-
1
-
-
84055184770
-
Approach to the patient with advanced differentiated thyroid cancer
-
SchlumbergerM,Sherman SI. Approach to the patient with advanced differentiated thyroid cancer. Eur J Endocrinol. 2012;166:5-11.
-
(2012)
Eur J Endocrinol.
, vol.166
, pp. 5-11
-
-
Schlumberger, M.1
Sherman, S.I.2
-
2
-
-
77749267722
-
Approach to the thyroid cancer patient with extracervical metastases
-
Haugen BR, Kane MA. Approach to the thyroid cancer patient with extracervical metastases. J Clin Endocrinol Metab. 2010;95:987-993.
-
(2010)
J Clin Endocrinol Metab.
, vol.95
, pp. 987-993
-
-
Haugen, B.R.1
Kane, M.A.2
-
3
-
-
50649095250
-
Phase II trial of sorafenib in advanced thyroid cancer
-
Gupta-Abramson V, Troxel AB, Nellore A, et al. Phase II trial of sorafenib in advanced thyroid cancer. J Clin Oncol. 2008;26:4714-4719.
-
(2008)
J Clin Oncol.
, vol.26
, pp. 4714-4719
-
-
Gupta-Abramson, V.1
Troxel, A.B.2
Nellore, A.3
-
4
-
-
63849265332
-
Phase II trial of sorafenib in metastatic thyroid cancer
-
Kloos RT, Ringel MD, Knopp MV, et al. Phase II trial of sorafenib in metastatic thyroid cancer. J Clin Oncol. 2009; 27:1675-1684.
-
(2009)
J Clin Oncol.
, vol.27
, pp. 1675-1684
-
-
Kloos, R.T.1
Ringel, M.D.2
Knopp, M.V.3
-
5
-
-
72949106263
-
Beneficial effects of sorafenib on tumor progression, but not on radioiodine uptake, in patients with differentiated thyroid carcinoma
-
Hoftijzer H, Heemstra KA, Morreau H, et al. Beneficial effects of sorafenib on tumor progression, but not on radioiodine uptake, in patients with differentiated thyroid carcinoma. Eur J Endocrinol. 2009;161:923-931.
-
(2009)
Eur J Endocrinol.
, vol.161
, pp. 923-931
-
-
Hoftijzer, H.1
Heemstra, K.A.2
Morreau, H.3
-
6
-
-
79952232216
-
Global cancer statistics
-
Jemal A, Bray F, CenterMM,Ferlay J, Ward E, Forman D. Global cancer statistics.CACancer J Clin. 2011;61:69-90.
-
(2011)
CACancer J Clin.
, vol.61
, pp. 69-90
-
-
Jemal, A.1
Bray, F.2
Center, M.M.3
Ferlay, J.4
Ward, E.5
Forman, D.6
-
7
-
-
70449370231
-
Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer
-
Cooper DS, DohertyGM,Haugen BR, et al. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 2009;19:1167-1214.
-
(2009)
Thyroid.
, vol.19
, pp. 1167-1214
-
-
Cooper, D.S.1
Doherty, G.M.2
Haugen, B.R.3
-
8
-
-
77954337467
-
Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
-
Pacini F, Castagna MG, Brilli L, Pentheroudakis G. Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.AnnOncol. 2010;21(suppl 5):v214-v219.
-
(2010)
AnnOncol.
, vol.21
, Issue.5 SUPPL.
-
-
Pacini, F.1
Castagna, M.G.2
Brilli, L.3
Pentheroudakis, G.4
-
9
-
-
84867268171
-
Update in utility of secondary node dissection for papillary thyroid cancer
-
Steward DL. Update in utility of secondary node dissection for papillary thyroid cancer. J Clin Endocrinol Metab. 2012;97:3393-3398.
-
(2012)
J Clin Endocrinol Metab.
, vol.97
, pp. 3393-3398
-
-
Steward, D.L.1
-
10
-
-
33747642244
-
Long-term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: benefits and limits of radioiodine therapy
-
Durante C, Haddy N, Baudin E, et al. Long-term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: benefits and limits of radioiodine therapy. J Clin Endocrinol Metab. 2006;91:2892-2899.
-
(2006)
J Clin Endocrinol Metab.
, vol.91
, pp. 2892-2899
-
-
Durante, C.1
Haddy, N.2
Baudin, E.3
-
12
-
-
0035875234
-
Pamidronate improves the quality of life and induces clinical remission of bone metastases in patients with thyroid cancer
-
Vitale G, Fonderico F, Martignetti A, et al. Pamidronate improves the quality of life and induces clinical remission of bone metastases in patients with thyroid cancer. Br J Cancer. 2001;84:1586-1590.
-
(2001)
Br J Cancer.
, vol.84
, pp. 1586-1590
-
-
Vitale, G.1
Fonderico, F.2
Martignetti, A.3
-
13
-
-
78651318407
-
Zoledronic acid in the treatment of bone metastases from differentiated thyroid carcinoma
-
Orita Y, Sugitani I, Toda K, Manabe J, Fujimoto Y. Zoledronic acid in the treatment of bone metastases from differentiated thyroid carcinoma. Thyroid. 2011;21:31-35.
-
(2011)
Thyroid.
, vol.21
, pp. 31-35
-
-
Orita, Y.1
Sugitani, I.2
Toda, K.3
Manabe, J.4
Fujimoto, Y.5
-
14
-
-
17744368257
-
Survival and therapeutic modalities in patients with bone metastases of differentiated thyroid carcinomas
-
Bernier MO, Leenhardt L, Hoang C, et al. Survival and therapeutic modalities in patients with bone metastases of differentiated thyroid carcinomas. J Clin Endocrinol Metab. 2001;86:1568-1573.
-
(2001)
J Clin Endocrinol Metab.
, vol.86
, pp. 1568-1573
-
-
Bernier, M.O.1
Leenhardt, L.2
Hoang, C.3
-
15
-
-
0036226649
-
Long-term follow-up of patients with bone metastases from differentiated thyroid carcinoma-surgery or conventional therapy?
-
Zettinig G, Fueger BJ, Passler C, et al. Long-term follow-up of patients with bone metastases from differentiated thyroid carcinoma-surgery or conventional therapy? Clin Endocrinol (Oxf). 2002;56:377-382.
-
(2002)
Clin Endocrinol (Oxf)
, vol.56
, pp. 377-382
-
-
Zettinig, G.1
Fueger, B.J.2
Passler, C.3
-
16
-
-
77954762933
-
Cytotoxic chemotherapy for differentiated thyroid carcinoma
-
Sherman SI. Cytotoxic chemotherapy for differentiated thyroid carcinoma. Clin Oncol. 2010;22:464-468.
-
(2010)
Clin Oncol.
, vol.22
, pp. 464-468
-
-
Sherman, S.I.1
-
17
-
-
0016401039
-
Chemotherapy of thyroid cancer with adriamycin. Experience with 30 patients
-
Gottlieb JA, Hill CS Jr. Chemotherapy of thyroid cancer with adriamycin. Experience with 30 patients. N Engl J Med. 1974;290:193-197.
