The role of Syk/CARD9 coupled C-type lectins in antifungal immunity

European Journal of Immunology

Volumn 41, Issue 2, 2011, Pages 276-281

  Drummond, Rebecca A ^a   Saijo, Shinobu ^b   Iwakura, Yoichiro ^c   Brown, Gordon D ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b CHIBA UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Antifungal immunity; Dectin 1; Dectin 2; Mincle

Indexed keywords

ADAPTOR PROTEIN; C TYPE LECTIN RECEPTOR; CARD9 PROTEIN; DECTIN 1; DECTIN 2; INTERLEUKIN 23; INTERLEUKIN 6; LECTIN RECEPTOR; MINCLE PROTEIN; PATTERN RECOGNITION RECEPTOR; PROTEIN KINASE SYK; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; ASPERGILLOSIS; CANDIDIASIS; CYTOKINE PRODUCTION; FUNGUS IMMUNITY; HUMAN; INNATE IMMUNITY; NONHUMAN; PNEUMOCYSTOSIS; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CARD SIGNALING ADAPTOR PROTEINS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LECTINS, C-TYPE; MYCOSES; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION;

EID: 78851471443     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201041252     Document Type: Review

References (49)

1. Saijo, S., Fujikado, N., Furuta, T., Chung, S.H., Kotaki, H., Seki, K., Sudo, K. et al., Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans. Nat. Immunol. 2007. 8: 39-46.
2. Taylor, P. R., Tsoni, S. V., Willment, J. A., Dennehy, K. M., Rosas, M., Findon, H., Haynes, K. et al., Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nat. Immunol. 2007. 8: 31-38.
3. Saijo, S., Ikeda, S., Yamabe, K., Kakuta, S., Ishigame, H., Akitsu, A., Fujikado, N. et al., Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans. Immunity 2010. 32: 681-691.
4. Graham, L. M. and Brown, G. D., The Dectin-2 family of C-type lectins in immunity and homeostasis. Cytokine 2009. 48: 148-155.
5. Hara, H., Ishihara, C., Takeuchi, A., Imanishi, T., Xue, L., Morris, S. W., Inui, M. et al., The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors. Nat. Immunol. 2007. 8: 619-629.
6. Taylor, P. R., Tsoni, S. V., Willment, J. A., Dennehy, K. M., Rosas, M., Findon, H., Haynes, K. et al., Dectin-1 is required for [beta]-glucan recognition and control of fungal infection. Nat. Immunol. 2007. 8: 31-38.
7. Werner, J. L., Metz, A. E., Horn, D., Schoeb, T. R., Hewitt, M. M., Schwiebert, L. M., Faro-Trindade, I. et al., Requisite role for the dectin-1 beta-glucan receptor in pulmonary defense against Aspergillus fumigatus. J. Immunol. 2009. 182: 4938-4946.
8. Saijo, S., Fujikado, N., Furuta, T., Chung, S.-h., Kotaki, H., Seki, K., Sudo, K. et al., Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans. Nat. Immunol. 2007. 8: 39-46.
9. Ferwerda, B., Ferwerda, G., Plantinga, T. S., Willment, J. A., van Spriel, A. B., Venselaar, H., Elbers, C. C. et al., Human Dectin-1 deficiency and mucocutaneous fungal infections. N. Engl. J. Med. 2009. 361: 1760-1767.
10. Heinsbroek, S. E. M., Taylor, P. R., Rosas, M., Willment, J. A., Williams, D. L., Gordon, S. and Brown, G. D., Expression of functionally different dectin-1 isoforms by murine macrophages. J. Immunol. 2006. 176: 5513-5518.
11. Brown, G. D., Dectin-1: a signalling non-TLR pattern-recognition receptor. Nat. Rev. Immunol. 2006. 6: 33-43.
12. Kumar, H., Kumagai, Y., Tsuchida, T., Koenig, P. A., Satoh, T., Guo, Z., Jang, M. H. et al., Involvement of the NLRP3 inflammasome in innate and humoral adaptive immune responses to fungal beta-glucan. J. Immunol. 2009. 183: 8061-8067.
13. LeibundGut-Landmann, S., Osorio, F., Brown, G. D. and Sousa, C. R. E., Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responses. Blood 2008. 112: 4971-4980.
14. Ni, L., Gayet, I., Zurawski, S., Duluc, D., Flamar, A. L., Li, X. H., O'Bar, A. et al., Concomitant activation and antigen uptake via human Dectin-1 results in potent antigen-specific CD8(+) T cell responses. J. Immunol. 2010. 185: 3504-3513.
