Ficus racemosa stem bark extract: A potent antioxidant and a probable natural radioprotector

Evidence-based Complementary and Alternative Medicine

Volumn 6, Issue 3, 2009, Pages 317-324

  Veerapur, V P ^a   Prabhakar, K R ^a   Parihar, Vipan Kumar ^a   Kandadi, Machendar Reddy ^a   Ramakrishana, S ^b   Mishra, B ^c   Satish Rao, B S ^b   Srinivasan, K K ^a   Priyadarsini, K I ^c   Unnikrishnan, M K ^a  

^a MANIPAL COLLEGE OF PHARMACEUTICAL SCIENCES   (India)

^b KASTURBA MEDICAL COLLEGE   (India)

^c BHABHA ATOMIC RESEARCH CENTRE   (India)

Author keywords

Chinese hamster lung fibroblast (V79) cells; Ficus racemosa; Free radical scavenger; Micronucleus assay; Radioprotection

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 2,2' AZINOBIS(3 ETHYLBENZOTHIAZOLINE 6 SULFONIC ACID); ALCOHOL; ANTIOXIDANT; FICUS RACEMOSA EXTRACT; HYDROXYL RADICAL; LIPID; PLANT EXTRACT; RADIOPROTECTIVE AGENT; SUPEROXIDE; UNCLASSIFIED DRUG; WATER;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; BARK; CELL CYCLE ARREST; CELL PROLIFERATION; CELL STRAIN V 79; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINESIS; DRUG ISOLATION; FICUS; FICUS RACEMOSA; GAMMA IRRADIATION; IC 50; LIPID PEROXIDATION; MICRONUCLEUS TEST; NONHUMAN; PRIORITY JOURNAL; PULSE RADIOLYSIS; RADIATION PROTECTION;

EID: 68849097538     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1093/ecam/nem119     Document Type: Article

References (26)