-
(1974)
N Engl J Med.
, vol.290
, pp. 193-197
-
-
Gottlieb, J.A.1
Hill, C.S.2
-
18
-
-
43249107532
-
Chemotherapy with doxorubicin in progressive medullary and thyroid carcinoma of the follicular epithelium
-
Matuszczyk A, Petersenn S, Bockisch A, et al. Chemotherapy with doxorubicin in progressive medullary and thyroid carcinoma of the follicular epithelium. Horm Metab Res. 2008;40:210-213.
-
(2008)
Horm Metab Res.
, vol.40
, pp. 210-213
-
-
Matuszczyk, A.1
Petersenn, S.2
Bockisch, A.3
-
19
-
-
79953329570
-
Targeted therapies for thyroid tumors
-
Sherman SI. Targeted therapies for thyroid tumors. Mod Pathol. 2011;24:S44-S52.
-
(2011)
Mod Pathol.
, vol.24
-
-
Sherman, S.I.1
-
20
-
-
0026677495
-
Genetic basis of endocrine disease 3: molecular defects in thyroid gland neoplasia
-
Fagin JA. Genetic basis of endocrine disease 3: molecular defects in thyroid gland neoplasia. J Clin Endocrinol Metab. 1992;75:1398-1400.
-
(1992)
J Clin Endocrinol Metab.
, vol.75
, pp. 1398-1400
-
-
Fagin, J.A.1
-
21
-
-
70350554104
-
The BRAFV600E oncogene induces transforming growth factor β secretion leading to sodium iodide symporter repression and increased malignancy in thyroid cancer
-
Riesco-Eizaguirre G, Rodriquiz I, De la Vieja A, et al. The BRAFV600E oncogene induces transforming growth factor β secretion leading to sodium iodide symporter repression and increased malignancy in thyroid cancer. Cancer Res. 2009;69:8317-8325.
-
(2009)
Cancer Res.
, vol.69
, pp. 8317-8325
-
-
Riesco-Eizaguirre, G.1
Rodriquiz, I.2
De la Vieja, A.3
-
22
-
-
77950920870
-
Prognostic utility of BRAF mutation in papillary thyroid cancer
-
Xing M. Prognostic utility of BRAF mutation in papillary thyroid cancer. Mol Cell Endocrinol. 2010;321:86-93.
-
(2010)
Mol Cell Endocrinol.
, vol.321
, pp. 86-93
-
-
Xing, M.1
-
23
-
-
33644843087
-
Poorly differentiated thyroid carcinomas defined on the basis of mitosis and necrosis: a clinicopathologic study of 58 patients
-
Hiltzik D, Carlson DL, Tuttle RM, et al. Poorly differentiated thyroid carcinomas defined on the basis of mitosis and necrosis: a clinicopathologic study of 58 patients. Cancer. 2006;106:1286.
-
(2006)
Cancer.
, vol.106
, pp. 1286
-
-
Hiltzik, D.1
Carlson, D.L.2
Tuttle, R.M.3
-
25
-
-
47149102563
-
Histopathologic characterization of radioactive iodine-refractory fluorodeoxyglucose-positron emission tomography-positive thyroid carcinoma
-
RiveraM,Ghossein RA, Schoder H, Gomez D, Larson SM, Tuttle RM. Histopathologic characterization of radioactive iodine-refractory fluorodeoxyglucose-positron emission tomography-positive thyroid carcinoma. Cancer. 2008;113:48-56.
-
(2008)
Cancer.
, vol.113
, pp. 48-56
-
-
Rivera, M.1
Ghossein, R.A.2
Schoder, H.3
Gomez, D.4
Larson, S.M.5
Tuttle, R.M.6
-
26
-
-
28544452359
-
Mutation of the PIK3CA gene in anaplastic thyroid cancer
-
Garcia-Rostan G. Mutation of the PIK3CA gene in anaplastic thyroid cancer. Cancer Res. 2012;65:10199-10207.
-
(2012)
Cancer Res.
, vol.65
, pp. 10199-10207
-
-
Garcia-Rostan, G.1
-
27
-
-
33947284529
-
Genetic alterations and their relationship in the phosphatidylinositol 3-kinase/Akt pathway in thyroid cancer
-
Hou P, Liu D, Sha Y, et al. Genetic alterations and their relationship in the phosphatidylinositol 3-kinase/Akt pathway in thyroid cancer. Clin Cancer Res. 2007;13:1161-1170.
-
(2007)
Clin Cancer Res.
, vol.13
, pp. 1161-1170
-
-
Hou, P.1
Liu, D.2
Sha, Y.3
-
28
-
-
49249127826
-
Highly prevalent genetic alterations in receptor tyrosine kinases and phosphatidylinositol 3-kinase/akt and mitogen-activated protein kinase pathways in anaplastic and follicular thyroid cancers
-
Liu Z, Hou P, Ji M, et al. Highly prevalent genetic alterations in receptor tyrosine kinases and phosphatidylinositol 3-kinase/akt and mitogen-activated protein kinase pathways in anaplastic and follicular thyroid cancers. J Clin Endocrinol Metab. 2008;93:3106-3116.
-
(2008)
J Clin Endocrinol Metab.
, vol.93
, pp. 3106-3116
-
-
Liu, Z.1
Hou, P.2
Ji, M.3
-
29
-
-
66349098309
-
Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1
-
Ricarte-Filho JC, Ryder M, Chitale Da, et al. Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1. Cancer Res. 2009;69:4885-4893.
-
(2009)
Cancer Res.
, vol.69
, pp. 4885-4893
-
-
Ricarte-Filho, J.C.1
Ryder, M.2
Da, C.3
-
30
-
-
22244457075
-
Multiple signaling pathways converge on β-catenin in thyroid cancer
-
Abbosh PH, Nephew KP. Multiple signaling pathways converge on β-catenin in thyroid cancer. Thyroid. 2005; 15:551-561.
-
(2005)
Thyroid.
, vol.15
, pp. 551-561
-
-
Abbosh, P.H.1
Nephew, K.P.2
-
31
-
-
0033561515
-
Frequent mutation and nuclear localization of β-catenin in anaplastic thyroid carcinoma
-
Garcia-Rostan G, Tallini G, Herrero A, D'Aquila TG, Carcanqiu ML, Rimm DL. Frequent mutation and nuclear localization of β-catenin in anaplastic thyroid carcinoma. Cancer Res. 1999;59:1811-1815.
-
(1999)
Cancer Res.
, vol.59
, pp. 1811-1815
-
-
Garcia-Rostan, G.1
Tallini, G.2
Herrero, A.3
D'Aquila, T.G.4
Carcanqiu, M.L.5
Rimm, D.L.6
-
32
-
-
0038170599
-
E-Cadherin loss rather than β-catenin alterations is a common feature of poorly differentiated thyroid carcinomas
-
Rocha AS, Soares P, Fonseca E, Cameselle-Teijeiro J, Oliveira MC, Sobrinho-Simoes M. E-Cadherin loss rather than β-catenin alterations is a common feature of poorly differentiated thyroid carcinomas. Histopathology. 2003; 42:580-587.
