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Volumn 34, Issue 6, 2013, Pages 243-250

Caspase recruitment domain-containing protein 9 signaling in innate immunity and inflammation

Author keywords

Host protection; Inflammatory disease; Innate immunity; Pattern recognition receptor signaling NF B

Indexed keywords

CARRIER PROTEINS AND BINDING PROTEINS; CASPASE RECRUITMENT DOMAIN CONTAINING PROTEIN 9; DECTIN 1; PATTERN RECOGNITION RECEPTOR; PROTEIN KINASE C; PROTEIN KINASE SYK; UNCLASSIFIED DRUG;

EID: 84878523947     PISSN: 14714906     EISSN: 14714981     Source Type: Journal    
DOI: 10.1016/j.it.2013.02.006     Document Type: Review
Times cited : (96)

References (61)
  • 1
    • 66949122854 scopus 로고    scopus 로고
    • Approaching the asymptote: 20 years later
    • Medzhitov R. Approaching the asymptote: 20 years later. Immunity 2009, 30:766-775.
    • (2009) Immunity , vol.30 , pp. 766-775
    • Medzhitov, R.1
  • 2
    • 77950343791 scopus 로고    scopus 로고
    • Pattern recognition receptors and inflammation
    • Takeuchi O., Akira S. Pattern recognition receptors and inflammation. Cell 2010, 140:805-820.
    • (2010) Cell , vol.140 , pp. 805-820
    • Takeuchi, O.1    Akira, S.2
  • 3
    • 79953102822 scopus 로고    scopus 로고
    • Syk-coupled C-type lectins in immunity
    • Kerrigan A.M., Brown G.D. Syk-coupled C-type lectins in immunity. Trends Immunol. 2011, 32:151-156.
    • (2011) Trends Immunol. , vol.32 , pp. 151-156
    • Kerrigan, A.M.1    Brown, G.D.2
  • 4
    • 79956292569 scopus 로고    scopus 로고
    • Myeloid C-type lectin receptors in pathogen recognition and host defense
    • Osorio F., Reis e Sousa C. Myeloid C-type lectin receptors in pathogen recognition and host defense. Immunity 2011, 34:651-664.
    • (2011) Immunity , vol.34 , pp. 651-664
    • Osorio, F.1    Reis e Sousa, C.2
  • 5
    • 84859405717 scopus 로고    scopus 로고
    • Signaling by myeloid C-type lectin receptors in immunity and homeostasis
    • Sancho D., Reis e Sousa C. Signaling by myeloid C-type lectin receptors in immunity and homeostasis. Annu. Rev. Immunol. 2012, 30:491-529.
    • (2012) Annu. Rev. Immunol. , vol.30 , pp. 491-529
    • Sancho, D.1    Reis e Sousa, C.2
  • 6
    • 65449139593 scopus 로고    scopus 로고
    • CARD9 versus CARMA1 in innate and adaptive immunity
    • Hara H., Saito T. CARD9 versus CARMA1 in innate and adaptive immunity. Trends Immunol. 2009, 30:234-242.
    • (2009) Trends Immunol. , vol.30 , pp. 234-242
    • Hara, H.1    Saito, T.2
  • 7
    • 56549104117 scopus 로고    scopus 로고
    • CARD9 signaling in the innate immune response
    • Ruland J. CARD9 signaling in the innate immune response. Ann. N. Y. Acad. Sci. 2008, 1143:35-44.
    • (2008) Ann. N. Y. Acad. Sci. , vol.1143 , pp. 35-44
    • Ruland, J.1
  • 8
    • 84878400790 scopus 로고    scopus 로고
    • Invasive fungal infection and impaired neutrophil killing in human CARD9 deficiency
    • Drewniak A.A., et al. Invasive fungal infection and impaired neutrophil killing in human CARD9 deficiency. Blood 2013, 10.1182/blood-2012-08-450551.
    • (2013) Blood
    • Drewniak, A.A.1
  • 9
    • 70350545720 scopus 로고    scopus 로고
    • A homozygous CARD9 mutation in a family with susceptibility to fungal infections
    • Glocker E.O., et al. A homozygous CARD9 mutation in a family with susceptibility to fungal infections. N. Engl. J. Med. 2009, 361:1727-1735.
