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Volumn 9, Issue 3, 2009, Pages 193-205

Investigational positive inotropic agents for acute heart failure

Author keywords

Acute heart failure; CK 1827452; Inotropic drugs; Istaroxime; Levosimendan

Indexed keywords

ADRENALIN; ADRENERGIC RECEPTOR STIMULATING AGENT; AMIODARONE; AMRINONE; ANGIOTENSIN RECEPTOR ANTAGONIST; BETA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM; CALCIUM SENSITIZER; CATECHOLAMINE; DENOPAMINE; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; DOBUTAMINE; DOPAMINE; ENOXIMONE; INOTROPIC AGENT; ISTAROXIME; LEVOSIMENDAN; LOPRINONE; MILRINONE; NITRATE; NORADRENALIN; PHOSPHODIESTERASE III INHIBITOR; PIPERANOMETOZINE; PLACEBO; PST 2744; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASOACTIVE AGENT; VASODILATOR AGENT;

EID: 73249114314     PISSN: 1871529X     EISSN: None     Source Type: Journal    
DOI: 10.2174/187152909789007070     Document Type: Review
Times cited : (21)

References (82)
  • 1
    • 20044379730 scopus 로고    scopus 로고
    • Nieminen, M.S, Böhm, M, Cowie, M.R, Drexler, H, Filippatos, G.S, Jondeau, G, Hasin, Y, Lopez-Sendon, J, Mebazaa, A, Metra, M, Rhodes, A, Swedberg, K, Priori, S.G, Garcia, M.A, Blanc, J.J, Budaj, A, Cowie, M.R, Dean, V, Deckers, J, Burgos, E.F, Lekakis, J, Lindahl, B, Mazzotta, G, Morais, J, Oto, A, Smiseth, O.A, Garcia, M.A, Dickstein, K, Albuquerque, A, Conthe, P, Crespo-Leiro, M, Ferrari, R, Follath, F, Gavazzi, A, Janssens, U, Komajda, M, Morais, J, Moreno, R, Singer, M, Singh, S, Tendera, M, Thygesen, K, for the ESC Committee for Practice Guideline CPG, Executive summary of the guidelines on the diagnosis and treatment of acute heart failure: the Task Force on Acute Heart Failure of the European Society of Cardiology. Eur. Heart J, 2005, 26, 384-416
    • Nieminen, M.S.; Böhm, M.; Cowie, M.R.; Drexler, H.; Filippatos, G.S.; Jondeau, G.; Hasin, Y.; Lopez-Sendon, J.; Mebazaa, A.; Metra, M.; Rhodes, A.; Swedberg, K.; Priori, S.G.; Garcia, M.A.; Blanc, J.J.; Budaj, A.; Cowie, M.R.; Dean, V.; Deckers, J.; Burgos, E.F.; Lekakis, J.; Lindahl, B.; Mazzotta, G.; Morais, J.; Oto, A.; Smiseth, O.A.; Garcia, M.A.; Dickstein, K.; Albuquerque, A.; Conthe, P.; Crespo-Leiro, M.; Ferrari, R.; Follath, F.; Gavazzi, A.; Janssens, U.; Komajda, M.; Morais, J.; Moreno, R.; Singer, M.; Singh, S.; Tendera, M.; Thygesen, K.; for the ESC Committee for Practice Guideline (CPG). Executive summary of the guidelines on the diagnosis and treatment of acute heart failure: the Task Force on Acute Heart Failure of the European Society of Cardiology. Eur. Heart J., 2005, 26, 384-416.
  • 3
    • 33144483487 scopus 로고    scopus 로고
    • Executive summary: HFSA 2006 comprehensive heart failure practice guideline
    • Adams, K.F.; Lindenfeld, J.; Arnold, J.; et al. Executive summary: HFSA 2006 comprehensive heart failure practice guideline. J. Card. Fail., 2006, 12, 10-38.
    • (2006) J. Card. Fail , vol.12 , pp. 10-38
    • Adams, K.F.1    Lindenfeld, J.2    Arnold, J.3
  • 4
    • 53249090182 scopus 로고    scopus 로고
    • Dickstein, K, Cohen-Solal, A, Filippatos, G, McMurray, J.J, Ponikowski, P, Poole-Wilson, P.A, Strömberg, A, van Veldhuisen, D.J, Atar, D, Hoes, A.W, Keren, A, Mebazaa, A, Nieminen, M, Priori, S.G, Swedberg, K, ESC Committee for Practice Guidelines, Vahanian, A, Camm, J, De Caterina, R, Dean, V, Dickstein, K, Filippatos, G, Funck-Brentano, C, Hellemans, I, Kristensen, S.D, McGregor, K, Sechtem, U, Silber, S, Tendera, M, Widimsky, P, Zamorano, J.L. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine ESICM, Eur. Heart J, 2008, 29, 2388-2442
    • Dickstein, K.; Cohen-Solal, A.; Filippatos, G.; McMurray, J.J.; Ponikowski, P.; Poole-Wilson, P.A.; Strömberg, A.; van Veldhuisen, D.J.; Atar, D.; Hoes, A.W.; Keren, A.; Mebazaa, A.; Nieminen, M.; Priori, S.G.; Swedberg, K.; ESC Committee for Practice Guidelines, Vahanian, A.; Camm, J.; De Caterina, R.; Dean, V.; Dickstein, K.; Filippatos, G.; Funck-Brentano, C.; Hellemans, I.; Kristensen, S.D.; McGregor, K.; Sechtem, U.; Silber, S.; Tendera, M.; Widimsky, P.; Zamorano, J.L. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur. Heart J., 2008, 29, 2388-2442.