-
(2003)
Histopathology.
, vol.42
, pp. 580-587
-
-
Rocha, A.S.1
Soares, P.2
Fonseca, E.3
Cameselle-Teijeiro, J.4
Oliveira, M.C.5
Sobrinho-Simoes, M.6
-
33
-
-
19944426556
-
Immunohistochemical and sequencing analyses of the Wnt signaling components in Japanese anaplastic thyroid cancers
-
Kurihara T, Ikeda S, Ishizaki Y, et al. Immunohistochemical and sequencing analyses of the Wnt signaling components in Japanese anaplastic thyroid cancers. Thyroid. 2004;14:1020-1029.
-
(2004)
Thyroid.
, vol.14
, pp. 1020-1029
-
-
Kurihara, T.1
Ikeda, S.2
Ishizaki, Y.3
-
34
-
-
0026575904
-
Unique association of p53 mutations with undifferentiated but not with differentiated carcinomas of the thyroid gland
-
Ito T, Seyama T, Mizuno T, et al. Unique association of p53 mutations with undifferentiated but not with differentiated carcinomas of the thyroid gland. Cancer Res. 1992;52:1369-1371.
-
(1992)
Cancer Res.
, vol.52
, pp. 1369-1371
-
-
Ito, T.1
Seyama, T.2
Mizuno, T.3
-
35
-
-
0027455042
-
High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas
-
Fagin JA, Matsuo K, Karmarkar A, Chen DL, Tang SH, Koeffler HP. High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas. J Clin Invest. 1993;91:179-184.
-
(1993)
J Clin Invest.
, vol.91
, pp. 179-184
-
-
Fagin, J.A.1
Matsuo, K.2
Karmarkar, A.3
Chen, D.L.4
Tang, S.H.5
Koeffler, H.P.6
-
36
-
-
56649105350
-
Molecular pathology of thyroid cancer: diagnostic and clinical implications
-
Fagin JA, Mitsiades N. Molecular pathology of thyroid cancer: diagnostic and clinical implications. Best Pract Res Clin Endocrinol Metab. 2008;22:955-969.
-
(2008)
Best Pract Res Clin Endocrinol Metab.
, vol.22
, pp. 955-969
-
-
Fagin, J.A.1
Mitsiades, N.2
-
37
-
-
18844437226
-
Evidence that one subset of anaplastic thyroid carcinomas are derived from papillary carcinomas due to BRAF and p53 mutations
-
Quiros RM, Ding HG, Gattuso P, Prinz RA, Xu X. Evidence that one subset of anaplastic thyroid carcinomas are derived from papillary carcinomas due to BRAF and p53 mutations. Cancer. 2005;103:2261-2268.
-
(2005)
Cancer.
, vol.103
, pp. 2261-2268
-
-
Quiros, R.M.1
Ding, H.G.2
Gattuso, P.3
Prinz, R.A.4
Xu, X.5
-
38
-
-
34548088376
-
Identification of molecular markers altered during transformation of differentiated into anaplastic thyroid carcinoma
-
Wiseman SM, Griffith OL, Deen S, et al. Identification of molecular markers altered during transformation of differentiated into anaplastic thyroid carcinoma. Arch Surg. 2007;142:717-729.
-
(2007)
Arch Surg.
, vol.142
, pp. 717-729
-
-
Wiseman, S.M.1
Griffith, O.L.2
Deen, S.3
-
39
-
-
65949117244
-
Oncogenic Kras requires simultaneous PI3K signaling to induce ERK activation and transform thyroid epithelial cells in vivo
-
Miller KA, Yeager N, Baker K, Liao XH, Refetoff S, Di Cristofano A. Oncogenic Kras requires simultaneous PI3K signaling to induce ERK activation and transform thyroid epithelial cells in vivo. Cancer Res. 2009;69:3689-3694.
-
(2009)
Cancer Res.
, vol.69
, pp. 3689-3694
-
-
Miller, K.A.1
Yeager, N.2
Baker, K.3
Liao, X.H.4
Refetoff, S.5
Di Cristofano, A.6
-
40
-
-
33947189050
-
Fetal cell carcinogenesis of the thyroid: theory and practice
-
Takano T. Fetal cell carcinogenesis of the thyroid: theory and practice. Semin Cancer Biol. 2007;17:233-240.
-
(2007)
Semin Cancer Biol.
, vol.17
, pp. 233-240
-
-
Takano, T.1
-
41
-
-
78449281896
-
Tumorigenic and metastatic activity of human thyroid cancer stem cells
-
Todaro M, Iovino F, Eterno V, et al. Tumorigenic and metastatic activity of human thyroid cancer stem cells. Cancer Res. 2010;70:8874-8885.
-
(2010)
Cancer Res.
, vol.70
, pp. 8874-8885
-
-
Todaro, M.1
Iovino, F.2
Eterno, V.3
-
42
-
-
84858608410
-
Cancer stem cells: impact, heterogeneity, and uncertainty
-
Magee JA, Piskounova E, Morrison SJ. Cancer stem cells: impact, heterogeneity, and uncertainty. Cancer Cell. 2012; 21:283-296.
-
(2012)
Cancer Cell.
, vol.21
, pp. 283-296
-
-
Magee, J.A.1
Piskounova, E.2
Morrison, S.J.3
-
43
-
-
33847298591
-
Gene expression and functional evidence of epithelial-to-mesenchymal transition in papillary thyroid carcinoma invasion
-
Vasko V, Espinosa AV, Scouten W, et al. Gene expression and functional evidence of epithelial-to-mesenchymal transition in papillary thyroid carcinoma invasion. Proc Natl Acad Sci USA. 2007;104:2803-2808.
-
(2007)
Proc Natl Acad Sci USA.
, vol.104
, pp. 2803-2808
-
-
Vasko, V.1
Espinosa, A.V.2
Scouten, W.3
-
44
-
-
79960381628
-
Progression of BRAF-induced thyroid cancer is associated with epithelialmesenchymal transition requiring concomitant MAP kinase and TGFβ signaling
-
Knauf JA, Sartor MA, Medvedovic M, et al. Progression of BRAF-induced thyroid cancer is associated with epithelialmesenchymal transition requiring concomitant MAP kinase and TGFβ signaling. Oncogene. 2011;30:3153-3162.
-
(2011)
Oncogene.
, vol.30
, pp. 3153-3162
-
-
Knauf, J.A.1
Sartor, M.A.2
Medvedovic, M.3
-
45
-
-
40449117749
-
Molecular profiling related to poor prognosis in thyroid carcinoma. Combining gene expression data and biological information
-
Montero-Conde C, Martin-Campos JM, Lerma E, et al. Molecular profiling related to poor prognosis in thyroid carcinoma. Combining gene expression data and biological information. Oncogene. 2008;27:1554-1561.
