Mutations in the R2 subunit of ribonucleotide reductase that confer resistance to hydroxyurea

Journal of Biological Chemistry

Volumn 279, Issue 39, 2004, Pages 40723-40728

  Sneeden, Jessica L ^a   Loeb, Lawrence A ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DRUG PRODUCTS; ESCHERICHIA COLI; MUTAGENESIS; SYNTHESIS (CHEMICAL);

MUTANTS; PROTEIN SURFACE; RIBONUCLEOTIDE REDUCTASE;

ENZYMES;

DEOXYRIBONUCLEOTIDE; DNA; HYDROXYUREA; ISOPROPYL 1 THIO BETA GALACTOPYRANOSIDE; MUTANT PROTEIN; PROTEIN SUBUNIT; PYRANOSIDE; RIBONUCLEOTIDE REDUCTASE; RIBONUCLEOTIDE REDUCTASE R2; SCAVENGER; SOLVENT; THYMIDINE DERIVATIVE; TYROSINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CELL SURFACE; CHEMICAL MUTAGENESIS; CONCENTRATION RESPONSE; DNA SYNTHESIS; DRUG RESISTANCE; ENZYME STRUCTURE; ENZYME SUBUNIT; ESCHERICHIA COLI; GENE MUTATION; HALF LIFE TIME; HYDROPHOBICITY; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION; RANDOM OLIGONUCLEOTIDE MUTAGENESIS; REGULATORY MECHANISM; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DNA; DNA PRIMERS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; GENE LIBRARY; GENETIC COMPLEMENTATION TEST; HYDROXYUREA; LYSINE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PLASMIDS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RIBONUCLEOTIDE REDUCTASES; TIME FACTORS; TYROSINE;

ESCHERICHIA COLI; LETHRINIDAE;

EID: 4644320688     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M402699200     Document Type: Article

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