Penetration of doripenem in human brain: An observational microdialysis study in patients with acute brain injury

International Journal of Antimicrobial Agents

Volumn 39, Issue 4, 2012, Pages 343-345

  Poeppl, Wolfgang ^a   Zeitlinger, Markus ^a   Donath, Oliver ^b   Wurm, Gabriele ^c   Müller, Markus ^a   Botha, Florin ^c   Illievich, Udo M ^c   Burgmann, Heinz ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

^c KEPLER UNIVERSITY HOSPITAL   (Austria)

Author keywords

Antibiotic therapy; Central nervous system; Pharmacokinetics

Indexed keywords

DORIPENEM;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; BRAIN INJURY; CLINICAL ARTICLE; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG PENETRATION; FEMALE; HUMAN; MALE; MICRODIALYSIS; OBSERVATIONAL STUDY; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL;

AGED; ANTI-BACTERIAL AGENTS; AREA UNDER CURVE; BACTERIA; BACTERIAL INFECTIONS; BRAIN; BRAIN INJURIES; CARBAPENEMS; FEMALE; HUMANS; MALE; MICROBIAL SENSITIVITY TESTS; MICRODIALYSIS; MIDDLE AGED; PLASMA; TIME FACTORS;

EID: 84863397018     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2011.11.019     Document Type: Article

References (15)

1. Nau R, Sorgel F, Eiffert H. Penetration of drugs through the blood-cerebrospinal fluid/blood-brain barrier for treatment of central nervous system infections. Clin Microbiol Rev 2010;23:858-83.
2. Dahyot-Fizelier C, Timofeev I, Marchand S, Hutchinson P, Debaene B, Menon D, et al. Brain microdialysis study of meropenem in two patients with acute brain injury. Antimicrob Agents Chemother 2010;54:3502-4.
3. Brunner M, Reinprecht A, Illievich U, Spiss CK, Dittrich P, van Houte M, et al. Penetration of fosfomycin into the parenchyma of human brain: a case study in three patients. Br J Clin Pharmacol 2002;54:548-50.
4. Caricato A, Pennisi M, Mancino A, Vigna G, Sandroni C, Arcangeli A, et al. Levels of vancomycin in the cerebral interstitial fluid after severe head injury. Intensive Care Med 2006;32:325-8. (Pubitemid 43251159)
5. Mindermann T, Zimmerli W, Gratzl O. Rifampin concentrations in various compartments of the human brain: a novel method for determining drug levels in the cerebral extracellular space. Antimicrob Agents Chemother 1998;42:2626-9. (Pubitemid 28462904)
6. Greer ND. Doripenem (Doribax): the newest addition to the carbapenems. Proc (Bayl Univ Med Cent) 2008;21:337-41.
7. Margetis K, Dimaraki E, Charkoftaki G, Vryonis E, Markantonis S, Boutos N, et al. Penetration of intact blood-brain barrier by doripenem. Antimicrob Agents Chemother 2011;55:3637-8.
8. Muller M, Brunner M, Hollenstein U, Joukhadar C, Schmid R, Minar E, et al. Penetration of ciprofloxacin into the interstitial space of inflamed foot lesions in non-insulin-dependent diabetes mellitus patients. Antimicrob Agents Chemother 1999;43:2056-8. (Pubitemid 29395209)
9. Zeitlinger MA, Dehghanyar P, Mayer BX, Schenk BS, Neckel U, Heinz G, et al. Relevance of soft-tissue penetration by levofloxacin for target site bacterial killing in patients with sepsis. Antimicrob Agents Chemother 2003;47:3548-53. (Pubitemid 37345718)
10. Blakeley JO, Olson J, Grossman SA, He X, Weingart J, Supko JG. Effect of blood brain barrier permeability in recurrent high grade gliomas on the intratumoral pharmacokinetics of methotrexate: a microdialysis study. J Neurooncol 2009;91:51-8.
11. Portnow J, Badie B, Chen M, Liu A, Blanchard S, Synold TW. The neuropharma-cokinetics of temozolomide in patients with resectable brain tumors: potential implications for the current approach to chemoradiation. Clin Cancer Res 2009;15:7092-8.
12. Kuhnen E, Pfeifer G, Frenkel C. Penetration of fosfomycin into cerebrospinal fluid across non-inflamed and inflamed meninges. Infection 1987;15:422-4. (Pubitemid 18082256)
13. International Transporter Consortium, Giacomini KM, Huang SM, Tweedie DJ, Benet LZ, Brouwer KL, et al. Membrane transporters in drug development. Nat Rev Drug Discov 2010;9:215-36.
14. White RL, Friedrich LV, Manduru M, Mihm LB, Bosso JA. Comparative in vitro pharmacodynamics of imipenem and meropenem against ATCC strains of Escherichia coli Staphylococcus aureus and Bacteroides fragilis. Diagn Microbiol Infect Dis 2001;39:39-47. (Pubitemid 32149954)
15. Samtani MN, Flamm R, Kaniga K, Nandy P. Pharmacokinetic-pharmaco-dynamic- model-guided doripenem dosing in critically ill patients. Antimicrob Agents Chemother 2010;54:2360-4.