Sesamol prevents doxorubicin-induced oxidative damage and toxicity on H9c2 cardiomyoblasts

Journal of Pharmacy and Pharmacology

Volumn 65, Issue 7, 2013, Pages 1083-1093

  Nayak, Pawan G ^a   Paul, Piya ^a   Bansal, Punit ^a   Kutty, Nampurath Gopalan ^a   Pai, Karkala Sreedhara Ranganath ^a  

^a MANIPAL COLLEGE OF PHARMACEUTICAL SCIENCES   (India)

Author keywords

Anti apoptotic; Doxorubicin; Free radical; pBR322 DNA; Reactive oxygen species; Sesamol

Indexed keywords

CASPASE 3; CATALASE; DOXORUBICIN; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHENOL DERIVATIVE; PROTEIN BAD; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SESAMOL; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CARDIOTOXICITY; CELL PROTECTION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DRUG CYTOTOXICITY; EMBRYO; GENOTOXICITY; HEART MUSCLE CELL; HEART PROTECTION; LIPID PEROXIDATION; NONHUMAN; RAT;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIOXIDANTS; APOPTOSIS; BENZODIOXOLES; CELL LINE; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; MUTAGENICITY TESTS; MYOBLASTS, CARDIAC; OXIDATIVE STRESS; PHENOLS; RATS; REACTIVE OXYGEN SPECIES;

EID: 84878785156     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/jphp.12073     Document Type: Article

References (72)