    • (2009) N. Engl. J. Med. , vol.361 , pp. 1727-1735
    • Glocker, E.O.1
  • 10
    • 33747036397 scopus 로고    scopus 로고
    • Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity
    • Gross O., et al. Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature 2006, 442:651-656.
    • (2006) Nature , vol.442 , pp. 651-656
    • Gross, O.1
  • 11
    • 33846963844 scopus 로고    scopus 로고
    • Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans
    • Saijo S., et al. Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans. Nat. Immunol. 2007, 8:39-46.
    • (2007) Nat. Immunol. , vol.8 , pp. 39-46
    • Saijo, S.1
  • 12
    • 77953289487 scopus 로고    scopus 로고
    • Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans
    • Saijo S., et al. Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans. Immunity 2010, 32:681-691.
    • (2010) Immunity , vol.32 , pp. 681-691
    • Saijo, S.1
  • 13
    • 33846962860 scopus 로고    scopus 로고
    • Dectin-1 is required for beta-glucan recognition and control of fungal infection
    • Taylor P.R., et al. Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nat. Immunol. 2007, 8:31-38.
    • (2007) Nat. Immunol. , vol.8 , pp. 31-38
    • Taylor, P.R.1
  • 14
    • 47249089542 scopus 로고    scopus 로고
    • The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans
    • Wells C.A., et al. The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans. J. Immunol. 2008, 180:7404-7413.
    • (2008) J. Immunol. , vol.180 , pp. 7404-7413
    • Wells, C.A.1
  • 15
    • 78649489009 scopus 로고    scopus 로고
    • Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
    • Franke A., et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat. Genet. 2010, 42:1118-1125.
    • (2010) Nat. Genet. , vol.42 , pp. 1118-1125
    • Franke, A.1
  • 16
    • 77950298959 scopus 로고    scopus 로고
    • Genome-wide association identifies multiple ulcerative colitis susceptibility loci
    • McGovern D.P., et al. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat. Genet. 2010, 42:332-337.
    • (2010) Nat. Genet. , vol.42 , pp. 332-337
    • McGovern, D.P.1
  • 17
    • 84860585350 scopus 로고    scopus 로고
    • Genetics of spondyloarthritis - beyond the MHC
    • Reveille J.D. Genetics of spondyloarthritis - beyond the MHC. Nat. Rev. Rheumatol. 2012, 8:296-304.
    • (2012) Nat. Rev. Rheumatol. , vol.8 , pp. 296-304
    • Reveille, J.D.1
  • 18
    • 80054975975 scopus 로고    scopus 로고
    • Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease
    • Rivas M.A., et al. Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease. Nat. Genet. 2011, 43:1066-1073.
    • (2011) Nat. Genet. , vol.43 , pp. 1066-1073
    • Rivas, M.A.1
  • 19
    • 42749096082 scopus 로고    scopus 로고
    • Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP
    • Zhernakova A., et al. Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP. Am. J. Hum. Genet. 2008, 82:1202-1210.
    • (2008) Am. J. Hum. Genet. , vol.82 , pp. 1202-1210
    • Zhernakova, A.1
  • 20
    • 0034731443 scopus 로고    scopus 로고
    • CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B
    • Bertin J., et al. CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B. J. Biol. Chem. 2000, 275:41082-41086.
    • (2000) J. Biol. Chem. , vol.275 , pp. 41082-41086
    • Bertin, J.1
  • 21
    • 33846469538 scopus 로고    scopus 로고
    • The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens
    • Hsu Y.M., et al. The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat. Immunol. 2007, 8:198-205.
    • (2007) Nat. Immunol. , vol.8 , pp. 198-205
    • Hsu, Y.M.1
  • 22
    • 77952887713 scopus 로고    scopus 로고
    • The SYK tyrosine kinase: a crucial player in diverse biological functions
    • Mocsai A., et al. The SYK tyrosine kinase: a crucial player in diverse biological functions. Nat. Rev. Immunol. 2010, 10:387-402.
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 387-402
    • Mocsai, A.1
  • 23
    • 46249085882 scopus 로고    scopus 로고
    • Multifunctional roles for MALT1 in T-cell activation
    • Thome M. Multifunctional roles for MALT1 in T-cell activation. Nat. Rev. Immunol. 2008, 8:495-500.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 495-500
    • Thome, M.1
  • 24
    • 79955592698 scopus 로고    scopus 로고
    • T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1
    • Staal J., et al. T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1. EMBO J. 2011, 30:1742-1752.
