메뉴 건너뛰기




Volumn 114, Issue 5, 2013, Pages 566-577

Critical role for free radicals on sprint exercise-induced CaMKII and AMPKα phosphorylation in human skeletal muscle

Author keywords

Antioxidants; Antioxidants. AMP actived protein kinase; Exercise; Fatigue; Sprint

Indexed keywords

ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; ANTIOXIDANT; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; FREE RADICAL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; LACTIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE; PRKAA1 PROTEIN, HUMAN; PRKAA2 PROTEIN, HUMAN; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE;

EID: 84878566982     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01246.2012     Document Type: Article
Times cited : (49)

References (76)
  • 2
    • 0028872347 scopus 로고
    • Recovery of power output and muscle metabolites following 30 s of maximal sprint cycling in man
    • Bogdanis GC, Nevill ME, Boobis LH, Lakomy HK, Nevill AM. Recovery of power output and muscle metabolites following 30 s of maximal sprint cycling in man. J Physiol 482: 467-480, 1995.
    • (1995) J Physiol , vol.482 , pp. 467-480
    • Bogdanis, G.C.1    Nevill, M.E.2    Boobis, L.H.3    Lakomy, H.K.4    Nevill, A.M.5
  • 3
    • 0001359488 scopus 로고
    • Wege des Wasserstoffs in der lebendigen Organization
    • Bücher T, Klingenberg M. Wege des Wasserstoffs in der lebendigen Organization. Angew Chemie 70: 552-570, 1958.
    • (1958) Angew Chemie , vol.70 , pp. 552-570
    • Bücher, T.1    Klingenberg, M.2
  • 4
    • 0028470598 scopus 로고
    • Vitamin E: Molecular and biological function
    • Burton GW. Vitamin E: molecular and biological function. Proc Nutr Soc 53: 251-262, 1994.
    • (1994) Proc Nutr Soc , vol.53 , pp. 251-262
    • Burton, G.W.1
  • 5
    • 0030667467 scopus 로고    scopus 로고
    • Fractional use of anaerobic capacity during a 30-and a 45-s Wingate test
    • Calbet JA, Chavarren J, Dorado C. Fractional use of anaerobic capacity during a 30-and a 45-s Wingate test. Eur J Appl Physiol Occup Physiol 76: 308-313, 1997.
    • (1997) Eur J Appl Physiol Occup Physiol , vol.76 , pp. 308-313
    • Calbet, J.A.1    Chavarren, J.2    Dorado, C.3
  • 6
    • 12244269097 scopus 로고    scopus 로고
    • Anaerobic energy provision does not limit Wingate exercise performance in endurance-trained cyclists
    • Calbet JA, De Paz JA, Garatachea N, Cabeza de Vaca S, Chavarren J. Anaerobic energy provision does not limit Wingate exercise performance in endurance-trained cyclists. J Appl Physiol 94: 668-676, 2003.
    • (2003) J Appl Physiol , vol.94 , pp. 668-676
    • Calbet, J.A.1    De Paz, J.A.2    Garatachea, N.3    Cabeza De Vaca, S.4    Chavarren, J.5
  • 7
    • 0023642627 scopus 로고
    • A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis
    • Carling D, Zammit VA, Hardie DG. A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis. FEBS Lett 223: 217-222, 1987.
    • (1987) FEBS Lett , vol.223 , pp. 217-222
    • Carling, D.1    Zammit, V.A.2    Hardie, D.G.3
  • 11
    • 77954070031 scopus 로고    scopus 로고
    • Exercise intensity-dependent regulation of peroxisome proliferator-activated receptor coactivator-1 mRNA abundance is associated with differential activation of upstream signalling kinases in human skeletal muscle
    • Egan B, Carson BP, Garcia-Roves PM, Chibalin AV, Sarsfield FM, Barron N, McCaffrey N, Moyna NM, Zierath JR, O'Gorman DJ. Exercise intensity-dependent regulation of peroxisome proliferator-activated receptor coactivator-1 mRNA abundance is associated with differential activation of upstream signalling kinases in human skeletal muscle. J Physiol 588: 1779-1790, 2010.
