메뉴 건너뛰기




Volumn 34, Issue 9, 2010, Pages 1224-1231

Reduced proliferation of non-megakaryocytic acute myelogenous leukemia and other leukemia and lymphoma cell lines in response to eltrombopag

Author keywords

Apoptosis; Differentiation; FAB; MPL; QRT PCR; TpoR

Indexed keywords

BETA ACTIN; CYCLOPHILIN A; ELTROMBOPAG; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; ONCOPROTEIN; PROTEIN MPL; UNCLASSIFIED DRUG;

EID: 77955271313     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2010.02.005     Document Type: Article
Times cited : (39)

References (28)
  • 1
    • 34247646400 scopus 로고    scopus 로고
    • The incidence and impact of thrombocytopenia in myelodysplastic syndromes
    • Kantarjian H., Giles F., List A., Lyons R., Sekeres M., Pierce S., et al. The incidence and impact of thrombocytopenia in myelodysplastic syndromes. Cancer 2007, 109:1705-1714.
    • (2007) Cancer , vol.109 , pp. 1705-1714
    • Kantarjian, H.1    Giles, F.2    List, A.3    Lyons, R.4    Sekeres, M.5    Pierce, S.6
  • 2
    • 36348930556 scopus 로고    scopus 로고
    • Establishment of baseline toxicity expectations with standard frontline chemotherapy in acute myelogenous leukemia
    • Atallah E., Cortes J., O'Brien S., Pierce S., Rios M.B., Estey E., et al. Establishment of baseline toxicity expectations with standard frontline chemotherapy in acute myelogenous leukemia. Blood 2007, 110:3547-3551.
    • (2007) Blood , vol.110 , pp. 3547-3551
    • Atallah, E.1    Cortes, J.2    O'Brien, S.3    Pierce, S.4    Rios, M.B.5    Estey, E.6
  • 3
    • 34249719511 scopus 로고    scopus 로고
    • Phase I clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist
    • Jenkins J.M., Williams D., Deng Y., Uhl J., Kitchen V., Collins D., et al. Phase I clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist. Blood 2007, 109:4739-4741.
    • (2007) Blood , vol.109 , pp. 4739-4741
    • Jenkins, J.M.1    Williams, D.2    Deng, Y.3    Uhl, J.4    Kitchen, V.5    Collins, D.6
  • 4
    • 36549001698 scopus 로고    scopus 로고
    • Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura
    • Bussel J., Cheng G., Saleh M.N., Psaila B., Kovaleva K., Meddeb B., et al. Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura. N Engl J Med 2007, 357:2237-2247.
    • (2007) N Engl J Med , vol.357 , pp. 2237-2247
    • Bussel, J.1    Cheng, G.2    Saleh, M.N.3    Psaila, B.4    Kovaleva, K.5    Meddeb, B.6
  • 5
    • 60249099882 scopus 로고    scopus 로고
    • Effect of eltrombopag on platelet counts and bleeding during treatment of chronic idiopathic thrombocytopenic purpura: a randomized, double-blind, placebo-controlled trial
    • Bussel J., Provan D., Shamsi T., Cheng G., Psaila B., Kovaleva L., et al. Effect of eltrombopag on platelet counts and bleeding during treatment of chronic idiopathic thrombocytopenic purpura: a randomized, double-blind, placebo-controlled trial. The Lancet 2009, 373:641-648.
    • (2009) The Lancet , vol.373 , pp. 641-648
    • Bussel, J.1    Provan, D.2    Shamsi, T.3    Cheng, G.4    Psaila, B.5    Kovaleva, L.6
  • 7
    • 62549113252 scopus 로고    scopus 로고
    • The discovery of eltrombopag, an orally bioavailable TpoR agonist
    • Academic Press, Burlington, MA, B.W. Metcalf, S. Dillon (Eds.)
    • Duffy K.J., Erickson-Miller C.L. The discovery of eltrombopag, an orally bioavailable TpoR agonist. Target validation in drug discovery 2007, 241-254. Academic Press, Burlington, MA. 1st ed. B.W. Metcalf, S. Dillon (Eds.).
    • (2007) Target validation in drug discovery , pp. 241-254
    • Duffy, K.J.1    Erickson-Miller, C.L.2
  • 8
    • 62549153611 scopus 로고    scopus 로고
    • Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist
    • Erickson-Miller C.L., Delorme E., Tian S.-S., Hopson C.B., Landis A., Valoret E.I., et al. Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist. Stem Cells 2009, 27:424-430.
    • (2009) Stem Cells , vol.27 , pp. 424-430
    • Erickson-Miller, C.L.1    Delorme, E.2    Tian, S.-S.3    Hopson, C.B.4    Landis, A.5    Valoret, E.I.6
  • 9
    • 0027257805 scopus 로고
