PI3K-delta mediates double-stranded RNA-induced upregulation of B7-H1 in BEAS-2B airway epithelial cells

Biochemical and Biophysical Research Communications

Volumn 435, Issue 2, 2013, Pages 195-201

  Kan o, Keiko ^a   Matsumoto, Koichiro ^a   Asai Tajiri, Yukari ^a   Fukuyama, Satoru ^a   Hamano, Saaka ^a   Seki, Nanae ^a   Nakanishi, Yoichi ^a   Inoue, Hiromasa ^a,b  

^a KYUSHU UNIVERSITY   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

Airway epithelium; B7 H1; PI3K delta; Virus

Indexed keywords

DOUBLE STRANDED RNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OXIPURINOL; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE DELTA; POLYINOSINIC POLYCYTIDYLIC ACID; PROGRAMMED DEATH 1 LIGAND 1; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; WORTMANNIN;

ARTICLE; ENZYME ACTIVATION; FLOW CYTOMETRY; IMMUNOFLUORESCENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY EPITHELIUM; UPREGULATION; WESTERN BLOTTING;

ANTIGENS, CD274; CELL LINE; DNA, VIRAL; EPITHELIAL CELLS; HUMANS; RESPIRATORY MUCOSA; RNA, DOUBLE-STRANDED; UP-REGULATION;

RESPIRATORY SYNCYTIAL VIRUS;

EID: 84878429967     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.04.082     Document Type: Article

References (31)

