Regenerative strategies for preserving and restoring cardiac function

Frontiers in Bioscience - Elite

Volumn 5 E, Issue 1, 2013, Pages 232-248

  Finan, Amanda ^a   Dong, Feng ^b   Penn, Marc S ^b,c  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Northeastern Ohio Medical University   (United States)

^c NORTHEAST OHIO MEDICAL UNIVERSITY   (United States)

Author keywords

Cardiovascular disease; Cell therapy; Endogenous stem cells; Exogenous stem cells; Regenerative medicine; Review

Indexed keywords

ACTIVIN A; AZACITIDINE; GRANULOCYTE COLONY STIMULATING FACTOR; HIGH MOBILITY GROUP PROTEIN; OXYTOCIN; STEM CELL ANTIGEN 1; STEM CELL FACTOR; THYMOSIN BETA4;

ACUTE HEART INFARCTION; AMNION; ANGIOGENESIS; APOPTOSIS; ARTICLE; BLASTOCYST; BONE MARROW CELL; CELL DIFFERENTIATION; CELL PROTECTION; CLINICAL TRIAL (TOPIC); COLONY FORMING UNIT; CORONARY ARTERY BYPASS GRAFT; DOWN REGULATION; EMBRYONIC STEM CELL; ENDOTHELIAL PROGENITOR CELL; ENDOTHELIUM CELL; EPICARDIUM; GENE THERAPY; HEART EJECTION FRACTION; HEART FAILURE; HEART FUNCTION; HEART MUSCLE; HEART MUSCLE CELL; HEMANGIOBLAST; HEMATOPOIETIC STEM CELL; HUMAN; IN VIVO STUDY; INNER CELL MASS; ISCHEMIC CARDIOMYOPATHY; MESENCHYMAL STEM CELL; MYOBLAST; NONHUMAN; PHENOTYPE; PLURIPOTENT STEM CELL; PROTEIN EXPRESSION; REGENERATIVE MEDICINE; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SMOOTH MUSCLE FIBER; STEM CELL; STEM CELL TRANSPLANTATION; BONE MARROW TRANSPLANTATION; CARDIOVASCULAR DISEASE; METHODOLOGY; REVIEW; TRANSPLANTATION;

BONE MARROW TRANSPLANTATION; CARDIOVASCULAR DISEASES; CLINICAL TRIALS AS TOPIC; EMBRYONIC STEM CELLS; HUMANS; MYOBLASTS; REGENERATIVE MEDICINE;

MLCS; MLOWN;

EID: 84878480983     PISSN: 19450494     EISSN: 19450508     Source Type: Journal    
DOI: 10.2741/e611     Document Type: Article

References (169)

1. D. Lloyd-Jones, R. J. Adams, T. M. Brown, M. Carnethon, S. Dai, G. De Simone, T. B. Ferguson, E. Ford, K. Furie, C. Gillespie, A. Go, K. Greenlund, N. Haase, S. Hailpern, P. M. Ho, V. Howard, B. Kissela, S. Kittner, D. Lackland, L. Lisabeth, A. Marelli, M. M. McDermott, J. Meigs, D. Mozaffarian, M. Mussolino, G. Nichol, V. L. Roger, W. Rosamond, R. Sacco, P. Sorlie, T. Thom, S. Wasserthiel-Smoller, N. D. Wong and J. Wylie-Rosett: Heart disease and stroke statistics-2010 update: a report from the American Heart Association. Circulation, 121(7), e46-e215 (2010)
2. Topol. E. and Penn MS: The challenge for stem cell therapy. In: Stem Cells and Myocardial Regeneration. Ed Penn. MS. Humana Press, New York (2007)
3. M. Jessup and S. Brozena: Heart failure. N Engl J Med, 348(20), 2007-18 (2003)
4. J. Tamargo, R. Caballero, R. Gomez, A. Barana, I. Amoros and E. Delpon: Investigational positive inotropic agents for acute heart failure. Cardiovasc Hematol Disord Drug Targets, 9(3), 193-205 (2009)
5. W. R. Mills, N. Mal, M. J. Kiedrowski, R. Unger, F. Forudi, Z. B. Popovic, M. S. Penn and K. R. Laurita: Stem cell therapy enhances electrical viability in myocardial infarction. J Mol Cell Cardiol, 42(2), 304-14 (2007) (Pubitemid 46135598)
6. H. Reinecke, V. Poppa and C. E. Murry: Skeletal muscle stem cells do not transdifferentiate into cardiomyocytes after cardiac grafting. J Mol Cell Cardiol, 34(2), 241-9 (2002) (Pubitemid 35222833)
7. I. Deglurkar, N. Mal, W. R. Mills, Z. B. Popovic, P. McCarthy, E. H. Blackstone, K. R. Laurita and M. S. Penn: Mechanical and electrical effects of cell-based gene therapy for ischemic cardiomyopathy are independent. Hum Gene Ther, 17(11), 1144-51 (2006) (Pubitemid 44749715)
8. M. H. Soonpaa, G. Y. Koh, M. G. Klug and L. J. Field: Formation of nascent intercalated disks between grafted fetal cardiomyocytes and host myocardium. Science, 264(5155), 98-101 (1994) (Pubitemid 24144494)
9. H. Reinecke, M. Zhang, T. Bartosek and C. E. Murry: Survival, integration, and differentiation of cardiomyocyte grafts: a study in normal and injured rat hearts. Circulation, 100(2), 193-202 (1999) (Pubitemid 29330019)
10. S. Etzion, A. Battler, I. M. Barbash, E. Cagnano, P. Zarin, Y. Granot, L. H. Kedes, R. A. Kloner and J. Leor: Influence of embryonic cardiomyocyte transplantation on the progression of heart failure in a rat model of extensive myocardial infarction. J Mol Cell Cardiol, 33(7), 1321-30 (2001) (Pubitemid 32613424)
11. M. J. Evans and M. H. Kaufman: Establishment in culture of pluripotential cells from mouse embryos. Nature, 292(5819), 154-156 (1981) (Pubitemid 11050741)
12. G. R. Martin: Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci U S A, 78(12), 7634-8 (1981) (Pubitemid 12186197)
13. O. Caspi, I. Huber, I. Kehat, M. Habib, G. Arbel, A. Gepstein, L. Yankelson, D. Aronson, R. Beyar and L. Gepstein: Transplantation of human embryonic stem cellderived cardiomyocytes improves myocardial performance in infarcted rat hearts. J Am Coll Cardiol, 50(19), 1884-93 (2007) (Pubitemid 350007960)
14. M. A. Laflamme, K. Y. Chen, A. V. Naumova, V. Muskheli, J. A. Fugate, S. K. Dupras, H. Reinecke, C. Xu, M. Hassanipour, S. Police, C. O'Sullivan, L. Collins, Y. Chen, E. Minami, E. A. Gill, S. Ueno, C. Yuan, J. Gold and C. E. Murry: Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nat Biotechnol, 25(9), 1015-24 (2007) (Pubitemid 47517637)
15. J. R. Van Orman, K. Si-Tayeb, S. A. Duncan and J. Lough: Induction of Cardiomyogenesis in Human Embryonic Stem Cells (hESCs) by hESC-Derived Definitive Endoderm. Stem Cells Dev (2011)
16. S. J. Kattman, A. D. Witty, M. Gagliardi, N. C. Dubois, M. Niapour, A. Hotta, J. Ellis and G. Keller: Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines. Cell Stem Cell, 8(2), 228-240 (2011)
17. S. Fernandes, A. V. Naumova, W. Z. Zhu, M. A. Laflamme, J. Gold and C. E. Murry: Human embryonic stem cell-derived cardiomyocytes engraft but do not alter cardiac remodeling after chronic infarction in rats. J Mol Cell Cardiol, 49(6), 941-9 (2010)