    • (2010) J Physiol , vol.588 , pp. 1779-1790
    • Egan, B.1    Carson, B.P.2    Garcia-Roves, P.M.3    Chibalin, A.V.4    Sarsfield, F.M.5    Barron, N.6    McCaffrey, N.7    Moyna, N.M.8    Zierath, J.R.9    O'Gorman, D.J.10
  • 16
    • 38149131289 scopus 로고    scopus 로고
    • Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance
    • Gomez-Cabrera MC, Domenech E, Romagnoli M, Arduini A, Borras C, Pallardo FV, Sastre J, Vina J. Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. Am J Clin Nutr 87: 142-149, 2008.
    • (2008) Am J Clin Nutr , vol.87 , pp. 142-149
    • Gomez-Cabrera, M.C.1    Domenech, E.2    Romagnoli, M.3    Arduini, A.4    Borras, C.5    Pallardo, F.V.6    Sastre, J.7    Vina, J.8
  • 22
    • 80054029513 scopus 로고    scopus 로고
    • Deacetylation of PGC-1α by SIRT1: Importance for skeletal muscle function and exercise-induced mitochondrial biogenesis
    • Gurd BJ. Deacetylation of PGC-1α by SIRT1: importance for skeletal muscle function and exercise-induced mitochondrial biogenesis. Appl Physiol Nutr Metab 36: 589-597, 2011.
    • (2011) Appl Physiol Nutr Metab , vol.36 , pp. 589-597
    • Gurd, B.J.1
  • 24
    • 34648828532 scopus 로고    scopus 로고
    • AMP-activated/SNF1 protein kinases: Conserved guardians of cellular energy
    • Hardie DG. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol 8: 774-785, 2007.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 774-785
    • Hardie, D.G.1
  • 25
    • 0031717105 scopus 로고    scopus 로고
    • The AMP-activated/SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell?
    • Hardie DG, Carling D, Carlson M. The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu Rev Biochem 67: 821-855, 1998.
    • (1998) Annu Rev Biochem , vol.67 , pp. 821-855
    • Hardie, D.G.1    Carling, D.2    Carlson, M.3
  • 26
    • 0017047070 scopus 로고
    • The time course of phosphorylcreatine resynthesis during recovery of the quadriceps muscle in man
    • Harris RC, Edwards RH, Hultman E, Nordesjo LO, Nylind B, Sahlin K. The time course of phosphorylcreatine resynthesis during recovery of the quadriceps muscle in man. Pflügers Arch 367: 137-142, 1976.
    • (1976) Pflügers Arch , vol.367 , pp. 137-142
    • Harris, R.C.1    Edwards, R.H.2    Hultman, E.3    Nordesjo, L.O.4    Nylind, B.5    Sahlin, K.6
  • 28
    • 33646828975 scopus 로고    scopus 로고
    • Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase α-subunits in heart via hierarchical phosphorylation of Ser485/491
    • Horman S, Vertommen D, Heath R, Neumann D, Mouton V, Woods A, Schlattner U, Wallimann T, Carling D, Hue L, Rider MH. Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase α-subunits in heart via hierarchical phosphorylation of Ser485/491. J Biol Chem 281: 5335-5340, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 5335-5340
    • Horman, S.1    Vertommen, D.2    Heath, R.3    Neumann, D.4    Mouton, V.5    Woods, A.6    Schlattner, U.7    Wallimann, T.8    Carling, D.9    Hue, L.10    Rider, M.H.11
  • 30
    • 33645860825 scopus 로고    scopus 로고
    • Reactive oxygen species have a causal role in multiple forms of insulin resistance
    • Houstis N, Rosen ED, Lander ES. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 440: 944-948, 2006.
