Cerebral microdialysis in clinical studies of drugs: Pharmacokinetic applications

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 40, Issue 3, 2013, Pages 343-358

  Shannon, Richard J ^a   Carpenter, Keri L H ^a   Guilfoyle, Mathew R ^a   Helmy, Adel ^a   Hutchinson, Peter J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Brain; Human; Microdialysis; Pharmacokinetics

Indexed keywords

ANTIINFECTIVE AGENT; BETA LACTAM ANTIBIOTIC; CARBAPENEM DERIVATIVE; CYCLOSPORIN A; DORIPENEM; GADOBUTROL; GADOLINIUM PENTETATE MEGLUMINE; IMIPENEM; MEROPENEM; MULTIDRUG RESISTANCE PROTEIN; TEMOZOLOMIDE; VIGABATRIN;

ANTIBIOTIC THERAPY; AREA UNDER THE CURVE; ASTROCYTE; BACTERIAL MENINGITIS; BLOOD BRAIN BARRIER; BRAIN INJURY; BRAIN TUMOR; CENTRAL NERVOUS SYSTEM INFECTION; CEREBRAL MICRODIALYSIS; DRUG BLOOD LEVEL; DRUG BONE LEVEL; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; EXTRACELLULAR FLUID; FLOW RATE; GENETIC POLYMORPHISM; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INTERSTITIAL FLUID; MEMBRANE PERMEABILITY; MICRODIALYSIS; MINIMUM INHIBITORY CONCENTRATION; NERVE CELL; PRIORITY JOURNAL; REVIEW; SEIZURE; TIME TO MAXIMUM PLASMA CONCENTRATION; TRAUMATIC BRAIN INJURY;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; BLOOD-BRAIN BARRIER; CENTRAL NERVOUS SYSTEM AGENTS; CEREBRAL CORTEX; CLINICAL TRIALS AS TOPIC; DRUG DISCOVERY; EQUIPMENT DESIGN; HUMANS; METABOLIC CLEARANCE RATE; MICRODIALYSIS;

EID: 84878758312     PISSN: 1567567X     EISSN: 15738744     Source Type: Journal    
DOI: 10.1007/s10928-013-9306-4     Document Type: Review

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