Long-Term Effects of Early Overnutrition in the Heart of Male Adult Rats: Role of the Renin-Angiotensin System

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Granado, Miriam ^a,b   Fernández, Nuria ^a   Monge, Luis ^a   Carreño Tarragona, Gonzalo ^a   Figueras, Juan Carlos ^a   Amor, Sara ^a   García Villalón, Ángel Luis ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b Instituto de Salud Carlos III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN II; ANGIOTENSINOGEN; BRADYKININ; CELL RECEPTOR; BIOLOGICAL MARKER; LEPTIN;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BODY FAT; BODY WEIGHT; CONTROLLED STUDY; CORONARY ARTERY CONSTRICTION; HEART MUSCLE CONTRACTILITY; HEART PERFUSION; IMMUNOBLOTTING; ISOLATED HEART; LACTATION; MALE; NONHUMAN; OVERNUTRITION; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REPERFUSION INJURY; VASODILATATION; AGING; ANIMAL; BLOOD; DRUG EFFECTS; FEEDING BEHAVIOR; GENE EXPRESSION REGULATION; GENETICS; HEART; HEART MUSCLE; HEMODYNAMICS; IN VITRO STUDY; INFLAMMATION; METABOLISM; ORGAN SIZE; PATHOLOGY; PATHOPHYSIOLOGY; PERFUSION; SPRAGUE DAWLEY RAT; TIME; VASOCONSTRICTION;

RATTUS;

AGING; ANGIOTENSIN II; ANIMALS; APOPTOSIS; BIOLOGICAL MARKERS; BRADYKININ; FEEDING BEHAVIOR; GENE EXPRESSION REGULATION; HEART; HEMODYNAMICS; IN VITRO TECHNIQUES; INFLAMMATION; LEPTIN; MALE; MYOCARDIUM; ORGAN SIZE; OVERNUTRITION; PERFUSION; RATS, SPRAGUE-DAWLEY; RENIN-ANGIOTENSIN SYSTEM; TIME FACTORS; VASOCONSTRICTION; VASODILATION;

EID: 84878625520     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0065172     Document Type: Article

References (70)

1. Nguyen DM, El-Serag HB, (2010) The epidemiology of obesity. Gastroenterol Clin North Am 39: 1-7.
2. Field AE, Coakley EH, Must A, Spadano JL, Laird N, et al. (2001) Impact of overweight on the risk of developing common chronic diseases during a 10-year period. Arch Intern Med 161: 1581-1586.
3. Schunkert H, (2002) Obesity and target organ damage: the heart. Int J Obes Relat Metab Disord 26Suppl 4: S15-S20.
4. Lavie CJ, Milani RV, Ventura HO, (2009) Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss. J Am Coll Cardiol 53: 1925-1932.
5. Klein S, Burke LE, Bray GA, Blair S, Allison DB, et al. (2004) Clinical implications of obesity with specific focus on cardiovascular disease: a statement for professionals from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism: endorsed by the American College of Cardiology Foundation. Circulation 110: 2952-2967.
6. Trivedi PS, Barouch LA, (2008) Cardiomyocyte apoptosis in animal models of obesity. Curr Hypertens Rep 10: 454-460.
7. Dyntar D, Eppenberger-Eberhardt M, Maedler K, Pruschy M, Eppenberger HM, et al. (2001) Glucose and palmitic acid induce degeneration of myofibrils and modulate apoptosis in rat adult cardiomyocytes. Diabetes 50: 2105-2113.
8. Listenberger LL, Schaffer JE, (2002) Mechanisms of lipoapoptosis: implications for human heart disease. Trends Cardiovasc Med 12: 134-138.
9. Zhou YT, Grayburn P, Karim A, Shimabukuro M, Higa M, et al. (2000) Lipotoxic heart disease in obese rats: implications for human obesity. Proc Natl Acad Sci U S A 97: 1784-1789.
10. Barouch LA, Gao D, Chen L, Miller KL, Xu W, et al. (2006) Cardiac myocyte apoptosis is associated with increased DNA damage and decreased survival in murine models of obesity. Circ Res 98: 119-124.
11. Gavras H, Kremer D, Brown JJ, Gray B, Lever AF, et al. (1975) Angiotensin- and norepinephrine-induced myocardial lesions: experimental and clinical studies in rabbits and man. Am Heart J 89: 321-332.
