malignancies. Blood, 82, 877-883.
16. Gunji, H., Kharbanda, S. and Kufe, D. (1991). Induction of internucleosomal DNA fragmentation in human myeloid leukemia cells by 1-beta-D-arabinofuranosylcytosine. Cancer Research, 51, 741-743.
17. Tosi, P., Visani, G., Ottaviani, E., Manfori, S., Zinzani, P. L. and Tura, S. (1994). Fludarabine + Ara-C + G-CSF: cytotoxic effect and induction of apoptosis on fresh acute myeloid leukemia cells. Leukemia, 8, 2076-2082.
18. Wyllie, A. H., Morris, R. G., Smith, A. L. and Dunlop, D. (1984). Chromatin cleavage in association with condensed chromatin morphology and dependence on macromolecular synthesis, Journal of Pathology, 142, 67-77.
19. Nicoletti, I., Migliorati, G., Pagliacci, M. C., Grignani, F. and Riccardi, C. (1991). A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. Journal of Immunological Methods, 139, 271-279.
20. Morella, K. K., Bruno, E., Kumaki, S., Lai, C-F., Fu, J., Wang, H-M., Murray, L., Hoffman, R., Timour, M., Benit, L., Gisselbracht, S., Zhuang, H., Wojchowski, D. M., Baumann, H. and Gearing, D. P. (1995). Signal transduction by the receptors for thrombopoietin (c-mpl) and interleukin-3 in hematopoietic and nonhematopoietic cells. Blood, 86, 557-571.
21. Wetzler, M., Talpaz, M., Van Etten, R. A., Hirsh-Ginsberg, C., Beran, M. and Kurzrock, R. (1993). Subcellular localization of Bcr, Abl, and Bcr-Abl proteins in normal and leukemic cells and correlation of expression with myeloid differentiation. Journal of Clinical Investigation, 92, 1925-1939.
22. Wetzler, M., Baer, M. R., Bernstein, S. H., Blumenson, L., Stewart, C., Barcos, M., Mrózek, K., Block, A. W., Herzig, G. P. and Bloomfield, C. D. (1997). Expression of c-mpl mRNA, the receptor for thrombopoietin. in acute myeloid leukemia blasts identifies a group of patients with poor response to intensive chemotherapy. Journal of Clinical Oncology, 15, 2262-2268.
23. Lotem, J. and Sachs, L. (1992). Hematopoietic cytokines inhibit apoptosis induced by transforming growth factor beta 1 and cancer chemotherapy compounds in myeloid leukemic cells. Blood, 80, 1750-1757.
24. Bouscary, D., Prudhomme, C., Quesnel, B., Melle, J., Picard, F. and Dreyfus, F. (1995). c-mpl expression in hematologic malignancies. Leukemia and Lymphoma, 17, 19-26.
25. Matsumura, I., Kanakura, Y., Kato, T., Ikeda, H., Ishikawa, J., Horikawa, Y., Hashimoto, K., Moriyama, Y., Tsujimura, T., Nishiura, T., Miyazaki, H. and Matsuzawa, Y. (1995). Growth response of acute myeloblastic leukemia cells to recombinant human thrombopoietin. Blood, 86, 703-709.
26. Quentmeier, H., Zaborski, M., Graf, G., Ludwig, W. D. and Drexler, H. G. (1996). Expression of the receptor MPL and proliferative effects of its ligand thrombopoietin on human leukemia cells. Leukemia, 10, 297-310.
27. Matsumura, I., Kanakura, Y., Kato, T., Ikeda, H., Horikawa, Y., Ishikawa, J., Kitayama, H., Nishiura, T., Tomiyama, Y., Miyazaki, H. and Matsuzawa, Y. (1996). The biologic properties of recombinant human thrombopoietin in the proliferation and megakaryocyte differentiation of acute myeloblastic leukemia cells. Blood, 88, 3074-3082.
28. Brawerman, G. (1987). Determinants of messenger RNA stability. Cell, 48, 5-6.
29. Ferrari, S., Tagliafico, E., D'Inca, M., Ceccherelli, G., Manfredini, R., Selleri, L., Donelli, A., Sacchi, S., Torelli, G. and Torelli, U. (1990). Ratios between the abundance of messenger RNA and the corresponding protein of two growth-related genes, c-myc and vimentin in leukemic blast cells. Cancer Research, 50, 1988-1991.
30. Ferrari, S., Mariano, M. T., Tagliafico, E., Sarti, M., Ceccherelli, G., Selleri, L., Merli, F., Narni, F., Donelli, A., Torelli, G. and Torelli, U. (1988). Myeloperoxidase gene expression in blast cells with a lymphoid phenotype in cases of acute lymphoblastic leukemia. Blood, 72, 873-876.
31. Wetzler, M., Kurzrock, R., Estrov, Z., Estey, E. and Talpaz, M. (1995). Cytokine expression in adherent layers from patients with myelodysplastic syndrome and acute myelogenous leukemia. Leukemia Research, 19, 23-34.