    • (2011) EMBO J. , vol.30 , pp. 1742-1752
    • Staal, J.1
  • 25
    • 80052282195 scopus 로고    scopus 로고
    • Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines
    • Hailfinger S., et al. Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:14596-14601.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 14596-14601
    • Hailfinger, S.1
  • 26
    • 39449085547 scopus 로고    scopus 로고
    • The proteolytic activity of the paracaspase MALT1 is key in T cell activation
    • Rebeaud F., et al. The proteolytic activity of the paracaspase MALT1 is key in T cell activation. Nat. Immunol. 2008, 9:272-281.
    • (2008) Nat. Immunol. , vol.9 , pp. 272-281
    • Rebeaud, F.1
  • 27
    • 39449131430 scopus 로고    scopus 로고
    • T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20
    • Coornaert B., et al. T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20. Nat. Immunol. 2008, 9:263-271.
    • (2008) Nat. Immunol. , vol.9 , pp. 263-271
    • Coornaert, B.1
  • 28
    • 78650883911 scopus 로고    scopus 로고
    • Regulation of NF-kappaB signaling by caspases and MALT1 paracaspase
    • Staal J., et al. Regulation of NF-kappaB signaling by caspases and MALT1 paracaspase. Cell Res. 2011, 21:40-54.
    • (2011) Cell Res. , vol.21 , pp. 40-54
    • Staal, J.1
  • 29
    • 34249048617 scopus 로고    scopus 로고
    • The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors
    • Hara H., et al. The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors. Nat. Immunol. 2007, 8:619-629.
    • (2007) Nat. Immunol. , vol.8 , pp. 619-629
    • Hara, H.1
  • 30
    • 0034733654 scopus 로고    scopus 로고
    • Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive cDNA cloning
    • Ariizumi K., et al. Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive cDNA cloning. J. Biol. Chem. 2000, 275:20157-20167.
    • (2000) J. Biol. Chem. , vol.275 , pp. 20157-20167
    • Ariizumi, K.1
  • 31
    • 0035817818 scopus 로고    scopus 로고
    • Immune recognition. A new receptor for beta-glucans
    • Brown G.D., Gordon S. Immune recognition. A new receptor for beta-glucans. Nature 2001, 413:36-37.
    • (2001) Nature , vol.413 , pp. 36-37
    • Brown, G.D.1    Gordon, S.2
  • 32
    • 60549104110 scopus 로고    scopus 로고
    • Differential use of CARD9 by dectin-1 in macrophages and dendritic cells
    • Goodridge H.S., et al. Differential use of CARD9 by dectin-1 in macrophages and dendritic cells. J. Immunol. 2009, 182:1146-1154.
    • (2009) J. Immunol. , vol.182 , pp. 1146-1154
    • Goodridge, H.S.1
  • 33
    • 34249026701 scopus 로고    scopus 로고
    • Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17
    • LeibundGut-Landmann S., et al. Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat. Immunol. 2007, 8:630-638.
    • (2007) Nat. Immunol. , vol.8 , pp. 630-638
    • LeibundGut-Landmann, S.1
  • 34
    • 65449131255 scopus 로고    scopus 로고
    • 2+ flux and cytokine production in dendritic cells
    • 2+ flux and cytokine production in dendritic cells. J. Biol. Chem. 2009, 284:7038-7046.
    • (2009) J. Biol. Chem. , vol.284 , pp. 7038-7046
    • Xu, S.1
  • 35
    • 79551547792 scopus 로고    scopus 로고
    • Selective C-Rel activation via Malt1 controls anti-fungal T(H)-17 immunity by dectin-1 and dectin-2
    • Gringhuis S.I., et al. Selective C-Rel activation via Malt1 controls anti-fungal T(H)-17 immunity by dectin-1 and dectin-2. PLoS Pathog. 2011, 7:e1001259.