  • 5
    • 12844281204 scopus 로고    scopus 로고
    • Risk stratification for in-hospital mortality in heart failure using classification and regression tree (CART) methodology: Analysis of 33,046 patients in the ADHERE registry
    • for the ADHERE Scientific Advisory Committee, Study Group, and Investigators
    • Fonarow, G.C.; Adams, K.F.; Jr.; Abraham, W.T.; Yancy, C.W.; Boscardin, W.J. for the ADHERE Scientific Advisory Committee, Study Group, and Investigators. Risk stratification for in-hospital mortality in heart failure using classification and regression tree (CART) methodology: analysis of 33,046 patients in the ADHERE registry. JAMA, 2005, 293, 572-580.
    • (2005) JAMA , vol.293 , pp. 572-580
    • Fonarow, G.C.1    Adams Jr., K.F.2    Abraham, W.T.3    Yancy, C.W.4    Boscardin, W.J.5
  • 6
    • 34250320026 scopus 로고    scopus 로고
    • Epidemiology of acute heart failure syndromes
    • Alla, F.; Zannad, F.; Filippatos, G. Epidemiology of acute heart failure syndromes. Heart Fail. Rev., 2007, 12, 91-95.
    • (2007) Heart Fail. Rev , vol.12 , pp. 91-95
    • Alla, F.1    Zannad, F.2    Filippatos, G.3
  • 8
    • 25144443947 scopus 로고    scopus 로고
    • Definition and epidemiology of acute heart failure syndromes
    • Nieminen, M.S.; Hariola, V.P. Definition and epidemiology of acute heart failure syndromes. Am. J. Cardiol., 2005, 96 (Suppl), 5G-10G.
    • (2005) Am. J. Cardiol , vol.96 , Issue.SUPPL.
    • Nieminen, M.S.1    Hariola, V.P.2
  • 9
    • 33750731595 scopus 로고    scopus 로고
    • OPTIMIZE-HF Investigators and Coordinators. Systolic blood pressure at admission, clinical characteristics, and outcomes in patients hospitalized with acute heart failure
    • Gheorghiade, M.; Abraham, W.T.; Albert, N.M.; Greenberg, B.H.; O'Connor, C.M.; She, L.; Stough, W.G.; Yancy, C.W.; Young, J.B.; Fonarow, G.C.; OPTIMIZE-HF Investigators and Coordinators. Systolic blood pressure at admission, clinical characteristics, and outcomes in patients hospitalized with acute heart failure. JAMA, 2006, 296, 2217-2226.
    • (2006) JAMA , vol.296 , pp. 2217-2226
    • Gheorghiade, M.1    Abraham, W.T.2    Albert, N.M.3    Greenberg, B.H.4    O'Connor, C.M.5    She, L.6    Stough, W.G.7    Yancy, C.W.8    Young, J.B.9    Fonarow, G.C.10
  • 10
    • 3342959172 scopus 로고    scopus 로고
    • Epidemiology and economic burden of chronic heart failure
    • Bundkirchen, A.; Scwinger, R.H.G. Epidemiology and economic burden of chronic heart failure. Eur. Heart J. Suppl., 2004, 6(Suppl D), D57-D60.
    • (2004) Eur. Heart J. Suppl , vol.6 , Issue.SUPPL. D
    • Bundkirchen, A.1    Scwinger, R.H.G.2
  • 12
    • 0346271500 scopus 로고    scopus 로고
    • The Acute Decompensated Heart Failure National Registry (ADHERE): Opportunities to improve care of patients hospitalized with acute decompensated heart failure
    • Fonarow, G.C. The Acute Decompensated Heart Failure National Registry (ADHERE): opportunities to improve care of patients hospitalized with acute decompensated heart failure. Rev. Cardiovasc. Med., 2003, 4 (Supplement 7), S21-S30.
    • (2003) Rev. Cardiovasc. Med , vol.4 , Issue.SUPPL.EMENT 7
    • Fonarow, G.C.1
  • 13
    • 3142546238 scopus 로고    scopus 로고
    • Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF): Rationale and design
    • Fonarow, G.C.; Abraham, W.T.; Albert, N.M.; et al. Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF): rationale and design. Am. Heart J., 2004, 148, 43-51.
    • (2004) Am. Heart J , vol.148 , pp. 43-51
    • Fonarow, G.C.1    Abraham, W.T.2    Albert, N.M.3
  • 14
    • 84995363390 scopus 로고    scopus 로고
    • EuroHeart Survey Investigators; Heart Failure Association, European Society of Cardiology. EuroHeart Failure Survey II (EHFS II): A survey on hospitalized acute heart failure patients: description of population
    • Nieminen, M.S.; Brutsaert, D.; Dickstein, K.; Drexler, H.; Follath, F.; Harjola, V.P.; Hochadel, M.; Komajda, M.; Lassus, J.; Lopez-Sendon, J.L.; Ponikowski, P.; Tavazzi, L; EuroHeart Survey Investigators; Heart Failure Association, European Society of Cardiology. EuroHeart Failure Survey II (EHFS II): a survey on hospitalized acute heart failure patients: description of population. Eur. Heart J., 2006, 27, 2725-2736.
    • (2006) Eur. Heart J , vol.27 , pp. 2725-2736
    • Nieminen, M.S.1    Brutsaert, D.2    Dickstein, K.3    Drexler, H.4    Follath, F.5    Harjola, V.P.6    Hochadel, M.7    Komajda, M.8    Lassus, J.9    Lopez-Sendon, J.L.10    Ponikowski, P.11    Tavazzi, L.12
  • 16
    • 33845629927 scopus 로고    scopus 로고
    • Characteristics, outcomes, and predictors of 1-year mortality in patients hospitalized for acute heart failure
    • Siirilia-Waris, K.; Lassus, J.; Melin, J.; Peuhkurinene, K.; Nieminen, M.S.; Harjola, V.P. Characteristics, outcomes, and predictors of 1-year mortality in patients hospitalized for acute heart failure. Eur. Heart J., 2006, 27, 3011-3017.