    • Expression of the c-mpl proto-oncogene in human hematologic malignancies
    • Vignon I., Dreyfus F., Melle J., Viguie F., Ribrag V., Cocault L., et al. Expression of the c-mpl proto-oncogene in human hematologic malignancies. Blood 1993, 82:877-883.
    • (1993) Blood , vol.82 , pp. 877-883
    • Vignon, I.1    Dreyfus, F.2    Melle, J.3    Viguie, F.4    Ribrag, V.5    Cocault, L.6
  • 12
    • 0029019022 scopus 로고
    • Growth response of acute myeloblastic leukemia cells to recombinant human thrombopoietin
    • Matsumura I., Kanakura Y., Kato T., Ikeda H., Ishikawa J., Horikawa Y., et al. Growth response of acute myeloblastic leukemia cells to recombinant human thrombopoietin. Blood 1995, 86:703-709.
    • (1995) Blood , vol.86 , pp. 703-709
    • Matsumura, I.1    Kanakura, Y.2    Kato, T.3    Ikeda, H.4    Ishikawa, J.5    Horikawa, Y.6
  • 13
    • 0029831997 scopus 로고    scopus 로고
    • Growth stimulatory effect of thrombopoietin on the blast cells of acute myelogenous leukaemia
    • Motoji T., Takanashi M., Motomura S., Yan-Hua W., Shiozaki H., Aoyama M., et al. Growth stimulatory effect of thrombopoietin on the blast cells of acute myelogenous leukaemia. Brit J Haematol 1996, 94:513-516.
    • (1996) Brit J Haematol , vol.94 , pp. 513-516
    • Motoji, T.1    Takanashi, M.2    Motomura, S.3    Yan-Hua, W.4    Shiozaki, H.5    Aoyama, M.6
  • 14
    • 0031887404 scopus 로고    scopus 로고
    • Quantitative expression of thrombopoietin receptor on leukaemia cells from patients with acute myeloid leukaemia and acute lymphoblastic leukaemia
    • Takeshita A., Shinjo K., Izumi M., Ling P., Nakamura S., Naito K., et al. Quantitative expression of thrombopoietin receptor on leukaemia cells from patients with acute myeloid leukaemia and acute lymphoblastic leukaemia. Brit J Haematol 1998, 100:283-290.
    • (1998) Brit J Haematol , vol.100 , pp. 283-290
    • Takeshita, A.1    Shinjo, K.2    Izumi, M.3    Ling, P.4    Nakamura, S.5    Naito, K.6
  • 15
    • 0030979448 scopus 로고    scopus 로고
    • Expression of c-mpl mRNA, the receptor for thrombopoietin, in acute myeloid leukemia blasts identifies a group of patients with poor response to intensive chemotherapy
    • Wetzler M., Baer M.R., Bernstein S.H., Blumenson L., Stewart C., Barcos M., et al. Expression of c-mpl mRNA, the receptor for thrombopoietin, in acute myeloid leukemia blasts identifies a group of patients with poor response to intensive chemotherapy. J Clin Oncol 1997, 15:2262-2268.
    • (1997) J Clin Oncol , vol.15 , pp. 2262-2268
    • Wetzler, M.1    Baer, M.R.2    Bernstein, S.H.3    Blumenson, L.4    Stewart, C.5    Barcos, M.6
  • 16
    • 0030905415 scopus 로고    scopus 로고
    • Megakaryocyte growth and development factor (MGDF)-induced acute leukemia cell proliferation and clonal growth is associated with functional c-mpl
    • Piacibello W., Sanavio F., Brizzi M.F., Garetto L., Severino A., Aronica M.G., et al. Megakaryocyte growth and development factor (MGDF)-induced acute leukemia cell proliferation and clonal growth is associated with functional c-mpl. Leukemia 1997, 11:531-540.
    • (1997) Leukemia , vol.11 , pp. 531-540
    • Piacibello, W.1    Sanavio, F.2    Brizzi, M.F.3    Garetto, L.4    Severino, A.5    Aronica, M.G.6
  • 17
    • 8544221847 scopus 로고    scopus 로고
    • Effects of thrombopoietin (c-mpl ligand) on growth of blast cells from patients with transient abnormal myelopoiesis and acute myeloblastic leukemia
    • Hirai H., Shimazaki C., Yamagata N., Goto H., Inaba T., Kikuta T., et al. Effects of thrombopoietin (c-mpl ligand) on growth of blast cells from patients with transient abnormal myelopoiesis and acute myeloblastic leukemia. Eur J Haematol 1997, 59:38-46.
    • (1997) Eur J Haematol , vol.59 , pp. 38-46
    • Hirai, H.1    Shimazaki, C.2    Yamagata, N.3    Goto, H.4    Inaba, T.5    Kikuta, T.6
  • 18
    • 9844268495 scopus 로고    scopus 로고
    • The in vitro effect of pegylated recombinant human megakaryocyte growth and development factor (PEG rHuMGDF) on megakaryopoiesis in normal subjects and patients with myelodysplasia and acute myeloid leukaemia
