Effects of megakaryocyte growth and development factor (thrombopoietin) on liver endothelial cells in vitro

Microvascular Research

Volumn 58, Issue 2, 1999, Pages 108-113

  Cardier, José E ^a,b  

^a INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

^b Cancer Prevention Institute Dayton   (United States)

Author keywords

Cytokines; Endothelial cells; LEC 1; Liver; Thrombopoietin

Indexed keywords

CYTOKINE; GAMMA INTERFERON; MEGAKARYOCYTE GROWTH AND DEVELOPMENT FACTOR; NITRIC OXIDE; THROMBOPOIETIN;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENDOTHELIUM CELL; MEGAKARYOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA; MURINAE;

EID: 0032875330     PISSN: 00262862     EISSN: None     Source Type: Journal    
DOI: 10.1006/mvre.1999.2161     Document Type: Article

References (38)

1. Lok S., Kaushanski K., Holly R., Kuijper J., Lofton-Day C., Oort P., Grant F., Helpel M., Burkhead S., Kramer J., Bell L., Sprecher C., Blumberg H., Johnson R., Prunkard D., Ching A., Mathewes S., Balley M., Forstrom J., Buddle M., Osborn S., Evans S., Sheppard P., Presnell S., O'Hara P., Hagen F., Roth G., Foster D. Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature. 369:1994;565-568.
2. de Sauvage F. J., Hass P. E., Spencer S. D., Malloy B., Gurney A., Spencer A., Darbonne W., Henzel W., Wong S., Kuang W., Oles K., Hultgren B., Solber L. Jr., Goeddel D., Eaton D. Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-mpl ligand. Nature. 369:1994;533-538.
3. Kaushansky K., Lok S., Holly R. D., Broudy V. C., Lin N., Balley M. C., Forstrom J. W., Buddle M. M., Oort P. J., Hagen F. S., Roth G. J., Papayannopoulou T., Foster D. Promotion of megakaryocyte progenitor expansion and differentiation by the c-mpl ligand thrombopoietin. Nature. 369:1994;568-571.
4. Wendling F., Maraskovsky E., Debili N., Florindo C., Teepe M., Titeux M., Methia N., Breton-Gorius J., Cosman D., Vainchenker W. c-mpl ligand is a humoral regulator of megakaryocytopoiesis. Nature. 369:1994;571-574.
5. Bartley T. D., Bogenberger J., Hunt P., Li Y. S., Lu H. S., Martin F., Chang M. S., Samal B., Nichol J. L., Swift S., Johnson M. J., Hsu R. Y., Parker V. P., Suggs S., Skrine J. D., Merewether L. A., Clogston C., Hsu E., Hokom M. M., Hornkohl A., Choi E., Pangelinan M., Sun Y., Mar V., McNinch J., Simonet L., Jacobsen F., Xie C., Shutter J., Chute H., Basu R., Selander L., Trollinger D., Sieu L., Padilla D., Trail G., Elliot G., Izumi R., Covey T., Crouse J., Garcia A., Xu W., Del Castillo J., Biron J., Cole S., Hu M. C., Pacifici R., Ponting I., Sris C., Wen D., Yung Y. P., Lin H., Bosselman R. A. Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell. 77:1994;1117-1124.
6. Cardier J., Foster D., Lok Si, Jacobsen S. E. W., Murphy M. J. Jr. Megakaryocytopoiesis in vitro: From the stem cells perspectives. Stem Cells. 14:1996;163-172.
7. Kaushansky K. Thrombopoietin: Biological and preclinical properties. Leukemia. 10:1996;S46-S48.
8. Kaushansky K., Broudy V. C., Grossmann A., Humes J., Lin N., Ren H. P., Bailey M. C., Papayannopoulou T., Forstrom J. W., Sprugel K. H. Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy. J. Clin. Invest. 96:1995;1683-1687.
9. Ramsfjell V., Borge O., Veiby O., Cardier J., Murphy M. J. Jr., Lyman S., Lok Si., Jacobsen S. E. W. Thrombopoietin, but not erythropoietin, directly stimulates growth and multilineage differentiation of primitive murine bone marrow progenitor cells in synergy with early acting cytokines: Distinct interactions with the ligands for c-kit and FLT3. Blood. 88:1996;4481-4492.
10. Stoffel R., Wiestner A., Skoda R. C. Thrombopoietin in thrombocytopenic mice: Evidence against regulation at the mRNA level and for a direct regulatory role of platelets. Blood. 87:1996;567-572.
11. Shimada Y., Kato T., Ogami K., Horie K., Kokubo A., Kudo Y., Maeda E., Sohma Y., Akahori H., Kawamura K., Miyazaki H. Production of thrombopoietin (TPO) by rat hepatocytes and hepatoma cell lines. Exp. Hematol. 23:1995;1388-1396.
12. Sungaran R., Markovic B., Chong B. H. Localization and regulation of thrombopoietin mRNA expression in human, kidney, liver, bone marrow, and spleen using in situ hybridization. Blood. 89:1997;101-107.
13. McCarty J. M., Sprugel K. H., Fox N. E., Sabath D. E., Kaushansky K. Murine thrombopoietin mRNA levels are modulated by platelet count. Blood. 86:1995;3668-3675.
14. Ballmaier M., Bogenberger J., Shutter A., Welcher N., Todow A., Konig A., Wilken A., Schweinitz D., Hadam M., Welter K. Analysis of expression of megakaryocyte growth and development factor mRNA in various human normal and malignant tissues. Blood. 84:1994.
15. Vigon I., Mornon J. P., Cocault L., Mitjavila M. T., Tambourin P., Gisselbrecht S., Souyri M. Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: Identification of a member of the hematopoietic growth factor receptor superfamily. Proc. Natl. Acad. Sci. USA. 89:1992;5640-5644.