12. Gavras H, Lever AF, Brown JJ, Macadam RF, Robertson JI, (1971) Acute renal failure, tubular necrosis, and myocardial infarction induced in the rabbit by intravenous angiotensin II. Lancet 2: 19-22.
13. Giacomelli F, Anversa P, Wiener J, (1976) Effect of angiotensin-induced hypertension on rat coronary arteries and myocardium. Am J Pathol 84: 111-138.
14. Goossens GH, Blaak EE, van Baak MA, (2003) Possible involvement of the adipose tissue renin-angiotensin system in the pathophysiology of obesity and obesity-related disorders. Obes Rev 4: 43-55.
15. Kremer D, Lindop G, Brown WC, Morton JJ, Robertson JI, (1981) Angiotensin-induced myocardial necrosis and renal failure in the rabbit: distribution of lesions and severity in relation to plasma angiotensin II concentration and arterial pressure. Cardiovasc Res 15: 43-46.
16. Mello WD, (2003) Effect of extracellular and intracellular angiotensins on heart cell function; on the cardiac renin-angiotensin system. Regul Pept 114: 87-90.
17. Marchesi C, Paradis P, Schiffrin EL, (2008) Role of the renin-angiotensin system in vascular inflammation. Trends Pharmacol Sci 29: 367-374.
18. Dimmeler S, Zeiher AM, (2000) Reactive oxygen species and vascular cell apoptosis in response to angiotensin II and pro-atherosclerotic factors. Regul Pept 90: 19-25.
19. Batenburg WW, Danser AHJ, (2012) (Pro)renin and its receptors: pathophysiological implications. Clin Sci (Lond) 123: 121-133.
20. Schefe JH, Menk M, Reinemund J, Effertz K, Hobbs RM, et al. (2006) A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein. Circ Res 99: 1355-1366.
21. Mello WCD, Frohlich ED, (2011) On the local cardiac renin angiotensin system. Basic and clinical implications. Peptides 32: 1774-1779.
22. Lamarche B, Lemieux S, Dagenais GR, Després JP (1998) Visceral obesity and the risk of ischaemic heart disease: insights from the Québec Cardiovascular Study. Growth Horm IGF Res 8 Suppl B: 1-8.
23. Viner RM, Cole TJ, (2006) Who changes body mass between adolescence and adulthood? Factors predicting change in BMI between 16 year and 30 years in the 1970 British Birth Cohort. Int J Obes (Lond) 30: 1368-1374.
24. Logue J, Sattar N, (2011) Childhood obesity: a ticking time bomb for cardiovascular disease? Clin Pharmacol Ther 90: 174-178.
25. Davidowa H, Plagemann A, (2000) Different responses of ventromedial hypothalamic neurons to leptin in normal and early postnatally overfed rats. Neurosci Lett 293: 21-24.
26. Davidowa H, Plagemann A, (2007) Insulin resistance of hypothalamic arcuate neurons in neonatally overfed rats. Neuroreport 18: 521-524.
27. García-Villalón AL, Amezquita YM, Monge L, Fernández N, Climent B, et al. (2005) Effect of ischemia duration and nitric oxide on coronary vasoconstriction after ischemia-reperfusion. Eur J Pharmacol 509: 165-170.
28. García-Villalón AL, Monge L, Fernández N, Salcedo A, Narváez-Sánchez R, et al. (2009) Coronary response to diadenosine pentaphosphate after ischaemia-reperfusion in the isolated rat heart. Cardiovasc Res 81: 336-343.
29. Chomczynski P (1993) A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. Biotechniques 15: 532-534, 536-537.
30. Livak KJ, Schmittgen TD, (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408.
31. Eisenmann JC, Wickel EE, Welk GJ, Blair SN, (2005) Relationship between adolescent fitness and fatness and cardiovascular disease risk factors in adulthood: the Aerobics Center Longitudinal Study (ACLS). Am Heart J 149: 46-53.
32. Li Z-L, Woollard JR, Ebrahimi B, Crane JA, Jordan KL, et al. (2012) Transition from obesity to metabolic syndrome is associated with altered myocardial autophagy and apoptosis. Arterioscler Thromb Vasc Biol 32: 1132-1141.
33. Lee S-D, Tzang B-S, Kuo W-W, Lin Y-M, Yang A-L, et al. (2007) Cardiac fas receptor-dependent apoptotic pathway in obese Zucker rats. Obesity (Silver Spring) 15: 2407-2415.