15. LeibundGut-Landmann, S., Grosz, O., Robinson, M. J., Osorio, F., Slack, E. C., Tsoni, S. V., Schweighoffer, E. et al., Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat. Immunol. 2007. 8: 630-638.
16. Osorio, F., LeibundGut-Landmann, S., Lochner, M., Lahl, K., Sparwasser, T., Eberl, G. and Sousa, C. R. E., DC activated via dectin-1 convert Treg into IL-17 producers. Eur. J. Immunol. 2008. 38: 3274-3281.
17. Ariizumi, K., Shen, G. L., Shikano, S., Ritter, R., Zukas, P., Edelbaum, D., Morita, A. et al., Cloning of a second dendritic cell-associated C-type lectin (Dectin-2) and its alternatively spliced isoforms. J. Biol. Chem. 2000. 275: 11957-11963.
18. Fernandes, M. J., Finnegan, A. A., Siracusa, L. D., Brenner, C., Iscove, N. N. and Calabretta, B., Characterization of a novel receptor that maps near the natural killer gene complex: demonstration of carbohydrate binding and expression in hematopoietic cells. Cancer Res. 1999. 59: 2709-2717.
19. Taylor, P. R., Reid, D. M., Heinsbroek, S. E., Brown, G. D., Gordon, S. and Wong, S. Y., Dectin-2 is predominantly myeloid restricted and exhibits unique activation-dependent expression on maturing inflammatory monocytes elicited in vivo. Eur. J. Immunol. 2005. 35: 2163-2174.
20. Sato, K., Yang, X. L., Yudate, T., Chung, J. S., Wu, J., Luby-Phelps, K., Kimberly, R. P. et al., Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor gamma chain to induce innate immune responses. J. Biol. Chem. 2006. 281: 38854-38866.
21. McGreal, E. P., Rosas, M., Brown, G. D., Zamze, S., Wong, S. Y., Gordon, S., Martinez-Pomares, L. et al., The carbohydrate-recognition domain of Dectin-2 is a C-type lectin with specificity for high mannose. Glycobiology 2006. 16: 422-430.
22. Barrett, N. A., Maekawa, A., Rahman, O. M., Austen, K. F. and Kanaoka, Y., Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells. J. Immunol. 2009. 182: 1119-1128.
23. Robinson, M. J., Osorio, F., Rosas, M., Freitas, R. P., Schweighoffer, E., Gross, O., SjefVerbeek, J. et al., Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection. J. Exp. Med. 2009. 206: 2037-2051.
24. Conti, H. R., Shen, F., Nayyar, N., Stocum, E., Sun, J. N., Lindemann, M. J., Ho, A. W. et al., Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis. J. Exp. Med. 2009. 206: 299-311.
25. Huang, W., Na, L., Fidel, P. L. and Schwarzenberger, P., Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice. J. Infect. Dis. 2004. 190: 624-631.
26. Puel, A., Daffinger, R., Natividad, A., Chrabieh, M., Barcenas-Morales, G., Picard, C., Cobat, A. et al., Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I. J. Exp. Med. 2010. 207: 291-297.
27. Kisand, K., Bøe Wolff, A. S., Podkrajsoek, K. T., Tserel, L., Link, M., Kisand, K. V., Ersvaer, E. et al., Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines. J. Exp. Med. 2010. 207: 299-308.
28. Puel, A., Picard, C., Cypowyj, S., Lilic, D., Abel, L. and Casanova, J.-L., Inborn errors of mucocutaneous immunity to Candida albicans in humans: a role for IL-17 cytokines? Curr. Opin. Immunol. 2010. 22: 467-474.
29. Zelante, T., De Luca, A., Bonifazi, P., Montagnoli, C., Bozza, S., Moretti, S., Belladonna, M. L. et al., IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance. Eur. J. Immunol. 2007. 37: 2695-2706.
30. Conti, H. R. and Gaffen, S. L., Host responses to Candida albicans: Th17 cells and mucosal candidiasis. Microbes Infect. 2010. 12: 518-527.
31. Yamasaki, S., Matsumoto, M., Takeuchi, O., Matsuzawa, T., Ishikawa, E., Sakuma, M., Tateno, H. et al., C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia. Proc. Natl. Acad. Sci. USA 2009. 106: 1897-1902.
