Effect of Polysorbate 80 concentration on thermal and photostability of a monoclonal antibody

AAPS PharmSciTech

Volumn 14, Issue 1, 2013, Pages 1-9

  Agarkhed, Meera ^a   O'Dell, Courtney ^a   Hsieh, Ming Ching ^a   Zhang, Jingming ^a   Goldstein, Joel ^a   Srivastava, Arvind ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

aggregation; monoclonal antibody; non ionic surfactant; oxidation; photostability; Polysorbate 80; thermal stability

Indexed keywords

IMMUNOGLOBULIN G1 ANTIBODY; MONOCLONAL ANTIBODY; POLYSORBATE 80;

ARTICLE; CIRCULAR DICHROISM; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DETERMINATION; DRUG FORMULATION; LIGHT EXPOSURE; LIGHT STRESS; PRIORITY JOURNAL; PROTEIN STABILITY; TEMPERATURE STRESS; THERMOSTABILITY; TURBIDITY;

ANTIBODIES, MONOCLONAL; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, ION EXCHANGE; CIRCULAR DICHROISM; HOT TEMPERATURE; PEPTIDE MAPPING; POLYSORBATES;

EID: 84878615128     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-012-9878-0     Document Type: Article

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