18. H. Tsuji, S. Miyoshi, Y. Ikegami, N. Hida, H. Asada, I. Togashi, J. Suzuki, M. Satake, H. Nakamizo, M. Tanaka, T. Mori, K. Segawa, N. Nishiyama, J. Inoue, H. Makino, K. Miyado, S. Ogawa, Y. Yoshimura and A. Umezawa: Xenografted human amniotic membrane-derived mesenchymal stem cells are immunologically tolerated and transdifferentiated into cardiomyocytes. Circ Res, 106(10), 1613-23 (2010)
19. M. S. Penn and M. E. Mayorga: Searching for understanding with the cellular lining of life. Circ Res, 106(10), 1554-6 (2010)
20. K. Takahashi and S. Yamanaka: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell, 126(4), 663-676 (2006) (Pubitemid 44233629)
21. K. Takahashi, K. Tanabe, M. Ohnuki, M. Narita, T. Ichisaka, K. Tomoda and S. Yamanaka: Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell, 131(5), 861-72 (2007) (Pubitemid 350138099)
22. R. Blelloch, M. Venere, J. Yen and M. Ramalho-Santos: Generation of induced pluripotent stem cells in the absence of drug selection. Cell Stem Cell, 1(3), 245-247 (2007) (Pubitemid 47355331)
23. J. Yu, M. A. Vodyanik, K. Smuga-Otto, J. Antosiewicz-Bourget, J. L. Frane, S. Tian, J. Nie, G. A. Jonsdottir, V. Ruotti, R. Stewart, Slukvin, II and J. A. Thomson: Induced pluripotent stem cell lines derived from human somatic cells. Science, 318(5858), 1917-20 (2007)
24. K. Schenke-Layland, K. E. Rhodes, E. Angelis, Y. Butylkova, S. Heydarkhan-Hagvall, C. Gekas, R. Zhang, J. I. Goldhaber, H. K. Mikkola, K. Plath and W. R. MacLellan: Reprogrammed mouse fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages. Stem Cells, 26(6), 1537-46 (2008)
25. C. Mauritz, A. Martens, S. V. Rojas, T. Schnick, C. Rathert, N. Schecker, S. Menke, S. Glage, R. Zweigerdt, A. Haverich, U. Martin and I. Kutschka: Induced pluripotent stem cell (iPSC)-derived Flk-1 progenitor cells engraft, differentiate, and improve heart function in a mouse model of acute myocardial infarction. Eur Heart J (2011)
26. J. Zhang, G. F. Wilson, A. G. Soerens, C. H. Koonce, J. Yu, S. P. Palecek, J. A. Thomson and T. J. Kamp: Functional cardiomyocytes derived from human induced pluripotent stem cells. Circ Res, 104(4), e30-41 (2009)
27. G. Narazaki, H. Uosaki, M. Teranishi, K. Okita, B. Kim, S. Matsuoka, S. Yamanaka and J. K. Yamashita: Directed and systematic differentiation of cardiovascular cells from mouse induced pluripotent stem cells. Circulation, 118(5), 498-506 (2008)
28. M. Ieda, J. D. Fu, P. Delgado-Olguin, V. Vedantham, Y. Hayashi, B. G. Bruneau and D. Srivastava: Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell, 142(3), 375-386 (2010)
29. T. J. Nelson, A. Martinez-Fernandez, S. Yamada, C. Perez-Terzic, Y. Ikeda and A. Terzic: Repair of acute myocardial infarction by human stemness factors induced pluripotent stem cells. Circulation, 120(5), 408-416 (2009)
30. Y. Zhang, D. Wang, M. Chen, B. Yang, F. Zhang and K. Cao: Intramyocardial transplantation of undifferentiated rat induced pluripotent stem cells causes tumorigenesis in the heart. PLoS One, 6(4), e19012 (2011)
31. I. L. Weissman and J. A. Shizuru: The origins of the identification and isolation of hematopoietic stem cells, and their capability to induce donor-specific transplantation tolerance and treat autoimmune diseases. Blood, 112(9), 3543-3553 (2008)
32. D. Orlic, J. Kajstura, S. Chimenti, F. Limana, I. Jakoniuk, F. Quaini, B. Nadal-Ginard, D. M. Bodine, A. Leri and P. Anversa: Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci U S A, 98(18), 10344-9 (2001) (Pubitemid 32803022)
33. C. E. Murry, M. H. Soonpaa, H. Reinecke, H. Nakajima, H. O. Nakajima, M. Rubart, K. B. Pasumarthi, J. I. Virag, S. H. Bartelmez, V. Poppa, G. Bradford, J. D. Dowell, D. A. Williams and L. J. Field: Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature, 428(6983), 664-668 (2004) (Pubitemid 38524810)
34. J. M. Nygren, S. Jovinge, M. Breitbach, P. Sawen, W. Roll, J. Hescheler, J. Taneera, B. K. Fleischmann and S. E. Jacobsen: Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation. Nat Med, 10(5), 494-501 (2004) (Pubitemid 38667908)
35. E. T. Yeh, S. Zhang, H. D. Wu, M. Korbling, J. T. Willerson and Z. Estrov: Transdifferentiation of human peripheral blood CD34+-enriched cell population into cardiomyocytes, endothelial cells, and smooth muscle cells in vivo. Circulation, 108(17), 2070-2073 (2003) (Pubitemid 37337581)
36. S. Zhang, D. Wang, Z. Estrov, S. Raj, J. T. Willerson and E. T. Yeh: Both cell fusion and transdifferentiation account for the transformation of human peripheral blood CD34-positive cells into cardiomyocytes in vivo. Circulation, 110(25), 3803-3807 (2004) (Pubitemid 40023979)
37. T. Yoshioka, N. Ageyama, H. Shibata, T. Yasu, Y. Misawa, K. Takeuchi, K. Matsui, K. Yamamoto, K. Terao, K. Shimada, U. Ikeda, K. Ozawa and Y. Hanazono: Repair of infarcted myocardium mediated by transplanted bone marrow-derived CD34+ stem cells in a nonhuman primate model. Stem Cells, 23(3), 355-364 (2005) (Pubitemid 40404454)
38. A. A. Kocher, M. D. Schuster, M. J. Szabolcs, S. Takuma, D. Burkhoff, J. Wang, S. Homma, N. M. Edwards and S. Itescu: Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med, 7(4), 430-6 (2001) (Pubitemid 32298545)
39. A. I. Caplan: Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. J Cell Physiol, 213(2), 341-7 (2007) (Pubitemid 47509711)
40. M. E. Mayorga, F. Dong, S. Sundararaman, Y. Huang, Y. Jiang, P. H. Howe and M. S. Penn: Central role for disabled-2 in mesenchymal stem cardiac protein expression and functional consequences after engraftment in acute myocardial infarction. Stem Cells Dev, 20(4), 681-93 (2011)
41. F. P. Barry, J. M. Murphy, K. English and B. P. Mahon: Immunogenicity of adult mesenchymal stem cells: lessons from the fetal allograft. Stem Cells Dev, 14(3), 252-65 (2005) (Pubitemid 40885249)
42. M. Zhang, N. Mal, M. Kiedrowski, M. Chacko, A. T. Askari, Z. B. Popovic, O. N. Koc and M. S. Penn: SDF-1 expression by mesenchymal stem cells results in trophic support of cardiac myocytes after myocardial infarction. FASEB J, 21(12), 3197-207 (2007) (Pubitemid 47565538)
