E-cadherin loss rather than β-catenin alterations is a common feature of poorly differentiated thyroid carcinomas

Histopathology

Volumn 42, Issue 6, 2003, Pages 580-587

  Rocha, A S ^a   Soares, P ^a,b   Fonseca, E ^a,b,c   Cameselle Teijeiro, J ^d   Oliveira, M C ^a,b,c   Sobrinho Simões, Manuel ^a,b,c  

^a UNIVERSITY OF PORTO   (Portugal)

^b University of Porto   (Portugal)

^c HOSPITAL DE SÃO JOÃO   (Portugal)

^d University Hospital of Santiago de Compostela   (Spain)

Author keywords

catenin; catenin; catenin; E cadherin; Poorly differentiated carcinomas; Thyroid

Indexed keywords

ALPHA CATENIN; BETA CATENIN; NERVE CELL ADHESION MOLECULE; P CADHERIN; PLAKOGLOBIN; UNCLASSIFIED DRUG; UVOMORULIN;

ADULT; AGED; ARTICLE; CELL MEMBRANE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; EXON; FEMALE; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOLOCALIZATION; MALE; MOLECULAR GENETICS; POLYMERASE CHAIN REACTION; POORLY DIFFERENTIATED THYROID CARCINOMA; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN LOCALIZATION; SINGLE STRAND CONFORMATION POLYMORPHISM; THYROID CARCINOMA;

ADULT; AGED; AGED, 80 AND OVER; BETA CATENIN; CADHERINS; CARCINOMA; CYTOSKELETAL PROTEINS; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MICRODISSECTION; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; THYROID NEOPLASMS; TRANS-ACTIVATORS; TUMOR MARKERS, BIOLOGICAL;

EID: 0038170599     PISSN: 03090167     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2559.2003.01642.x     Document Type: Article

References (30)