1. Fernandes AS, et al. Oxidative injury in V79 Chinese hamster cells: protective role of the superoxide dismutase mimetic MnTM-4-PyP. Cell Biol Toxicol 2010; 2: 91-101.
2. Baker ES, Connor TH,. Monitoring occupational exposure to cancer chemotherapy drugs. Am J Health Syst Pharm 1996; 22: 2713-2723.
3. Howe GR, Burch JD,. Nutrition and pancreatic cancer. Cancer Causes Control 1996; 1: 69-82.
4. Gandini S, et al. Meta-analysis of studies on breast cancer risk and diet: the role of fruit and vegetable consumption and the intake of associated micronutrients. Eur J Cancer 2000; 5: 636-646.
5. Bankar GR, et al. Vasorelaxant and antihypertensive effect of Cocos nucifera Linn. endocarp on isolated rat thoracic aorta and DOCA salt-induced hypertensive rats. J Ethnopharmacol 2011; 1: 50-54.
6. Veerapur VP, et al. Ficus racemosa stem bark extract: a potent antioxidant and a probable natural radioprotector. Evid Based Complement Alternat Med 2009; 3: 317-324.
7. Veerapur VP, et al. Antidiabetic effect of Dodonaea viscosa aerial parts in high fat diet and low dose streptozotocin-induced type 2 diabetic rats: a mechanistic approach. Pharm Biol 2010; 10: 1137-1148.
8. Gentile JM, et al. Effect of selected antimutagens on the genotoxicity of antitumor agents. Mutat Res 1998; 1-2: 289-298.
9. Aparecida Resende F, et al. Antimutagenicity of ursolic acid and oleanolic acid against doxorubicin-induced clastogenesis in Balb/c mice. Life Sci 2006; 13: 1268-1273.
10. Furtado MA, et al. Antimutagenicity of rosmarinic acid in Swiss mice evaluated by the micronucleus assay. Mutat Res 2008; 2: 150-154.
11. Furtado RA, et al. Ursolic acid and oleanolic acid suppress preneoplastic lesions induced by 1,2-dimethylhydrazine in rat colon. Toxicol Pathol 2008; 4: 576-580.
12. Budowski P,. Recent research on sesamin, sesamolin, and related compounds. J Am Oil Chem Soc 1964; 4: 280-285.
13. Hou RC, et al. Effect of sesame antioxidants on LPS-induced NO production by BV2 microglial cells. Neuroreport 2003; 14: 1815-1819.
14. Kurechi T, et al. Transformation of hemoglobin A into methemoglobin by sesamol. Life Sci 1980; 20: 1675-1681.
15. Nakagawa K, et al. EPR and TREPR spectroscopic studies of antioxidant sesamoyl and related phenoxyl radicals. Photochem Photobiol 1994; 3: 199-204.
16. Jan KC, et al. Bioavailability and tissue distribution of sesamol in rat. J Agric Food Chem 2008; 16: 7032-7037.
17. Kaur IP, Saini A,. Sesamol exhibits antimutagenic activity against oxygen species mediated mutagenicity. Mutat Res 2000; 1: 71-76.
18. Sharma S, Kaur IP,. Development and evaluation of sesamol as an antiaging agent. Int J Dermatol 2006; 3: 200-208.
19. Kapadia GJ, et al. Chemopreventive effect of resveratrol, sesamol, sesame oil and sunflower oil in the Epstein-Barr virus early antigen activation assay and the mouse skin two-stage carcinogenesis. Pharmacol Res 2002; 6: 499-505.
20. Uchida M, et al. Antioxidative effect of sesamol and related compounds on lipid peroxidation. Biol Pharm Bull 1996; 4: 623-626.
21. Mazzio EA, et al. Food constituents attenuate monoamine oxidase activity and peroxide levels in C6 astrocyte cells. Planta Med 1998; 7: 603-606.
22. Hsu DZ, et al. Sesamol delays mortality and attenuates hepatic injury after cecal ligation and puncture in rats: role of oxidative stress. Shock 2006; 5: 528-532.
23. Hsu DZ, et al. Attenuation of endotoxin-induced oxidative stress and multiple organ injury by 3,4-methylenedioxyphenol in rats. Shock 2006; 3: 300-305.
24. Shenoy RR, et al. Normal and delayed wound healing is improved by sesamol, an active constituent of Sesamum indicum (L.) in albino rats. J Ethnopharmacol 2011; 2: 608-612.
25. Parihar VK, et al. Effect of sesamol on radiation-induced cytotoxicity in Swiss albino mice. Mutat Res 2006; 1-2: 9-16.
26. Keizer HG, et al. Doxorubicin (adriamycin): a critical review of free radical-dependent mechanisms of cytotoxicity. Pharmacol Ther 1990; 2: 219-231.
27. Berthiaume JM, Wallace KB,. Adriamycin-induced oxidative mitochondrial cardiotoxicity. Cell Biol Toxicol 2007; 1: 15-25.
28. Minotti G, et al. Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev 2004; 2: 185-229.
29. Denicola A, Radi R,. Peroxynitrite and drug-dependent toxicity. Toxicology 2005; 2: 273-288.
30. Takemura G, Fujiwara H,. Doxorubicin-induced cardiomyopathy from the cardiotoxic mechanisms to management. Prog Cardiovasc Dis 2007; 5: 330-352.
31. Kiyomiya K, et al. Differences in intracellular sites of action of adriamycin in neoplastic and normal differentiated cells. Cancer Chemother Pharmacol 2001; 1: 51-56.
32. Bachur NR, et al. A general mechanism for microsomal activation of quinone anticancer agents to free radicals. Cancer Res 1978; 6: 1745-1750.
33. Mukhopadhyay P, et al. Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro. Am J Physiol Heart Circ Physiol 2009; 5: H1466-H1483.
34. Davies KJ, Doroshow JH,. Redox cycling of anthracyclines by cardiac mitochondria. I. Anthracycline radical formation by NADH dehydrogenase. J Biol Chem 1986; 7: 3060-3067.
35. Sardao VA, et al. Doxorubicin-induced mitochondrial dysfunction is secondary to nuclear p53 activation in H9c2 cardiomyoblasts. Cancer Chemother Pharmacol 2009; 4: 811-827.