43. S. Schenk, N. Mal, A. Finan, M. Zhang, M. kiedrowski, Z. Popovic, P. M. McCarthy and M. S. Penn: Monocyte chemotactic protein-3 is a myocardial mesenchymal stem cell homing factor. Stem Cells, 25(1), 245-251 (2007) (Pubitemid 46052996)
44. K. E. Hatzistergos, H. Quevedo, B. N. Oskouei, Q. Hu, G. S. Feigenbaum, I. S. Margitich, R. Mazhari, A. J. Boyle, J. P. Zambrano, J. E. Rodriguez, R. Dulce, P. M. Pattany, D. Valdes, C. Revilla, A. W. Heldman, I. McNiece and J. M. Hare: Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation. Circ Res, 107(7), 913-22 (2010)
45. Y. Jiang, B. Vaessen, T. Lenvik, M. Blackstad, M. Reyes and C. M. Verfaillie: Multipotent progenitor cells can be isolated from postnatal murine bone marrow, muscle, and brain. Exp Hematol, 30(8), 896-904 (2002) (Pubitemid 34845893)
46. W. Van't Hof, N. Mal, Y. Huang, M. Zhang, Z. Popovic, F. Forudi, R. Deans and M. S. Penn: Direct delivery of syngeneic and allogeneic large-scale expanded multipotent adult progenitor cells improves cardiac function after myocardial infarct. Cytotherapy, 9(5), 477-87 (2007) (Pubitemid 47386685)
47. O. Agbulut, M. Mazo, C. Bressolle, M. Gutierrez, K. Azarnoush, L. Sabbah, N. Niederlander, G. Abizanda, E. J. Andreu, B. Pelacho, J. J. Gavira, M. Perez-Ilzarbe, S. Peyrard, P. Bruneval, J. L. Samuel, M. Soriano-Navarro, J. M. Garcia-Verdugo, A. A. Hagege, F. Prosper and P. Menasche: Can bone marrow-derived multipotent adult progenitor cells regenerate infarcted myocardium? Cardiovasc Res, 72(1), 175-83 (2006) (Pubitemid 44321918)
48. B. Pelacho, Y. Nakamura, J. Zhang, J. Ross, Y. Heremans, M. Nelson-Holte, B. Lemke, J. Hagenbrock, Y. Jiang, F. Prosper, A. Luttun and C. M. Verfaillie: Multipotent adult progenitor cell transplantation increases vascularity and improves left ventricular function after myocardial infarction. J Tissue Eng Regen Med, 1(1), 51-9 (2007)
49. M. Gnecchi, Z. Zhang, A. Ni and V. J. Dzau: Paracrine mechanisms in adult stem cell signaling and therapy. Circ Res, 103(11), 1204-19 (2008)
50. N. Dib, J. Dinsmore, Z. Lababidi, B. White, S. Moravec, A. Campbell, A. Rosenbaum, K. Seyedmadani, W. A. Jaber, C. S. Rizenhour and E. Diethrich: One-year follow-up of feasibility and safety of the first U. S., randomized, controlled study using 3-dimensional guided catheter-based delivery of autologous skeletal myoblasts for ischemic cardiomyopathy (CAuSMIC study). JACC Cardiovasc Interv, 2(1), 9-16 (2009)
51. H. J. Duckers, J. Houtgraaf, C. Hehrlein, J. Schofer, J. Waltenberger, A. Gershlick, J. Bartunek, C. Nienaber, C. Macaya, N. Peters, P. Smits, T. Siminiak, W. van Mieghem, V. Legrand and P. W. Serruys: Final results of a phase IIa, randomised, open-label trial to evaluate the percutaneous intramyocardial transplantation of autologous skeletal myoblasts in congestive heart failure patients: the SEISMIC trial. EuroIntervention, 6(7), 805-12 (2011)
52. P. Menasche, O. Alfieri, S. Janssens, W. McKenna, H. Reichenspurner, L. Trinquart, J. T. Vilquin, J. P. Marolleau, B. Seymour, J. Larghero, S. Lake, G. Chatellier, S. Solomon, M. Desnos and A. A. Hagege: The Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) trial: first randomized placebo-controlled study of myoblast transplantation. Circulation, 117(9), 1189-1200 (2008) (Pubitemid 351552018)
53. M. S. Penn and A. A. Mangi: Genetic enhancement of stem cell engraftment, survival, and efficacy. Circ Res, 102(12), 1471-82 (2008)
54. A. Abdel-Latif, R. Bolli, I. M. Tleyjeh, V. M. Montori, E. C. Perin, C. A. Hornung, E. K. Zuba-Surma, M. Al-Mallah and B. Dawn: Adult bone marrow-derived cells for cardiac repair: a systematic review and meta-analysis. Arch Intern Med, 167(10), 989-97 (2007) (Pubitemid 46835786)
55. S. Janssens, C. Dubois, J. Bogaert, K. Theunissen, C. Deroose, W. Desmet, M. Kalantzi, L. Herbots, P. Sinnaeve, J. Dens, J. Maertens, F. Rademakers, S. Dymarkowski, O. Gheysens, J. Van Cleemput, G. Bormans, J. Nuyts, A. Belmans, L. Mortelmans, M. Boogaerts and F. Van de Werf: Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: doubleblind, randomised controlled trial. Lancet, 367(9505), 113-21 (2006) (Pubitemid 43077127)
56. J. H. Traverse, D. H. McKenna, K. Harvey, B. C. Jorgenso, R. E. Olson, N. Bostrom, D. Kadidlo, J. R. Lesser, V. Jagadeesan, R. Garberich and T. D. Henry: Results of a phase 1, randomized, double-blind, placebo-controlled trial of bone marrow mononuclear stem cell administration in patients following ST-elevation myocardial infarction. Am Heart J, 160(3), 428-34 (2010)
57. S. Charwat, I. Lang, M. Dettke, S. Graf, N. Nyolczas, R. Hemetsberger, S. Zamini, A. Khorsand, H. Sochor, G. Maurer, D. Glogar and M. Gyongyosi: Effect of intramyocardial delivery of autologous bone marrow mononuclear stem cells on the regional myocardial perfusion. NOGA-guided subanalysis of the MYSTAR prospective randomised study. Thromb Haemost, 103(3), 564-71 (2010)
58. M. F. Piepoli, D. Vallisa, M. Arbasi, L. Cavanna, L. Cerri, M. Mori, F. Passerini, L. Tommasi, A. Rossi and A. Capucci: Bone marrow cell transplantation improves cardiac, autonomic, and functional indexes in acute anterior myocardial infarction patients (Cardiac Study). Eur J Heart Fail, 12(2), 172-80 (2010)
59. J. O. Beitnes, E. Hopp, K. Lunde, S. Solheim, H. Arnesen, J. E. Brinchmann, K. Forfang and S. Aakhus: Long-term results after intracoronary injection of autologous mononuclear bone marrow cells in acute myocardial infarction: the ASTAMI randomised, controlled study. Heart, 95(24), 1983-1989 (2009)
