Dexamethasone/PLGA microspheres for continuous delivery of an anti-inflammatory drug for implantable medical devices

Biomaterials

Volumn 23, Issue 7, 2002, Pages 1649-1656

  Hickey, T ^a   Kreutzer, D ^a   Burgess, D J ^b   Moussy, F ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Anti inflammatory; Biosensor; Continuous release; Dexamethasone; Implant; Microspheres; PLGA

Indexed keywords

BIOSENSORS; METHANOL; POLYETHYLENE GLYCOLS;

MICROSPHERES;

DRUG PRODUCTS;

ANTIINFLAMMATORY AGENT; DEXAMETHASONE; DICHLOROMETHANE; MACROGOL; METHANOL; MICROSPHERE; OIL; POLYGLACTIN;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIOSENSOR; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; EMULSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMPLANT; PRIORITY JOURNAL; TECHNIQUE; TEMPERATURE;

ANTI-INFLAMMATORY AGENTS; BIOCOMPATIBLE MATERIALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEXAMETHASONE; DRUG DELIVERY SYSTEMS; LACTIC ACID; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; POLYGLYCOLIC ACID; POLYMERS; TIME FACTORS; ULTRAVIOLET RAYS;

EID: 0036533085     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0142-9612(01)00291-5     Document Type: Article

References (42)

1. Engineering the tissue which encapsulates subcutaneous implants. I. Diffusion properties
2. Engineering the tissue which encapsulates subcutaneous implants. II. Plasma-tissue exchange properties
3. Engineering the tissue which encapsulates subcutaneous implants. III. Effective tissue response times
4. Inhaled glucocorticoids in asthma
5. Microsphere technology and applications
6. Controlled delivery systems for proteins based on poly(lactic/glycolic acid) microspheres
7. Delivering neuroactive molecules from biodegradable microspheres for application in central nervous system disorders
8. Controlled release of bioactive agents from lactide/glycolide polymers
9. Cancer, drug delivery to treat - Local and systemic
10. Polyglycolide and polylactide
11. Comparitive degradation study of biodegradable microspheres of poly(DL-lactide-co-glycolide) with poly(ethylene glycol) derivatives
12. Biodegradable long-circulating polymeric nanospheres
13. Poly(glycolic acid-co-DL-lactic acid): Diffusion or degradation controlled drug delivery
14. Initial concentration distribution as a mechanism for regulating drug release from diffusion controlled and surface erosion controlled matrix systems
15. A theoretical model of erosion and macro-molecular drug release from biodegrading microspheres
16. Analysis of theoretical behavior of a proposed zero-order drug delivery system
17. Zero-order release of micro and macromolecules from polymeric devices: The role of the burst effect
18. Modeling monomer release from bioerodible polymers
19. High-performance liquid chromatographic determination of dexamethasone in human plasma
20. Characterization of a polymeric PLGA-injectable implant delivery system for the controlled release of proteins
21. 125I-bovine calcitonin in vitro-in vivo studies
22. Ketoprofen-poly(D,L-lactic-co-glycolic acid) microspheres: Influence of manufacturing parameters and type of polymer on the release characteristics
23. Adjuvant activity of linear aliphatic polyester and branched aliphatic oligoester microspheres
24. Utilization of poly(DL-lactide-co-glycolide) nanoparticles for preparation of mini-depot tablets by direct compression
25. Biodegradable microspheres as controlled-release tetanus toxoid delivery system
26. Zero-order controlled-release polymer matrices for micro- and macro-molecules
27. Polymers for sustained macromolecule release: Procedures to fabricate reproducible delivery systems and control release kinetics
28. PEG-coated nanospheres from amphiphilic diblock and multiblock copolymers: Investigation of their drug encapsulation and release characteristics
29. Drug delivery in poly(lactide-co-glycolide) nanoparticles surface modified with poloxamer 407 and poloxamine 908: In vitro characterization and in vivo evaluation
30. Stabilization of proteins encapsulated in injectable poly(lactide-co-glycolide)
31. Optimization of the encapsulation and release of β-lactoglobulin entrapped poly(DL-lactide-co-glycolide) microspheres
32. Stabilization of proteins encapsulated in injectable poly(lactide-co-glycolide)
33. Influence of the co-encapsulation of different non-ionic surfactants on the properties of PLGA insulin-loaded microspheres
34. Modulated release of IdUrd from poly(D,L-lactide-co-glycolide) microspheres by addition of poly(D,L-lactide) oligomers
35. Monitoring microviscosity and microacidity of the albumin microenvironment inside degrading microparticles from poly(lactide-co-glycolide) (PLG) or ABA-triblock polymers containing hydrophobic poly(lactide-co-glycolide) A blocks and hydrophilic poly(ethylene oxide) B block
36. pH and osmotic pressure inside biodegradable microspheres during erosion
37. The importance of drug stability in release medium for analyzing release data from PLGA microspheres
38. Formulation and release characteristics of poly(lactic-co-glycolic acid) microspheres containing chemically modified protein
39. Dissolution