Potential mechanism of the anti-trypanosomal activity of organoruthenium complexes with bioactive thiosemicarbazones

Biological Trace Element Research

Volumn 153, Issue 1-3, 2013, Pages 371-381

  Demoro, Bruno ^a   Rossi, Miriam ^b   Caruso, Francesco ^c   Liebowitz, Daniel ^b   Olea Azar, Claudio ^d   Kemmerling, Ulrike ^e   Maya, Juan Diego ^e   Guiset, Helena ^f   Moreno, Virtudes ^f   Pizzo, Chiara ^a   Mahler, Graciela ^a   Otero, Lucía ^a   Gambino, Dinorah ^a  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^b VASSAR COLLEGE   (United States)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d UNIVERSITY OF CHILE   (Chile)

^e UNIVERSITY OF CHILE   (Chile)

^f UNIVERSITY OF BARCELONA   (Spain)

Author keywords

5 Nitrofuryl containing thiosemicarbazones; American trypanosomiasis; Chagas disease; Mechanism of trypanosomicidal action; Ruthenium p cymene compounds; Trypanosoma cruzi

Indexed keywords

CRUZIPAIN; DNA; FREE RADICAL; NIFURTIMOX; ORGANORUTHENIUM COMPLEX; RUTHENIUM DERIVATIVE; THIOSEMICARBAZONE DERIVATIVE; UNCLASSIFIED DRUG; ANTITRYPANOSOMAL AGENT; ORGANIC COMPOUND;

ANIMAL CELL; ANTIPROTOZOAL ACTIVITY; ARTICLE; ATOMIC FORCE MICROSCOPY; CHAGAS DISEASE; CONTROLLED STUDY; DRUG DNA INTERACTION; DRUG MECHANISM; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; EPIMASTIGOTE; GROWTH INHIBITION; IC 50; IN VITRO STUDY; MACROPHAGE; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; REDUCTION; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE; VISCOSITY; X RAY CRYSTALLOGRAPHY; ANIMAL; CHEMISTRY;

MAMMALIA; MURINAE; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI; TRYPANOSOMATIDAE;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; MICROSCOPY, ATOMIC FORCE; ORGANIC CHEMICALS; RUTHENIUM COMPOUNDS; THIOSEMICARBAZONES; TRYPANOCIDAL AGENTS;

EID: 84878408441     PISSN: 01634984     EISSN: 15590720     Source Type: Journal    
DOI: 10.1007/s12011-013-9653-4     Document Type: Article

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