In silico prediction of brain exposure: Drug free fraction, unbound brain to plasma concentration ratio and equilibrium half-life

Current Topics in Medicinal Chemistry

Volumn 13, Issue 6 7, 2013, Pages 813-820

  Spreafico, Morena ^a   Jacobson, Matthew P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Brain equilibration time; Brain unbound volume of distribution; CNS exposure; Unbound brain to plasma concentration ratio

Indexed keywords

CAFFEINE; CIGLITAZONE; DIGOXIN; DOXORUBICIN; FLUOXETINE; IVERMECTIN; N [3 (4 FLUOROPHENYL) 3 (4 PHENYLPHENOXY) PROPYL] SARCOSINE; NELFINAVIR; PROPRANOLOL; SAQUINAVIR; SULFONAMIDE; THEOBROMINE; THEOPHYLLINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; COMPUTER MODEL; COMPUTER PREDICTION; DISTRIBUTION VOLUME; DRUG BRAIN LEVEL; DRUG EXPOSURE; DRUG HALF LIFE; HUMAN; MOUSE; NONHUMAN; PARTITION COEFFICIENT; RAT; STEADY STATE; VALIDATION STUDY;

EID: 84878797123     PISSN: 15680266     EISSN: 18734294     Source Type: Journal    
DOI: 10.2174/1568026611313070004     Document Type: Article

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