    • (2006) Eur. Heart J , vol.27 , pp. 3011-3017
    • Siirilia-Waris, K.1    Lassus, J.2    Melin, J.3    Peuhkurinene, K.4    Nieminen, M.S.5    Harjola, V.P.6
  • 17
    • 34250347996 scopus 로고    scopus 로고
    • Classical inotropes and new cardiac enhancers
    • Parissis, J.T.; Farmakis, D.; Nieminen, M. Classical inotropes and new cardiac enhancers. Heart Fail. Rev., 2007, 12, 149-156.
    • (2007) Heart Fail. Rev , vol.12 , pp. 149-156
    • Parissis, J.T.1    Farmakis, D.2    Nieminen, M.3
  • 18
    • 43549098268 scopus 로고    scopus 로고
    • Calcium cycling and signaling in cardiac myocytes
    • Bers, D.M. Calcium cycling and signaling in cardiac myocytes. Annu. Rev. Physiol., 2008, 70, 23-49.
    • (2008) Annu. Rev. Physiol , vol.70 , pp. 23-49
    • Bers, D.M.1
  • 19
    • 0004212171 scopus 로고    scopus 로고
    • Lippincott Williams & Wilkins: Philadelphia
    • Katz, A. Physiology of the heart, Lippincott Williams & Wilkins: Philadelphia, 2009.
    • (2009) Physiology of the heart
    • Katz, A.1
  • 20
    • 0032494188 scopus 로고    scopus 로고
    • Troponin and tropomyosin: Proteins that switch on and tune in the activity of cardiac myofilaments
    • Solaro, R.J.; Rarick, H.M. Troponin and tropomyosin: proteins that switch on and tune in the activity of cardiac myofilaments. Circ. Res., 1998, 83, 471-480.
    • (1998) Circ. Res , vol.83 , pp. 471-480
    • Solaro, R.J.1    Rarick, H.M.2
  • 21
    • 0037454137 scopus 로고    scopus 로고
    • The OPTIME-CHF Investigators. Heart failure etiology and response to milrinone in decompensated heart failure: Results from the OPTIME-CHF study
    • Felker, G.M.; Benza, R.L.; Chandler, A.B.; Leimberger, J.D.; Cuffe, M.S.; Califf, R.M.; Gheorghiade, M.; O'Connor, C.M.; The OPTIME-CHF Investigators. Heart failure etiology and response to milrinone in decompensated heart failure: results from the OPTIME-CHF study. J. Am. Coll. Cardiol., 2003, 41, 997-1003.
    • (2003) J. Am. Coll. Cardiol , vol.41 , pp. 997-1003
    • Felker, G.M.1    Benza, R.L.2    Chandler, A.B.3    Leimberger, J.D.4    Cuffe, M.S.5    Califf, R.M.6    Gheorghiade, M.7    O'Connor, C.M.8
  • 22
    • 0036673089 scopus 로고    scopus 로고
    • The effectiveness and relative effectiveness of intravenous inotropic drugs acting through the adrenergic pathway in patients with heart failure-a meta-regression analysis
    • Thackray, S.; Easthaugh, J.; Freemantle, N.; Cleland, J.G. The effectiveness and relative effectiveness of intravenous inotropic drugs acting through the adrenergic pathway in patients with heart failure-a meta-regression analysis. Eur. J. Heart Fail., 2002, 4, 515-529.
    • (2002) Eur. J. Heart Fail , vol.4 , pp. 515-529
    • Thackray, S.1    Easthaugh, J.2    Freemantle, N.3    Cleland, J.G.4
  • 23
    • 0042092537 scopus 로고    scopus 로고
    • Clinical use of inotropic therapy for heart failure: Looking backward or forward? Part I: inotropic infusions during hospitalization
    • Stevenson, L. Clinical use of inotropic therapy for heart failure: looking backward or forward? Part I: inotropic infusions during hospitalization. Circulation, 2003, 108, 367-372.
    • (2003) Circulation , vol.108 , pp. 367-372
    • Stevenson, L.1
  • 24
    • 25144443006 scopus 로고    scopus 로고
    • Reassessment of dobutamine, dopamine, and milrinone in the management of acute heart failure syndromes
    • Bayram, M.; De Luca, L.; Massie, M.B.; Gheorghiade, M. Reassessment of dobutamine, dopamine, and milrinone in the management of acute heart failure syndromes. Am. J. Cardiol., 2005, 96, 47G-58G.
    • (2005) Am. J. Cardiol , vol.96
    • Bayram, M.1    De Luca, L.2    Massie, M.B.3    Gheorghiade, M.4
  • 26
    • 21344469500 scopus 로고    scopus 로고
    • The ADHERE Scientific Advisory Committee and Investigators and ADHERE Study Group. In-hospital mortality in patients with acute decompensated heart failure requiring intravenous vasoactive medications: Analysis from the Acute Decompensated Heart Failure National Registry (ADHERE)
    • Abraham, W.T.; Adams, K.F.; Fonarow, G.C.; Costanzo, M.R.; Berkowitz, R.L.; LeJemtel, T.H.; Cheng, M.L.; Wynne, J. The ADHERE Scientific Advisory Committee and Investigators and ADHERE Study Group. In-hospital mortality in patients with acute decompensated heart failure requiring intravenous vasoactive medications: analysis from the Acute Decompensated Heart Failure National Registry (ADHERE). J. Am. Coll. Cardiol., 2005, 46, 57-64.
    • (2005) J. Am. Coll. Cardiol , vol.46 , pp. 57-64
    • Abraham, W.T.1    Adams, K.F.2    Fonarow, G.C.3    Costanzo, M.R.4    Berkowitz, R.L.5    LeJemtel, T.H.6    Cheng, M.L.7    Wynne, J.8
  • 27
    • 0032814621 scopus 로고    scopus 로고
    • Continuous intravenous dobutamine is associated with an increased risk of death in patients with advanced heart failure: Insights from the Flolan International Randomized Survival Trial (FIRST)
    • O'Connor, C.M.; Gattis, W.A.; Uretsky, B.F.; Adams, K.F.; Jr, McNulty, S.E.; Grossman, S.H.; McKenna, W.J.; Zannad, F.; Swedberg, K.; Gheorghiade, M.; Califf, R.M. Continuous intravenous dobutamine is associated with an increased risk of death in patients with advanced heart failure: insights from the Flolan International Randomized Survival Trial (FIRST). Am. Heart J., 1999, 138, 78-86.