    • (2006) Nature , vol.440 , pp. 944-948
    • Houstis, N.1    Rosen, E.D.2    Lander, E.S.3
  • 31
    • 33845972272 scopus 로고    scopus 로고
    • Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP
    • Hurley RL, Barre LK, Wood SD, Anderson KA, Kemp BE, Means AR, Witters LA. Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP. J Biol Chem 281: 36662-36672, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 36662-36672
    • Hurley, R.L.1    Barre, L.K.2    Wood, S.D.3    Anderson, K.A.4    Kemp, B.E.5    Means, A.R.6    Witters, L.A.7
  • 33
    • 34547545892 scopus 로고    scopus 로고
    • AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
    • Jager S, Handschin C, St-Pierre J, Spiegelman BM. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α. Proc Natl Acad Sci USA 104: 12017-12022, 2007.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 12017-12022
    • Jager, S.1    Handschin, C.2    St-Pierre, J.3    Spiegelman, B.M.4
  • 34
    • 0141925771 scopus 로고    scopus 로고
    • Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart
    • Kovacic S, Soltys CL, Barr AJ, Shiojima I, Walsh K, Dyck Jr. Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart. J Biol Chem 278: 39422-39427, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 39422-39427
    • Kovacic, S.1    Soltys, C.L.2    Barr, A.J.3    Shiojima, I.4    Walsh, K.5    Dyck, J.R.6
  • 35
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685, 1970.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 37
    • 0031408823 scopus 로고    scopus 로고
    • Effects of ubiquinone-10 supplementation and high intensity training on physical performance in humans
    • Malm C, Svensson M, Ekblom B, Sjodin B. Effects of ubiquinone-10 supplementation and high intensity training on physical performance in humans. Acta Physiol Scand 161: 379-384, 1997.
    • (1997) Acta Physiol Scand , vol.161 , pp. 379-384
    • Malm, C.1    Svensson, M.2    Ekblom, B.3    Sjodin, B.4
  • 38
    • 70350337093 scopus 로고    scopus 로고
    • Vitamin C: Update on physiology and pharmacology
    • Mandl J, Szarka A, Banhegyi G. Vitamin C: update on physiology and pharmacology. Br J Pharmacol 157: 1097-1110, 2009.
    • (2009) Br J Pharmacol , vol.157 , pp. 1097-1110
    • Mandl, J.1    Szarka, A.2    Banhegyi, G.3
  • 39
    • 14744294827 scopus 로고    scopus 로고
    • Bcl-2 in endothelial cells is increased by vitamin e and α-lipoic acid supplementation but not exercise training
    • Marsh SA, Laursen PB, Pat BK, Gobe GC, Coombes JS. Bcl-2 in endothelial cells is increased by vitamin E and α-lipoic acid supplementation but not exercise training. J Mol Cell Cardiol 38: 445-451, 2005.
    • (2005) J Mol Cell Cardiol , vol.38 , pp. 445-451
    • Marsh, S.A.1    Laursen, P.B.2    Pat, B.K.3    Gobe, G.C.4    Coombes, J.S.5
  • 40
    • 0031425839 scopus 로고    scopus 로고
    • AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle
    • Merrill GF, Kurth EJ, Hardie DG, Winder WW. AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. Am J Physiol Endocrinol Metab 273: E1107-E1112, 1997.
    • (1997) Am J Physiol Endocrinol Metab , vol.273
    • Merrill, G.F.1    Kurth, E.J.2    Hardie, D.G.3    Winder, W.W.4
  • 41
    • 77952929323 scopus 로고    scopus 로고
    • N-acetylcysteine infusion does not affect glucose disposal during prolonged moderate-intensity exercise in humans
    • Merry TL, Wadley GD, Stathis CG, Garnham AP, Rattigan S, Hargreaves M, McConell GK. N-acetylcysteine infusion does not affect glucose disposal during prolonged moderate-intensity exercise in humans. J Physiol 588: 1623-1634, 2010.