60. T. Dill, V. Schachinger, A. Rolf, S. Mollmann, H. Thiele, H. Tillmanns, B. Assmus, S. Dimmeler, A. M. Zeiher and C. Hamm: Intracoronary administration of bone marrow-derived progenitor cells improves left ventricular function in patients at risk for adverse remodeling after acute ST-segment elevation myocardial infarction: results of the Reinfusion of Enriched Progenitor cells And Infarct Remodeling in Acute Myocardial Infarction study (REPAIR-AMI) cardiac magnetic resonance imaging substudy. Am Heart J, 157(3), 541-7 (2009)
61. G. P. Meyer, K. C. Wollert, J. Lotz, J. Pirr, U. Rager, P. Lippolt, A. Hahn, S. Fichtner, A. Schaefer, L. Arseniev, A. Ganser and H. Drexler: Intracoronary bone marrow cell transfer after myocardial infarction: 5-year follow-up from the randomized-controlled BOOST trial. Eur Heart J, 30(24), 2978-84 (2009)
62. D. M. Leistner, U. Fischer-Rasokat, J. Honold, F. H. Seeger, V. Schachinger, R. Lehmann, H. Martin, I. Burck, C. Urbich, S. Dimmeler, A. M. Zeiher and B. Assmus: Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction (TOPCAREAMI): final 5-year results suggest long-term safety and efficacy. Clin Res Cardiol (2011)
63. S. Zhang, A. Sun, D. Xu, K. Yao, Z. Huang, H. Jin, K. Wang, Y. Zou and J. Ge: Impact of timing on efficacy and safetyof intracoronary autologous bone marrow stem cells transplantation in acute myocardial infarction: a pooled subgroup analysis of randomized controlled trials. Clin Cardiol, 32(8), 458-66 (2009)
64. M. S. Penn, S. Anwaruddin, R. Nair and S. Ellis: From mice to men. Commonalities in physiology for stem cell-based cardiac repair. J Am Coll Cardiol, 54(24), 2287-9 (2009)
65. S. Dimmeler, A. M. Zeiher and M. D. Schneider: Unchain my heart: the scientific foundations of cardiac repair. J Clin Invest, 115(3), 572-83 (2005) (Pubitemid 40322227)
66. E. C. Perin, H. F. Dohmann, R. Borojevic, S. A. Silva, A. L. Sousa, G. V. Silva, C. T. Mesquita, L. Belem, W. K. Vaughn, F. O. Rangel, J. A. Assad, A. C. Carvalho, R. V. Branco, M. I. Rossi, H. J. Dohmann and J. T. Willerson: Improved exercise capacity and ischemia 6 and 12 months after transendocardial injection of autologous bone marrow mononuclear cells for ischemic cardiomyopathy. Circulation, 110(11 Suppl 1), II213-8 (2004) (Pubitemid 39263725)
67. B. E. Strauer, M. Yousef and C. M. Schannwell: The acute and long-term effects of intracoronary Stem cell Transplantation in 191 patients with chronic heARt failure: the STAR-heart study. Eur J Heart Fail, 12(7), 721-9 (2010)
68. U. Fischer-Rasokat, B. Assmus, F. H. Seeger, J. Honold, D. Leistner, S. Fichtlscherer, V. Schachinger, T. Tonn, H. Martin, S. Dimmeler and A. M. Zeiher: A pilot trial to assess potential effects of selective intracoronary bone marrow-derived progenitor cell infusion in patients with nonischemic dilated cardiomyopathy: final 1-year results of the transplantation of progenitor cells and functional regeneration enhancement pilot trial in patients with nonischemic dilated cardiomyopathy. Circ Heart Fail, 2(5), 417-23 (2009)
69. J. M. Hare, J. H. Traverse, T. D. Henry, N. Dib, R. K. Strumpf, S. P. Schulman, G. Gerstenblith, A. N. DeMaria, A. E. Denktas, R. S. Gammon, J. B. Hermiller, Jr., M. A. Reisman, G. L. Schaer and W. Sherman: A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction. J Am Coll Cardiol, 54(24), 2277-86 (2009)
70. A. R. Williams, B. Trachtenberg, D. L. Velazquez, I. McNiece, P. Altman, D. Rouy, A. M. Mendizabal, P. M. Pattany, G. A. Lopera, J. Fishman, J. P. Zambrano, A. W. Heldman and J. M. Hare: Intramyocardial stem cell injection in patients with ischemic cardiomyopathy: functional recovery and reverse remodeling. Circ Res, 108(7), 792-6 (2011)
71. B. Assmus, U. Fischer-Rasokat, J. Honold, F. H. Seeger, S. Fichtlscherer, T. Tonn, E. Seifried, V. Schachinger, S. Dimmeler and A. M. Zeiher: Transcoronary transplantation of functionally competent BMCs is associated with a decrease in natriuretic peptide serum levels and improved survival of patients with chronic postinfarction heart failure: results of the TOPCARE-CHD Registry. Circ Res, 100(8), 1234-41 (2007) (Pubitemid 46684137)
72. A. T. Askari, S. Unzek, Z. B. Popovic, C. K. Goldman, F. Forudi, M. Kiedrowski, A. Rovner, S. G. Ellis, J. D. Thomas, P. E. DiCorleto, E. J. Topol and M. S. Penn: Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy. Lancet, 362(9385), 697-703 (2003) (Pubitemid 37101067)
73. M. S. Penn: Importance of the SDF-1:CXCR4 axis in myocardial repair. Circ Res, 104(10), 1133-5 (2009)
74. S. Sundararaman, T. J. Miller, J. M. Pastore, M. Kiedrowski, R. Aras and M. S. Penn: Plasmid-based transient human stromal cell-derived factor-1 gene transfer improves cardiac function in chronic heart failure. Gene Therapy (2011)
75. S. Neragi-Miandoab, J. Kim and G. J. Vlahakes: Malignant tumours of the heart: a review of tumour type, diagnosis and therapy. Clin Oncol (R Coll Radiol), 19(10), 748-56 (2007) (Pubitemid 350011918)
76. J. M. Gonzalez-Rosa, V. Martin, M. Peralta, M. Torres and N. Mercader: Extensive scar formation and regression during heart regeneration after cryoinjury in zebrafish. Development, 138(9), 1663-1674 (2011)
77. K. Schnabel, C. C. Wu, T. Kurth and G. Weidinger: Regeneration of cryoinjury induced necrotic heart lesions in zebrafish is associated with epicardial activation and cardiomyocyte proliferation. PLoS One, 6(4), e18503 (2011)
78. K. D. Poss, L. G. Wilson and M. T. Keating: Heart regeneration in zebrafish. Science, 298(5601), 2188-2190 (2002) (Pubitemid 35471243)
79. K. Kikuchi, J. E. Holdway, A. A. Werdich, R. M. Anderson, Y. Fang, G. F. Egnaczyk, T. Evans, C. A. Macrae, D. Y. Stainier and K. D. Poss: Primary contribution to zebrafish heart regeneration by gata4 (+) cardiomyocytes. Nature, 464(7288), 601-605 (2010)
80. E. R. Porrello, A. I. Mahmoud, E. Simpson, J. A. Hill, J. A. Richardson, E. N. Olson and H. A. Sadek: Transient regenerative potential of the neonatal mouse heart. Science, 331(6020), 1078-1080 (2011)
81. P. C. Hsieh, V. F. Segers, M. E. Davis, C. MacGillivray, J. Gannon, J. D. Molkentin, J. Robbins and R. T. Lee: Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury. Nat Med, 13(8), 970-4 (2007) (Pubitemid 47222045)