    • (1999) Am. Heart J , vol.138 , pp. 78-86
    • O'Connor, C.M.1    Gattis, W.A.2    Uretsky, B.F.3    Adams Jr, K.F.4    McNulty, S.E.5    Grossman, S.H.6    McKenna, W.J.7    Zannad, F.8    Swedberg, K.9    Gheorghiade, M.10    Califf, R.M.11
  • 30
    • 34547837711 scopus 로고    scopus 로고
    • OPTIMIZE-HF Investigators and Hospitals. Characteristics, treatments, and outcomes of patients with preserved systolic function hospitalized for heart failure: A report from the OPTIMIZE-HF Registry
    • Fonarow, G.C.; Stough, W.G.; Abraham, W.T.; Albert, N.M.; Gheorghiade, M.; Greenberg, B.H.; O'Connor, C.M.; Sun, J.L.; Yancy, C.W.; Young, J.B.; OPTIMIZE-HF Investigators and Hospitals. Characteristics, treatments, and outcomes of patients with preserved systolic function hospitalized for heart failure: a report from the OPTIMIZE-HF Registry. J. Am. Coll. Cardiol., 2007, 50, 768-777.
    • (2007) J. Am. Coll. Cardiol , vol.50 , pp. 768-777
    • Fonarow, G.C.1    Stough, W.G.2    Abraham, W.T.3    Albert, N.M.4    Gheorghiade, M.5    Greenberg, B.H.6    O'Connor, C.M.7    Sun, J.L.8    Yancy, C.W.9    Young, J.B.10
  • 31
    • 0037626650 scopus 로고    scopus 로고
    • Carvedilol hibrenating reversible ischaemia trial: Marker of success investigators. Myocardial viability as a determinant of ejection fraction response to carvediol in patients with heart failure (CHRISTMAS trial): randomized control trial
    • Cleland, J.G.; Pennell, D.J.; Ray, S.G.; Coats, A.J.; Macfarlane, P.W.; Murray, G.D.; Dalle M.J, Vered, Z.; Lahiri, A. Carvedilol hibrenating reversible ischaemia trial: marker of success investigators. Myocardial viability as a determinant of ejection fraction response to carvediol in patients with heart failure (CHRISTMAS trial): randomized control trial. Lancet, 2003, 362, 14-21.
    • (2003) Lancet , vol.362 , pp. 14-21
    • Cleland, J.G.1    Pennell, D.J.2    Ray, S.G.3    Coats, A.J.4    Macfarlane, P.W.5    Murray, G.D.6    Dalle, M.J.7    Vered, Z.8    Lahiri, A.9
  • 32
    • 0030819472 scopus 로고    scopus 로고
    • Clinical determinants of mortality in patients with angiographically diagnosed ischemic or non-ischemic cardiomyopathy
    • Bart, B.A.; Shaw, L.K.; McCants, C.B.; Jr, Fortin, D.F.; Lee, K.L.; Califf, R.M.; O'Connor, C.M. Clinical determinants of mortality in patients with angiographically diagnosed ischemic or non-ischemic cardiomyopathy. J. Am. Coll. Cardiol., 1997, 30, 1002-1008.
    • (1997) J. Am. Coll. Cardiol , vol.30 , pp. 1002-1008
    • Bart, B.A.1    Shaw, L.K.2    McCants Jr, C.B.3    Fortin, D.F.4    Lee, K.L.5    Califf, R.M.6    O'Connor, C.M.7
  • 33
    • 33644872067 scopus 로고    scopus 로고
    • Neurohormonal Inhibition in heart failure: Insights from recent clinical trials
    • Gheorghiade, M.; De Luca, L.; Bonow, R.O. Neurohormonal Inhibition in heart failure: insights from recent clinical trials. Am. J. Cardiol., 2005, 96, 3L-9L.
    • (2005) Am. J. Cardiol , vol.96
    • Gheorghiade, M.1    De Luca, L.2    Bonow, R.O.3
  • 34
    • 0027321634 scopus 로고
    • Development of short-term myocardial hibernation: Its limitation by the severity of ischemia and inotropic stimulation
    • Schulz, R.; Rose, J.; Martin, C.; Brodde, O.E.; Heusch, G. Development of short-term myocardial hibernation: its limitation by the severity of ischemia and inotropic stimulation. Circulation, 1993, 88, 684-695.
    • (1993) Circulation , vol.88 , pp. 684-695
    • Schulz, R.1    Rose, J.2    Martin, C.3    Brodde, O.E.4    Heusch, G.5
  • 36
    • 0035399986 scopus 로고    scopus 로고
    • Comparison of the occurrence of ventricular arrhythmias in patients with acutely decompensated congestive heart failure receiving dobutamine versus nesiritide therapy
    • Burger, A.J.; Elkayam, U.; Neibaur, M.T.; Haught, H.; Ghali, J.; Horton, D.P.; Aronson, D.Comparison of the occurrence of ventricular arrhythmias in patients with acutely decompensated congestive heart failure receiving dobutamine versus nesiritide therapy. Am. J. Cardiol., 2001, 88, 35-39.
