Molecular origins of surfactant-mediated stabilization of protein drugs

Advanced Drug Delivery Reviews

Volumn 63, Issue 13, 2011, Pages 1160-1171

  Lee, Hyo Jin ^a,b   McAuley, Arnold ^b   Schilke, Karl F ^a   McGuire, Joseph ^a  

^a Oregon State University   (United States)

^b AMGEN INC   (United States)

Author keywords

Adsorption; Aggregation; Formulation; Protein; Stabilization; Surfactant

Indexed keywords

COATING INTERFACES; DOWNSTREAM-PROCESSING; DRUG FORMULATIONS; FORMULATION; INTERFACIAL BEHAVIORS; INTERFACIAL INTERACTION; MOLECULAR FACTORS; MOLECULAR ORIGINS; PROTEIN DRUGS; PROTEIN LOSS; SURFACTANT; SURFACTANT PROPERTIES; THERAPEUTIC PROTEIN; THERMODYNAMIC MODEL;

ADSORPTION; AGGLOMERATION; COMPLEXATION; STABILIZATION; SURFACE ACTIVE AGENTS;

PROTEINS;

ALBUMIN; ALBUTROPIN; AMYLIN; DODECYL SULFATE SODIUM; HEPARIN; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G ANTIBODY; INSULIN; LUNG SURFACTANT; LYSOZYME; MACROGOL; METHIONINE; NOVEL ERYTHROPOIESIS STIMULATING PROTEIN; POLOXAMER; POLYSORBATE 20; POLYSORBATE 80; PROTEIN; RECOMBINANT BLOOD CLOTTING FACTOR 8; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; SILICONE OIL; SUCROSE; SURFACTANT; SURFACTANT PROTEIN B; SURFACTANT PROTEIN C; TAU INTERFERON; UNCLASSIFIED DRUG;

ADSORPTION; CELL SURFACE; CHEMICAL REACTION; CONCENTRATION (PARAMETERS); CONFORMATIONAL TRANSITION; CRITICAL MICELLE CONCENTRATION; DRUG FORMULATION; DRUG STABILITY; MOLECULAR INTERACTION; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; REVIEW; THERMODYNAMICS;

ADSORPTION; DRUG DESIGN; DRUG STABILITY; HUMANS; POLOXAMER; POLYSORBATES; PROTEINS; SURFACE-ACTIVE AGENTS; THERMODYNAMICS;

EID: 80054734435     PISSN: 0169409X     EISSN: 18728294     Source Type: Journal    
DOI: 10.1016/j.addr.2011.06.015     Document Type: Review

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