36. 2 induced oxidative damage on pBR322 DNA and RBC cellular membrane. Mol Cell Biochem 2009; 1-2: 21-29.
37. Archana PR, et al. Thymol, a naturally occurring monocyclic dietary phenolic compound protects Chinese hamster lung fibroblasts from radiation-induced cytotoxicity. Mutat Res 2009; 1-2: 70-77.
38. Carmichael J, et al. Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res 1987; 4: 936-941.
39. Renvoizé C, et al. Apoptosis: identification of dying cells. Cell Biol Toxicol 1998; 2: 111-120.
40. Beauchamp C, Fridovich I,. Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. Anal Biochem 1971; 1: 276-287.
41. Aebi H,. Catalase in vitro. Methods Enzymol 1984; 105: 121-126.
42. Habig WH, et al. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 1974; 22: 7130-7139.
43. Paglia DE, Valentine WN,. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967; 1: 158-169.
44. Tietze F,. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem 1969; 3: 502-522.
45. Gelvan D, Saltman P,. Different cellular targets for Cu- and Fe-catalyzed oxidation observed using a Cu-compatible thiobarbituric acid assay. Biochim Biophys Acta 1990; 3: 353-360.
46. Nair V, Turner GA,. The thiobarbituric acid test for lipid peroxidation: structure of the adduct with malondialdehyde. Lipids 1984; 19: 804-805.
47. Levine RL, et al. Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol 1990; 186: 464-478.
48. Lowry OH, et al. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 1: 265-275.
49. Blum RH, Carter SK,. Adriamycin. A new anticancer drug with significant clinical activity. Ann Intern Med 1974; 2: 249-259.
50. Singal PK, et al. Subcellular effects of adriamycin in the heart: a concise review. J Mol Cell Cardiol 1987; 8: 817-828.
51. Fadillioǧlu E, et al. Protective effects of erdosteine against doxorubicin-induced cardiomyopathy in rats. J Appl Toxicol 2003; 1: 71-74.
52. Hasinoff BB, et al. Biochemical and proteomics approaches to characterize topoisomerase IIalpha cysteines and DNA as targets responsible for cisplatin-induced inhibition of topoisomerase II-alpha. Mol Pharmacol 2005; 3: 937-947.
53. Thompson T, et al. Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis. J Biol Chem 2004; 51: 53015-53022.
54. Wolff S, et al. p53's mitochondrial translocation and MOMP action is independent of Puma and Bax and severely disrupts mitochondrial membrane integrity. Cell Res 2008; 7: 733-744.
55. Boulares AH, et al. Role of poly(ADP-ribose) polymerase (PARP) cleavage in apoptosis. Caspase 3-resistant PARP mutant increases rates of apoptosis in transfected cells. J Biol Chem 1999; 33: 22932-22940.
56. Goodman J, Hochstein P,. Generation of free radicals and lipid peroxidation by redox cycling of adriamycin and daunomycin. Biochem Biophys Res Commun 1977; 2: 797-803.
57. Gille L, Nohl H,. Analyses of the molecular mechanism of adriamycin-induced cardiotoxicity. Free Radic Biol Med 1997; 5: 775-782.
58. Minotti G, et al. Role of iron in anthracycline cardiotoxicity: new tunes for an old song? FASEB J 1999; 2: 199-212.
59. Evans CA,. On the catalytic decomposition of hydrogen peroxide by the catalase of blood. Biochem J 1907; 4: 133-155.
60. McCord JM, Fridovich I,. The utility of superoxide dismutase in studying free radical reactions. I. Radicals generated by the interaction of sulfite, dimethyl sulfoxide, and oxygen. J Biol Chem 1969; 22: 6056-6063.
61. Joshi R, et al. Free radical reactions and antioxidant activities of sesamol: pulse radiolytic and biochemical studies. J Agric Food Chem 2005; 7: 2696-2703.
62. Armstrong JS, et al. Role of glutathione depletion and reactive oxygen species generation in apoptotic signaling in a human B lymphoma cell line. Cell Death Differ 2002; 3: 252-263.
63. Choi EH, et al. Schisandra fructus extract ameliorates doxorubicin-induce cytotoxicity in cardiomyocytes: altered gene expression for detoxification enzymes. Genes Nutr 2008; 4: 337-345.
64. Kim Y, et al. Anthracycline-induced suppression of GATA-4 transcription factor: implication in the regulation of cardiac myocyte apoptosis. Mol Pharmacol 2003; 2: 368-377.
65. Stadtman ER, Levine RL,. Protein oxidation. Ann N Y Acad Sci 2000; 899: 191-208.
66. Agrawal A, Kale RK,. Radiation induced peroxidative damage: mechanism and significance. Indian J Exp Biol 2001; 4: 291-309.
67. Coussens LM, Werb Z,. Inflammation and cancer. Nature 2002; 6917: 860-867.
68. Wu CH, et al. Rutin inhibits oleic acid induced lipid accumulation via reducing lipogenesis and oxidative stress in hepatocarcinoma cells. J Food Sci 2011; 2: T65-T72.
69. Seelinger G, et al. Anti-carcinogenic effects of the flavonoid luteolin. Molecules 2008; 10: 2628-2651.
70. Arjumand W, et al. Rutin attenuates cisplatin induced renal inflammation and apoptosis by reducing NFκB, TNF-α and caspase-3 expression in Wistar rats. Food Chem Toxicol 2011; 9: 2013-2021.
71. Spitz DR, et al. Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology. Cancer Metastasis Rev 2004; 3-4: 311-322.
72. Kalinina EV, et al. Involvement of thio-, peroxi-, and glutaredoxins in cellular redox-dependent processes. Biochemistry (Mosc) 2008; 13: 1493-1510.