    • (2011) PLoS Pathog. , vol.7
    • Gringhuis, S.I.1
  • 36
    • 84863393017 scopus 로고    scopus 로고
    • Syk kinase-coupled C-type lectin receptors engage protein kinase C-delta to elicit Card9 adaptor-mediated innate immunity
    • Strasser D., et al. Syk kinase-coupled C-type lectin receptors engage protein kinase C-delta to elicit Card9 adaptor-mediated innate immunity. Immunity 2012, 36:32-42.
    • (2012) Immunity , vol.36 , pp. 32-42
    • Strasser, D.1
  • 37
    • 67349271142 scopus 로고    scopus 로고
    • Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence
    • Gross O., et al. Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence. Nature 2009, 459:433-436.
    • (2009) Nature , vol.459 , pp. 433-436
    • Gross, O.1
  • 38
    • 84857175933 scopus 로고    scopus 로고
    • Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1beta via a noncanonical caspase-8 inflammasome
    • Gringhuis S.I., et al. Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1beta via a noncanonical caspase-8 inflammasome. Nat. Immunol. 2012, 13:246-254.
    • (2012) Nat. Immunol. , vol.13 , pp. 246-254
    • Gringhuis, S.I.1
  • 39
    • 69549108298 scopus 로고    scopus 로고
    • Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection
    • Robinson M.J., et al. Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection. J. Exp. Med. 2009, 206:2037-2051.
    • (2009) J. Exp. Med. , vol.206 , pp. 2037-2051
    • Robinson, M.J.1
  • 40
    • 73949117849 scopus 로고    scopus 로고
    • Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle
    • Ishikawa E., et al. Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle. J. Exp. Med. 2009, 206:2879-2888.
    • (2009) J. Exp. Med. , vol.206 , pp. 2879-2888
    • Ishikawa, E.1
  • 41
    • 77951932177 scopus 로고    scopus 로고
    • Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate
    • Schoenen H., et al. Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate. J. Immunol. 2010, 184:2756-2760.
    • (2010) J. Immunol. , vol.184 , pp. 2756-2760
    • Schoenen, H.1
  • 42
    • 52549125928 scopus 로고    scopus 로고
    • Mincle is an ITAM-coupled activating receptor that senses damaged cells
    • Yamasaki S., et al. Mincle is an ITAM-coupled activating receptor that senses damaged cells. Nat. Immunol. 2008, 9:1179-1188.
    • (2008) Nat. Immunol. , vol.9 , pp. 1179-1188
    • Yamasaki, S.1
  • 43
    • 60549116006 scopus 로고    scopus 로고
    • Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation
    • Werninghaus K., et al. Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation. J. Exp. Med. 2009, 206:89-97.
    • (2009) J. Exp. Med. , vol.206 , pp. 89-97
    • Werninghaus, K.1
  • 44
    • 77951037591 scopus 로고    scopus 로고
    • The adaptor molecule CARD9 is essential for tuberculosis control
    • Dorhoi A., et al. The adaptor molecule CARD9 is essential for tuberculosis control. J. Exp. Med. 2010, 207:777-792.
    • (2010) J. Exp. Med. , vol.207 , pp. 777-792
    • Dorhoi, A.1
  • 45
    • 80052146101 scopus 로고    scopus 로고
    • The machinery of Nod-like receptors: refining the paths to immunity and cell death
    • Saleh M. The machinery of Nod-like receptors: refining the paths to immunity and cell death. Immunol. Rev. 2011, 243:235-246.
    • (2011) Immunol. Rev. , vol.243 , pp. 235-246
    • Saleh, M.1
  • 46
    • 79956314622 scopus 로고    scopus 로고
    • Immune signaling by RIG-I-like receptors
    • Loo Y.M., Gale M. Immune signaling by RIG-I-like receptors. Immunity 2011, 34:680-692.
    • (2011) Immunity , vol.34 , pp. 680-692
    • Loo, Y.M.1    Gale, M.2
  • 47
    • 74049126045 scopus 로고    scopus 로고
    • Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production
    • Poeck H., et al. Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production. Nat. Immunol. 2010, 11:63-69.
    • (2010) Nat. Immunol. , vol.11 , pp. 63-69
    • Poeck, H.1
  • 48
    • 84868569570 scopus 로고    scopus 로고
    • RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids
    • Abdullah Z., et al. RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids. EMBO J. 2012, 31:4153-4156.