16. Skoda R. C., Seldin D. C., Chiang M. K., Peichel C., Vogt T., Leder P. Murine c-mpl: A member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal. EMBO J. 12:1993;2645-2653.
17. Methia N., Louache F., Vainchenker W., Wendling F. Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis. Blood. 82:1993;1395-1401.
18. Debili N., Wendling F., Cosman D., Titeux M., Florindo C., Dusanter-Fourt I., Schooley K., Methia N., Charon M., Nador R., Bettaieb A., Vainchenker W. The Mpl receptor is expressed in the megakaryocytic lineage from late progenitors to platelets. Blood. 85:1995;391-401.
19. Drachman J. G., Griffin J. D., Kaushansky K. The c-mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-mpl. J. Biol. Chem. 270:1996;4979-4982.
20. Drachman J. G., Kaushansky K. Dissecting the thrombopoietin receptor: Functional elements of the Mpl cytoplasmic domain. Proc. Natl. Acad. Sci. USA. 94:1997;2350-2355.
21. Gurney A. L., Wong S. C., Henzel W. J., de Sauvage F. J. Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylation. Proc. Natl. Acad. Sci. USA. 92:1995;5292-5296.
22. Pallard C. F., Gouilleus F., Bénit L., Cocault L., Souyri M., Levy D., Groner B., Gisselbrecht S., Dusanter-Fourt I. Thrombopoietin activates a STAT-5 like factor in hematopietic cells. EMBO J. 14:1995;2847-2856.
23. Porteu F., Rouyez M., Cocault L., Bénit L., Charon M., Picard F., Gisselbrecht S., Souyri M., Dusanter-Fourt I. Functional regions of the mouse thrombopoietin receptor cytoplasmic domain: Evidence for a critical region which is involved in differentiation and can be complemented by erythropoietin. Mol. Cell. Biol. 16:1996;2473-2482.
24. Cardier J. E., Dempsey J. Thrombopoietin and its receptor, c-mpl, are constitutively expressed by mouse liver endothelial cells: Evidence of thrombopoietin as a growth factor for liver endothelial cells. Blood. 91:1998;923-929.
25. Barberá-Guillem E., Rocha M., Alvarez A., Vidal-Vanaclocha F. Differences in the lectin-binding patterns of the periportal and perivenous endothelial domains in the liver sinusoids. Hepatology. 14:1991;131-139.
26. Vidal-Vanaclocha F., Rocha M., Asumendi A., Barberá-Guillem E. Isolation and enrichment of two sublobular compartment-specific endothelial cell subpopulations from liver sinusoids. Hepatology. 18:1993;328-339.
27. Cardier J. E., Barberá-Guillem E. Extramedullary hematopoiesis in the adult mouse liver is associated with specific hepatic sinusoidal endothelial cells. Hepatology. 26:1997;165-175.
28. Cotran R. S. New roles for the endothelium in inflammation and immunity. Am. J. Pathol. 129:1987;407-413.
29. Jackson J., Sedd M., Kircher C., Willoughby D., Winkler J. The codependence of angiogenesis and chronic inflammation. FASEB J. 11:1997;457-465.
30. Mantovani A., Bussolino F., Introna M. Cytokine regulation of endothelial cell function: From molecular level to the bedside. Immunol. Today. 18:1997;231-240.
31. Pober J., Gimbrone L., Lapierre D., Mendrick D., Fiers W., Rothlein R., Springer T. Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon. J. Immunol. 137:1986;1893-1896.
32. Detmar M., Tenorio S., Hettmannsperger U., Ruszczak, Orfanos C. Cytokine regulation of proliferation and ICAM-1 expression of human dermal microvascular endothelial cells in vitro. J. Invest. Dermatol. 98:1992;147-153.
33. Folkman J., Klagsbrun M. Angiogenic factors. Science. 235:1987;442-447.
34. Ogami K., Kawagishi M., Kudo Y., Kato T., Miyazaki H., Kawamura K. Promoter analysis and transcriptional regulation of the human thrombopoietin gene. Blood. 86:1995;1447.
35. Ulich T. R., del Castillo J., Yin S., Swift S., Padilla D., Senaldi G., Bennet L., Shutter J., Bogenberger J., Sunt D., Samal B., Shimamoto G., Lee R., Steinbrink R., Boone T., Sheridan W. T., Hunt P. Megakaryocyte growth and development factor ameliorates carboplatin-induced thrombocytopenia in mice. Blood. 86:1995;971-976.
36. Ulich T. R., del Castillo J., Senaldi G., Kinstler O., Yin S., Kaufman S., Tarpley J., Choi E., Kirley T., Hunt P., Sheridan W. Systemic hematologic effects of PEG-rHuMGDF-induced megakaryocyte hyperplasia in mice. Blood. 87:1997;5006-5015.
37. Yan X., Lacey D., Hill D., Chen Y., Fletcher F., Hawley R., McNiece I. A model of myelofibrosis and osteosclerosis in mice induced by overexpressing thrombopoietin (mpl ligand): Reversal of disease by bone marrow transplantation. Blood. 88:1996;402-409.
38. Villeval J. L., Cohen-Solal K., Micheline T., Giraudier S., Guichard J., Burnstein S. A., Cramer E., Vainchenker W., Wendling F. High thrombopoietin production by hematopoietic cells induces a fatal myeloproliferative syndrome in mice. Blood. 90:1997;4369-4383.