Use of losartan to examine the role of the cardiac renin-angiotensin system in myocardial dysfunction during ischemia and reperfusion

Journal of Cardiovascular Pharmacology

Volumn 27, Issue 2, 1996, Pages 177-182

  Werrmann, Jeffrey G ^a   Cohen, Sheila M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

31P nuclear magnetic resonance; Angiotensin II antagonist; angiotensin system; Ischemia; Isolated working heart; Losartan; Renin

Indexed keywords

2 BUTYL 4 CHLORO 1 [[2' (1H TETRAZOL 5 YL) 4 BIPHENYLYL]METHYL] 5 IMIDAZOLECARBOXYLIC ACID; ALDOSTERONE; ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; L 158338; LISINOPRIL; LOSARTAN; RENIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PH; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART OUTPUT; ISOLATED HEART; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM;

ADENOSINE TRIPHOSPHATE; ANALYSIS OF VARIANCE; ANIMALS; ANTIHYPERTENSIVE AGENTS; BIPHENYL COMPOUNDS; CARDIAC OUTPUT; CORONARY CIRCULATION; HEART; HYDROGEN-ION CONCENTRATION; IMIDAZOLES; LOSARTAN; MALE; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION; MYOCARDIUM; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ANGIOTENSIN; RENIN-ANGIOTENSIN SYSTEM; TETRAZOLES;

EID: 0030069720     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199602000-00001     Document Type: Article

References (35)