1. Jackson D.J., Sykes A., Mallia P., Johnston S.L. Asthma exacerbations: origin, effect, and prevention. J. Allergy Clin. Immunol. 2011, 128:1165-1174.
2. Dimopoulos G., Lerikou M., Tsiodras S., Charanioti A., Perros E., Anagnostopoulou U., Armaganidis A., Karakisos P. Viral epidemiology of acute exacerbations of chronic obstructive pulmonary disease. Pulm. Pharmacol. Ther. 2012, 25:12-18.
3. Alexopoulou L., Holt A.C., Medzhitov R., Flavell R.A. Recognition of double-stranded RNA and activation of NF-kappaB by toll-like receptor 3. Nature 2001, 413:732-738.
4. Yoneyama M., Kikuchi M., Natsukawa T., Shinobu N., Imaizumi T., Miyagishi M., Taira K., Akira S., Fujita T. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat. Immunol. 2004, 5:730-737.
5. Kato H., Takeuchi O., Sato S., Yoneyama M., Yamamoto M., Matsui K., Uematsu S., Jung A., Kawai T., Ishii K.J., Yamaguchi O., Otsu K., Tsujimura T., Koh C.S., Reis e Sousa C., Matsuura Y., Fujita T., Akira S. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 2006, 441:101-105.
6. Zeng R., Cui Y., Hai Y., Liu Y. Pattern recognition receptors for respiratory syncytial virus infection and design of vaccines. Virus Res. 2012, 167:138-145.
7. Slater L., Bartlett N.W., Haas J.J., Zhu J., Message S.D., Walton R.P., Sykes A., Dahdaleh S., Clarke D.L., Belvisi M.G., Kon O.M., Fujita T., Jeffery P.K., Johnston S.L., Edwards M.R. Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium. PLoS Pathog. 2010, 6:e1001178.
8. Okazaki T., Honjo T. PD-1 and PD-1 ligands: from discovery to clinical application. Int. Immunol. 2007, 19:813-824.
9. Singh A.K., Stock P., Akbari O. Role of PD-L1 and PD-L2 in allergic diseases and asthma. Allergy 2011, 66:155-162.
10. Barber D.L., Wherry E.J., Masopust D., Zhu B.G., Allison J.P., Sharpe A.H., Freeman G.J., Ahmed R. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 2006, 439:682-687.
11. Chen L., Zhang Z., Chen W., Li Y., Shi M., Zhang J., Chen L., Wang S., Wang F.S. B7-H1 up-regulation on myeloid dendritic cells significantly suppresses T cell immune function in patients with chronic hepatitis B. J. Immunol. 2007, 178:6634-6641.
12. Wilkinson T.M.A., Donaldson G.C., Johnston S.L., Openshaw P.J.M., Wedzicha J.M. Respiratory syncytial virus, airway inflammation, and FEV1 decline in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2006, 173:871-876.
13. Tsuda M., Matsumoto K., Inoue H., Matsumura M., Nakano T., Mori A., Azuma M., Nakanishi Y. Expression of B7-H1 and B7-DC on the airway epithelium is enhanced by double-stranded RNA. Biochem. Biophys. Res. Commun. 2005, 330:263-270.
14. Telcian A.G., Laza-Stanca V., Edwards M.R., Harker J.A., Wang H., Bartlett N.W., Mallia P., Zdrenghea M.T., Kebadze T., Coyle A.J. RSV-induced bronchial epithelial cell PD-L1 expression inhibits CD8+ T cell nonspecific antiviral activity. J. Infect. Dis. 2011, 203:85-94.
15. Erickson J.J., Gilchuk P., Hastings A.K., Tollefson S.J., Johnson M., Downing M.B., Boyd K.L., Johnson J.E., Kim A.S., Joyce S. Viral acute lower respiratory infections impair CD8+ T cells through PD-1. J. Clin. Invest. 2012, 122:2967-2982.
16. Kan-o K., Matsumoto K., Inoue H., Fukuyama S., Asai Y., Watanabe W., Kurokawa M., Araya J., Kuwano K., Nakanishi Y. Corticosteroids plus long-acting beta(2)-agonists prevent double-stranded RNA-induced upregulation of B7-H1 on airway epithelium. Int. Arch. Allergy Immunol. 2013, 160:27-36.
17. Fukao T., Tanabe M., Terauchi Y., Ota T., Matsuda S., Asano T., Kadowaki T., Takeuchi T., Koyasu S. PI3K-mediated negative feedback regulation of IL-12 production in DCs. Nat. Immunol. 2002, 3:875-881.
18. Hazeki K., Nigorikawa K., Hazeki O. Role of phosphoinositide 3-kinase in innate immunity. Biol. Pharm. Bull. 2007, 30:1617-1623.
19. Marwick J.A., Caramori G., Stevenson C.S., Casolari P., Jazrawi E., Barnes P.J., Ito K., Adcock I.M., Kirkham P.A., Papi A. Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice. Am. J. Respir. Crit. Care Med. 2009, 179:542-546.
20. To Y., Ito K., Kizawa Y., Failla Y., Ito M., Kusama T., Elliott W.N., Hogg J.C., Adcock I.M., Barnes P.J. Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2010, 182:897-904.
21. Katsuyama M. NOX/NADPH oxidase, the superoxide-generating enzyme: its transcriptional regulation and physiological roles. J. Pharmacol. Sci. 2010, 114:134-146.
22. Murphy M.P. How mitochondria produce reactive oxygen species. Biochem. J. 2009, 417:1-13.
23. Papi A., Contoli M., Gasparini P., Bristot L., Edwards M.R., Chicca M., Leis M., Ciaccia A., Caramori G., Johnston S.L. Role of xanthine oxidase activation and reduced glutathione depletion in rhinovirus induction of inflammation in respiratory epithelial cells. J. Biol. Chem. 2008, 283:28595-28606.
24. Harper R.W., Xu C., Eiserich J.P., Chen Y., Kao C.Y., Thai P., Setiadi H., Wu R. Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium. FEBS Lett. 2005, 579:4911-4917.
25. Turi J.L., Wang X., McKie A.T., Nozik-Grayck E., Mamo L.B., Crissman K., Piantadosi C.A., Ghio A.J. Duodenal cytochrome b: an novel ferrireductase in airway epithelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 2006, 291:L272-L280.
26. Parsa A.T., Wardron J.S., Panner A., Crane C.A., Parney I.F., Barry J.J., Cachola K.E., Murray J.C., Tihan T. Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma. Nat. Med. 2007, 13:84-88.
27. Crane C.A., Panner A., Murray J.C., Wilson S.P., Xu H., Chen L., Simko J.P., Waldman F.M., Pieper R.O., Parsa A.T. PI(3) kinase is associated with a mechanism of immunoresistance in breast and prostate cancer. Oncogene 2009, 28:306-312.
28. Araki N., Johnson M.T., Swanson J.A. A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages. J. Cell Biol. 1996, 135:1249-1260.
29. Moriwaki A., Matsumoto K., Matsunaga Y., Fukuyama S., Matsumoto T., Kan-o K., Noda N., Asai Y., Nakanishi Y., Inoue H. IL-13 suppresses double-stranded RNA-induced IFN-λ production in lung cells. Biochem. Biophys. Res. Commun. 2011, 404:922-927.
30. Fung-Leung W.P. Phosphoinositide 3-kinase delta (PI3Kδ) in leukocyte signaling and function. Cell. Signal. 2011, 23:603-608.
31. Liu P., Jamaluddin M., Li K., Garofalo R.P., Casola A., Brasier A.R. Retinoic acid-inducible gene 1 mediates early antiviral response and toll-like receptor 3 expression in respiratory syncytial virus-infected airway epithelial cells. J. Virol. 2007, 81:1401-1411.