Quantum-chemical approach to determining the high potency of clorgyline as an irreversible acetylenic monoamine oxidase inhibitor

Journal of Neural Transmission

Volumn 120, Issue 6, 2013, Pages 875-882

  Pavlin, Matic ^a   Mavri, Janez ^a,b   Repič, Matej ^a   Vianello, Robert ^c  

^a NATIONAL INSTITUTE OF CHEMISTRY   (Slovenia)

^b EN FIST CENTRE OF EXCELLENCE   (Slovenia)

^c RUDER BO KOVI INSTITUTE   (Croatia)

Author keywords

Acetylenic inhibitors; Antidepressant target; Flavoenzymes; Irreversible inhibition; Monoamine oxidase inhibitors

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING); CLORGYLINE; ELECTROPHILE; NEUROTRANSMITTER; RASAGILINE; SELEGILINE;

ARTICLE; CHEMICAL BOND; DENSITY FUNCTIONAL THEORY; DRUG MECHANISM; DRUG POTENCY; ENZYME INHIBITION; GEOMETRY; HOMEOSTASIS; PRIORITY JOURNAL; QUANTUM CHEMISTRY; THERMODYNAMICS;

CLORGYLINE; COMPUTERS, MOLECULAR; HUMANS; MODELS, CHEMICAL; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS;

EID: 84878698643     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-013-1016-y     Document Type: Article

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