    • Adams J.A., Liu Yin J.A., Brereton M.L., Briggs M., Burgess R., Hyde K. The in vitro effect of pegylated recombinant human megakaryocyte growth and development factor (PEG rHuMGDF) on megakaryopoiesis in normal subjects and patients with myelodysplasia and acute myeloid leukaemia. Br J Haematol 1997, 99:139-146.
    • (1997) Br J Haematol , vol.99 , pp. 139-146
    • Adams, J.A.1    Liu Yin, J.A.2    Brereton, M.L.3    Briggs, M.4    Burgess, R.5    Hyde, K.6
  • 19
    • 0032103562 scopus 로고    scopus 로고
    • Proliferative reaction of myelogenous leukemia cells with cytokines G-CSF, GM-CSF, M-CSF, SCF and TPO
    • Murayama T., Imoto S., Natazuka T., Chihara K., Matsui T. Proliferative reaction of myelogenous leukemia cells with cytokines G-CSF, GM-CSF, M-CSF, SCF and TPO. Leukemia Research 1998, 22:557-560.
    • (1998) Leukemia Research , vol.22 , pp. 557-560
    • Murayama, T.1    Imoto, S.2    Natazuka, T.3    Chihara, K.4    Matsui, T.5
  • 20
    • 0029932842 scopus 로고    scopus 로고
    • Expression of the receptor MPL and proliferative effects of its ligand thrombopoietin on human leukemia cells
    • Quentmeier H., Zaborski M., Graf G., Ludwig W.D., Drexler H.G. Expression of the receptor MPL and proliferative effects of its ligand thrombopoietin on human leukemia cells. Leukemia 1996, 10:297-310.
    • (1996) Leukemia , vol.10 , pp. 297-310
    • Quentmeier, H.1    Zaborski, M.2    Graf, G.3    Ludwig, W.D.4    Drexler, H.G.5
  • 21
    • 0035145597 scopus 로고    scopus 로고
    • Thrombopoietin, interleukin-11, and early-acting megakaryocyte growth factors in human myeloid leukemia cells
    • Petrucci M.T., Ricciardi M.R., Gregorj C., Ariola C., Mazzola F., Fogli M., et al. Thrombopoietin, interleukin-11, and early-acting megakaryocyte growth factors in human myeloid leukemia cells. Leuk Lymphoma 2000, 40:179-190.
    • (2000) Leuk Lymphoma , vol.40 , pp. 179-190
    • Petrucci, M.T.1    Ricciardi, M.R.2    Gregorj, C.3    Ariola, C.4    Mazzola, F.5    Fogli, M.6
  • 24
    • 36248962144 scopus 로고    scopus 로고
    • A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion
    • Overholtzer M., Mailleux A., Mouneimne G., Normand G., Schnitt S.J., King R.W., et al. A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion. Cell 2007, 131:966-979.
    • (2007) Cell , vol.131 , pp. 966-979
    • Overholtzer, M.1    Mailleux, A.2    Mouneimne, G.3    Normand, G.4    Schnitt, S.J.5    King, R.W.6
  • 25
    • 0035040596 scopus 로고    scopus 로고
    • Growth factors in acute myeloid leukemia
    • Estey E.H. Growth factors in acute myeloid leukemia. Best Pract Res: Clin Haematol 2001, 14:175-187.
    • (2001) Best Pract Res: Clin Haematol , vol.14 , pp. 175-187
    • Estey, E.H.1
  • 26
    • 47549100414 scopus 로고    scopus 로고
    • Phase 1/2 study of AMG531 in thrombocytopenic patients (pts) with low-risk myelodysplastic syndrome (MDS): update including extended treatment
    • Kantarjian H., Fenaux P., Sekeres M.A., Becker P., Boruchov A., Bowen D., et al. Phase 1/2 study of AMG531 in thrombocytopenic patients (pts) with low-risk myelodysplastic syndrome (MDS): update including extended treatment. Blood 2007, 110:250.
    • (2007) Blood , vol.110 , pp. 250
    • Kantarjian, H.1    Fenaux, P.2    Sekeres, M.A.3    Becker, P.4    Boruchov, A.5    Bowen, D.6
  • 27
    • 70449726874 scopus 로고    scopus 로고
    • Effect of the non-peptide thrombopoietin receptor agonist Eltrombopag on bone marrow cells from patients with acute myeloid leukemia and myelodysplastic syndromes
    • Will B., Kawahara M., Luciano J.P., Bruns I., Erickson-Miller C.L., Aivado M.A., et al. Effect of the non-peptide thrombopoietin receptor agonist Eltrombopag on bone marrow cells from patients with acute myeloid leukemia and myelodysplastic syndromes. Blood 2009, 14:3899-3908.
    • (2009) Blood , vol.14 , pp. 3899-3908
    • Will, B.1    Kawahara, M.2    Luciano, J.P.3    Bruns, I.4    Erickson-Miller, C.L.5    Aivado, M.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.