82. M. S. Penn, M. E. Mayorga and F. Dong: Youth is wasted on the young. Stem Cell Res Ther, 2(3), 24 (2011)
83. O. Bergmann, R. D. Bhardwaj, S. Bernard, S. Zdunek, F. Barnabe-Heider, S. Walsh, J. Zupicich, K. Alkass, B. A. Buchholz, H. Druid, S. Jovinge and J. Frisen: Evidence for cardiomyocyte renewal in humans. Science, 324(5923), 98-102 (2009)
84. A. P. Beltrami, L. Barlucchi, D. Torella, M. Baker, F. Limana, S. Chimenti, H. Kasahara, M. Rota, E. Musso, K. Urbanek, A. Leri, J. Kajstura, B. Nadal-Ginard and P. Anversa: Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell, 114(6), 763-776 (2003) (Pubitemid 37186770)
85. K. Urbanek, F. Quaini, G. Tasca, D. Torella, C. Castaldo, B. Nadal-Ginard, A. Leri, J. Kajstura, E. Quaini and P. Anversa: Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy. Proc Natl Acad Sci U S A, 100(18), 10440-5 (2003) (Pubitemid 37071897)
86. K. Urbanek, D. Torella, F. Sheikh, A. De Angelis, D. Nurzynska, F. Silvestri, C. A. Beltrami, R. Bussani, A. P. Beltrami, F. Quaini, R. Bolli, A. Leri, J. Kajstura and P. Anversa: Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure. Proc Natl Acad Sci U S A, 102(24), 8692-7 (2005) (Pubitemid 40862797)
87. J. Sandstedt, M. Jonsson, A. Lindahl, A. Jeppsson and J. Asp: C-kit+ CD45-cells found in the adult human heart represent a population of endothelial progenitor cells. Basic Res Cardiol, 105(4), 545-56 (2010)
88. S. Miyamoto, N. Kawaguchi, G. M. Ellison, R. Matsuoka, T. Shin'oka and H. Kurosawa: Characterization of long-term cultured c-kit+ cardiac stem cells derived from adult rat hearts. Stem Cells Dev, 19(1), 105-16 (2010)
89. F. Limana, A. Zacheo, D. Mocini, A. Mangoni, G. Borsellino, A. Diamantini, R. De Mori, L. Battistini, E. Vigna, M. Santini, V. Loiaconi, G. Pompilio, A. Germani and M. C. Capogrossi: Identification of myocardial and vascular precursor cells in human and mouse epicardium. Circ Res, 101(12), 1255-65 (2007) (Pubitemid 350294642)
90. F. Quaini, K. Urbanek, A. P. Beltrami, N. Finato, C. A. Beltrami, B. Nadal-Ginard, J. Kajstura, A. Leri and P. Anversa: Chimerism of the transplanted heart. N Engl J Med, 346(1), 5-15 (2002) (Pubitemid 34438914)
91. A. Itzhaki-Alfia, J. Leor, E. Raanani, L. Sternik, D. Spiegelstein, S. Netser, R. Holbova, M. Pevsner-Fischer, J. Lavee and I. M. Barbash: Patient characteristics and cell source determine the number of isolated human cardiac progenitor cells. Circulation, 120(25), 2559-2566 (2009)
92. J. Fransioli, B. Bailey, N. A. Gude, C. T. Cottage, J. A. Muraski, G. Emmanuel, W. Wu, R. Alvarez, M. Rubio, S. Ottolenghi, E. Schaefer and M. A. Sussman: Evolution of the c-kit-positive cell response to pathological challenge in the myocardium. Stem Cells, 26(5), 1315-1324 (2008)
93. H. Kubo, N. Jaleel, A. Kumarapeli, R. M. Berretta, G. Bratinov, X. Shan, H. Wang, S. R. Houser and K. B. Margulies: Increased cardiac myocyte progenitors in failing human hearts. Circulation, 118(6), 649-657 (2008)
94. J. Kajstura, N. Gurusamy, B. Ogorek, P. Goichberg, C. Clavo-Rondon, T. Hosoda, D. D'Amario, S. Bardelli, A. P. Beltrami, D. Cesselli, R. Bussani, F. del Monte, F. Quaini, M. Rota, C. A. Beltrami, B. A. Buchholz, A. Leri and P. Anversa: Myocyte turnover in the aging human heart. Circ Res, 107(11), 1374-86 (2010)
95. R. Mishra, K. Vijayan, E. J. Colletti, D. A. Harrington, T. S. Matthiesen, D. Simpson, S. K. Goh, B. L. Walker, G. Almeida-Porada, D. Wang, C. L. Backer, S. C. Dudley, Jr., L. E. Wold and S. Kaushal: Characterization and functionality of cardiac progenitor cells in congenital heart patients. Circulation, 123(4), 364-373 (2011)
96. C. Chimenti, J. Kajstura, D. Torella, K. Urbanek, H. Heleniak, C. Colussi, F. Di Meglio, B. Nadal-Ginard, A. Frustaci, A. Leri, A. Maseri and P. Anversa: Senescence and death of primitive cells and myocytes lead to premature cardiac aging and heart failure. Circ Res, 93(7), 604-13 (2003) (Pubitemid 37222156)
97. H. Oh, S. B. Bradfute, T. D. Gallardo, T. Nakamura, V. Gaussin, Y. Mishina, J. Pocius, L. H. Michael, R. R. Behringer, D. J. Garry, M. L. Entman and M. D. Schneider: Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc Natl Acad Sci U S A, 100(21), 12313-8 (2003) (Pubitemid 37271557)
98. K. Matsuura, T. Nagai, N. Nishigaki, T. Oyama, J. Nishi, H. Wada, M. Sano, H. Toko, H. Akazawa, T. Sato, H. Nakaya, H. Kasanuki and I. Komuro: Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes. J Biol Chem, 279(12), 11384-91 (2004) (Pubitemid 38401637)
99. K. Matsuura, A. Honda, T. Nagai, N. Fukushima, K. Iwanaga, M. Tokunaga, T. Shimizu, T. Okano, H. Kasanuki, N. Hagiwara and I. Komuro: Transplantation of cardiac progenitor cells ameliorates cardiac dysfunction after myocardial infarction in mice. J Clin Invest, 119(8), 2204-17 (2009)
100. C. L. Cai, X. Liang, Y. Shi, P. H. Chu, S. L. Pfaff, J. Chen and S. Evans: Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Dev Cell, 5(6), 877-89 (2003) (Pubitemid 37527688)
101. R. Genead, C. Danielsson, A. B. Andersson, M. Corbascio, A. Franco-Cereceda, C. Sylven and K. H. Grinnemo: Islet-1 cells are cardiac progenitors present during the entire lifespan: from the embryonic stage to adulthood. Stem Cells Dev, 19(10), 1601-15 (2010)
102. K. L. Laugwitz, A. Moretti, J. Lam, P. Gruber, Y. Chen, S. Woodard, L. Z. Lin, C. L. Cai, M. M. Lu, M. Reth, O. Platoshyn, J. X. Yuan, S. Evans and K. R. Chien: Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature, 433(7026), 647-653 (2005) (Pubitemid 40282999)
103. L. Bu, X. Jiang, S. Martin-Puig, L. Caron, S. Zhu, Y. Shao, D. J. Roberts, P. L. Huang, I. J. Domian and K. R. Chien: Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages. Nature, 460(7251), 113-117 (2009)