-
(2008)
Oncogene
, vol.27
, pp. 1554-1561
-
-
Montero-Conde, C.1
Martin-Campos, J.M.2
Lerma, E.3
-
46
-
-
84863230465
-
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
-
Prahallad A, Sun C, Huang S, et al. Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature. 2012;483:100-103.
-
(2012)
Nature.
, vol.483
, pp. 100-103
-
-
Prahallad, A.1
Sun, C.2
Huang, S.3
-
47
-
-
84861943484
-
Chemical genetic discovery of targets and anti-targets for cancer polypharmacology
-
Dar AC, Das TK, ShokatKM,Cagan RL. Chemical genetic discovery of targets and anti-targets for cancer polypharmacology. Nature. 2012;486:80-84.
-
(2012)
Nature.
, vol.486
, pp. 80-84
-
-
Dar, A.C.1
Das, T.K.2
Shokat, K.M.3
Cagan, R.L.4
-
48
-
-
46449117698
-
Motesanib diphosphate in progressive differentiated thyroid cancer
-
Motesanib Thyroid Cancer Study Group
-
Sherman SI, Wirth LJ, Droz JP, et al; Motesanib Thyroid Cancer Study Group. Motesanib diphosphate in progressive differentiated thyroid cancer. N Engl J Med. 2008; 359:31-42.
-
(2008)
N Engl J Med.
, vol.359
, pp. 31-42
-
-
Sherman, S.I.1
Wirth, L.J.2
Droz, J.P.3
-
49
-
-
79960179069
-
Analysis of the efficacy and toxicity of sorafenib in thyroid cancer: a phase II study in aUKbased population
-
Ahmed M, Barbachano Y, Riddel A, et al. Analysis of the efficacy and toxicity of sorafenib in thyroid cancer: a phase II study in aUKbased population. Eur J Endocrinol. 2011; 165:315-322.
-
(2011)
Eur J Endocrinol.
, vol.165
, pp. 315-322
-
-
Ahmed, M.1
Barbachano, Y.2
Riddel, A.3
-
50
-
-
0022355480
-
A randomized trial of doxorubicin versus doxorubicin plus cisplatin in patients with advanced thyroid carcinoma
-
Shimaoka K, Schoenfeld DA, DeWys WD, Creech RH, DeConti R. A randomized trial of doxorubicin versus doxorubicin plus cisplatin in patients with advanced thyroid carcinoma. Cancer. 1985;56:2155-2160.
-
(1985)
Cancer.
, vol.56
, pp. 2155-2160
-
-
Shimaoka, K.1
Schoenfeld, D.A.2
Dewys, W.D.3
Creech, R.H.4
DeConti, R.5
-
51
-
-
80051479922
-
Rationale and design of decision: a double-blind, randomized, placebocontrolled phase III trial evaluating the efficacy and safety of sorafenib in patients with locally advanced or metastatic radioactive iodine (RAI)-refractory, differentiated thyroid cancer
-
Brose MS, Nutting CM, Sherman SI, et al. Rationale and design of decision: a double-blind, randomized, placebocontrolled phase III trial evaluating the efficacy and safety of sorafenib in patients with locally advanced or metastatic radioactive iodine (RAI)-refractory, differentiated thyroid cancer. BMC Cancer. 2011;11:349.
-
(2011)
BMC Cancer.
, vol.11
, pp. 349
-
-
Brose, M.S.1
Nutting, C.M.2
Sherman, S.I.3
-
52
-
-
77957359933
-
Efficacy of pazopanib in progressive, radioiodine-refractory, metastatic differentiated thyroid cancers: results of a phase 2 consortium study
-
Endocrine Malignancies Disease Oriented Group,MayoClinic Cancer Center, Mayo Phase 2 Consortium
-
Bible KC, Suman VJ, Molina JR, et al; Endocrine Malignancies Disease Oriented Group,MayoClinic Cancer Center, Mayo Phase 2 Consortium. Efficacy of pazopanib in progressive, radioiodine-refractory, metastatic differentiated thyroid cancers: results of a phase 2 consortium study. Lancet Oncol. 2010;11:962-972.
-
(2010)
Lancet Oncol.
, vol.11
, pp. 962-972
-
-
Bible, K.C.1
Suman, V.J.2
Molina, J.R.3
-
53
-
-
84865552505
-
Vandetanib in locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 2 trial
-
Leboulleux S, Bastholt L, Krause T, et al. Vandetanib in locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 2 trial. Lancet Oncol. 2012;13:897-905.
-
(2012)
Lancet Oncol.
, vol.13
, pp. 897-905
-
-
Leboulleux, S.1
Bastholt, L.2
Krause, T.3
-
54
-
-
80053160399
-
A phase II trial of the multitargeted kinase inhibitor E7080 in advanced radioiodine (RAI)-refractory differentiated thyroid cancer (DTC)
-
Sherman SI, Jarzab B, Cabanillas ME, et al. A phase II trial of the multitargeted kinase inhibitor E7080 in advanced radioiodine (RAI)-refractory differentiated thyroid cancer (DTC). J Clin Oncol. 2011;29:5503.
-
(2011)
J Clin Oncol.
, vol.29
, pp. 5503
-
-
Sherman, S.I.1
Jarzab, B.2
Cabanillas, M.E.3
-
55
-
-
84875151746
-
Antitumor activity of cabozantinib (XL184) in a cohort of patients with differentiated thyroid cancer (DTC)
-
(Meeting Abstract)
-
Cabanillas ME, Brose MS, Ramies DA, Lee Y, Miles D, Sherman SI. Antitumor activity of cabozantinib (XL184) in a cohort of patients with differentiated thyroid cancer (DTC). J Clin Oncol. 2012;30(suppl):5547 (Meeting Abstract).
-
(2012)
J Clin Oncol.
, vol.30
, Issue.SUPPL.
, pp. 5547
-
-
Cabanillas, M.E.1
Brose, M.S.2
Ramies, D.A.3
Lee, Y.4
Miles, D.5
Sherman, S.I.6
-
56
-
-
50649095801
-
Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: results from a phase II study
-
Cohen EE, Rosen LS, Vokes EE, et al. Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: results from a phase II study. J Clin Oncol. 2008; 26:4708-4713.
-
(2008)
J Clin Oncol.
, vol.26
, pp. 4708-4713
-
-
Cohen, E.E.1
Rosen, L.S.2
Vokes, E.E.3
-
57
-
-
84877581959
-
Lenvatinib treatment of advanced RAI-refractory differentiated thyroid cancer (DTC): cytokine and angiogenic factor (CAF) profiling in combination with tumor genetic analysis to identify markers associated with response
-
(Meeting Abstract)
-
Ball DW, Sherman SI, Jarzab B, et al. Lenvatinib treatment of advanced RAI-refractory differentiated thyroid cancer (DTC): cytokine and angiogenic factor (CAF) profiling in combination with tumor genetic analysis to identify markers associated with response. J Clin Oncol. 2012; 30(suppl):5518 (Meeting Abstract).
