Construction and modelling of an inducible positive feedback loop stably integrated in a mammalian Cell-Line

PLoS Computational Biology

Volumn 7, Issue 6, 2011, Pages

  Siciliano, Velia ^a   Menolascina, Filippo ^a,b   Marucci, Lucia ^a,b   Fracassi, Chiara ^a   Garzilli, Immacolata ^a   Moretti, Maria Nicoletta ^a   di Bernardo, Diego ^a,b  

^a TELETHON INSTITUTE OF GENETICS AND MEDICINE TIGEM   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CELL SIGNALING; FEEDBACK; FLUORESCENCE; MAMMALS; NETWORK TOPOLOGY;

CELL/B.E; DOXYCYCLINE; LOOP NETWORKS; MAMMALIAN CELL LINES; MAMMALIAN CELLS; POSITIVE FEEDBACK LOOP; POSITIVE FEEDBACK NETWORKS; SIGNALLING PATHWAYS; TRANSACTIVATORS; TRANSCRIPTIONAL REGULATORY NETWORKS;

DYNAMICS;

DOXYCYCLINE; LENTIVIRUS VECTOR; MESSENGER RNA; TETRACYCLINE CONTROLLED TRANSACTIVATOR PROTEIN; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG; YELLOW FLUORESCENT PROTEIN; DNA;

ANIMAL CELL; ARTICLE; AUTOREGULATION; CELL EXPANSION; CELL MOTILITY; CELL POPULATION; CHO CELL; CLONAL SPECIES; CONTROLLED STUDY; DNA SEQUENCE; ENZYME REPRESSION; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; NONHUMAN; POSITIVE FEEDBACK; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; REPORTER GENE; RESPONSE TIME; SIGNAL TRANSDUCTION; SYNTHETIC BIOLOGY; TIME LAPSE IMAGING; TRANSCRIPTION REGULATION; ANIMAL; BIOLOGICAL MODEL; CELL STRAIN HEK293; CRICETULUS; FEEDBACK SYSTEM; GENETIC TRANSCRIPTION; GENETICS; HAMSTER; HOMEOSTASIS; NONLINEAR SYSTEM; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYSTEMS BIOLOGY;

MAMMALIA;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; DNA; DOXYCYCLINE; FEEDBACK, PHYSIOLOGICAL; GENE EXPRESSION REGULATION; HEK293 CELLS; HOMEOSTASIS; HUMANS; MODELS, GENETIC; NONLINEAR DYNAMICS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SYNTHETIC BIOLOGY; SYSTEMS BIOLOGY; TRANSCRIPTION, GENETIC;

EID: 79959814519     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1002074     Document Type: Article

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