32. Dokter, W. H. A., Borger, P., Hendriks, D., van der Horst, I., Ruud Halie, M. and Vellenga, E. (1992). Interleukin-4 (IL-4) receptor expression on human T cells is affected by different intracellular signaling pathways and by IL-4 at transcriptional and posttranscriptional level. Blood, 80, 2721-2728.
33. Murohashi, I., Tohda, S., Suzuki, T., Nagata, K., Yamashita, Y., Nara, N. and Aoki, N. (1989). Expression of interleukin-1β receptors on blast cells in acute mycloblastic leukemia: comparison with interleukin-1β proliferative activity. Cancer Research, 49, 3431-3435.
34. Budel, L. M., Touw, I. P., Delwel, R., Clark, S. C. and Lowenberg, B. (1989). Interleukin-3 and granulocyte-monocyte colony-stimulating factor receptors on human acute myelocytic leukemia cells and relationship to the proliferative response. Blood, 74, 565-571.
35. Bernstein, S. H., Baer, M. R., Lawrence, D., Herzig, G. P., Bloomfield, C. D. and Wetzler, M. (1995). Serial determination of thrombopoietin (TPO), IL-3, IL-6, IL-11 and leukemia inhibitory factor (LIF) levels in patients undergoing chemotherapy for acute myeloid leukemia (AML). Blood, 86, 46a, (Abstr.).
36. Hunt, P., Li, Y. S., Nichol, J. L., Hokom, M. M., Bogenberger, J. M., Swift, S. E., Skrine, J. D., Hornkohl, A. C. Lu, H., Clogston, C., Merewether, L. A., Johnson, M. J., Parker, V., Knudten, A., Farese, A., Hsu, R. Y., Garcia, A., Stead, R., Bosselman, R. A. and Bartley, T. (1995). Purification and biologic characterization of plasma-derived megakaryocyte growth and development factor. Blood, 86, 540-547.
37. Nichol, J. L., Hokom, M. M., Hornkohl, A., Sheridan, W. P., Ohashi, H., Kato, T., Li, Y. S., Bartley, T. D., Choi, E., Bogenberger, J., Skrine, J. D., Knudten, A., Chen, J., Trail, G., Sleeman, L., Cole, S., Grampp, G. and Hunt, P. (1995). Megakaryocyte growth and development factor. Analyses of in vitro effects on human megakaryopoiesis and endogenous serum levels during chemotherapy-induced thrombocytopenia. Journal of Clinical Investigation, 95, 2973-2978.
38. Ulich, T. R., del Castillo, J., Yin, S., Swift, S., Padilla, D., Senaldi, G., Bennett, L., Shutter, J., Bogenberger, J., Sun, D., Samal, B., Shimamoto, G., Lee, R., Steinbrink, R., Boone, T., Sheridan, W. T. and Hunt, P. (1995). Megakaryocyte growth and development factor ameliorates carboplatin-induced thrombocytopenia in mice. Blood, 86, 971-976.
39. Farese, A. M., Hunt, P., Boone, T. and MacVittie, T. J. (1995). Recombinant human megakaryocyte growth and development factor stimulates thrombocylopoiesis in normal nonhuman primates, Blood, 86, 54-59.
40. Basser, R. L., Rasko, J. E., Clarke, K., Cehon, J., Green, M. D., Hussein, S., Alt, C., Menchaca, D., Tomita, D., Marty, J., Fox, R. M. and Begley, C. G. (1996). Thrombopoietic effects of pegylaled recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) in patients with advanced cancer. Lancet, 348(9037), 1279-1281.
41. Geller, R. B. (1996). Use of cytokines in the treatment of acute myelocytic leukemia: A critical review. Journal of Clinical Oncology, 14, 1371-1382.
42. Cairo, M. S., Suen, Y., Sender, L., Gillan, E. R., Ho, W., Plunkett, J. M. and van de Ven, C. (1992). Circulating granulocyte colony-stimulating factor (G-CSF) levels after allogeneic and autologous bone marrow transplantation: endogenous G-CSF production correlates with myeloid engraftment. Blood, 79, 1869-1873.
43. Greendyke, R. M., Sharma, K. and Gifford, F. R. (1994). Serum cytokine levels in patients with neutropenia. Archives of Pathology and Laboratory Medicine, 118, 1193-1195.
44. Testa, U., Martucci, R., Rutella, S., Scambia, G., Sica, S., Benedetti Punici, P., Pierelli, L., Menichella, G., Leone, G., Muncuso, S. and Peschle, C. (1994). Autologous stem cell transplantation: release of early and late acting growth factors relates with hematopoietic ablation and recovery. Blood, 84, 3532-3539.
45. Ho, A. D., Maruyania, M., Maghazachi, A., Mason, J. R., Gluck, S. and Corringham, R. E. (1994). Soluble CD4, soluble CD8, soluble CD25, lymphopoietic recovery, and endogenous cytokines after high-dose chemotherapy and blood stem cell transplantation. Blood, 84, 3550-3557.