-
(2012)
J Clin Oncol.
, vol.30
, Issue.SUPPL.
, pp. 5518
-
-
Ball, D.W.1
Sherman, S.I.2
Jarzab, B.3
-
59
-
-
67649770887
-
Ras signaling and therapies
-
Young A, Lyons J, Miller AL, Phan VT, Alarcon IR, Mc-Cormick F. Ras signaling and therapies. Adv Cancer Res. 2009;102:1-17.
-
(2009)
Adv Cancer Res.
, vol.102
, pp. 1-17
-
-
Young, A.1
Lyons, J.2
Miller, A.L.3
Phan, V.T.4
Alarcon, I.R.5
Mc-Cormick, F.6
-
61
-
-
0030923192
-
K-and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors
-
Whyte DB, Kirschmeier P, Hockenberry TN, et al. K-and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors. J Biol Chem. 1997;272: 14459-14464.
-
(1997)
J Biol Chem.
, vol.272
, pp. 14459-14464
-
-
Whyte, D.B.1
Kirschmeier, P.2
Hockenberry, T.N.3
-
62
-
-
0033951052
-
Manumycin enhances the cytotoxic effect of paclitaxel on anaplastic thyroid carcinoma cells
-
Yeung SC, Xu G, Pan J, Christgen M, Bamiagis A. Manumycin enhances the cytotoxic effect of paclitaxel on anaplastic thyroid carcinoma cells. Cancer Res. 2000;60:650-656.
-
(2000)
Cancer Res.
, vol.60
, pp. 650-656
-
-
Yeung, S.C.1
Xu, G.2
Pan, J.3
Christgen, M.4
Bamiagis, A.5
-
63
-
-
18144363210
-
Farnesyltransferase inhibitors induceDNAdamage via reactive oxygen species in human cancer cells
-
Pan J, SheM,XuZX,Sun L,YeungSC. Farnesyltransferase inhibitors induceDNAdamage via reactive oxygen species in human cancer cells. Cancer Res. 2005;65:3671-3681.
-
(2005)
Cancer Res.
, vol.65
, pp. 3671-3681
-
-
Pan, J.1
She, M.2
Xu, Z.X.3
Sun, L.4
Yeung, S.C.5
-
64
-
-
65649130809
-
The protein farnesyltransferase regulates HDAC6 activity in a microtubuledependent manner
-
Zhou J, Vos CC, Gjyrezi A, et al. The protein farnesyltransferase regulates HDAC6 activity in a microtubuledependent manner. J Biol Chem. 2009;284:9648-9655.
-
(2009)
J Biol Chem.
, vol.284
, pp. 9648-9655
-
-
Zhou, J.1
Vos, C.C.2
Gjyrezi, A.3
-
65
-
-
79953904634
-
Inhibition of the Ras/Raf/MEK/ERK and RET kinase pathways with the combination of the multikinase inhibitor sorafenib and the farnesyltransferase inhibitor tipifarnib in medullary and differentiated thyroid malignancies
-
Hong DS, Cabanillas ME, Wheler J, et al. Inhibition of the Ras/Raf/MEK/ERK and RET kinase pathways with the combination of the multikinase inhibitor sorafenib and the farnesyltransferase inhibitor tipifarnib in medullary and differentiated thyroid malignancies. J Clin Endocrinol Metab. 2011;96:997-1005.
-
(2011)
J Clin Endocrinol Metab.
, vol.96
, pp. 997-1005
-
-
Hong, D.S.1
Cabanillas, M.E.2
Wheler, J.3
-
66
-
-
33645698808
-
Inhibitors of Raf kinase activity block growth of thyroid cancer cells with RET/PTC or BRAF mutations in vitro and in vivo
-
Ouyang B, Knauf JA, Smith EP, et al. Inhibitors of Raf kinase activity block growth of thyroid cancer cells with RET/PTC or BRAF mutations in vitro and in vivo. Clin Cancer Res. 2006;12:1785-1793.
-
(2006)
Clin Cancer Res.
, vol.12
, pp. 1785-1793
-
-
Ouyang, B.1
Knauf, J.A.2
Smith, E.P.3
-
67
-
-
34147144679
-
Targeting BRAFV600E in thyroid carcinoma: therapeutic implications
-
Mitsiades CS, Negri J, McMullan C, et al. Targeting BRAFV600E in thyroid carcinoma: therapeutic implications. Mol Cancer Ther. 2007;6:1070-1078.
-
(2007)
Mol Cancer Ther.
, vol.6
, pp. 1070-1078
-
-
Mitsiades, C.S.1
Negri, J.2
Mcmullan, C.3
-
68
-
-
84855648341
-
Small molecule inhibitors of BRAF in clinical trials
-
Zambon A, Niculescu-Duvaz I, Niculescu-Duvaz D, Marais R, Springer CJ. Small molecule inhibitors of BRAF in clinical trials. Bioorg Med Chem Lett. 2012;22:789-792.
-
(2012)
Bioorg Med Chem Lett.
, vol.22
, pp. 789-792
-
-
Zambon, A.1
Niculescu-Duvaz, I.2
Niculescu-Duvaz, D.3
Marais, R.4
Springer, C.J.5
-
69
-
-
77955602211
-
Gatekeeper mutations mediate resistance to BRAF-targeted therapies
-
Whittaker S, Kirk R, Hayward R, et al. Gatekeeper mutations mediate resistance to BRAF-targeted therapies. Sci Transl Med. 2010;2:35-41.
-
(2010)
Sci Transl Med.
, vol.2
, pp. 35-41
-
-
Whittaker, S.1
Kirk, R.2
Hayward, R.3
-
70
-
-
33748325763
-
Sorafenib in advanced melanoma: a phase II randomised discontinuation trial analysis
-
Eisen T, Ahmad T, Flaherty KT, et al. Sorafenib in advanced melanoma: a phase II randomised discontinuation trial analysis. Br J Cancer. 2006;95:581-586.
-
(2006)
Br J Cancer.
, vol.95
, pp. 581-586
-
-
Eisen, T.1
Ahmad, T.2
Flaherty, K.T.3
-
71
-
-
79955984428
-
Phase I doseescalation study of continuously administered regorafenib (BAY 73-4506), an inhibitor of oncogenic and angiogenic kinases, in patients with advanced solid tumors
-
Shimizu T, Tolcher AW, Patnaik A, et al. Phase I doseescalation study of continuously administered regorafenib (BAY 73-4506), an inhibitor of oncogenic and angiogenic kinases, in patients with advanced solid tumors. J Clin Oncol. 2010;28:3035.
-
(2010)
J Clin Oncol.
, vol.28
, pp. 3035
-
-
Shimizu, T.1
Tolcher, A.W.2
Patnaik, A.3
-
72
-
-
79954499886
-
Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity
-
Wilhelm SM, Dumas J, Adnane L, et al. Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int J Cancer. 2011;129: 245-255.
-
(2011)
Int J Cancer.
