Pharmacokinetic-pharmacodynamic modelling of the EEG effects of midazolam in individual rats: Influence of rate and route of administration

British Journal of Pharmacology

Volumn 102, Issue 3, 1991, Pages 663-668

  Mandema, J W ^a   Tukker, E ^a   Danhof, M ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

MIDAZOLAM;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; ELECTROENCEPHALOGRAM; INTRAVENOUS DRUG ADMINISTRATION; MALE; MODEL; NONHUMAN; ORAL DRUG ADMINISTRATION; PHARMACODYNAMICS; PHARMACOKINETICS; PRIORITY JOURNAL; RAT;

EID: 0026058369     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1991.tb12230.x     Document Type: Article

References (20)

1. ARENDT 1983 In vitro correlates of benzodiazepine cerebrospinal fluid uptake, pharmacodynamic action and peripheral distribution J. Pharmacol. Exp. Ther. 227 98
2. BREIMER 1990 10.2165/00003088-199018030-00006 Quantification of the EEG effect of midazolam by aperiodic analysis in volunteers. Pharmacokinetic/pharmacodynamic modelling Clin. Pharmacokin. 18 245
3. FINK 1976 10.1002/cpt1976202184 Blood levels and electroencephalographic effects of diazepam and bromazepan Clin. Pharmacol. Ther. 20 184
4. GERECKE 1983 10.1111/j.1365-2125.1983.tb02266.x Chemical structure and properties of midazolam compared with other benzodiazepines Br. J. Clin. Pharmacol. 16 11S
5. GIBALDI 1982 10.1201/b14095 Pharmacokinetics 409
6. GREENBLATT 1977 10.1176/ajp.134.5.559 Absorption rate, blood concentrations, and early response to oral chlordiazepoxide Am. J. Psychiatry 134 559
7. GREENBLATT 1989 10.1038/clpt.1989.41 Pharmacokinetic and electroencephalographic study of intravenous diazepam, midazolam and placebo Clin. Pharmacol. Ther. 45 356
8. GREGORY 1986 10.1007/BF01620551 An electroencephalographic processing algorithm specifically intended for analysis of cerebral electrical activity J. Clin. Monit. 2 190
9. HEIZMANN 1983 10.1111/j.1365-2125.1983.tb02270.x Pharmacokinetics and bioavailability of midazolam in man Br. J. Clin. Pharmacol. 16 43S
10. HOLFORD 1982 10.1016/0163-7258(82)90051-1 Kinetics of pharmacologic response Pharmacol. Ther. 16 143
11. KOOPMANS 1988 10.1038/clpt.1988.106 Pharmacokinetic-pharmacodynamic modeling of midazolam effects on the human central nervous system Clin. Pharmacol. Ther. 44 14
12. KUROWSKI 1982 10.1055/s-2007-1019513 Relationship between EEG dynamics and pharmacokinetics of the benzodiazepine lormetazepam Pharmacopsychiatry 15 77
13. LAURIAN 1984 10.1159/000118052 Effects of benzodiazepine antagonist on the diazepam-induced electrical brain activity modifications Neuropsychobiology 11 55
14. MacLEOD 1977 10.1007/BF00566531 Diazepam actions and plasma concentrations following ethanol ingestion Eur. J. Clin. Pharmacol. 11 345
15. MANDEMA 1990 10.1007/BF01061705 Pharmacokinetic-pharmacodynamic modelling of the central nervous system effects of heptabarbital using aperiodic EEG analysis J. Pharmacokin. Biopharmacol. 18 459
16. REVES 1985 10.1097/00000542-198503000-00017 Midazolam pharmacology and uses Anesthesiology 62 310
17. SALETU 1986 10.1111/j.1600-0447.1986.tb08984.x Pharmaco-EEG, behavioural methods and blood levels in the comparison of temazepam and flunitrazepam Acta Psychiatr. Scand. Suppl. 332 74 67
18. SELLERS 1978 10.3109/03602537808993774 Addictive drugs: disposition, tolerance, and dependence interrelationships Drug Metabol. Rev. 8 5
19. WOO 1981 10.3109/00498258109045848 Biotransformation of [14C]midazolam in the rat in vitro and in vivo Xenobiotica 6 373
20. ZIEGLER 1983 10.1111/j.1365-2125.1983.tb02272.x Comparison of the effects of intravenously administered midazolam, triazolam and their hydroxy metabolites Br. J. Clin. Pharmacol. 16 63S