A microdialysis study of oral vigabatrin administration in head injury patients: Preliminary evaluation of multimodality monitoring

Acta Neurochirurgica, Supplementum

Volumn 114, Issue , 2012, Pages 271-276

  Carpenter, Keri L H ^a,b   Timofeev, Ivan ^a,b   Nortje, Jürgens ^b,c   Czosnyka, Marek ^a   Pickard, John D ^a,b   Hutchinson, Peter J ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

GABA; Head injury (human); Microdialysis; Multimodality monitoring; Vigabatrin

Indexed keywords

4 AMINOBUTYRIC ACID; AMINO ACID; GLUCOSE; GLUTAMIC ACID; GLYCEROL; LACTIC ACID; PYRUVIC ACID; VIGABATRIN;

BLOOD BRAIN BARRIER; CLINICAL ARTICLE; CLINICAL EVALUATION; CONFERENCE PAPER; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG PENETRATION; HEAD INJURY; HUMAN; INTRACRANIAL PRESSURE MONITORING; MICRODIALYSIS; NEUROMONITORING; RANDOMIZED CONTROLLED TRIAL;

EID: 85052608759     PISSN: 00651419     EISSN: 00016268     Source Type: Book Series    
DOI: 10.1007/978-3-7091-0956-4_53     Document Type: Conference Paper

References (10)

1. Czosnyka M, Smielewski P, Kirkpatrick P, Laing RJ, Menon D, Pickard JD (1997) Continuous assessment of the cerebral vasomotor reactivity in head injury. Neurosurgery 41:11-17, discussion 17-19
2. Czosnyka M, Steiner L, Balestreri M, Schmidt E, Smielewski P, Hutchinson PJ, Pickard JD (2005) Concept of "true ICP" in monitoring and prognostication in head trauma. Acta Neurochir Suppl 95:341-344
3. Gratzfeld-Huesgen A (1999) Sensitive and reliable amino acid analysis in protein hydrolysates using the Agilent 1100 Series HPLC. Technical note. Agilent Technologies publication number 5968-5658E
4. Hutchinson PJ, O'Connell MT, Al-Rawi PG, Kett-White CR, Gupta AK, Maskell LB, Pickard JD, Kirkpatrick PJ (2002) Increases in GABA concentrations during cerebral ischaemia: a microdialysis study of extracellular amino acids. J Neurol Neurosurg Psychiatry 72:99-105 (Pubitemid 34073104)
5. Lindberger M, Luhr O, Johannessen SI, Larsson S, Tomson T (2003) Serum concentrations and effects of gabapentin and vigaba-trin: observations from a dose titration study. Ther Drug Monit 25:457-462 (Pubitemid 36927977)
6. 1H-NMR-spectroscopy: responder characteristics. Epilepsia 42:29-40 (Pubitemid 32171481)
7. Petroff OA, Rothman DL, Behar KL, Collins TL, Mattson RH (1996) Human brain GABA levels rise rapidly after initiation of vigabatrin therapy. Neurology 47:1567-1571 (Pubitemid 26422556)
8. Pitkanen A, Matilainen R, Ruutiainen T, Riekkinen P (1988) Levels of total gamma-aminobutyric acid (GABA), free GABA and homo-carnosine in cerebrospinal fluid of epileptic patients before and during gamma-vinyl-GABA (vigabatrin) treatment. J Neurol Sci 88:83-93 (Pubitemid 19016585)
9. Smielewski P, Czosnyka M, Steiner L, Belestri M, Piechnik S, Pickard JD (2005) ICM+: software for on-line analysis of bedside monitoring data after severe head trauma. Acta Neurochir Suppl 95:43-49
10. Tong X, Ratnaraj N, Patsalos PN (2009) Vigabatrin extracellular pharmacokinetics and concurrent gamma-aminobutyric acid neu-rotransmitter effects in rat frontal cortex and hippocampus using microdialysis. Epilepsia 50:174-183