, vol.129
, pp. 245-255
-
-
Wilhelm, S.M.1
Dumas, J.2
Adnane, L.3
-
73
-
-
68949106943
-
A phase I study of XL281, a selective oral RAF kinase inhibitor, in patients (Pts) with advanced solid tumors
-
Schwartz GK, Robertson S, Shen A, et al. A phase I study of XL281, a selective oral RAF kinase inhibitor, in patients (Pts) with advanced solid tumors. J Clin Oncol. 2009;27: 3513.
-
(2009)
J Clin Oncol.
, vol.27
, pp. 3513
-
-
Schwartz, G.K.1
Robertson, S.2
Shen, A.3
-
74
-
-
47249097988
-
BRAF silencing by short hairpin RNA or chemical blockade by PLX4032 leads to different responses in melanoma and thyroid carcinoma cells
-
Sala E, Mologni L, Truffa S, Gaetano C, Bollag GE, Gambacorti-Passerini C. BRAF silencing by short hairpin RNA or chemical blockade by PLX4032 leads to different responses in melanoma and thyroid carcinoma cells. Mol Cancer Res. 2008;6:751-759.
-
(2008)
Mol Cancer Res.
, vol.6
, pp. 751-759
-
-
Sala, E.1
Mologni, L.2
Truffa, S.3
Gaetano, C.4
Bollag, G.E.5
Gambacorti-Passerini, C.6
-
75
-
-
77956513286
-
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
-
Bollag G, Hirth P, Tsai J, et al. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature. 2010;467:596-599.
-
(2010)
Nature.
, vol.467
, pp. 596-599
-
-
Bollag, G.1
Hirth, P.2
Tsai, J.3
-
76
-
-
77954376912
-
RG7204 (PLX4032), a selective BRAFV600E inhibitor, displays potent antitumor activity in preclinical melanoma models
-
Yang H, Higgins B, Kolinsky K, et al. RG7204 (PLX4032), a selective BRAFV600E inhibitor, displays potent antitumor activity in preclinical melanoma models. Cancer Res. 2010;70:5518-5527.
-
(2010)
Cancer Res.
, vol.70
, pp. 5518-5527
-
-
Yang, H.1
Higgins, B.2
Kolinsky, K.3
-
77
-
-
77956030786
-
Inhibition of mutated, activated BRAF in metastatic melanoma
-
Flaherty KT, Puzanov I, Kim KB, et al. Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med. 2010;363:809-819.
-
(2010)
N Engl J Med.
, vol.363
, pp. 809-819
-
-
Flaherty, K.T.1
Puzanov, I.2
Kim, K.B.3
-
78
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
Chapman PB, Hauschild A, Robert C, et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med. 2011;364:2507-2516.
-
(2011)
N Engl J Med.
, vol.364
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
-
79
-
-
84862908097
-
RASmutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors
-
Su F, Viros A, Milagre C, et al.RASmutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors. N Engl J Med. 2012;366:207-215.
-
(2012)
N Engl J Med.
, vol.366
, pp. 207-215
-
-
Su, F.1
Viros, A.2
Milagre, C.3
-
80
-
-
84862908526
-
RAS mutations are associated with the development of cutaneous squamous cell tumors in patients treated with RAF inhibitors
-
Oberholzer PA, Kee D, Dziunycz P, et al. RAS mutations are associated with the development of cutaneous squamous cell tumors in patients treated with RAF inhibitors. J Clin Oncol. 2012;30:316-321.
-
(2012)
J Clin Oncol.
, vol.30
, pp. 316-321
-
-
Oberholzer, P.A.1
Kee, D.2
Dziunycz, P.3
-
81
-
-
75149188152
-
Cytostatic activity of adenosine triphosphate-competitive kinase inhibitors in BRAF mutant thyroid carcinoma cells
-
Salerno P, De Falco, V, Tamburrino A, et al. Cytostatic activity of adenosine triphosphate-competitive kinase inhibitors in BRAF mutant thyroid carcinoma cells. J Clin Endocrinol Metab. 2010;95:450-455.
-
(2010)
J Clin Endocrinol Metab.
, vol.95
, pp. 450-455
-
-
Salerno, P.1
De Falco, V.2
Tamburrino, A.3
-
82
-
-
77949732073
-
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
-
Poulikakos PI, Zhang C, Bollag G, Shokat KM, Rosen N. RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature. 2010;464:427-430.
-
(2010)
Nature.
, vol.464
, pp. 427-430
-
-
Poulikakos, P.I.1
Zhang, C.2
Bollag, G.3
Shokat, K.M.4
Rosen, N.5
-
83
-
-
79953021811
-
Targeting BRAFV600EwithPLX4720displays potent antimigratory and anti-invasive activity in preclinical models of human thyroid cancer
-
Nucera C, Nehs MA, Nagarkatti SS, et al. Targeting BRAFV600EwithPLX4720displays potent antimigratory and anti-invasive activity in preclinical models of human thyroid cancer. Oncologist. 2011;16:296-309.
-
(2011)
Oncologist.
, vol.16
, pp. 296-309
-
-
Nucera, C.1
Nehs, M.A.2
Nagarkatti, S.S.3
-
84
-
-
84855460594
-
Identification of MET and SRC activation in melanoma cell lines showing primary resistance to PLX4032
-
Vergani E, Vallacchi V, Frigerio S, et al. Identification of MET and SRC activation in melanoma cell lines showing primary resistance to PLX4032. Neoplasia. 2012;13: 1132-1142.
-
(2012)
Neoplasia.
, vol.13
, pp. 1132-1142
-
-
Vergani, E.1
Vallacchi, V.2
Frigerio, S.3
-
85
-
-
84863115580
-
Resistance to selective BRAF inhibition can be mediated by modest upstream pathway activation
-
Su F, Bradley WD, Wang Q, et al. Resistance to selective BRAF inhibition can be mediated by modest upstream pathway activation. Cancer Res. 2012;72:969-978.
-
(2012)
Cancer Res.
, vol.72
, pp. 969-978
-
-
Su, F.1
Bradley, W.D.2
Wang, Q.3
-
86
-
-
83455254767
-
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
-
Poulikakos PI, Persaud Y, Janakiraman M, et al. RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). Nature. 2011;480:387-390.
-
(2011)
Nature.
, vol.480
, pp. 387-390
-
-
Poulikakos, P.I.1
Persaud, Y.2
Janakiraman, M.3
-
87
-
-
84863012433
-
Antitumor activity of BRAF inhibitor vemurafenib in preclinical models of BRAF-mutant colorectal cancer
-
Yang H, Higgins B, Kolinsky K, et al. Antitumor activity of BRAF inhibitor vemurafenib in preclinical models of BRAF-mutant colorectal cancer. Cancer Res. 2012;72: 779-789.
-
(2012)
Cancer Res.
