Synthesis and invitro Evaluation of West Nile Virus Protease Inhibitors Based on the 2-{6-[2-(5-Phenyl-4H-{1,2,4]triazol-3-ylsulfanyl)acetylamino]benzothiazol-2-ylsulfanyl}acetamide Scaffold

ChemMedChem

Volumn 8, Issue 6, 2013, Pages 994-1001

  Samanta, Sanjay ^a   Lim, Ting Liang ^a   Lam, Yulin ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Antiviral agents; Docking studies; Inhibitors; Proteases; West Nile virus

Indexed keywords

2 [6 [2 (5 PHENYL 4H [1,2,4]TRIAZOL 3 YLSULFANYL)ACETYLAMINO]BENZOTHIAZOL 2 YLSULFANYL]ACETAMIDE; ACETAMIDE DERIVATIVE; ANTIVIRUS AGENT; MOLECULAR SCAFFOLD; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; BENZOTHIAZOLE DERIVATIVE; NS2B PROTEIN, FLAVIVIRUS; NS3 PROTEIN, FLAVIVIRUS; RNA HELICASE; SERINE PROTEINASE; THIOGLYCOLIC ACID DERIVATIVE; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; CELL MEDIATED CYTOTOXICITY; CONTROLLED STUDY; DRUG SYNTHESIS; IN VITRO STUDY; MICROWAVE IRRADIATION; MOLECULAR DOCKING; MOLECULAR LIBRARY; NONHUMAN; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PROTEINASE INHIBITION; STRUCTURE ACTIVITY RELATION; WEST NILE FLAVIVIRUS; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; MICROBIAL SENSITIVITY TEST; SYNTHESIS; DRUG ANTAGONISM; DRUG EFFECT;

ANTIVIRAL AGENTS; BENZOTHIAZOLES; DOSE-RESPONSE RELATIONSHIP, DRUG; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEASE INHIBITORS; RNA HELICASES; SERINE ENDOPEPTIDASES; STRUCTURE-ACTIVITY RELATIONSHIP; THIOGLYCOLATES; VIRAL NONSTRUCTURAL PROTEINS; WEST NILE VIRUS;

EID: 84878367059     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201300114     Document Type: Article

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