    • (2001) Am. J. Cardiol , vol.88 , pp. 35-39
    • Burger, A.J.1    Elkayam, U.2    Neibaur, M.T.3    Haught, H.4    Ghali, J.5    Horton, D.P.6    Aronson, D.7
  • 37
    • 0028922806 scopus 로고
    • Troponin C-mediated calcium sensitization induced by levosimendan does not impair relaxation
    • Haikala, H.; Nissinen, E.; Etemadzadeh, E.; Levijoki, J.; Linden, I.B. Troponin C-mediated calcium sensitization induced by levosimendan does not impair relaxation. J. Cardiovasc. Pharmacol., 1995, 25, 794-801.
    • (1995) J. Cardiovasc. Pharmacol , vol.25 , pp. 794-801
    • Haikala, H.1    Nissinen, E.2    Etemadzadeh, E.3    Levijoki, J.4    Linden, I.B.5
  • 41
    • 2942574937 scopus 로고    scopus 로고
    • The calcium sensitizer levosimendan improves the function of stunned myocardium after percutaneous transluminal coronary angioplasty in acute myocardial ischemia
    • Sonntag, S.; Sundberg, S.; Lehtonen, L.A.; Kleber, F.X. The calcium sensitizer levosimendan improves the function of stunned myocardium after percutaneous transluminal coronary angioplasty in acute myocardial ischemia. J. Am. Coll. Cardiol., 2004, 43, 2177-2182.
    • (2004) J. Am. Coll. Cardiol , vol.43 , pp. 2177-2182
    • Sonntag, S.1    Sundberg, S.2    Lehtonen, L.A.3    Kleber, F.X.4
  • 43
    • 0033959417 scopus 로고    scopus 로고
    • Levosimendan, a new positive inotropic drug, decreases myocardial infarct size via activation of K(ATP) channels
    • Kersten, J.R.; Montgomery, M.W.; Pagel, P.S.; Warltier, D.C. Levosimendan, a new positive inotropic drug, decreases myocardial infarct size via activation of K(ATP) channels. Anesth. Analg., 2000, 90, 5-11.
    • (2000) Anesth. Analg , vol.90 , pp. 5-11
    • Kersten, J.R.1    Montgomery, M.W.2    Pagel, P.S.3    Warltier, D.C.4
  • 44
  • 45
    • 0034634284 scopus 로고    scopus 로고
    • Myocardial K(ATP) channels in preconditioning
    • O'Rourke, B. Myocardial K(ATP) channels in preconditioning. Circ. Res., 2000, 87, 845-855.
    • (2000) Circ. Res , vol.87 , pp. 845-855
    • O'Rourke, B.1
  • 46
    • 25144460454 scopus 로고    scopus 로고
    • Cardioprotection: A new paradigm in the management of acute heart failure syndromes
    • Maytin, M.; Colucci, W.S. Cardioprotection: a new paradigm in the management of acute heart failure syndromes. Am. J. Cardiol., 2005, 96, 26G-31G.
    • (2005) Am. J. Cardiol , vol.96
    • Maytin, M.1    Colucci, W.S.2
  • 48
    • 0036795429 scopus 로고    scopus 로고
    • Pharmacokinetics of levosimendan and its metabolites during and after a 24-hour continuous infusion in patients with severe heart failure
    • Kivikko, M.; Antila, S.; Eha, J.; Lehtonen, L.; Pentikainen, P.J. Pharmacokinetics of levosimendan and its metabolites during and after a 24-hour continuous infusion in patients with severe heart failure. Int. J. Clin. Pharmacol. Ther., 2002, 40, 465-471.
    • (2002) Int. J. Clin. Pharmacol. Ther , vol.40 , pp. 465-471
    • Kivikko, M.1    Antila, S.2    Eha, J.3    Lehtonen, L.4    Pentikainen, P.J.5
  • 51
    • 0037142946 scopus 로고    scopus 로고
    • Steering Committee and Investigators of the Levosimendan Infusion versus Dobutamine (LIDO) Study. Efficacy and safety of intravenous levosimendan compared with dobutamine in severe low-output heart failure (the LIDO study): A randomised double-blind trial
    • Follath, F.; Cleland, J.G.; Just, H.; Papp, J.G.; Scholz, H.; Peuhkurinen, K.; Harjola, V.P.; Mitrovic, V.; Abdalla, M.; Sandell, E.P.; Lehtonen, L. Steering Committee and Investigators of the Levosimendan Infusion versus Dobutamine (LIDO) Study. Efficacy and safety of intravenous levosimendan compared with dobutamine in severe low-output heart failure (the LIDO study): a randomised double-blind trial. Lancet, 2002, 360, 196-202.
    • (2002) Lancet , vol.360 , pp. 196-202
    • Follath, F.1    Cleland, J.G.2    Just, H.3    Papp, J.G.4    Scholz, H.5    Peuhkurinen, K.6    Harjola, V.P.7    Mitrovic, V.8    Abdalla, M.9    Sandell, E.P.10    Lehtonen, L.11
  • 52
    • 16344362711 scopus 로고    scopus 로고
    • Effects of intravenous levosimendan on human coronary vasomotor regulation, left ventricular wall stress, and myocardial oxygen uptake
    • Michaels, A.D.; McKeown, B.; Kostal, M.; Vakharia, K.T.; Jordan, M.V.; Gerber, I.L.; Foster, E.; Chatterjee, K. Effects of intravenous levosimendan on human coronary vasomotor regulation, left ventricular wall stress, and myocardial oxygen uptake. Circulation, 2005, 111, 1504-1509.
    • (2005) Circulation , vol.111 , pp. 1504-1509
    • Michaels, A.D.1    McKeown, B.2    Kostal, M.3    Vakharia, K.T.4    Jordan, M.V.5    Gerber, I.L.6    Foster, E.7    Chatterjee, K.8
  • 54
    • 0033600153 scopus 로고    scopus 로고
    • Effects of intravenous levosimendan on plasma neurohormone levels in patients with heart failure: Relation to hemodynamic response
    • Nicklas, J.M.; Monsur, J.C.; Bleske, B.E. Effects of intravenous levosimendan on plasma neurohormone levels in patients with heart failure: relation to hemodynamic response. Am. J. Cardiol., 1999, 83, 12I-15I.