    • (2010) J Physiol , vol.588 , pp. 1623-1634
    • Merry, T.L.1    Wadley, G.D.2    Stathis, C.G.3    Garnham, A.P.4    Rattigan, S.5    Hargreaves, M.6    McConell, G.K.7
  • 42
    • 0036070514 scopus 로고    scopus 로고
    • Antioxidant and prooxidant activities of alpha-lipoic acid and dihydrolipoic acid
    • Moini H, Packer L, Saris NE. Antioxidant and prooxidant activities of alpha-lipoic acid and dihydrolipoic acid. Toxicol Appl Pharmacol 182: 84-90, 2002.
    • (2002) Toxicol Appl Pharmacol , vol.182 , pp. 84-90
    • Moini, H.1    Packer, L.2    Saris, N.E.3
  • 44
    • 80052317552 scopus 로고    scopus 로고
    • Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels
    • Mungai PT, Waypa GB, Jairaman A, Prakriya M, Dokic D, Ball MK, Schumacker PT. Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels. Mol Cell Biol 31: 3531-3545, 2011.
    • (2011) Mol Cell Biol , vol.31 , pp. 3531-3545
    • Mungai, P.T.1    Waypa, G.B.2    Jairaman, A.3    Prakriya, M.4    Dokic, D.5    Ball, M.K.6    Schumacker, P.T.7
  • 48
    • 77951870544 scopus 로고    scopus 로고
    • Differential AMPK phosphorylation sites associated with phenylephrine vs. antihypertrophic effects of adenosine agonists in neonatal rat ventricular myocytes
    • Pang T, Rajapurohitam V, Cook MA, Karmazyn M. Differential AMPK phosphorylation sites associated with phenylephrine vs. antihypertrophic effects of adenosine agonists in neonatal rat ventricular myocytes. Am J Physiol Heart Circ Physiol 298: H1382-H1390, 2010.
    • (2010) Am J Physiol Heart Circ Physiol , vol.298
    • Pang, T.1    Rajapurohitam, V.2    Cook, M.A.3    Karmazyn, M.4
  • 49
    • 0034027343 scopus 로고    scopus 로고
    • The distribution of rest periods affects performance and adaptations of energy metabolism induced by high-intensity training in human muscle
    • Parra J, Cadefau JA, Rodas G, Amigo N, Cusso R. The distribution of rest periods affects performance and adaptations of energy metabolism induced by high-intensity training in human muscle. Acta Physiol Scand 169: 157-165, 2000.
    • (2000) Acta Physiol Scand , vol.169 , pp. 157-165
    • Parra, J.1    Cadefau, J.A.2    Rodas, G.3    Amigo, N.4    Cusso, R.5
  • 51
    • 79953177835 scopus 로고    scopus 로고
    • Adrenergic regulation of AMP-activated protein kinase in brown adipose tissue in vivo
    • Pulinilkunnil T, He H, Kong D, Asakura K, Peroni OD, Lee A, Kahn BB. Adrenergic regulation of AMP-activated protein kinase in brown adipose tissue in vivo. J Biol Chem 286: 8798-8809, 2011.
    • (2011) J Biol Chem , vol.286 , pp. 8798-8809
    • Pulinilkunnil, T.1    He, H.2    Kong, D.3    Asakura, K.4    Peroni, O.D.5    Lee, A.6    Kahn, B.B.7
  • 52
    • 45149088263 scopus 로고    scopus 로고
    • Evidence for the involvement of CaMKII and AMPK in Ca2+-dependent signaling pathways regulating FA uptake and oxidation in contracting rodent muscle
    • Raney MA, Turcotte LP. Evidence for the involvement of CaMKII and AMPK in Ca2+-dependent signaling pathways regulating FA uptake and oxidation in contracting rodent muscle. J Appl Physiol 104: 1366-1373, 2008.
    • (2008) J Appl Physiol , vol.104 , pp. 1366-1373
    • Raney, M.A.1    Turcotte, L.P.2
  • 53
    • 13844256289 scopus 로고    scopus 로고
    • AMPK activation is not critical in the regulation of muscle FA uptake and oxidation during low-intensity muscle contraction
    • Raney MA, Yee AJ, Todd MK, Turcotte LP. AMPK activation is not critical in the regulation of muscle FA uptake and oxidation during low-intensity muscle contraction. Am J Physiol Endocrinol Metab 288: E592-E598, 2005.