104. C. M. Martin, A. P. Meeson, S. M. Robertson, T. J. Hawke, J. A. Richardson, S. Bates, S. C. Goetsch, T. D. Gallardo and D. J. Garry: Persistent expression of the ATP-binding cassette transporter, Abcg2, identifies cardiac SP cells in the developing and adult heart. Dev Biol, 265(1), 262-75 (2004) (Pubitemid 38018836)
105. M. Huls, F. G. Russel and R. Masereeuw: The role of ATP binding cassette transporters in tissue defense and organ regeneration. J Pharmacol Exp Ther, 328(1), 3-9 (2009)
106. O. Pfister, F. Mouquet, M. Jain, R. Summer, M. Helmes, A. Fine, W. S. Colucci and R. Liao: CD31-but Not CD31+ cardiac side population cells exhibit functional cardiomyogenic differentiation. Circ Res, 97(1), 52-61 (2005) (Pubitemid 40982322)
107. T. Oyama, T. Nagai, H. Wada, A. T. Naito, K. Matsuura, K. Iwanaga, T. Takahashi, M. Goto, Y. Mikami, N. Yasuda, H. Akazawa, A. Uezumi, S. Takeda and I. Komuro: Cardiac side population cells have a potential to migrate and differentiate into cardiomyocytes in vitro and in vivo. J Cell Biol, 176(3), 329-41 (2007) (Pubitemid 46184884)
108. F. Mouquet, O. Pfister, M. Jain, A. Oikonomopoulos, S. Ngoy, R. Summer, A. Fine and R. Liao: Restoration of cardiac progenitor cells after myocardial infarction by self-proliferation and selective homing of bone marrow-derived stem cells. Circ Res, 97(11), 1090-2 (2005)
109. D. R. Davis, Y. Zhang, R. R. Smith, K. Cheng, J. Terrovitis, K. Malliaras, T. S. Li, A. White, R. Makkar and E. Marban: Validation of the cardiosphere method to culture cardiac progenitor cells from myocardial tissue. PLoS One, 4(9), e7195 (2009)
110. E. Messina, L. De Angelis, G. Frati, S. Morrone, S. Chimenti, F. Fiordaliso, M. Salio, M. Battaglia, M. V. Latronico, M. Coletta, E. Vivarelli, L. Frati, G. Cossu and A. Giacomello: Isolation and expansion of adult cardiac stem cells from human and murine heart. Circ Res, 95(9), 911-21 (2004) (Pubitemid 39435006)
111. R. R. Smith, L. Barile, H. C. Cho, M. K. Leppo, J. M. Hare, E. Messina, A. Giacomello, M. R. Abraham and E. Marban: Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens. Circulation, 115(7), 896-908 (2007) (Pubitemid 46294730)
112. I. Chimenti, R. R. Smith, T. S. Li, G. Gerstenblith, E. Messina, A. Giacomello and E. Marban: Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice. Circ Res, 106(5), 971-80 (2010)
113. S. T. Lee, A. J. White, S. Matsushita, K. Malliaras, C. Steenbergen, Y. Zhang, T. S. Li, J. Terrovitis, K. Yee, S. Simsir, R. Makkar and E. Marban: Intramyocardial injection of autologous cardiospheres or cardiospherederived cells preserves function and minimizes adverse ventricular remodeling in pigs with heart failure postmyocardial infarction. J Am Coll Cardiol, 57(4), 455-65 (2011)
114. D. C. Andersen, P. Andersen, M. Schneider, H. B. Jensen and S. P. Sheikh: Murine "cardiospheres" are not a source of stem cells with cardiomyogenic potential. Stem Cells, 27(7), 1571-1581 (2009)
115. Q. Li, Y. Guo, Q. Ou, N. Chen, W. J. Wu, F. Yuan, E. O'Brien, T. Wang, L. Luo, G. N. Hunt, X. Zhu and R. Bolli: Intracoronary administration of cardiac stem cells in mice: a new, improved technique for cell therapy in murine models. Basic Res Cardiol, 106(5), 849-64 (2011)
116. F. Mouquet, O. Pfister, M. Jain, A. Oikonomopoulos, S. Ngoy, R. Summer, A. Fine and R. Liao: Restoration of cardiac progenitor cells after myocardial infarction by self-proliferation and selective homing of bone marrow-derived stem cells. Circ. Res., 97(11), 1090-1092 (2005)
117. S. Unzek, M. Zhang, N. Mal, W. R. Mills, K. R. Laurita and M. S. Penn: SDF-1 recruits cardiac stem celllike cells that depolarize in vivo. Cell Transplant, 16(9), 879-86 (2007) (Pubitemid 351448605)
118. W. R. Mills, N. Mal, M. J. Kiedrowski, R. Unger, F. Forudi, Z. B. Popovic, M. S. Penn and K. R. laurita: Stem cell therapy enhances electrical viability in myocardial infarction. J Mol. Cell Cardiol., 42(304), 314 (2007)
119. R. Bolli, A. R. Chugh, D. D'Amario, J. H. Loughran, M. F. Stoddard, S. Ikram, G. M. Beache, S. G. Wagner, A. Leri, T. Hosoda, F. Sanada, J. B. Elmore, P. Goichberg, D. Cappetta, N. K. Solankhi, I. Fahsah, D. G. Rokosh, M. S. Slaughter, J. Kajstura and P. Anversa: Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial. Lancet, 378(9806), 1847-57 (2011)
120. T. Asahara, T. Murohara, A. Sullivan, M. Silver, R. van der Zee, T. Li, B. Witzenbichler, G. Schatteman and J. M. Isner: Isolation of putative progenitor endothelial cells for angiogenesis. Science, 275(5302), 964-7 (1997) (Pubitemid 27087709)
121. E. Ciraci, S. Della Bella, O. Salvucci, C. Rofani, M. Segarra, C. Bason, A. Molinari, D. Maric, G. Tosato and A. C. Berardi: Adult human circulating CD34-Lin-CD45-CD133-cells can differentiate into hematopoietic and endothelial cells. Blood (2011)
122. A. Caprioli, T. Jaffredo, R. Gautier, C. Dubourg and F. Dieterlen-Lievre: Blood-borne seeding by hematopoietic and endothelial precursors from the allantois. Proc Natl Acad Sci U S A, 95(4), 1641-6 (1998) (Pubitemid 28103446)
123. E. Pelosi, M. Valtieri, S. Coppola, R. Botta, M. Gabbianelli, V. Lulli, G. Marziali, B. Masella, R. Muller, C. Sgadari, U. Testa, G. Bonanno and C. Peschle: Identification of the hemangioblast in postnatal life. Blood, 100(9), 3203-3208 (2002) (Pubitemid 35217068)
124. C. Urbich, C. Heeschen, A. Aicher, E. Dernbach, A. M. Zeiher and S. Dimmeler: Relevance of monocytic features for neovascularization capacity of circulating endothelial progenitor cells. Circulation, 108(20), 2511-2516 (2003) (Pubitemid 37444414)
125. M. Massa, V. Rosti, M. Ferrario, R. Campanelli, I. Ramajoli, R. Rosso, G. M. De Ferrari, M. Ferlini, L. Goffredo, A. Bertoletti, C. Klersy, A. Pecci, R. Moratti and L. Tavazzi: Increased circulating hematopoietic and endothelial progenitor cells in the early phase of acute myocardial infarction. Blood, 105(1), 199-206 (2005) (Pubitemid 40053083)