, vol.72
, pp. 779-789
-
-
Yang, H.1
Higgins, B.2
Kolinsky, K.3
-
88
-
-
77957350123
-
Phase I/II study of GSK2118436, a selective inhibitor of oncogenic mutant BRAF kinase, in patients with metastatic melanoma and other solid tumors
-
Kefford R, Arkenau H, Brown MP, et al. Phase I/II study of GSK2118436, a selective inhibitor of oncogenic mutant BRAF kinase, in patients with metastatic melanoma and other solid tumors. J Clin Oncol. 2010;28:8503.
-
(2010)
J Clin Oncol.
, vol.28
, pp. 8503
-
-
Kefford, R.1
Arkenau, H.2
Brown, M.P.3
-
89
-
-
84861083983
-
Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial
-
Falchook GS, Long GV, Kurzrock R, et al. Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial. Lancet. 2012;379:1893-1901.
-
(2012)
Lancet.
, vol.379
, pp. 1893-1901
-
-
Falchook, G.S.1
Long, G.V.2
Kurzrock, R.3
-
90
-
-
45149098960
-
BRAFV600E mutation is associated with preferential sensitivity to mitogen-activated protein kinase kinase inhibition in thyroid cancer cell lines
-
Leboeuf R, Baumgartner JE, Benezra M, et al. BRAFV600E mutation is associated with preferential sensitivity to mitogen-activated protein kinase kinase inhibition in thyroid cancer cell lines. J Clin Endocrinol Metab. 2008;93:2194-2201.
-
(2008)
J Clin Endocrinol Metab.
, vol.93
, pp. 2194-2201
-
-
Leboeuf, R.1
Baumgartner, J.E.2
Benezra, M.3
-
91
-
-
23944439944
-
Phase I and pharmacodynamic study of the oral MEK inhibitor CI-1040in patients with advanced malignancies
-
Lorusso PM, Adjei AA, Varterasian M, et al. Phase I and pharmacodynamic study of the oral MEK inhibitor CI-1040in patients with advanced malignancies. J Clin Oncol. 2005;23:5281-5293.
-
(2005)
J Clin Oncol.
, vol.23
, pp. 5281-5293
-
-
Lorusso, P.M.1
Adjei, A.A.2
Varterasian, M.3
-
92
-
-
36849073741
-
Inhibitory effects of the mitogen-activated protein kinase kinase inhibitor CI-1040 on the proliferation and tumor growth of thyroid cancer cells with BRAF or RAS mutations
-
Liu D, Liu Z, Jiang D, Dackiw AP, Xing M. Inhibitory effects of the mitogen-activated protein kinase kinase inhibitor CI-1040 on the proliferation and tumor growth of thyroid cancer cells with BRAF or RAS mutations. J Clin Endocrinol Metab. 2007;92:4686-4695.
-
(2007)
J Clin Endocrinol Metab.
, vol.92
, pp. 4686-4695
-
-
Liu, D.1
Liu, Z.2
Jiang, D.3
Dackiw, A.P.4
Xing, M.5
-
93
-
-
50649099936
-
Potent inhibition of thyroid cancer cells by theMEKinhibitor PD0325901 and its potentiation by suppression of the PI3K and NF-κB pathways
-
Liu D, Xing M. Potent inhibition of thyroid cancer cells by theMEKinhibitor PD0325901 and its potentiation by suppression of the PI3K and NF-κB pathways. Thyroid. 2008; 18:853-864.
-
(2008)
Thyroid.
, vol.18
, pp. 853-864
-
-
Liu, D.1
Xing, M.2
-
94
-
-
77954599025
-
MEK inhibitor PD0325901 significantly reduces the growth of papillary thyroid carcinoma cells in vitro and in vivo
-
Henderson YC, Chen Y, Frederick MJ, Lai SY, Clayman GL. MEK inhibitor PD0325901 significantly reduces the growth of papillary thyroid carcinoma cells in vitro and in vivo. Mol Cancer Ther. 2010;9:1968-1976.
-
(2010)
Mol Cancer Ther.
, vol.9
, pp. 1968-1976
-
-
Henderson, Y.C.1
Chen, Y.2
Frederick, M.J.3
Lai, S.Y.4
Clayman, G.L.5
-
95
-
-
33947401129
-
Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor
-
Yeh TC, Marsh V, Bernat BA, et al. Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor. Clin Cancer Res. 2007;13:1576-1583.
-
(2007)
Clin Cancer Res.
, vol.13
, pp. 1576-1583
-
-
Yeh, T.C.1
Marsh, V.2
Bernat, B.A.3
-
96
-
-
36849031817
-
Selective growth inhibition in BRAF mutant thyroid cancer by the mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244
-
Ball DW, Jin N, Rosen DM, et al. Selective growth inhibition in BRAF mutant thyroid cancer by the mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244. J Clin Endocrinol Metab. 2007;92:4712-4718.
-
(2007)
J Clin Endocrinol Metab.
, vol.92
, pp. 4712-4718
-
-
Ball, D.W.1
Jin, N.2
Rosen, D.M.3
-
97
-
-
84859410770
-
Phase II efficacy and pharmacogenomic study of selumetinib (AZD6244; ARRY-142886) in iodine-131 refractory papillary thyroid carcinoma (IRPTC) with or without follicular elements
-
Hayes DN, Lucas AS, Tanvetyanon T, et al. Phase II efficacy and pharmacogenomic study of selumetinib (AZD6244; ARRY-142886) in iodine-131 refractory papillary thyroid carcinoma (IRPTC) with or without follicular elements. Clin Cancer Res. 2012;18:2056-2065.
-
(2012)
Clin Cancer Res.
, vol.18
, pp. 2056-2065
-
-
Hayes, D.N.1
Lucas, A.S.2
Tanvetyanon, T.3
-
98
-
-
84055191090
-
Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation
-
Chakravarty D, Santos E, Ryder M, et al. Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation. J Clin Invest. 2011;121:4700-4711.
-
(2011)
J Clin Invest.
, vol.121
, pp. 4700-4711
-
-
Chakravarty, D.1
Santos, E.2
Ryder, M.3
-
99
-
-
84873681262
-
Selumetinib-enhanced radioiodine uptake in advanced thyroid cancer
-
Ho AL, Grewal RK, Leboeuf R, et al. Selumetinib-enhanced radioiodine uptake in advanced thyroid cancer. N Engl J Med. 2013;368:623-632.
-
(2013)
N Engl J Med.
, vol.368
, pp. 623-632
-
-
Ho, A.L.1
Grewal, R.K.2
Leboeuf, R.3
-
100
-
-
77950921126
-
The PI3K-Akt-mTOR pathway in initiation and progression of thyroid tumors
-
Saji M, Ringel MD. The PI3K-Akt-mTOR pathway in initiation and progression of thyroid tumors. Mol Cell Endocrinol. 2010;321:20-28.
-
(2010)
Mol Cell Endocrinol.
, vol.321
, pp. 20-28
-
-
Saji, M.1
Ringel, M.D.2
-
101
-
-
70349909875
-
Dual inhibition of mitogen-activated protein kinase kinase and mammalian target of rapamycin in differentiated and anaplastic thyroid cancer
-
Jin N, Jiang T, Rosen DM, Nelkin BD, Ball DW. Dual inhibition of mitogen-activated protein kinase kinase and mammalian target of rapamycin in differentiated and anaplastic thyroid cancer. J Clin Endocrinol Metab. 2009;94: 4107-4112.