1. Wong PC, Price WA, Chiu AT, et al. Nonpeptide angiotensin II receptor antagonists. IV. EXP6155 and EXP6803. Hypertension 1989;13:489-97.
2. Blankley CJ, Hodges JC, Klutchko SR, et al. Synthesis and structure-activity relationships of a novel series of nonpeptide angiotensin II receptor binding inhibitors specific for the AT-2 subtype. J Med Chem 1991;34:3248-60.
3. Chang RSL, Lotti VJ. Angiotensin receptor subtypes in rat, rabbit and monkey tissues: relative distribution and species dependency. Life Sci 1991;49:1485-90.
4. Hodges JC, Hamby JM, Blankley CJ. Angiotensin II receptor binding inhibitors. Drugs Fut 1992;17:575-93.
5. Raya TE, Fonken SJ, Lee RW, et al. Hemodynamic effects of direct angiotensin II blockade compared to converting enzyme inhibition in rat model of heart failure. Am J Hypertens 1991;4:334S-40S.
6. 1 receptor blockade on cardiac pump performance after myocardial infarction in rats. J Cardiovasc Pharmacol 1994; 23:584-93.
7. Schieffer B, Wirger A, Meybrunn M, et al. Comparative effects of chronic angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on cardiac remodeling after myocardial infarction in the rat. Circulation 1994;89:2273-82.
8. Capasso JM, Li P, Zhang X, Meggs LG, Anversa P. Alterations in ANG II responsiveness in left and right myocardium after infarction-induced heart failure in rats. Am J Physiol 1993;264(33):H2056-67.
9. Sun Y, Weber KT. Angiotensin II receptor binding following myocardial infarction in the rat. Cardiovasc Res 1994;28:1623-8.
10. Feolde E, Vigne P, Frelin C. Angiotensin II receptor subtypes and biological responses in the rat heart. J Mol Cell Cardiol 1993;25:1359-67.
11. de Graeff PA, van Gilst WH, Wesseling H. The cardiac renin-angiotensin system in different ischemic syndromes of the heart. In: Lindpaintner K, Ganten D, eds. The cardiacrenin angiotensin system. Armonk, NY: Futura Publishing, 1994:201-31.
12. Cohen SM, Werrmann JG, King BW. Simultaneous 31-P nuclear magnetic resonance spectroscopy and mechanical function in working heart models affected by drugs. Drug Dev Res 1989;18:305-25.
13. 31P NMR. J Cardiovasc Pharmacol 1994;24:573-86.
14. 1) receptor antagonist. Drug Dev Res 1994;32:161-71.
15. 1 angiotensin II receptors in rat brain, kidney and adrenals demonstrated by in vitro autoradiography. Clin Exp Pharmacol Physiol 1994;21:557-67.
16. Mantlo NB, Chakravarty PK, Ondeyka DL, et al. Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists. J Med Chem 1991;34:2919-22.
17. Neely JR, Liebermeister H, Battersby EJ, Morgan HE. Effect of pressure development on oxygen consumption by isolated rat heart. Am J Physiol 1967;212:804-14.
18. Neely JR, Rovetto MJ. Techniques for perfusing isolated rat hearts. In: Hardman JG, O'Malley BW, eds. Methods in enzymology. New York: Academic Press, 1975:43-60.
19. Taegtmeyer H, Hems R, Krebs HA. Utilization of energy-providing substrates in the isolated working rat heart. Biochem J 1980;186:701-11.
20. Zar JH. Biostatistical analysis. 2nd ed. Englewood Cliffs, NJ: Prentice-Hall, 1984:718.
21. Niesler RA, Fouche J, Peiser FE. The measurement of heat production, mechanical power, and oxygen consumption of the isolated working rat heart. Basic Res Cardiol 1985;80: 564-79.
22. Kannengiesser GJ, Opie LH, Van Der Werff TJ. Impaired cardiac work and oxygen uptake after reperfusion of regionally ischemic myocardium. J Mol Cell Cardiol 1979;11:197-207.
23. Reibel DK, Rovetto MJ. Myocardial ATP synthesis and mechanical function following oxygen deficiency. Am J Physiol 1978;234(5):H620-4.
24. + exchange on intracellular sodium and pH in working and ischemic hearts. Magn Reson Med 1994;32:556-64.
25. Chen TB, Lotti VJ, Chang RSL. Characterization of the binding of [3-H]L-158,809: a new potent and selective nonpeptide angiotensin II receptor (AT-1) antagonist radioligand. Mol Pharmacol 1992;42:1077-82.
26. Linz W, Scholkens BA, Han YF. Beneficial effects of the converting enzyme inhibitor, ramapril, in ischemic rat hearts. J Cardiovasc Pharmacol 1986;8(suppl 10):S91-9.
27. Li K, Chen X. Protective effects of captopril and enalapril on myocardial ischemia and reperfusion damage of rat. J Mol Cell Cardiol 1987;19:909-15.
28. Linz W, Martorana PA, Scholkens BA. Local inhibition of bradykinin degradation in ischemic hearts. J Cardiovasc Pharmacol 1990;15(suppl 6):S99-109.
29. Liu X, Engelman RM, Rousou JA, Cordis GA, Das DK. Attenuation of myocardial reperfusion injury by sulfhydryl-containing angiotensin converting enzyme inhibitors. Cardiovasc Drugs Ther 1992;6:437-43.
30. Wong PC, Price WA, Chiu AT, et al. Nonpeptide angiotensin II receptor antagonists. VIII. Characterization of functional antagonism displayed by DuP 753, an orally active antihypertensive agent. J Pharmacol Exp Ther 1990;252: 719-25.
31. 2 - receptors in endothelial cells and isolated ischemic rat hearts. Pharm Pharmacol Lett 1993;3:24-7.
32. Seyedi N, Xu XB, Nasjletti A, Hintze TH. Coronary kinin generation mediates nitric oxide release after angiotensin receptor stimulation. Hypertension 1995;26:164-70.
33. Mombouli JV, Vanhoutte PM. Kinins and endothelial control of vascular smooth muscle. Annu Rev Pharmacol Toxicol 1995;35:679-705.
34. Matsui H, Barry WH, Livsey C, Spitzer KW. Angiotensin II stimulates sodium-hydrogen exchange in adult rabbit ventricular myocytes. Cardiovasc Res 1995;29:215-21.
35. Cano A, Miller RT, Alpern RJ, Preisig PA. Angiotensin II stimulation of Na-H antiporter activity is cAMP independent in OKP cells. Am J Physiol 1994;266:C1603-8.