32. Brown, G. D., Sensing necrosis with Mincle. Nat. Immunol. 2008. 9: 1099-1100.
33. Wells, C. A., Salvage-Jones, J. A., Li, X., Hitchens, K., Butcher, S., Murray, R. Z., Beckhouse, A. G. et al., The macrophage-inducible C-type lectin, Mincle, is an essential component of the innate immune response to Candida albicans. J. Immunol. 2008. 180: 7404-7413.
34. Ishikawa, E., Ishikawa, T., Morita, Y. S., Toyonaga, K., Yamada, H., Takeuchi, O., Kinoshita, T. et al., Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle. J. Exp. Med. 2009. 206: 2879-2888.
35. Schoenen, H., Bodendorfer, B., Hitchens, K., Manzanero, S., Werninghaus, K., Nimmerjahn, F., Agger, E. M., et al., Cutting Edge: Mincle Is Essential for Recognition and Adjuvanticity of the Mycobacterial Cord Factor and its Synthetic Analog Trehalose-Dibehenate. J. Immunol., 2010. 184: 2756-2760.
36. Rogers, N. C., Slack, E. C., Edwards, A. D., Nolte, M. A., Schulz, O., Schweighoffer, E., Williams, D. L. et al., Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins. Immunity 2005. 22: 507-517.
37. Kerrigan, A. M. and Brown, G. D., Syk-coupled C-type lectin receptors that mediate cellular activation via single tyrosine based activation motifs. Immunol. Rev. 2010. 234: 335-352.
38. Kelly, E. K., Wang, L. and Ivashkiv, L. B., Calcium-activated pathways and oxidative burst mediate zymosan-induced signaling and IL-10 production in human macrophages. J. Immunol. 2010. 184: 5545-5552.
39. Hise, A. G., Tomalka, J., Ganesan, S., Patel, K., Hall, B. A., Brown, G. D. and Fitzgerald, K. A., An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans. Cell Host Microbe 2009. 5: 487-497.
40. Gringhuis, S. I., den Dunnen, J., Litjens, M., van der Vlist, M., Wevers, B., Bruijns, S. C. M. and Geijtenbeek, T. B. H., Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-[kappa]B activation through Raf-1 and Syk. Nat. Immunol. 2009. 10: 203-213.
41. Gringhuis, S. I., den Dunnen, J., Litjens, M., van der Vlist, M., Wevers, B., Bruijns, S. C. and Geijtenbeek, T. B., Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk. Nat. Immunol. 2009. 10: 203-213.
42. Yamasaki, S., Ishikawa, E., Sakuma, M., Hara, H., Ogata, K. and Saito, T., Mincle is an ITAM-coupled activating receptor that senses damaged cells. Nat. Immunol. 2008. 9: 1179-1188.
43. Bertin, J., Guo, Y., Wang, L., Srinivasula, S. M., Jacobson, M. D., Poyet, J. L., Merriam, S. et al., CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B. J. Biol. Chem. 2000. 275: 41082-41086.
44. Glocker, E. O., Hennigs, A., Nabavi, M., Schaffer, A. A., Woellner, C., Salzer, U., Pfeifer, D. et al., A homozygous CARD9 mutation in a family with susceptibility to fungal infections. N. Engl. J. Med. 2009. 361: 1727-1735.
45. Dennehy, K. M., Willment, J. A., Williams, D. L. and Brown, G. D., Reciprocal regulation of IL-23 and IL-12 following co-activation of Dectin-1 and TLR signaling pathways. Eur. J. Immunol. 2009. 39: 1379-1386.
46. Bauer, S., Hartmann, G., Goodridge, H. S. and Underhill, D. M., Fungal Recognition by TLR2 and Dectin-1. In: Hofmann, F (Ed.), Toll-Like Receptors (TLRs) and Innate Immunity. Springer, Berlin Heidelberg, 2008 p. 87-109.
47. Bonfim, C. V., Mamoni, R. L. and Blotta, M., TLR-2, TLR-4 and dectin-1 expression in human monocytes and neutrophils stimulated by Paracoccidioides brasiliensis. Med. Mycol. 2009. 47: 722-733.
48. Dennehy, K. M., Ferwerda, G., Faro-Trindade, I., Pyz, E., Willment, J. A., Taylor, P. R., Kerrigan, A. et al., Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors. Eur. J. Immunol. 2008. 38: 500-506.
49. Netea, M. G., Gow, N. A. R., Munro, C. A., Bates, S., Collins, C., Ferwerda, G., Hobson, R. P. et al., Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors. J. Clin. Invest. 2006. 116: 1642-1650.