    • (2005) Am J Physiol Endocrinol Metab , vol.288
    • Raney, M.A.1    Yee, A.J.2    Todd, M.K.3    Turcotte, L.P.4
  • 57
    • 84862610330 scopus 로고    scopus 로고
    • Upregulation of heart PFK-2/FBPase-2 isozyme in skeletal muscle after persistent contraction
    • Rovira J, Irimia JM, Guerrero M, Cadefau JA, Cusso R. Upregulation of heart PFK-2/FBPase-2 isozyme in skeletal muscle after persistent contraction. Pflügers Arch 463: 603-613, 2012.
    • (2012) Pflügers Arch , vol.463 , pp. 603-613
    • Rovira, J.1    Irimia, J.M.2    Guerrero, M.3    Cadefau, J.A.4    Cusso, R.5
  • 58
    • 0031683542 scopus 로고    scopus 로고
    • Prolonged oxidative stress impairs insulin-induced GLUT4 translocation in 3T3-L1 adipocytes
    • Rudich A, Tirosh A, Potashnik R, Hemi R, Kanety H, Bashan N. Prolonged oxidative stress impairs insulin-induced GLUT4 translocation in 3T3-L1 adipocytes. Diabetes 47: 1562-1569, 1998.
    • (1998) Diabetes , vol.47 , pp. 1562-1569
    • Rudich, A.1    Tirosh, A.2    Potashnik, R.3    Hemi, R.4    Kanety, H.5    Bashan, N.6
  • 59
    • 38649133871 scopus 로고    scopus 로고
    • α-Lipoic acid and ascorbate prevent LDL oxidation and oxidant stress in endothelial cells
    • Sabharwal AK, May JM. α-Lipoic acid and ascorbate prevent LDL oxidation and oxidant stress in endothelial cells. Mol Cell Biochem 309: 125-132, 2008.
    • (2008) Mol Cell Biochem , vol.309 , pp. 125-132
    • Sabharwal, A.K.1    May, J.M.2
  • 60
    • 0021925262 scopus 로고
    • NADH in human skeletal muscle during short-term intense exercise
    • Sahlin K. NADH in human skeletal muscle during short-term intense exercise. Pflügers Arch 403: 193-196, 1985.
    • (1985) Pflügers Arch , vol.403 , pp. 193-196
    • Sahlin, K.1
  • 61
    • 0016744282 scopus 로고
    • Creatine kinase equilibrium and lactate content compared with muscle pH in tissue samples obtained after isometric exercise
    • Sahlin K, Harris RC, Hultman E. Creatine kinase equilibrium and lactate content compared with muscle pH in tissue samples obtained after isometric exercise. Biochem J 152: 173-180, 1975.
    • (1975) Biochem J , vol.152 , pp. 173-180
    • Sahlin, K.1    Harris, R.C.2    Hultman, E.3
  • 62
    • 33746810466 scopus 로고    scopus 로고
    • Role of reactive oxygen species in contraction-mediated glucose transport in mouse skeletal muscle
    • Sandstrom ME, Zhang SJ, Bruton J, Silva JP, Reid MB, Westerblad H, Katz A. Role of reactive oxygen species in contraction-mediated glucose transport in mouse skeletal muscle. J Physiol 575: 251-262, 2006.
    • (2006) J Physiol , vol.575 , pp. 251-262
    • Sandstrom, M.E.1    Zhang, S.J.2    Bruton, J.3    Silva, J.P.4    Reid, M.B.5    Westerblad, H.6    Katz, A.7
  • 63
    • 0034545719 scopus 로고    scopus 로고
    • Quantification and significance of protein oxidation in biological samples
    • Shacter E. Quantification and significance of protein oxidation in biological samples. Drug Metab Rev 32: 307-326, 2000.
