Transferrin receptor-targeted lipid nanoparticles for delivery of an antisense oligodeoxyribonucleotide against bcl-2

Molecular Pharmaceutics

Volumn 6, Issue 1, 2009, Pages 221-230

  Yang, Xiaojuan ^a   Koh, Chee Guan ^a   Liu, Shujun ^b   Pan, Xiaogang ^a   Santhanam, Ramasamy ^b   Yu, Bo ^a   Peng, Yong ^a   Pang, Jiuxia ^b   Golan, Sharon ^c   Talmon, Yeshayahu ^c   Jin, Yan ^a   Muthusamy, Natarajan ^a   Byrd, John C ^a,b   Chan, Kenneth K ^a,b   Lee, L James ^a   Marcucci, Guido ^a,b   Lee, Robert J ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Antisense oligonucleotide; G3139; Lipid nanoparticles; Protamine; Transferrin receptor

Indexed keywords

3BETA [N (N',N' DIMETHYLAMINOETHANE)CARBAMOYL]CHOLESTEROL; CASPASE; DEFEROXAMINE; DISTEAROYLPHOSPHATIDYLETHANOLAMINE; DISTEAROYLPHOSPHATIDYLETHANOLAMINE N (MALEIMIDEPOLYETHYLENE GLYCOL, MW 2000); EGG PHOSPHATIDYLCHOLINE; MACROGOL 2000; MESSENGER RNA; NANOPARTICLE; OBLIMERSEN; PROTAMINE; PROTEIN BCL 2; TRANSFERRIN; TRANSFERRIN RECEPTOR; UNCLASSIFIED DRUG; ANTISENSE OLIGODEOXYNUCLEOTIDE; LIPID;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG STABILITY; DRUG SYNTHESIS; DRUG UPTAKE; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAJI CELL; UPREGULATION; ZETA POTENTIAL; CHEMISTRY; COLLOID; CRYOELECTRON MICROSCOPY; GENETICS; METABOLISM; TRANSMISSION ELECTRON MICROSCOPY; TUMOR CELL LINE; ULTRASTRUCTURE;

APOPTOSIS; CELL LINE, TUMOR; COLLOIDS; CRYOELECTRON MICROSCOPY; DOWN-REGULATION; DRUG DELIVERY SYSTEMS; HUMANS; LIPIDS; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; PARTICLE SIZE; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, TRANSFERRIN;

EID: 62649167009     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp800149s     Document Type: Article

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