1. Schulz JB, Lindnau J, Seyfriend J, Dichgans J. Glutathione oxidative stress and neuro-degeneration. Eur J Biochem 2000;267:4904-4911
2. Adelman R, Saul R, Ames B. Oxidative damage to DNA: Relation to species metabolic rate and life span. Proc Natl Acad Sci USA 1988;85:2706-2708
3. Pryor WA, Porter NA. Suggested mechanisms for the production of 4-hydroxy-2-nonenal from the autoxidation of polyunsaturated fatty acids. Free Rad Biol Med 1990;8:541-543 (Pubitemid 20204418)
4. Kulkarni PH,. Shahida Ansari. The Ayurvedic Plants. Delhi: Satguru publications, 2004, xvi, 334.
5. Mukherijee PK, Saha K, Murugesan T, Mandal SC, Pal M, Saha BP. Screening of anti-diarrhoeal profile of some plant extracts of a specific region of West Bengal, India. J Ethnopharmacol 1998;60:85-89 (Pubitemid 28098344)
6. Ratnasooriya WD, Jayakody JR, Nadarajah T. Antidiuretic activity of aqueous bark extract of Sri Lankan Ficus racemosa in rats. Acta Biol Hung 2003;54:357-363 (Pubitemid 38065661)
7. Bhaskara Rao R, Murugesan T, Pal M, Saha BP, Mandal SC. Antitussive potential of methanol extract of stem bark of Ficus racemosa Linn. Phytother Res 2003;17:1117-1118 (Pubitemid 37351593)
8. Rao RB, Anupama K, Swaroop KR, Murugesan T, Pal M, Mandal SC. Evaluation of anti-pyretic potential of Ficus racemosa bark. Phytomedicine 2002;9:731-733 (Pubitemid 36152133)
9. Bhaskara Rao R, Murugesan T, Sinha S, Saha BP, Pal M, Mandal SC. Glucose lowering efficacy of Ficus racemosa bark extract in normal and alloxan diabetic rats. Phytother Res 2002;16:590-592
10. Khan M, Sultana S. Chemomodulatory effect of Ficus racemosa extract against chemically induced renal carcinogenesis and oxidative damage response in wistar rats. Life Sci 2005;77:1194-1210 (Pubitemid 40898320)
11. Narla RS, Rao MNA. Scavenging of free radicals and inhibition of lipid peroxidation by 3-phenyl syndone. J Pharm Pharmacol 1995;47:623-625
12. Naik GH, Priyadarsini KI, Naik DB, Gangabhagirathi R, Mohan H. Studies on the aqueous extract of Terminalia chebula as a potent antioxidant and a probable radioprotector. Phytomedicine 2004;11:530-538 (Pubitemid 39312630)
13. Prabhakar KR, Veeresh VP, Vipan Kumar P, Sudheer Kumar M, Priyadarshini KI, Rao BSS, et al. Bioactivity guided fractionation of Coronopus didymus Linn.-A Free radical scavenging perspective. Phytomedicine 2006;13:591-595
14. Kunchandy E, Rao MNA. Effect of curcumin on hydroxyl radical generation through Fenton reaction. Int J Pharm 1989;57:173-176 (Pubitemid 20011842)
15. Naik GH, Priyadarsini KI, Mohan H. Free radical scavenging reactions and phytochemical analysis of triphala, an ayurvedic formulation. Current Sci 2006;90:1100-1106 (Pubitemid 43735981)
16. Sudheer Kumar M, Jagadish PC, Sridhar RB, Kiran BS, Unnikrishnan MK. In-vitro evaluation of antioxidant properties of Cocos nucifera Linn. Water. Nahrung/Food 2003;47:126-131
17. Nishimiki M, Rao NA, Yagi K. The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen. Biochem Biophys Res Commun 1972;46:849-853
18. Prieto P, Pineda M, Aguilar M. Spectrophotometric quantitation of antioxidant capacity through the formation of a phosphomolybdenum complex: specific application to the determination of vitamine E. Anal Biochem 1999;269:337-341 (Pubitemid 29201033)
19. Fenech M, Chang WP, Kirsch-Volders M, Holland N, Bonassi S, Zeiger E. Human MicroNucleus (HMN) project: detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated lymphocytes. Mutat Res 2003;534:65-75. (Pubitemid 36015839)
20. Surralles J, Xamena N, Creus A, Catalan J, Norppa H, Marcos R. Induction of micronuclei by five pyrethroid insecticides in whole-blood and isolated human lymphocyte cultures. Mutat Res 1995;341:169-184
21. Arora R, Gupta D, Chawla R, Sagar R, Sharma A, Kumar R, et al. Radioprotection by Plant Products: Present Status and Future Prospects. Phytother Res 2005;19:1-22. (Pubitemid 40444988)
22. Meenal K, Ravindra S, Madhu K, Senthamil R, Selvan, Begraj S, et al. Protective effect of Adhatoda vascia Nees against radiation-induced damage at cellular, biochemical and chromosomal levels in swiss albino mice. Evid Based Complement Alternat Med 2006; doi:10.1093/ecam/nel098.
23. Breen AP, Murphy JA. Reactions of oxyradicals with DNA. Free Rad Biol Med 1995;18:1033-1077
24. Rao BSS, Uma Devi P. Response of S 180 murine tumor to bleomycin combination with radiation and hyperthermia using micronucleus assay: a multimodality approach for therapeutic augmentation. Ind J Exp Biol 2005;43:596-600. (Pubitemid 40962667)
25. Baruah KK, Gohain AK. Chemical composation and nutritive value of Dimaru (Ficus glomerata Roxib.) leaves. Ind J Nutr 1992;9:107-108
26. Li RW, Leach DN, Myers SP, Lin GD, Leach GJ, Waterman PG. A new anti-inflammatory glucoside from Ficus racemosa L. Planta Med 2004;70:421-426