126. S. Shintani, T. Murohara, H. Ikeda, T. Ueno, T. Honma, A. Katoh, K. Sasaki, T. Shimada, Y. Oike and T. Imaizumi: Mobilization of endothelial progenitor cells in patients with acute myocardial infarction. Circulation, 103(23), 2776-2779 (2001) (Pubitemid 32550062)
127. C. K. Kissel, R. Lehmann, B. Assmus, A. Aicher, J. Honold, U. Fischer-Rasokat, C. Heeschen, I. Spyridopoulos, S. Dimmeler and A. M. Zeiher: Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with postinfarction heart failure. J Am Coll Cardiol, 49(24), 2341-9 (2007) (Pubitemid 46891715)
128. G. L. Hoetzer, G. P. Van Guilder, H. M. Irmiger, R. S. Keith, B. L. Stauffer and C. A. DeSouza: Aging, exercise, and endothelial progenitor cell clonogenic and migratory capacity in men. J Appl Physiol, 102(3), 847-52 (2007) (Pubitemid 46377004)
129. C. Heiss, S. Keymel, U. Niesler, J. Ziemann, M. Kelm and C. Kalka: Impaired progenitor cell activity in age-related endothelial dysfunction. J Am Coll Cardiol, 45(9), 1441-8 (2005) (Pubitemid 40615616)
130. E. I. Chang, S. A. Loh, D. J. Ceradini, S. E. Lin, N. Bastidas, S. Aarabi, D. A. Chan, M. L. Freedman, A. J. Giaccia and G. C. Gurtner: Age decreases endothelial progenitor cell recruitment through decreases in hypoxiainducible factor 1alpha stabilization during ischemia. Circulation, 116(24), 2818-29 (2007) (Pubitemid 350291224)
131. R. J. Scheubel, H. Zorn, R. E. Silber, O. Kuss, H. Morawietz, J. Holtz and A. Simm: Age-dependent depression in circulating endothelial progenitor cells in patients undergoing coronary artery bypass grafting. J Am Coll Cardiol, 42(12), 2073-80 (2003) (Pubitemid 37549887)
132. N. A. Sopko, B. A. Turturice, M. E. Becker, C. R. Brown, F. Dong, Z. B. Popovic and M. S. Penn: Bone marrow support of the heart in pressure overload is lost with aging. PLoS One, 5(12), e15187 (2010)
133. J. M. Edelberg, L. Tang, K. Hattori, D. Lyden and S. Rafii: Young adult bone marrow-derived endothelial precursor cells restore aging-impaired cardiac angiogenic function. Circ Res, 90(10), E89-93 (2002)
134. I. M. Conboy, M. J. Conboy, A. J. Wagers, E. R. Girma, I. L. Weissman and T. A. Rando: Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature, 433(7027), 760-764 (2005) (Pubitemid 40292986)
135. S. Fazel, M. Cimini, L. Chen, S. Li, D. Angoulvant, P. Fedak, S. Verma, R. D. Weisel, A. Keating and R. K. Li: Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines. J Clin Invest, 116(7), 1865-77 (2006) (Pubitemid 44033311)
136. A. Deb, S. Wang, K. A. Skelding, D. Miller, D. Simper and N. M. Caplice: Bone marrow-derived cardiomyocytes are present in adult human heart: A study of gender-mismatched bone marrow transplantation patients. Circulation, 107(9), 1247-1249 (2003) (Pubitemid 36314405)
137. R. A. de Weger, I. Verbrugge, A. H. Bruggink, M. M. van Oosterhout, Y. de Souza, D. F. van Wichen, F. H. Gmelig-Meyling, N. de Jonge and L. F. Verdonck: Stem cell-derived cardiomyocytes after bone marrow and heart transplantation. Bone Marrow Transplant, 41(6), 563-9 (2008) (Pubitemid 351472148)
138. P. Muller, A. Kazakov, A. Semenov, M. Bohm and U. Laufs: Pressure-induced cardiac overload induces upregulation of endothelial and myocardial progenitor cells. Cardiovasc Res, 77(1), 151-9 (2008) (Pubitemid 351195160)
139. K. A. Jackson, S. M. Majka, H. Wang, J. Pocius, C. J. Hartley, M. W. Majesky, M. L. Entman, L. H. Michael, K. K. Hirschi and M. A. Goodell: Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J Clin Invest, 107(11), 1395-402 (2001) (Pubitemid 32522033)
140. L. Barile, F. Cerisoli, G. Frati, R. Gaetani, I. Chimenti, E. Forte, L. Cassinelli, L. Spinardi, C. Altomare, E. Kizana, A. Giacomello, E. Messina, S. Ottolenghi and M. C. Magli: Bone marrow-derived cells can acquire cardiac stem cells properties in damaged heart. J Cell Mol Med, 15(1), 63-71 (2011)
141. A. J. White, R. R. Smith, S. Matsushita, T. Chakravarty, L. S. Czer, K. Burton, E. R. Schwarz, D. R. Davis, Q. Wang, N. L. Reinsmoen, J. S. Forrester, E. Marban and R. Makkar: Intrinsic cardiac origin of human cardiosphere-derived cells. Eur Heart J (2011)
142. U. Agarwal, W. Ghalayini, F. Dong, K. Weber, Y. R. Zou, S. Y. Rabbany, S. Rafii and M. S. Penn: Role of cardiac myocyte CXCR4 expression in development and left ventricular remodeling after acute myocardial infarction. Circ Res, 107(5), 667-76 (2010)
143. Y. L. Tang, W. Zhu, M. Cheng, L. Chen, J. Zhang, T. Sun, R. Kishore, M. I. Phillips, D. W. Losordo and G. Qin: Hypoxic preconditioning enhances the benefit of cardiac progenitor cell therapy for treatment of myocardial infarction by inducing CXCR4 expression. Circ Res, 104(10), 1209-16 (2009)
144. M. M. Zaruba, H. D. Theiss, M. Vallaster, U. Mehl, S. Brunner, R. David, R. Fischer, L. Krieg, E. Hirsch, B. Huber, P. Nathan, L. Israel, A. Imhof, N. Herbach, G. Assmann, R. Wanke, J. Mueller-Hoecker, G. Steinbeck and W. M. Franz: Synergy between CD26/DPP-IV inhibition and G-CSF improves cardiac function after acute myocardial infarction. Cell Stem Cell, 4(4), 313-323 (2009)
145. K. W. Christopherson, 2nd, G. Hangoc and H. E. Broxmeyer: Cell surface peptidase CD26/dipeptidylpeptidase IV regulates CXCL12/stromal cell-derived factor-1 alphamediated chemotaxis of human cord blood CD34+ progenitor cells. J Immunol, 169(12), 7000-8 (2002) (Pubitemid 36899288)
146. M. Dabusti, F. Lanza, D. Campioni, B. Castagnari, A. Tieghi, S. Moretti, M. Punturieri, C. De Angeli, R. Spanedda, E. Ferrazzi and G. Castoldi: CXCR-4 expression on bone marrow CD34+ cells prior to mobilization can predict mobilization adequacy in patients with hematologic malignancies. J Hematother Stem Cell Res, 12(4), 425-34 (2003) (Pubitemid 36993430)
147. Y. Guo, G. Hangoc, H. Bian, L. M. Pelus and H. E. Broxmeyer: SDF-1/CXCL12 enhances survival and chemotaxis of murine embryonic stem cells and production of primitive and definitive hematopoietic progenitor cells. Stem Cells, 23(9), 1324-1332 (2005) (Pubitemid 41504920)