34. Lu M-C, Tzang B-S, Kuo W-W, Wu F-L, Chen Y-S, et al. (2007) More activated cardiac mitochondrial-dependent apoptotic pathway in obese Zucker rats. Obesity (Silver Spring) 15: 2634-2642.
35. Granado M, Fernandez N, Monge L, Figueras JC, Carreno-Tarragona G, et al. (2013) Effects of coronary ischemia-reperfusion in a rat model of early overnutrition. Role of Angiotensin receptors. PLoS One 8: e54984.
36. Black MJ, Siebel AL, Gezmish O, Moritz KM, Wlodek ME, (2012) Normal lactational environment restores cardiomyocyte number after uteroplacental insufficiency: implications for the preterm neonate. Am J Physiol Regul Integr Comp Physiol 302: R1101-R1110.
37. Li F, Wang X, Capasso JM, Gerdes AM, (1996) Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development. J Mol Cell Cardiol 28: 1737-1746.
38. du Toit EF, Nabben M, Lochner A, (2005) A potential role for angiotensin II in obesity induced cardiac hypertrophy and ischaemic/reperfusion injury. Basic Res Cardiol 100: 346-354.
39. Sishi B, Loos B, Ellis B, Smith W, du Toit EF, et al. (2011) Diet-induced obesity alters signalling pathways and induces atrophy and apoptosis in skeletal muscle in a prediabetic rat model. Exp Physiol 96: 179-193.
40. Yim HE, Ha KS, Bae IS, Yoo KH, Hong YS, et al. (2011) Postnatal early overnutrition dysregulates the intrarenal renin-angiotensin system and extracellular matrix-linked molecules in juvenile male rats. J Nutr Biochem.
41. Bohlen HG, Nase GP, (2002) Obesity lowers hyperglycemic threshold for impaired in vivo endothelial nitric oxide function. Am J Physiol Heart Circ Physiol 283: H391-H397.
42. Frisbee JC, Stepp DW, (2001) Impaired NO-dependent dilation of skeletal muscle arterioles in hypertensive diabetic obese Zucker rats. Am J Physiol Heart Circ Physiol 281: H1304-H1311.
43. Fujiwara K, Hayashi K, Matsuda H, Kubota E, Honda M, et al. (1999) Altered pressure-natriuresis in obese Zucker rats. Hypertension 33: 1470-1475.
44. Erdös B, Snipes JA, Miller AW, Busija DW, (2004) Cerebrovascular dysfunction in Zucker obese rats is mediated by oxidative stress and protein kinase C. Diabetes. 53: 1352-1359.
45. Galili O, Versari D, Sattler KJ, Olson ML, Mannheim D, et al. (2007) Early experimental obesity is associated with coronary endothelial dysfunction and oxidative stress. Am J Physiol Heart Circ Physiol 292: H904-H911.
46. Miller AW, Katakam PV, Ujhelyi MR, (1999) Impaired endothelium-mediated relaxation in coronary arteries from insulin-resistant rats. J Vasc Res 36: 385-392.
47. Oltman CL, Richou LL, Davidson EP, Coppey LJ, Lund DD, et al. (2006) Progression of coronary and mesenteric vascular dysfunction in Zucker obese and Zucker diabetic fatty rats. Am J Physiol Heart Circ Physiol 291: H1780-H1787.
48. Dixon JL, Stoops JD, Parker JL, Laughlin MH, Weisman GA, et al. (1999) Dyslipidemia and vascular dysfunction in diabetic pigs fed an atherogenic diet. Arterioscler Thromb Vasc Biol 19: 2981-2992.
49. Knudson JD, Dincer UD, Dick GM, Shibata H, Akahane R, et al. (2005) Leptin resistance extends to the coronary vasculature in prediabetic dogs and provides a protective adaptation against endothelial dysfunction. Am J Physiol Heart Circ Physiol 289: H1038-H1046.
50. Prakash R, Mintz JD, Stepp DW, (2006) Impact of obesity on coronary microvascular function in the Zucker rat. Microcirculation 13: 389-396.
51. de Chantemele EJB, Stepp DW, (2012) Influence of obesity and metabolic dysfunction on the endothelial control in the coronary circulation. J Mol Cell Cardiol 52: 840-847.