    • (1999) Am. J. Cardiol , vol.83
    • Nicklas, J.M.1    Monsur, J.C.2    Bleske, B.E.3
  • 55
    • 0034126327 scopus 로고    scopus 로고
    • Electrophysiologic effects of a calcium sensitizer inotrope levosimendan administered intravenously in patients with normal cardiac function
    • Toivonen, L.; Viitasalo, M.; Sundberg, S.; Akkila, J.; Lehtonen, L. Electrophysiologic effects of a calcium sensitizer inotrope levosimendan administered intravenously in patients with normal cardiac function. J. Cardiovasc. Pharmacol., 2000, 35, 664-669.
    • (2000) J. Cardiovasc. Pharmacol , vol.35 , pp. 664-669
    • Toivonen, L.1    Viitasalo, M.2    Sundberg, S.3    Akkila, J.4    Lehtonen, L.5
  • 56
  • 57
    • 29444454634 scopus 로고    scopus 로고
    • Clinical trials update from the American Heart Association: REPAIR-AMI, ASTAMI, JELIS, MEGA, REVIVE-II, SURVIVE, and PROACTIVE
    • Cleland, J.G.; Freemantle, N.; Coletta, A.P.; Clark, A.L. Clinical trials update from the American Heart Association: REPAIR-AMI, ASTAMI, JELIS, MEGA, REVIVE-II, SURVIVE, and PROACTIVE. Eur. J. Heart Fail., 2006, 8, 105-110.
    • (2006) Eur. J. Heart Fail , vol.8 , pp. 105-110
    • Cleland, J.G.1    Freemantle, N.2    Coletta, A.P.3    Clark, A.L.4
  • 58
    • 0036764821 scopus 로고    scopus 로고
    • RUSSLAN Study Investigators. Safety and efficacy of a novel calcium sensitizer, levosimendan, in patients with left ventricular failure due to an acute myocardial infarction: A randomized, placebo-controlled, double-blind study (RUSSLAN)
    • Moiseyev, V.S.; Põder, P.; Andrejevs, N.; Ruda, M.Y.; Golikov, A.P.; Lazebnik, L.B.; Kobalava, Z.D.; Lehtonen, L.A.; Laine, T.; Nieminen, M.S.; Lie, K.I.; RUSSLAN Study Investigators. Safety and efficacy of a novel calcium sensitizer, levosimendan, in patients with left ventricular failure due to an acute myocardial infarction: a randomized, placebo-controlled, double-blind study (RUSSLAN). Eur. Heart J., 2002, 23, 1422-1432.
    • (2002) Eur. Heart J , vol.23 , pp. 1422-1432
    • Moiseyev, V.S.1    Põder, P.2    Andrejevs, N.3    Ruda, M.Y.4    Golikov, A.P.5    Lazebnik, L.B.6    Kobalava, Z.D.7    Lehtonen, L.A.8    Laine, T.9    Nieminen, M.S.10    Lie, K.I.11
  • 59
    • 3142584905 scopus 로고    scopus 로고
    • The effect of a calcium sensitizer or an inotrope or none in chronic low output decompensated heart failure: Results from the Calcium Sensitizer or Inotrope or None in Low Output Heart Failure Study (CASINO)
    • Zairis, M.N.; Apostolatos, C.; Anastasiadis, P. The effect of a calcium sensitizer or an inotrope or none in chronic low output decompensated heart failure: results from the Calcium Sensitizer or Inotrope or None in Low Output Heart Failure Study (CASINO). J. Am. Coll. Cardiol., 2004, 43 (Supplement 1), 206A-207A.
    • (2004) J. Am. Coll. Cardiol , vol.43 , Issue.SUPPL.EMENT 1
    • Zairis, M.N.1    Apostolatos, C.2    Anastasiadis, P.3
  • 60
    • 2942619175 scopus 로고    scopus 로고
    • Development of a comprehensive new endpoint for the evaluation of new treatments for acute decompensated heart failure results with levosimendan in the REVIVE-1 study
    • Packer, M.; Colucci, W.S.; Fisher, L.; Massie, B.M.; Teerlink, J.R.; YOUNG, J.B.; Garratt, C.J. Development of a comprehensive new endpoint for the evaluation of new treatments for acute decompensated heart failure results with levosimendan in the REVIVE-1 study. J. Card. Fail., 2003, 9, S61.
    • (2003) J. Card. Fail , vol.9
    • Packer, M.1    Colucci, W.S.2    Fisher, L.3    Massie, B.M.4    Teerlink, J.R.5    YOUNG, J.B.6    Garratt, C.J.7
  • 61
    • 17644420083 scopus 로고    scopus 로고
    • Effect of levosimendan treatment on length of hospital and intensive care stay in the REVIVE I study [abstract]
    • Johansson, S.; Apajasalo, M.; Sarapohja, T.; Garratt, C. Effect of levosimendan treatment on length of hospital and intensive care stay in the REVIVE I study [abstract]. Crit. Care, 2004, 8 (Suppl 1), P88.
    • (2004) Crit. Care , vol.8 , Issue.SUPPL. 1
    • Johansson, S.1    Apajasalo, M.2    Sarapohja, T.3    Garratt, C.4
  • 62
    • 73249126424 scopus 로고    scopus 로고
    • Packer, M. The Randomized multicenter EValuation of Intravenous leVosimendan Efficacy-2 (REVIVE-2) trial. Late-breaking Clinical Trials. Dallas, TX: American Heart Association, Annual Scientific Session; November 2005 13-6.
    • Packer, M. The Randomized multicenter EValuation of Intravenous leVosimendan Efficacy-2 (REVIVE-2) trial. Late-breaking Clinical Trials. Dallas, TX: American Heart Association, Annual Scientific Session; November 2005 pg. 13-6.