    • (2000) Drug Metab Rev , vol.32 , pp. 307-326
    • Shacter, E.1
  • 65
    • 33744937886 scopus 로고    scopus 로고
    • Activation of cardiac AMP-activated protein kinase by LKB1 expression or chemical hypoxia is blunted by increased Akt activity
    • Soltys CL, Kovacic S, Dyck Jr. Activation of cardiac AMP-activated protein kinase by LKB1 expression or chemical hypoxia is blunted by increased Akt activity. Am J Physiol Heart Circ Physiol 290: H2472-H2479, 2006.
    • (2006) Am J Physiol Heart Circ Physiol , vol.290
    • Soltys, C.L.1    Kovacic, S.2    Dyck, J.R.3
  • 66
    • 84858983392 scopus 로고    scopus 로고
    • Regulation of NAD(P)H oxidases by AMPK in cardiovascular systems
    • Song P, Zou MH. Regulation of NAD(P)H oxidases by AMPK in cardiovascular systems. Free Radic Biol Med 52: 1607-1619, 2012.
    • (2012) Free Radic Biol Med , vol.52 , pp. 1607-1619
    • Song, P.1    Zou, M.H.2
  • 70
    • 77953151523 scopus 로고    scopus 로고
    • High-dose antioxidant vitamin C supplementation does not prevent acute exercise-induced increases in markers of skeletal muscle mitochondrial biogenesis in rats
    • Wadley GD, McConell GK. High-dose antioxidant vitamin C supplementation does not prevent acute exercise-induced increases in markers of skeletal muscle mitochondrial biogenesis in rats. J Appl Physiol 108: 1719-1726, 2010.
    • (2010) J Appl Physiol , vol.108 , pp. 1719-1726
    • Wadley, G.D.1    McConell, G.K.2
  • 72
    • 80052985519 scopus 로고    scopus 로고
    • Emerging roles of ROS/RNS in muscle function and fatigue
    • Westerblad H, Allen DG. Emerging roles of ROS/RNS in muscle function and fatigue. Antioxid Redox Signal 15: 2487-2499, 2011.
    • (2011) Antioxid Redox Signal , vol.15 , pp. 2487-2499
    • Westerblad, H.1    Allen, D.G.2
  • 73
    • 0014082605 scopus 로고
    • The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver
    • Williamson DH, Lund P, Krebs HA. The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver. Biochem J 103: 514-527, 1967.
    • (1967) Biochem J , vol.103 , pp. 514-527
    • Williamson, D.H.1    Lund, P.2    Krebs, H.A.3
  • 74
    • 71249163851 scopus 로고    scopus 로고
    • Redox modulation of global phosphatase activity and protein phosphorylation in intact skeletal muscle
    • Wright VP, Reiser PJ, Clanton TL. Redox modulation of global phosphatase activity and protein phosphorylation in intact skeletal muscle. J Physiol 587: 5767-5781, 2009.
    • (2009) J Physiol , vol.587 , pp. 5767-5781
    • Wright, V.P.1    Reiser, P.J.2    Clanton, T.L.3
  • 75
    • 33745198418 scopus 로고    scopus 로고
    • Redox regulation of cardiac calcium channels and transporters
    • Zima AV, Blatter LA. Redox regulation of cardiac calcium channels and transporters. Cardiovasc Res 71: 310-321, 2006.
    • (2006) Cardiovasc Res , vol.71 , pp. 310-321
    • Zima, A.V.1    Blatter, L.A.2
  • 76
    • 0037058977 scopus 로고    scopus 로고
    • AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation
    • Zong H, Ren JM, Young LH, Pypaert M, Mu J, Birnbaum MJ, Shulman GI. AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proc Natl Acad Sci USA 99: 15983-15987, 2002.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 15983-15987
    • Zong, H.1    Ren, J.M.2    Young, L.H.3    Pypaert, M.4    Mu, J.5    Birnbaum, M.J.6    Shulman, G.I.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.