    • (2012) EMBO J. , vol.31 , pp. 4153-4156
    • Abdullah, Z.1
  • 49
    • 78649686666 scopus 로고    scopus 로고
    • The role of Th17 cytokines in primary mucosal immunity
    • Kolls J.K., Khader S.A. The role of Th17 cytokines in primary mucosal immunity. Cytokine Growth Factor Rev. 2010, 21:443-448.
    • (2010) Cytokine Growth Factor Rev. , vol.21 , pp. 443-448
    • Kolls, J.K.1    Khader, S.A.2
  • 50
  • 51
    • 79953284685 scopus 로고    scopus 로고
    • Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity
    • Puel A., et al. Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. Science 2011, 332:65-68.
    • (2011) Science , vol.332 , pp. 65-68
    • Puel, A.1
  • 52
    • 78851471443 scopus 로고    scopus 로고
    • The role of Syk/CARD9 coupled C-type lectins in antifungal immunity
    • Drummond R.A., et al. The role of Syk/CARD9 coupled C-type lectins in antifungal immunity. Eur. J. Immunol. 2011, 41:276-281.
    • (2011) Eur. J. Immunol. , vol.41 , pp. 276-281
    • Drummond, R.A.1
  • 53
    • 70350534272 scopus 로고    scopus 로고
    • Human dectin-1 deficiency and mucocutaneous fungal infections
    • Ferwerda B., et al. Human dectin-1 deficiency and mucocutaneous fungal infections. N. Engl. J. Med. 2009, 361:1760-1767.
    • (2009) N. Engl. J. Med. , vol.361 , pp. 1760-1767
    • Ferwerda, B.1
  • 54
    • 77958450338 scopus 로고    scopus 로고
    • Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity
    • Cunha C., et al. Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity. Blood 2010, 116:5394-5402.
    • (2010) Blood , vol.116 , pp. 5394-5402
    • Cunha, C.1
  • 55
    • 69949109204 scopus 로고    scopus 로고
    • Early stop polymorphism in human DECTIN-1 is associated with increased candida colonization in hematopoietic stem cell transplant recipients
    • Plantinga T.S., et al. Early stop polymorphism in human DECTIN-1 is associated with increased candida colonization in hematopoietic stem cell transplant recipients. Clin. Infect. Dis. 2009, 49:724-732.
    • (2009) Clin. Infect. Dis. , vol.49 , pp. 724-732
    • Plantinga, T.S.1
  • 56
    • 70350464358 scopus 로고    scopus 로고
    • CARD9 facilitates microbe-elicited production of reactive oxygen species by regulating the LyGDI-Rac1 complex
    • Wu W., et al. CARD9 facilitates microbe-elicited production of reactive oxygen species by regulating the LyGDI-Rac1 complex. Nat. Immunol. 2009, 10:1208-1214.
    • (2009) Nat. Immunol. , vol.10 , pp. 1208-1214
    • Wu, W.1
  • 58
    • 84867581318 scopus 로고    scopus 로고
    • Mucosal genome-wide methylation changes in inflammatory bowel disease
    • Cooke J., et al. Mucosal genome-wide methylation changes in inflammatory bowel disease. Inflamm. Bowel Dis. 2012, 18:2128-2137.
    • (2012) Inflamm. Bowel Dis. , vol.18 , pp. 2128-2137
    • Cooke, J.1
  • 59
    • 79957502386 scopus 로고    scopus 로고
    • Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9
    • Janse M., et al. Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9. Hepatology 2011, 53:1977-1985.
    • (2011) Hepatology , vol.53 , pp. 1977-1985
    • Janse, M.1
  • 60
    • 79960899377 scopus 로고    scopus 로고
    • Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility
    • Evans D.M., et al. Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nat. Genet. 2011, 43:761-767.
    • (2011) Nat. Genet. , vol.43 , pp. 761-767
    • Evans, D.M.1
  • 61
    • 77956344915 scopus 로고    scopus 로고
    • Elucidating the chromosome 9 association with AS; CARD9 is a candidate gene
    • Pointon J.J., et al. Elucidating the chromosome 9 association with AS; CARD9 is a candidate gene. Genes Immun. 2010, 11:490-496.
    • (2010) Genes Immun. , vol.11 , pp. 490-496
    • Pointon, J.J.1


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