  • 65
    • 0041302190 scopus 로고    scopus 로고
    • Hemodynamic effects of a new inotropic compound, PST-2744, in dogs with chronic ischemic heart failure
    • Adamson, P.B.; Vanoli, E.; Mattera, G.G.; et al. Hemodynamic effects of a new inotropic compound, PST-2744, in dogs with chronic ischemic heart failure. J. Cardiovasc. Pharmacol., 2003, 42, 169-173.
    • (2003) J. Cardiovasc. Pharmacol , vol.42 , pp. 169-173
    • Adamson, P.B.1    Vanoli, E.2    Mattera, G.G.3
  • 66
    • 33846239374 scopus 로고    scopus 로고
    • Hemodynamic properties of a new-generation positive luso-inotropic agent for the acute treatment of advanced heart failure
    • Sabbah, H.N.; Imai, M.; Cowart, D.; Amato, A.; Carminati, P.; Gheorghiade, M. Hemodynamic properties of a new-generation positive luso-inotropic agent for the acute treatment of advanced heart failure. Am. J. Cardiol., 2007, 99, 41A-46A
    • (2007) Am. J. Cardiol , vol.99
    • Sabbah, H.N.1    Imai, M.2    Cowart, D.3    Amato, A.4    Carminati, P.5    Gheorghiade, M.6
  • 68
    • 33846225206 scopus 로고    scopus 로고
    • A phase 1-2 dose-escalating study evaluating the safety and tolerability of istaroxime and specific effects on electrocardiographic and hemodynamic parameters in patients with chronic heart failure and reduced systolic function
    • Ghali, J.K.; Smith, W.B.; Torre-Amione, G.; Haynos, W.; Rayburn, B.K.; Amato, A.; Zhang, D.; Cowart, D.; Valentini, G.; Carminati, P.; Gheorghiade, M. A phase 1-2 dose-escalating study evaluating the safety and tolerability of istaroxime and specific effects on electrocardiographic and hemodynamic parameters in patients with chronic heart failure and reduced systolic function. J. Am. Coll. Cardiol., 2007, 99, 47A-56A.
    • (2007) J. Am. Coll. Cardiol , vol.99
    • Ghali, J.K.1    Smith, W.B.2    Torre-Amione, G.3    Haynos, W.4    Rayburn, B.K.5    Amato, A.6    Zhang, D.7    Cowart, D.8    Valentini, G.9    Carminati, P.10    Gheorghiade, M.11
  • 70
    • 33750309957 scopus 로고    scopus 로고
    • Activating cardiac myosin, a novel inotropic mechanism to improve cardiac function in conscious dogs with congestive heart failure
    • Shen, Y.T.; Vatner, S.F.; Morgans, D.J.; Malik, F. Activating cardiac myosin, a novel inotropic mechanism to improve cardiac function in conscious dogs with congestive heart failure. J. Card. Fail., 2006, 12, S87.
    • (2006) J. Card. Fail , vol.12
    • Shen, Y.T.1    Vatner, S.F.2    Morgans, D.J.3    Malik, F.4
  • 72
    • 37548999218 scopus 로고    scopus 로고
    • The Selective Cardiac Myosin Activator, CK-1827452, a calcium-independent inotrope, increases left ventricular systolic function by increasing ejection time rather than the velocity of contraction
    • Malik, F.; Teerlink, J.R.; Escandon, R.; Clarke, C.P.; Wolff, A.A. The Selective Cardiac Myosin Activator, CK-1827452, a calcium-independent inotrope, increases left ventricular systolic function by increasing ejection time rather than the velocity of contraction. Circulation, 2006, 114, II-441.
    • (2006) Circulation , vol.114 , Issue.II-441
    • Malik, F.1    Teerlink, J.R.2    Escandon, R.3    Clarke, C.P.4    Wolff, A.A.5
  • 73
    • 70449112931 scopus 로고    scopus 로고
    • A novel approach to improve cardiac performance: Cardiac myosin activators
    • Rev, Feb 21, Epub ahead of print
    • Teerlink, J. R. A novel approach to improve cardiac performance: cardiac myosin activators. Heart Fail. Rev., 2009; Feb 21. [Epub ahead of print].
    • (2009) Heart Fail
    • Teerlink, J.R.1
  • 74
    • 37549009772 scopus 로고    scopus 로고
    • In vitro and in vivo characterization of CK-1827452, a selective cardiac myosin activator
    • Anderson, R.L.; Sueoka, S.H.; Lee, K.H.; et al. In vitro and in vivo characterization of CK-1827452, a selective cardiac myosin activator. J. Cardiac. Fail., 2006, 12 (Suppl), S86.
    • (2006) J. Cardiac. Fail , vol.12 , Issue.SUPPL.
    • Anderson, R.L.1    Sueoka, S.H.2    Lee, K.H.3
  • 75
    • 73249136797 scopus 로고    scopus 로고
    • Anderson, R.; Pokrovskii, M.; Elias, K. Effects of Cardiac Myosin Activators on Excitation-Contraction (E-C) Coupling in Ventricular Myocytes. 2007 Biophysical Society Meeting Abstracts. Biophys. J., 2007, Suppl: 133A.
    • Anderson, R.; Pokrovskii, M.; Elias, K. Effects of Cardiac Myosin Activators on Excitation-Contraction (E-C) Coupling in Ventricular Myocytes. 2007 Biophysical Society Meeting Abstracts. Biophys. J., 2007, Suppl: 133A.
  • 76
    • 73249129803 scopus 로고    scopus 로고
    • Malik, F.; Elias, K.A.; Finer, J.T.; Morgan, B.P.; Sakowicz, R.; Anderson, R.; Baliga, R.; Conn, L.; Cox, D.; Garard, M.; Hartman, J.; Irvine, J.; Kawas, R.; Kraynack, E.; Kuklov, A.; Lee, K.H.; Lu, P.; Muci, D.; Pierce, D.W.; Rodriguez, H.; Suehiro, I.; Sueoka, S.H.; Sylvester, S.; Tochimoto, T.; Valdez, C.; Wang, W.; Katori, T.; Kass, D.A.; Shen, Y.T.; Vatner, S.F.; Morgans, D.J. Direct activation of cardiac myosin by CK-1827452 improves cardiac function in a dog heart failure model. J. Card. Fail., 2005, 11 (suppl), S95.