1. Takeichi M. Cadherin cell adhesion receptors as a morphogenetic regulator. Science 1991: 22; 1451-1455.
2. Gumbiner BM. Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell 1996: 84; 345-357.
3. Gumbiner BM. Regulation of cadherin adhesive activity. J. Cell Biol. 2000: 7; 399-404.
4. Pötter E, Bergwitz C, Brabant G. The cadherin - catenin system: implications for growth and differentiation of endocrine tissues. Endocr. Ver. 1999: 20: 207-239.
5. Ozawa M, Baribault H, Kemler R. The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins related in different species. EMBO J. 1989: 8; 1711-1717.
6. Ozawa M, Kemler R. Molecular organisation of the uvomorulin-catenin complex. J. Cell Biol. 1992: 116; 989-996.
7. Butz S, Kemler R. Distinct cadherin-catenin complexes in Ca(2+)-dependent cell-cell adhesion. FEBBS Letters 1994: 355; 195-200.
8. Hinck L, Nathke IS, Papkoff J, Nelson WJ. Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly. J. Cell Biol. 1994: 125; 1327-1340.
9. Van Aken E, De Wever O, Correia da Rocha AS, Mareel M. Defective E-cadherin/catenin complexes in human cancer. Virchows Arch. 2001: 439; 725-751.
10. Bracke ME, Van Roy FM, Mareel MM. The E-cadherin/catenin complex in invasion and metastasis. Curr. Top. Microbiol. Immunol. 1996: 213; 123-161.
11. Soares P, Berx G, van Roy F, Sobrinho-Simoes M. E-cadherin gene alterations are rare events in thyroid tumors. Int. J. Cancer 1997: 70; 32-38.
12. Cerrato A, Fulciniti F, Avallone A, Benincasa G, Palombini L, Grieco M. Beta- and gamma-catenin expression in thyroid carcinomas. J. Pathol. 1998: 185; 267-272.
13. Garcia-Rostan G, Tallini G, Herrero A, D'Aquila TG, Carcangiu ML, Rimm DL. Frequent mutation and nuclear localization of beta-catenin in anaplastic thyroid carcinoma. Cancer Res. 1999: 59; 1811-1815.
14. Garcia-Rostan G, Camp RL, Herrero A, Carcangiu ML, Rimm DL, Tallini G. Beta-catenin dysregulation in thyroid neoplasms: down-regulation, aberrant nuclear expression, and CTNNB1 exon 3 mutations are markers for aggressive tumor phenotypes and poor prognosis. Am. J. Pathol. 2001: 158; 987-996.
15. Rocha AS, Soares P, Seruca R et al. Abnormalities of the E-cadherin/catenin adhesion complex in classical papillary thyroid carcinoma and in its diffuse sclerosing variant. J. Pathol. 2001: 194; 358-366.
16. Rocha AS, Soares P, Machado JC et al. Mucoepidermoid carcinoma of the thyroid: a tumour histotype characterised by P-cadherin neoexpression and marked abnormalities of E-cadherin/catenins complex. Virchows Arch. 2002: 440; 498-504.
17. Sakamoto A, Kasai N, Sugano H. Poorly differentiated carcinoma of the thyroid. A clinicopathologic entity for a high risk group of papillary and follicular carcinomas. Cancer 1983: 52; 1849-1855.
18. Papotti M, Micca B, Favero A, Palestini N, Bussolati G. Poorly differentiated thyroid carcinomas with primordial cell component. A group of aggressive lesions sharing insular, trabecular and solid patterns. Am. J. Surg. Pathol. 1993: 17; 291-301.
19. Pilloti S, Collini P, Manzari A, Marubini E, Rilke F. Poorly differentiated forms of papillary thyroid carcinoma: distinctive entities or morphological patterns? Semin. Diagn. Pathol. 1995: 12; 245-255.
20. Sobrinho-Simoes M, Sambade C, Fonseea E, Soares P. Poorly differentiated carcinomas of the thyroid gland: a review of the clinicopathologic features of a series of 28 cases of a heterogeneous, clinically aggressive group of thyroid tumors. Int. J. Surg. Pathol. 2002: 10; 123-131.
21. Baloch ZW, LiVolsi VA. Newly described tumours of the thyroid. Cur. Diagn. Pathol. 2000: 6; 151-164.
22. Hedinger C, Williams ED, Sobin LH. (eds) Histological typing of thyroid tumours. In International histologic classification of tumours. 2nd edn. Berlin: World Health Organization - Springer Verlag. 1998: 9.
23. Berx G, Cleton-Jansen AM, Strumane K et al. E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain. Oncogene 1996: 9; 1919-1925.
24. Scheumann GF, Hoang-Vu C, Cetin Y et al. Clinical significance of E-cadherin as a prognostic marker in thyroid carcinomas. J. Clin. Endocrinol. Metab. 1995: 80; 2168-2172.
25. Brabant G, Hoang-Vu Cetin Y, Dralle H et al. E-cadherin: a differentiation marker in thyroid malignancies. Cancer Res. 1993: 53; 4987-4993.
26. Vasioukhin V, Bauer C, Yin M, Fuchs E. Directed actin polymerization is the driving force for epithelial cell-cell adhesion. Cell 2000: 100; 209-219.
27. Graff J, Greenberg VE, Herman JG et al. Distinct patterns of E-cadherin CpG island methylation in papillary, follicular, Hurthle's cell, and poorly differentiated human thyroid carcinoma. Cancer Res. 1998: 58; 2063-2066.
28. Hüsmark J, Heldin NE, Nilsson M. N-cadherin-mediated adhesion and aberrant catenin expression in anaplastic thyroid-carcinoma cell lines. Int. J. Cancer 1999: 83; 692-699.
29. Pötter E, Braun S, Lehmann U, Brabant G. Molecular cloning of a functional promoter of the human plakoglobin gene. Eur. J. Endocrinol. 2001: 145; 625-633.
30. Schulz S, Becker KF, Braungart E et al. Molecular analysis of E-cadherin and cadherin-11 in Wilms' tumours. J. Pathol. 2000: 191; 162-169.