148. J. H. Traverse, T. D. Henry, S. G. Ellis, C. J. Pepine, J. T. Willerson, D. X. Zhao, J. R. Forder, B. J. Byrne, A. K. Hatzopoulos, M. S. Penn, E. C. Perin, K. W. Baran, J. Chambers, C. Lambert, G. Raveendran, D. I. Simon, D. E. Vaughan, L. M. Simpson, A. P. Gee, D. A. Taylor, C. R. Cogle, J. D. Thomas, G. V. Silva, B. C. Jorgenson, R. E. Olson, S. Bowman, J. Francescon, C. Geither, E. Handberg, D. X. Smith, S. Baraniuk, L. B. Piller, C. Loghin, D. Aguilar, S. Richman, C. Zierold, J. Bettencourt, S. L. Sayre, R. W. Vojvodic, S. I. Skarlatos, D. J. Gordon, R. F. Ebert, M. Kwak, L. A. Moye, R. D. Simari and R. Cardiovascular Cell Therapy: Effect of intracoronary delivery of autologous bone marrow mononuclear cells 2 to 3 weeks following acute myocardial infarction on left ventricular function: the LateTIME randomized trial. JAMA, 306(19), 2110-9 (2011)
149. X. Hu, S. Dai, W. J. Wu, W. Tan, X. Zhu, J. Mu, Y. Guo, R. Bolli and G. Rokosh: Stromal cell derived factor-1 alpha confers protection against myocardial ischemia/reperfusion injury: role of the cardiac stromal cell derived factor-1 alpha CXCR4 axis. Circulation, 116(6), 654-63 (2007) (Pubitemid 47356350)
150. A. Saxena, J. E. Fish, M. D. White, S. Yu, J. W. Smyth, R. M. Shaw, J. M. DiMaio and D. Srivastava: Stromal cellderived factor-1alpha is cardioprotective after myocardial infarction. Circulation, 117(17), 2224-31 (2008)
151. J. M. Tang, J. N. Wang, L. Zhang, F. Zheng, J. Y. Yang, X. Kong, L. Y. Guo, L. Chen, Y. Z. Huang, Y. Wan and S. Y. Chen: VEGF/SDF-1 promotes cardiac stem cell mobilization and myocardial repair in the infarcted heart. Cardiovasc Res, 91(3), 402-11 (2011)
152. M. Majka, A. Janowska-Wieczorek, J. Ratajczak, M. A. Kowalska, G. Vilaire, Z. K. Pan, M. Honczarenko, L. A. Marquez, M. Poncz and M. Z. Ratajczak: Stromal-derived factor 1 and thrombopoietin regulate distinct aspects of human megakaryopoiesis. Blood, 96(13), 4142-51 (2000)
153. M. S. Penn: SDF-1:CXCR4 axis is fundamental for tissue preservation and repair. Am J Pathol, 177(5), 2166-8 (2010)
154. B. R. Avalos: The granulocyte colony-stimulating factor receptor and its role in disorders of granulopoiesis. Leuk Lymphoma, 28(3-4), 265-73 (1998) (Pubitemid 28105033)
155. G. Srinivas, P. Anversa and W. H. Frishman: Cytokines and myocardial regeneration: a novel treatment option for acute myocardial infarction. Cardiol Rev, 17(1), 1-9 (2009)
156. A. M. Leone, L. Galiuto, S. Rutella, M. B. Giannico, S. Brugaletta, B. Garramone, V. De Stefano, G. Liuzzo, M. L. Calcagni, F. Cirillo, A. Giordano, G. Niccoli, L. M. Biasucci, A. G. Rebuzzi, G. Leone and F. Crea: Safety of granulocyte-colony-stimulating factor in acute myocardial infarction (the Rigenera study). Heart, 92(12), 1850-1 (2006) (Pubitemid 44851339)
157. B. R. Avalos: Molecular analysis of the granulocyte colony-stimulating factor receptor. Blood, 88(3), 761-777 (1996) (Pubitemid 26333294)
158. S. G. Ellis, M. S. Penn, B. Bolwell, M. Garcia, M. Chacko, T. Wang, K. J. Brezina, G. McConnell and E. J. Topol: Granulocyte colony stimulating factor in patients with large acute myocardial infarction: results of a pilot doseescalation randomized trial. Am Heart J, 152(6), 1051 e9-14 (2006)
159. K. Jujo, H. Hamada, A. Iwakura, T. Thorne, H. Sekiguchi, T. Clarke, A. Ito, S. Misener, T. Tanaka, E. Klyachko, K. Kobayashi, J. Tongers, J. Roncalli, Y. Tsurumi, N. Hagiwara and D. W. Losordo: CXCR4 blockade augments bone marrow progenitor cell recruitment to the neovasculature and reduces mortality after myocardial infarction. Proc Natl Acad Sci U S A, 107(24), 11008-13 (2010)
160. P. Rovere-Querini, A. Capobianco, P. Scaffidi, B. Valentinis, F. Catalanotti, M. Giazzon, I. E. Dumitriu, S. Muller, M. Iannacone, C. Traversari, M. E. Bianchi and A. A. Manfredi: HMGB1 is an endogenous immune adjuvant released by necrotic cells. EMBO Rep, 5(8), 825-30 (2004) (Pubitemid 39199174)
161. F. Limana, A. Germani, A. Zacheo, J. Kajstura, A. Di Carlo, G. Borsellino, O. Leoni, R. Palumbo, L. Battistini, R. Rastaldo, S. Muller, G. Pompilio, P. Anversa, M. E. Bianchi and M. C. Capogrossi: Exogenous high-mobility group box 1 protein induces myocardial regeneration after infarction via enhanced cardiac C-kit+ cell proliferation and differentiation. Circ Res, 97(8), e73-83 (2005)
162. F. Limana, G. Esposito, D. D'Arcangelo, A. Di Carlo, S. Romani, G. Melillo, A. Mangoni, C. Bertolami, G. Pompilio, A. Germani and M. C. Capogrossi: HMGB1 Attenuates Cardiac Remodelling in the Failing Heart via Enhanced Cardiac Regeneration and miR-206-Mediated Inhibition of TIMP-3. PLoS One, 6(6), e19845 (2011)
163. A. Rossini, A. Zacheo, D. Mocini, P. Totta, A. Facchiano, R. Castoldi, P. Sordini, G. Pompilio, D. Abeni, M. C. Capogrossi and A. Germani: HMGB1-stimulated human primary cardiac fibroblasts exert a paracrine action on human and murine cardiac stem cells. J Mol Cell Cardiol, 44(4), 683-93 (2008)
164. D. Safer, M. Elzinga and V. T. Nachmias: Thymosin beta 4 and Fx, an actin-sequestering peptide, are indistinguishable. J Biol Chem, 266(7), 4029-32 (1991) (Pubitemid 21909312)
165. I. Bock-Marquette, A. Saxena, M. D. White, J. M. Dimaio and D. Srivastava: Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature, 432(7016), 466-472 (2004) (Pubitemid 39576522)
166. N. Sopko, Y. Qin, A. Finan, A. Dadabayev, S. parvin (PIP) complex in human dilated cardiomyopathy. PLoS One, 6(5), e20184 (2011)
167. D. Srivastava, A. Saxena, J. Michael Dimaio and I. Bock-Marquette: Thymosin beta4 is cardioprotective after myocardial infarction. Ann N Y Acad Sci, 1112, 161-70 (2007) (Pubitemid 47598683)
168. S. Shrivastava, D. Srivastava, E. N. Olson, J. M. DiMaio and I. Bock-Marquette: Thymosin beta4 and cardiac repair. Ann N Y Acad Sci, 1194, 87-96 (2010)
169. M. E. Mayorga and M. S. Penn: miR-145 is differentially regulated by TGFbeta1 and ischemia and targets disabled-2 expression and wnt/beta-catenin activity. J Cell Mol Med (2011)