52. Pascual M, Pascual DA, Soria F, Vicente T, Hernández AM, et al. (2003) Effects of isolated obesity on systolic and diastolic left ventricular function. Heart 89: 1152-1156.
53. Stepp DW, Nishikawa Y, Chilian WM, (1999) Regulation of shear stress in the canine coronary microcirculation. Circulation 100: 1555-1561.
54. Zhang C, Park Y, Picchi A, Potter BJ, (2008) Maturation-induces endothelial dysfunction via vascular inflammation in diabetic mice. Basic Res Cardiol 103: 407-416.
55. García-Villalón AL, Sanz E, Monge L, Fernández N, Climent B, et al. (2004) Urocortin protects coronary endothelial function during ischemia-reperfusion: a brief communication. Exp Biol Med (Maywood) 229: 118-120.
56. Fowler JD, Krueth SB, Bernlohr DA, Katz SA, (2009) Renin dynamics in adipose tissue: adipose tissue control of local renin concentrations. Am J Physiol Endocrinol Metab 296: E343-E350.
57. Trask AJ, Jessup JA, Chappell MC, Ferrario CM, (2008) Angiotensin-(1-12) is an alternate substrate for angiotensin peptide production in the heart. Am J Physiol Heart Circ Physiol 294: H2242-H2247.
58. Jan Danser AH, Saris JJ, (2002) Prorenin uptake in the heart: a prerequisite for local angiotensin generation? J Mol Cell Cardiol 34: 1463-1472.
59. Müller DN, Fischli W, Clozel JP, Hilgers KF, Bohlender J, et al. (1998) Local angiotensin II generation in the rat heart: role of renin uptake. Circ Res 82: 13-20.
60. Lindpaintner K, Jin MW, Niedermaier N, Wilhelm MJ, Ganten D, (1990) Cardiac angiotensinogen and its local activation in the isolated perfused beating heart. Circ Res 67: 564-573.
61. Altarche-Xifró W, Curato C, Kaschina E, Grzesiak A, Slavic S, et al. (2009) Cardiac c-kit+AT2+ cell population is increased in response to ischemic injury and supports cardiomyocyte performance. Stem Cells 27: 2488-2497.
62. Busche S, Gallinat S, Bohle RM, Reinecke A, Seebeck J, et al. (2000) Expression of angiotensin AT(1) and AT(2) receptors in adult rat cardiomyocytes after myocardial infarction. A single-cell reverse transcriptase-polymerase chain reaction study. Am J Pathol 157: 605-611.
63. Nio Y, Matsubara H, Murasawa S, Kanasaki M, Inada M, (1995) Regulation of gene transcription of angiotensin II receptor subtypes in myocardial infarction. J Clin Invest 95: 46-54.
64. Shimizu M, Wang QD, Sjöquist PO, Rydén L, (1999) Combination of a calcium antagonist, a lipid-peroxidation inhibitor, and an angiotensin AT1-receptor antagonist provides additive myocardial infarct size-limiting effect in pigs. J Cardiovasc Pharmacol 34: 512-517.
65. Wang QD, Sjöquist PO, (1999) Effects of the insurmountable angiotensin AT1 receptor antagonist candesartan and the surmountable antagonist losartan on ischemia/reperfusion injury in rat hearts. Eur J Pharmacol 380: 13-21.
66. Werrmann JG, Cohen SM, (1996) Use of losartan to examine the role of the cardiac renin-angiotensin system in myocardial dysfunction during ischemia and reperfusion. J Cardiovasc Pharmacol 27: 177-182.
67. Nguyen G, Delarue F, Burcklé C, Bouzhir L, Giller T, et al. (2002) Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest 109: 1417-1427.
68. Saris JJ, 't Hoen PAC, Garrelds IM, Dekkers DHW, den Dunnen JT, et al. (2006) Prorenin induces intracellular signaling in cardiomyocytes independently of angiotensin II. Hypertension 48: 564-571.
69. Hirose T, Mori N, Totsune K, Morimoto R, Maejima T, et al. (2009) Gene expression of (pro)renin receptor is upregulated in hearts and kidneys of rats with congestive heart failure. Peptides 30: 2316-2322.
70. Ichihara A, Kaneshiro Y, Takemitsu T, Sakoda M, Suzuki F, et al. (2006) Nonproteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension. Hypertension 47: 894-900.