-
(2009)
J Clin Endocrinol Metab.
, vol.94
, pp. 4107-4112
-
-
Jin, N.1
Jiang, T.2
Rosen, D.M.3
Nelkin, B.D.4
Ball, D.W.5
-
102
-
-
80054118460
-
Synergistic action of a RAF inhibitor and a dual PI3K/mTOR inhibitor in thyroid cancer
-
Jin N, Jiang T, Rosen DM, Nelkin BD, Ball DW. Synergistic action of a RAF inhibitor and a dual PI3K/mTOR inhibitor in thyroid cancer. Clin Cancer Res. 2011;17: 6482-6489.
-
(2011)
Clin Cancer Res.
, vol.17
, pp. 6482-6489
-
-
Jin, N.1
Jiang, T.2
Rosen, D.M.3
Nelkin, B.D.4
Ball, D.W.5
-
103
-
-
84863012398
-
The Akt inhibitor MK2206 synergizes, but perifosine antagonizes, the BRAFV600E inhibitor PLX4032 and the MEK1/2 inhibitor AZD6244 in the inhibition of thyroid cancer cells
-
Liu R, Liu D, Xing M. The Akt inhibitor MK2206 synergizes, but perifosine antagonizes, the BRAFV600E inhibitor PLX4032 and the MEK1/2 inhibitor AZD6244 in the inhibition of thyroid cancer cells. J Clin Endocrinol Metab. 2012;97:E173-E182.
-
(2012)
J Clin Endocrinol Metab.
, vol.97
-
-
Liu, R.1
Liu, D.2
Xing, M.3
-
104
-
-
84866775134
-
A phase II study of temsirolimus/sorafenib in patients with radioactive iodine (RAI)-refractory thyroid carcinoma
-
(Meeting Abstract)
-
Sherman EJ, Ho AL, Fury MG, et al. A phase II study of temsirolimus/sorafenib in patients with radioactive iodine (RAI)-refractory thyroid carcinoma. J Clin Oncol. 2012; 30(suppl):5514 (Meeting Abstract).
-
(2012)
J Clin Oncol.
, vol.30
, Issue.SUPPL.
, pp. 5514
-
-
Sherman, E.J.1
Ho, A.L.2
Fury, M.G.3
-
105
-
-
81155124389
-
The"SWOT"of BRAF inhibition in melanoma: RAF inhibitors, MEK inhibitors or both?
-
NissanMH,Solit DB. The"SWOT"of BRAF inhibition in melanoma: RAF inhibitors, MEK inhibitors or both? Curr Oncol Rep. 2011;13:479-487.
-
(2011)
Curr Oncol Rep
, vol.13
, pp. 479-487
-
-
Nissan, M.H.1
Solit, D.B.2
-
106
-
-
78650008177
-
Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/ PI3K
-
Villanueva J, Vultur A, Lee JT, et al. Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/ PI3K. Cancer Cell. 2010;18:683-695.
-
(2010)
Cancer Cell.
, vol.18
, pp. 683-695
-
-
Villanueva, J.1
Vultur, A.2
Lee, J.T.3
-
107
-
-
80053154225
-
Phase I/II study to assess safety, pharmacokinetics, and efficacy of the oralMEK1/2 inhibitor GSK1120212 (GSK212) dosed in combination with the oralBRAFinhibitorGSK2118436 (GSK436)
-
(Meeting Abstract)
-
Infante JR, Falchook GS, Lawrence DP, et al. Phase I/II study to assess safety, pharmacokinetics, and efficacy of the oralMEK1/2 inhibitor GSK1120212 (GSK212) dosed in combination with the oralBRAFinhibitorGSK2118436 (GSK436). J Clin Oncol. 2011;29(suppl):8503 (Meeting Abstract).
-
(2011)
J Clin Oncol.
, vol.29
, Issue.SUPPL.
, pp. 8503
-
-
Infante, J.R.1
Falchook, G.S.2
Lawrence, D.P.3
-
108
-
-
84861778428
-
Challenges associated with tyrosine kinase inhibitor therapy for metastatic thyroid cancer
-
[published online October 4, 2011], doi:10.4061/2011/985780
-
Cabanillas ME, Hu MI, Durand JB, Busaidy NL. Challenges associated with tyrosine kinase inhibitor therapy for metastatic thyroid cancer. [published online October 4, 2011]. J Thyroid Res. doi:10.4061/2011/985780.
-
J Thyroid Res.
-
-
Cabanillas, M.E.1
Hu, M.I.2
Durand, J.B.3
Busaidy, N.L.4
-
110
-
-
84872078679
-
The noninvestigational use of tyrosine kinase inhibitors in thyroid cancer: establishing a standard for patient safety and monitoring
-
Carhill AA, Cabanillas ME, Jimenez C, et al. The noninvestigational use of tyrosine kinase inhibitors in thyroid cancer: establishing a standard for patient safety and monitoring. J Clin Endocrinol Metab. 2013;98:31-42
-
(2013)
J Clin Endocrinol Metab.
, vol.98
, pp. 31-34
-
-
Carhill, A.A.1
Cabanillas, M.E.2
Jimenez, C.3
-
111
-
-
84877631604
-
Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF mutant thyroid carcinomas
-
[published online January 29, 2013], doi:10.1158/ 2159-8290.CD-12-0531
-
Montero-Conde C, Ruiz-Llorente S, Dominguez JM, et al. Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF mutant thyroid carcinomas. [published online January 29, 2013]. Cancer Discov. doi:10.1158/ 2159-8290.CD-12-0531.
-
Cancer Discov.
-
-
Montero-Conde, C.1
Ruiz-Llorente, S.2
Dominguez, J.M.3
-
112
-
-
40949130884
-
Aphase II study of gefitinib in patients with advanced thyroid cancer
-
PennellNA,DanielsGH,Haddad RI, et al.Aphase II study of gefitinib in patients with advanced thyroid cancer. Thyroid. 2008;18:317-323.
-
(2008)
Thyroid.
, vol.18
, pp. 317-323
-
-
Pennell, N.A.1
Daniels, G.H.2
Haddad, R.I.3
-
113
-
-
78049462514
-
Phase II study of daily sunitinib in FDG-PET positive, iodine-refractory differentiated thyroid cancer and metastatic medullary carcinoma of the thyroid with functional imaging correlation
-
Carr LL, Mankoff DA, Goulart BH, et al. Phase II study of daily sunitinib in FDG-PET positive, iodine-refractory differentiated thyroid cancer and metastatic medullary carcinoma of the thyroid with functional imaging correlation. Clin Cancer Res. 2010;16:5260-5268.
-
(2010)
Clin Cancer Res.
, vol.16
, pp. 5260-5268
-
-
Carr, L.L.1
Mankoff, D.A.2
Goulart, B.H.3
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