Software automation tools for increased throughput metabolic soft-spot identification in early drug discovery

Bioanalysis

Volumn 5, Issue 10, 2013, Pages 1165-1179

  Zelesky, Veronica ^a   Schneider, Richard ^a   Janiszewski, John ^a   Zamora, Ismael ^b   Ferguson, James ^c   Troutman, Matthew ^a  

^a PFIZER INC   (United States)

^b Molecular Discovery   (United Kingdom)

^c MDS SCIEX   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALBENDAZOLE; BUFURALOL; BUSPIRONE; CLOZAPINE; DEXTROMETHORPHAN; DILTIAZEM; EBASTINE; GLIBENCLAMIDE; LOSARTAN; MIDAZOLAM; NEFAZODONE; PROPAFENONE; VERAPAMIL;

ACCURACY; ANALYTIC METHOD; AUTOMATION; BIOTRANSFORMATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DATA ANALYSIS SOFTWARE; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; LIVER MICROSOME; METABOLIC SOFT SPOT IDENTIFICATION; METABOLITE; QUADRUPOLE MASS SPECTROMETRY; REVIEW; STRUCTURE ANALYSIS; TIME OF FLIGHT MASS SPECTROMETRY;

AUTOMATION; CHROMATOGRAPHY, LIQUID; CLOZAPINE; DRUG DESIGN; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; HUMANS; MASS SPECTROMETRY; MICROSOMES, LIVER; SOFTWARE;

EID: 84878500287     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.13.89     Document Type: Review

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