    • Malik, F.; Elias, K.A.; Finer, J.T.; Morgan, B.P.; Sakowicz, R.; Anderson, R.; Baliga, R.; Conn, L.; Cox, D.; Garard, M.; Hartman, J.; Irvine, J.; Kawas, R.; Kraynack, E.; Kuklov, A.; Lee, K.H.; Lu, P.; Muci, D.; Pierce, D.W.; Rodriguez, H.; Suehiro, I.; Sueoka, S.H.; Sylvester, S.; Tochimoto, T.; Valdez, C.; Wang, W.; Katori, T.; Kass, D.A.; Shen, Y.T.; Vatner, S.F.; Morgans, D.J. Direct activation of cardiac myosin by CK-1827452 improves cardiac function in a dog heart failure model. J. Card. Fail., 2005, 11 (suppl), S95.
  • 77
    • 70449117085 scopus 로고    scopus 로고
    • A novel inotropic agent that activates cardiac myosin and increases cardiac contractility without increasing MVO2 in heart failure with left ventricular hypertrophy
    • Shen, Y.; Zhang, Y.; Morgans, D.J.; Vatner, S.F.; Malik, F. A novel inotropic agent that activates cardiac myosin and increases cardiac contractility without increasing MVO2 in heart failure with left ventricular hypertrophy. J. Am. Coll. Cardiol., 2008, 51 (Suppl), A54.
    • (2008) J. Am. Coll. Cardiol , vol.51 , Issue.SUPPL.
    • Shen, Y.1    Zhang, Y.2    Morgans, D.J.3    Vatner, S.F.4    Malik, F.5
  • 78
    • 37549012800 scopus 로고    scopus 로고
    • The selective cardiac myosin activator CK-1827452, a calcium-independent inotrope, increases LV systolic function by increasing ejection time: Results of a first-in-human study of a unique and novel mechanism
    • Teerlink, J.R.; Malik, F.I.; Clarke, C.P.; Saikali, K.; Escandon, R.; Lee, J.H.; Wolff, A.A. The selective cardiac myosin activator CK-1827452, a calcium-independent inotrope, increases LV systolic function by increasing ejection time: results of a first-in-human study of a unique and novel mechanism. J. Card. Fail., 2006, 12, 763.
    • (2006) J. Card. Fail , vol.12 , pp. 763
    • Teerlink, J.R.1    Malik, F.I.2    Clarke, C.P.3    Saikali, K.4    Escandon, R.5    Lee, J.H.6    Wolff, A.A.7
  • 79
    • 64349098324 scopus 로고    scopus 로고
    • Systolic ejection time is a sensitive indicator of left ventricular systolic function during treatment with the selective cardiac myosin activator, CK-1827452
    • Malik, F.; Saikai, K.G.; Clarke, C.O.; Teerlink, J.R.; Wolff, A.A. Systolic ejection time is a sensitive indicator of left ventricular systolic function during treatment with the selective cardiac myosin activator, CK-1827452. J. Cardiac. Fail., 2007, 13 (Suppl 2), S145-S146.
    • (2007) J. Cardiac. Fail , vol.13 , Issue.SUPPL. 2
    • Malik, F.1    Saikai, K.G.2    Clarke, C.O.3    Teerlink, J.R.4    Wolff, A.A.5
  • 80
    • 55849111145 scopus 로고    scopus 로고
    • First clinical trial of the selective cardiac myosin activator, CK-1827452, in heart failure: Effect of dose and plasma concentration on systolic function
    • Abstract Suppl
    • Cleland, J.G.F.; McMurray, J.J.; Lang, C.C.; et al. First clinical trial of the selective cardiac myosin activator, CK-1827452, in heart failure: effect of dose and plasma concentration on systolic function. Eur. Heart J., 2008, 29(Abstract Suppl), 299.
    • (2008) Eur. Heart J , Issue.29 , pp. 299
    • Cleland, J.G.F.1    McMurray, J.J.2    Lang, C.C.3
  • 81
    • 73249144386 scopus 로고    scopus 로고
    • The selective cardiac myosin activator, CK-1827452, increases systolic function in a concentration-dependent manner in patients with stable heat failure
    • Senior, R.; Malik, F.; Saikali, K.; Lee, J.; Brand, G.; Wolff, A.A. The selective cardiac myosin activator, CK-1827452, increases systolic function in a concentration-dependent manner in patients with stable heat failure. J. Am. Coll. Cardiol., 2009; 53: A160.
    • (2009) J. Am. Coll. Cardiol , vol.53
    • Senior, R.1    Malik, F.2    Saikali, K.3    Lee, J.4    Brand, G.5    Wolff, A.A.6
  • 82
    • 70449110814 scopus 로고    scopus 로고
    • Oral bioavailability of the selective cardiac myosin activator ck-1827452: Chronic oral inotropic therapy for heart failure?
    • Jerling, M.; Chew, T.; Escandon, R.; Lee, J.; Saikali, K.; Venables, E.; Clarke, C.; Malik, F.; Wolff, A. Oral bioavailability of the selective cardiac myosin activator ck-1827452: chronic oral inotropic therapy for heart failure? J. Cardiac. Fail., 2007, 13, S148 .
    • (2007) J. Cardiac. Fail , vol.13
    • Jerling, M.1    Chew, T.2    Escandon, R.3    Lee, J.4    Saikali, K.5    Venables, E.6    Clarke, C.7    Malik, F.8    Wolff, A.9


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